1.Three Cases of Congenital Adrenal Hyperplasia Owing to Multiple Mutations of CYP21 Gene.
Jun HEO ; Jae Hong YU ; Dong Ki JEONG
Journal of Korean Society of Pediatric Endocrinology 2001;6(2):176-181
Congenital adrenal hyperplasia(CAH) results from an inherited defect in enzymatic steps required to synthesize cortisol from cholesterol. 21-hydroxylase deficiency accounts for 95% cases of CAH. We have analyzed CYP21 genes of CAH by PCR direct sequencing. Our results shows three cases of CAH owing to multiple mutations of CYP21 gene; first case, IVS2AS, A/G, -13, Ile172Asn; second case, IVS2AS, A/G, -13, Ile236Asn, Val237Glu, Met239Lys; third case, Ile172Asn, C to G at 1590nt, Val281Leu, Arg484Pro, G to A at 2697nt. Mutations such as Ile236Asn, Val237Glu, Met239Lys, and Arg484Pro are first noted in Korea.
Adrenal Hyperplasia, Congenital*
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Cholesterol
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Hydrocortisone
;
Korea
;
Polymerase Chain Reaction
;
Steroid 21-Hydroxylase
2.A case of retroauricular neurothekeoma.
Kil Yang JEONG ; Tong Suk CHUN ; Ki Hwan HONG
Korean Journal of Otolaryngology - Head and Neck Surgery 1992;35(1):139-142
No abstract available.
Neurothekeoma*
3.Cases of the surgical correction of facial asymmetry
Hong Yell HUH ; Sung Ki MIN ; Sang Ki CHO ; In Won JEONG
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons 1991;13(2):191-198
No abstract available.
Facial Asymmetry
4.A case of nocardiosis.
Jeong Hee KIM ; Ki Heon YOON ; Jee Hong YOO ; Hong Mo KANG ; Jin Tae SUH
Tuberculosis and Respiratory Diseases 1992;39(4):355-360
No abstract available.
Nocardia Infections*
5.Antiarrhythmic Effect of Artemisinin in an Ex-vivo Model of Brugada Syndrome Induced by NS5806
Hyung Ki JEONG ; Seo Na HONG ; Namsik YOON ; Ki Hong LEE ; Hyung Wook PARK ; Jeong Gwan CHO
Korean Circulation Journal 2023;53(4):239-250
Background and Objectives:
Brugada syndrome (BrS) is an inherited arrhythmia syndrome that presents as sudden cardiac death (SCD) without structural heart disease. One of the mechanisms of SCD has been suggested to be related to the uneven dispersion of transient outward potassium current (Ito ) channels between the epicardium and endocardium, thus inducing ventricular tachyarrhythmia. Artemisinin is widely used as an antimalarial drug. Its antiarrhythmic effect, which includes suppression of Ito channels, has been previously reported. We investigated the effect of artemisinin on the suppression of electrocardiographic manifestations in a canine experimental model of BrS.
Methods:
Transmural pseudo-electrocardiograms and epicardial/endocardial transmembrane action potentials (APs) were recorded from coronary-perfused canine right ventricular wedge preparations (n=8). To mimic the BrS phenotypes, acetylcholine (3 μM), calcium channel blocker verapamil (1 μM), and Ito agonist NS5806 (6–10 μM) were used.Artemisinin (100–150 μM) was then perfused to ameliorate the ventricular tachyarrhythmia in the BrS models.
Results:
The provocation agents induced prominent J waves in all the models on the pseudoelectrocardiograms. The epicardial AP dome was attenuated. Ventricular tachyarrhythmia was induced in six out of 8 preparations. Artemisinin suppressed ventricular tachyarrhythmia in all 6 of these preparations and recovered the AP dome of the right ventricular epicardium in all preparations (n=8). J wave areas and epicardial notch indexes were also significantly decreased after artemisinin perfusion.
Conclusions
Our findings suggest that artemisinin has an antiarrhythmic effect on wedge preparation models of BrS. It might work by inhibition of potassium channels including Ito channels, subsequently suppressing ventricular tachycardia/ventricular fibrillation.
6.A Case of Congenital Hemangiopericytoma of Small Bowel Associated with Intestinal Obstruction.
Ki Min KIM ; Seong Hee PARK ; Eun Jeong KIM ; Ki Hong PARK ; Byung Heon KIM ; Seong Ryul RYU
Journal of the Korean Society of Neonatology 1997;4(2):276-279
Hemangiopericytoma was first described by Stout & Murray in 1942 and was an uncommon soft tissue tumor thought to be derived from vascular pericytes. Approximately 10-15% of the cases occur in children have a propensity to develop in the region of head, neck and lower extremities. We experienced a case of congenital hemangiopericytoma of small bowel in a male neonate who showed vomiting and abdorninal distension. We reported a case of congenital hemangiopericytoma of small bowel with brief review of related literature.
Child
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Head
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Hemangiopericytoma*
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Humans
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Infant, Newborn
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Intestinal Obstruction*
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Intestine, Small
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Lower Extremity
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Male
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Neck
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Pericytes
;
Vomiting
7.Two Cases of Clear Cell Carcinoma of Ovary.
Chang Jin JEONG ; Ki Hong CHANG ; Yoon Ho LEE ; Jang Ho LEE
Korean Journal of Gynecologic Oncology and Colposcopy 1993;4(3):86-91
Clear cell carcinoma of ovary is a rare epithelial ovarian tumor, and increased in its incidence recently. Clear cell carcinoma of ovary was known t,o be highly malignant than other epithelial ovarian tumors. The clinical and pathologic findings of two casea af clear cell carcinoma of ovary are reported and reviewed briefly.
Female
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Incidence
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Ovary*
8.Value of the Left Portal Vein Angle (LPVA) on CT for the Diagnosis of Liver Cirrhosis: Comparison with the Caudateto Right Lobe (C/RL) Ratio.
Byung Ihn CHOI ; Joon Koo HAN ; Kyung Mo YEON ; Yoong Ki JEONG ; Hong Dae KIM
Journal of the Korean Radiological Society 1995;32(5):737-742
PURPOSE: To verify the usefulness of left portal vein angle (LPVA) on CT scan in the diagnosis of liver cirrhosis and to compare its diagnostic value with that of caudate to right lobe ratio (C/RL ratio). MATERIALS AND METHODS: LPVA, an angle formed by a vertical line and a line connecting the center of the vertebral body to the umbilical point of the left portal vein, and C/RL ratio were measured on CT scans of 100 cirrhotic and 100 normal livers. Diagnostic values of LPVA and C/RL ratio were compared statistically. RESULTS: The mean of LPVA was 18.9 degrees(SD; 7.6) for normal livers and 25.8 degreesSD; 8.4) for cirrhotic livers (P<0.001). The mean of C/RL ratio was 0.47(SD; 1.10) for normal livers and 0.58(SD;0.14) for cirrhotic livers (P<0.001). When LPVA was greater than 30 degreesliver cirrhosis was diagnosed with 36% sensitivity and 92% specificity. When C/RL ratio was greater than 0.60, the diagnose of liver cirrhosis was with 41% sensitivity and 90% specificity. There was no significant difference of the diagnostic accuracy between LPVA and C/R L ratio in ROC analysis. CONCLUSION: Both LPVA and C/RL ratio are useful diagnostic indices of liver cirrhosis on CTscan. LPVA is more convenient to measure than C/RL ratio.
Diagnosis*
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Fibrosis
;
Liver Cirrhosis*
;
Liver*
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Portal Vein*
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ROC Curve
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Sensitivity and Specificity
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Tomography, X-Ray Computed
9.Extrapelvic endometriosis.
Ki Hong CHANG ; Hye Jeong YEON ; Kyoung Soo PARK ; Yoon Ho LEE ; Dong Hun HWANG
Korean Journal of Fertility and Sterility 1993;20(2):177-181
No abstract available.
Endometriosis*
;
Female
10.A Case of Localized Axillary Syringomas.
Seung Hyun SOHNG ; Jeong Young PARK ; Dong Hoon SHIN ; Jong Soo CHOI ; Ki Hong KIM
Korean Journal of Dermatology 2012;50(5):489-490