1.Estimation of Glomerular Filtration Rate from Plasma Creatinine and Height in Children.
Jeong Lan KIM ; Yong Hoon PARK ; Jeong Ok HAH
Yeungnam University Journal of Medicine 1988;5(1):93-100
In clinical practice, creatinine clearance (Ccr) remains the most commonly used laboratory assessment of glomerular function despite methodological and technical problems of urine collection. Schwartz et al. in 1976, reported that an accurate estimate of glomerular filtration rate (GFR) could be obtained from the simple determinations of plasma creatinine (Per) and body length (L): GFR (ml/min/1.73m2)=kL (cm)/Per (mg/100 ml), (k=constant). The subject of this study were 81 children admitted to our pediatric department from July, 1985 to June, 1987 and they were divided into three groups; group I, from 1 to 5 years old, group II, from 6 to 10 years old, group III, from 11 to 15 years old. The results were as following: 1) Measured creatinine clearance Ccr(M), ml/min/1.73m²) were 109.73±9.97 in group I, 108.26±9.02 in group II, 96.20±4.72 in group III and 105.48±5.23 in all age group. 2) Measured k(k(M)) obtained from CcrM=k Ht/Pcr were 0.49±0.03 in group I, 0.48±0.02 in group II, 0.43±0.02 in group III, and 0.47±0.02 in all age group (Ht; height). 3) Linear equations and correlation coefficient between Ht/Pcr (x) and Ccr (y) were y=0.82x-65.63 (r=0.99) in group I, y=0.61x-23.46(r=0.72) in group II, y=0.18x+54.44 (r=0.54) in group III and y=0.58x-22.13 (r=0.81) in all age group. 4) Ccr(E) was again estimated from linear equations between Ht/Pcr and Ccr(M) and k(E) was calculated with Ht/Pcr and Ccr(E) were 0.48±0.01 in group I, 0.49±0.01 in group II, 0.43±0.01 in group III and 0.47±0.00 in all age group. 5) Consistent values of k(E) and k(M) were highly significant as 95~97.5% in group I and II, 90~95% in group III and 97.5~99% in all age group. In summary, we could estimate GFR with height, plasma creatinine and measured k(k(M)) according to the age in easy and rapid way.
Child*
;
Creatinine*
;
Glomerular Filtration Rate*
;
Humans
;
Plasma*
;
Urine Specimen Collection
2.Electrocardiographic Findings in School Children.
Jae Honng PARK ; Jin Gon JUN ; Jeong Lan KIM
Yeungnam University Journal of Medicine 1987;4(2):23-27
Mass electrocardiographic (ECG) examination was performed on 13,801 children (male 7,526 and female 6,275) of elementary and middle school in Taegu from May 1. 1986. to April 30. 1987. We read their ECG according to the “pediatric Electrocardiography”1) The results were as following: The incidence of ECG abnormality was 1.05% (male 1.3% and female 0.75%). Fifty eight children (0.42%) had atrial and ventricular hypertrophy; two right atrial hypertrophy, five left atrial hypertrophy, thirty five right ventricular hypertrophy and sixteen left ventricular hypertrophy respectively. Ectopic beats occurred in 25 children (0.18%); They were atrial in 12 children, ventricular in 8 children and junctional in 5 children. There were 62 children (0.45%) of conduction disturbance; They were first degree atrioventricular (A-V) block in 21 children, type I second degree A-V block in 1 child, A-V dissociation in 1 child, right, right bundle branch block in 36 children, left bundle branch block in 1 child and WPW syndrome in 2 children. Nonspecific ST, T changes and sinus tachycardia were found in 3 and one children respectively.
Bundle-Branch Block
;
Child*
;
Daegu
;
Electrocardiography*
;
Female
;
Heart Block
;
Humans
;
Hypertrophy
;
Hypertrophy, Left Ventricular
;
Hypertrophy, Right Ventricular
;
Incidence
;
Tachycardia, Sinus
;
Wolff-Parkinson-White Syndrome
3.Neuroglial Cell and Alzheimer's Disease.
Journal of the Korean Society of Biological Psychiatry 2015;22(2):40-46
Neuroglial cells are fundamental for brain homeostasis and defense to intrinsic or extrinsic changes. Loss of their function and overreactivity to stimuli contribute to the aging of brain. Alzheimer's disease (AD) could be caused by more dramatic response in neuroglia associated with various chemokines and cytokines. Neuroglia of the AD brain shares some phenotypes with aging neuroglia. In addition, neuroglial activation and neuroinflammation are commonly showed in neurodegeneration. Thus neuroglia would be a promising target for therapeutics of AD.
Aging
;
Alzheimer Disease*
;
Astrocytes
;
Brain
;
Chemokines
;
Cytokines
;
Homeostasis
;
Microglia
;
Neuroglia*
;
Phenotype
4.Association of Caregiver Burden With Malnutrition Among Spousal Caregiver of Cognitive Impairment
Journal of Korean Geriatric Psychiatry 2022;26(1):39-45
Objective:
Among old adults, caring for a spouse with cognitive decline is well-known to be associated with significant risk to the caregiver’s health such as cardiovascular disease, depression and, especially, cognitive impairment. It is important to understand the caregiving-related risk factors for caregiver’s cognitive decline. Therefore, in this study, we examined the impact of caregiver’s burden on the modifiable lifestyle factors influencing cognitive decline among spousal caregivers (SCGs), focusing on nutritional status which contribute to SCG’s cognitive decline.
Methods:
A total of 44 subjects were included in the analysis. As clinical assessment, we evaluated the care burden (Zarit Burden Interview), depression (Geriatric Depression Scale), sleep quality (Pittsburgh Sleep Quality Index), cognitive function (Mini-Mental State Examination, MMSE) physical activity (International Physical Activity Questionnaire), and nutritional status (Mini Nutritional Assessment).
Results:
High Neuropsychiatric Inventory (NPI) score and low MMSE score were significantly correlated with increased care burden. The SCG’s caregiving burden was significantly associated with the risk of malnutrition and increased level of depressed mood. These significant relationships unchanged even after adjusting for care-recipient’s MMSE or NPI score.
Conclusion
This study provides substantial evidence that SCGs of cognitive impairment are at risk for depression and malnutrition, which can further affect cognitive decline. As such, these factors should be well assessed and monitored among SCGs for patient with cognitive impairment.
5.Effect of Cognitive Function, Social Activity Participation and Social Support on Quality of Life of Community-Dwelling Elderly.
Jisoon KIM ; Rhayun SONG ; Ki Woong KIM ; Jeong Lan KIM
Journal of Korean Geriatric Psychiatry 2016;20(1):25-32
OBJECTIVE: This study aimed to explore the effect of cognitive function, social activity participation and social support on quality of life (QoL) of community-dwelling elderly. METHODS: The data on 194 elderly were selected from the nationwide community cohort named Korean Longitudinal Study on Cognitive Aging and Dementia. All subjects were assessed QoL-Alzheimer's Disease (QoL-AD), Cumulative Illness Rating Scale, exercise habit, Mini-Mental State Examination, social activities, The Medical Outcomes Study-Social Support Survey. The data were analyzed with SPSS WIN V. 21.0 program. RESULTS: The mean of QoL among community-dwelling elderly was 35.49 (24–46) for QoL measured by QoL-AD. The variables of professional, residence status, physical health, exercise, cognitive function, social activity participation and social support explained 29.3% of variance in QoL of community-dwelling elderly. Among these factors, the significant predictors of QoL were social support (β=0.322, p<0.001), cognitive function (β=0.152, p=0.021), and religion activity (β=0.152, p=0.025). CONCLUSION: The study suggests that the focus of intervention program should be on cognitive function and social activity participation to improve QoL for elderly. Improving cognitive function and social activity will lead to the network of social support, consequently to increase QoL for elderly living in the community.
Aged*
;
Aging
;
Cohort Studies
;
Dementia
;
Humans
;
Longitudinal Studies
;
Quality of Life*
6.Validation of the Korean Version of the Delirium Motor Subtype Scale
Hyunkyung KIM ; Miji LEE ; In Sun KWON ; Jeong Lan KIM
Psychiatry Investigation 2018;15(1):6-12
OBJECTIVE: The Delirium Motor Subtype Scale (DMSS) is a validated and reliable instrument developed from various methods previously used to assess delirium motor subtypes. It focuses on pure motor disturbances with a relative specificity for delirium. The aim of this study was to investigate the validity and reliability of a Korean version of the DMSS (K-DMSS). METHODS: We recruited 145 patients who were older than 60 years and had been referred for psychiatric consultation for delirium. These patients were evaluated using the K-DMSS, Liptzin & Levkoff criteria, and the Korean version of the Delirium Rating Scale-Revised-98 (K-DRS-R98) to compare delirium motor subtypes. RESULTS: The internal consistency of the K-DMSS in assessing delirium motor subtypes was acceptable (Cronbach's alpha=0.79). Delirium motor subtypes identified with the K-DMSS and K-DRS-R98 showed almost perfect agreement (Cohen's Kappa=0.81), while those identified with the K-DMSS and Liptzin & Levkoff criteria showed substantial agreement (Cohen's Kappa=0.78). CONCLUSION: Our results suggest that the K-DMSS is a valid and reliable tool for identifying delirium subtypes.
Delirium
;
Humans
;
Reproducibility of Results
;
Sensitivity and Specificity
7.Outcome Differences by Delirium Motor Subtype in Patients with Ischemic Stroke
Hee Won YANG ; Miji LEE ; Jong Wook SHIN ; Hye Seon JEONG ; Jei KIM ; Jeong Lan KIM
Psychiatry Investigation 2019;16(11):852-859
OBJECTIVE: This study evaluated the outcomes of ischemic stroke patients according to delirium motor subtype.METHODS: This study included patients who were admitted to the stroke unit between August 2017 and March 2019 and met the DSM-5 diagnostic criteria for delirium. Patients were assessed twice weekly throughout their delirium episodes using the Korean version of the Delirium Motor Subtype Scale (K-DMSS) and the Korean version of the Delirium Rating Scale-Revised-98 (K-DRS-98). The clinical characteristics and short-term outcomes of the patients were also assessed.RESULTS: A total of 943 stroke patients were included; the rate of incident delirium was 10.18%. Of the 95 delirium patients, 34 were classified as the hyperactive subtype, 30 as the mixed subtype, 25 as the hypoactive and six as no subtype. Among the subtype groups, the hypoactive subtype had the highest initial scores on the National Institutes of Health Stroke Scale (NIHSS; 6.72±4.75, p=0.02) and the modified Rankin Scale (mRS; 3.96±1.24, p<0.01). Additionally, the mixed and hypoactive subtypes had longer durations (p<0.01) and more severe symptoms of delirium (p=0.03) than the other motor subtypes, and the hypoactive subtype group had a significantly longer hospital stay (36.88±27.71 days, p<0.01) than the other subtype groups. After adjusting for baseline covariates in a multiple linear regression analysis, these differences remained significant.CONCLUSION: The present results suggest that the motor subtype of delirium is associated with different characteristics and outcomes in ischemic stroke patients.
Delirium
;
Humans
;
Length of Stay
;
Linear Models
;
National Institutes of Health (U.S.)
;
Stroke
8.A Preliminary Study for the Development of a Korean Version of the Body Dysmormphic Disorder Examination-Self Report(BDDE-SR).
Jeong Lan KIM ; Ik Seung CHEE ; Suk Chul SHIN
Journal of Korean Neuropsychiatric Association 1999;38(4):754-763
OBJECTIVE: The purposes of this study were to develop a Korean version of the Body Dysmorphic Disorder Examination-Self Report (BDDE-SR)and to get informations about the body dissatisfaction of the Korean adolescents. METHOD: A Korean version of the BDDE-SR was applied to 417 Korean high school adolescents. Retest was conducted with 6-week interval in 100 adolescents. RESULTS: 1)Test-retest reliability of the total scores (Pearson's correlation coefficiency) was 0.883 (p<0.001)and test-retest reliabilities of each item also showed high correlation (Spearman's correlation coefficency range: 0.159-0.761) 2) Internal consistency by Cronbach's alpha of 0.922 (p<0.001)was very much high. 3) Five factors were extracted by factor analysis with the Varimax rotation. They were 'the distressing and embarrassment factor', 'the self-consciousness and negative self-evaluation factor', 'the avoidance factor', 'the camouflage factor', and 'the comparison factor'. 4)The total score of BDDE-SR of girls was statistically higher (52.4+/-24.8) than that of boys (37.7+/-20.6) The most dissatisfied body part was abdomen(6.8%) nose(6.4%) entire leg(6.0%) teeth (5.9%)and eyes(5.9%)in all the subjects. CONCLUSION: These results indicate that a Korean version of the BDDE-SR is a reliable instrument for the assessment of Body Dysmorphic Disorder (BDD) The authors suggest that future researches should be directed to obtaining clinical data of the patients with BDD and should test the validity of a Korean version of the BDDE-SR.
Adolescent
;
Body Dysmorphic Disorders
;
Diagnostic Self Evaluation
;
Female
;
Humans
;
Tooth
9.Colonic wall abnormalities on enhanced CT:Differentiation between inflammatory and neoplastic diseases.
Heoung Keun KANG ; Jeong Jin SEO ; Jae Kyu KIM ; Jin Gyoon PARK ; Byung Lan PARK ; Hyon De CHUNG
Journal of the Korean Radiological Society 1993;29(6):1253-1259
The computed tomographic(CT) findings of fourteen patients with inflammatory disease and 28 with neoplasm who had an abnormal colonic wall thickening, were retrospectively studied to establish CT criteria for each disorder in differentiating inflammatory from neoplastic lesions. According to homogeneity, density and contour of mural thickening and pericolic inflammatory change in enhanced CT scans, we classified colonic wall abnormalities into 6 patterns: I) multilayering with inner and outer hyper- and middle hypodensities, II) homogeneously hyperdense with pericolic inflammatory change, III) heterogeneously hyperdense with pericolic inflammatory change, IV) homogeneously heperdense with lobulated contour, V) heterogeneously hypodense with lobulated contour and VI) heterogeneously mixed densities with irregular lobulated contour. Type I, II and III were distinctively identified in inflammatory disease, type IV, V in neoplasm, and type VI in boty diseases. We conclude that enhanced CT could be helpful in the initial diagnosis and/or suggestion of abnormal colonic wall disease and differentiation of inflammatory from neoplastic diseases.
Colon*
;
Diagnosis
;
Humans
;
Retrospective Studies
;
Tomography, X-Ray Computed
10.Cognitive Function and Self-Care in Patients with Chronic Heart Failure.
Jin Shil KIM ; Seon Young HWANG ; Jae Lan SHIM ; Myung Ho JEONG
Korean Circulation Journal 2015;45(4):310-316
BACKGROUND AND OBJECTIVES: This examined the association of cognitive function with self-care and major adverse cardiac events (MACE) among heart failure (HF) patients. SUBJECTS AND METHODS: In this prospective study, 86 outpatients with HF completed face-to-face interviews including neuropsychological testing to evaluate cognitive function and the use of the Self-Care of Heart Failure Index to measure self-care. Functional status was assessed with the New York Heart Association (NYHA) classification. Follow-up data on MACE were obtained at 24 months after enrollment. RESULTS: Compared with the Korean norm values, more than half of the HF patients had cognitive deficits in global function (33.0%), immediate recall (65.1%), delayed recall memory (65.1%), and executive function (60.5%). Patients with symptomatic HF (> or =NYHA class II) had the higher risk for substantially poor cognitive function in all areas of cognitive function than asymptomatic HF patients (NYHA class I, p<0.05). Most patients demonstrated poor self-care adequacy in maintenance (84.9%), management of symptoms (100%), and confidence (86.0%). After adjustment for age and gender, memory function was significantly associated with self-care confidence (odds ratio 1.41, 95% confidence interval 1.03-1.92, p=0.033). No relationship was found between cognition and self-care maintenance. There were 19 MACE's during the 24-month follow-up. Patients without MACE had a significantly higher global cognitive function (p=0.024), while no cognitive domains were significant predictors of MACE when adjusted for age and gender. CONCLUSION: HF patients with memory loss have poorer self-care confidence. Studies are warranted to examine the functional implication of cognitive deficits and adverse outcomes in a larger sample.
Classification
;
Cognition
;
Executive Function
;
Follow-Up Studies
;
Heart
;
Heart Failure*
;
Humans
;
Memory
;
Memory Disorders
;
Memory, Short-Term
;
Neuropsychological Tests
;
Outpatients
;
Prospective Studies
;
Self Care*