1.Metachronous Bilateral Renal Lymphangiomatosis Mimicking as a Simple Renal Cyst.
Hoon Ah JANG ; Jeong Hyun BAN ; Myeong Heon JIN ; Mi Mi OH ; Du Geon MOON ; Duck Ki YOON
Korean Journal of Urology 2008;49(5):454-456
Renal lymphangiomatosis is a rare developmental malformation of the perirenal lymphatic system, and this can result in the development of cystic masses in the peri-pelvic or peri-renal areas. This is difficult to differentiate from other cystic renal disease on imaging studies. We present here a case of metachronous bilateral renal lymphangiomatosis that was falsely diagnosed as a simple renal cyst. A 47 year-old man was referred for a large amount of drainage after right renal cyst marsupialization. The abdominal computed tomography(CT) findings and fluid analysis were compatible with a lymphangiomatosis. After 6 month, he presented with flank pain on his left side and CT showed intracystic hemorrhage on the left renal lymphangiomatosis. Percutaneus drainage and conservative management were done.
Male
;
Humans
;
Cysts
2.Metachronous Bilateral Renal Lymphangiomatosis Mimicking as a Simple Renal Cyst.
Hoon Ah JANG ; Jeong Hyun BAN ; Myeong Heon JIN ; Mi Mi OH ; Du Geon MOON ; Duck Ki YOON
Korean Journal of Urology 2008;49(5):454-456
Renal lymphangiomatosis is a rare developmental malformation of the perirenal lymphatic system, and this can result in the development of cystic masses in the peri-pelvic or peri-renal areas. This is difficult to differentiate from other cystic renal disease on imaging studies. We present here a case of metachronous bilateral renal lymphangiomatosis that was falsely diagnosed as a simple renal cyst. A 47 year-old man was referred for a large amount of drainage after right renal cyst marsupialization. The abdominal computed tomography(CT) findings and fluid analysis were compatible with a lymphangiomatosis. After 6 month, he presented with flank pain on his left side and CT showed intracystic hemorrhage on the left renal lymphangiomatosis. Percutaneus drainage and conservative management were done.
Male
;
Humans
;
Cysts
3.A Case of Pyoderma Gangrenosum Occurring in Behcet's Disease.
Dea Hyun BAN ; Jeong Hun PARK ; Joo Heung LEE ; Sang Wahn KOO ; Gwang Seong CHOI ; Young Keun KIM
Korean Journal of Dermatology 2000;38(8):1094-1098
Pyoderma gangrenosum occuring in Behcet's disease have been rarely reported, but there are several clinical and histological similarities between Behcet's disease and pyoderma gangrenosum. We report the case of pyoderma gangrenosum occuring in Behcet's disease and describe the similarities of these diseases.
Pyoderma Gangrenosum*
;
Pyoderma*
4.A case of Annlular Elastolytic Giant Cell Granuloma.
Jeong Hun PARK ; Dae Hyun BAN ; Sang Whan KOO ; Joo Heung LEE ; Young Keun KIM ; Gwang Seong CHOI
Korean Journal of Dermatology 1999;37(12):1834-1836
Annular elastolytic giant cell granuloma (AEGCG) is an inflammatory disorder characterized by the annular plaques with serpiginous raised borders on the sun-exposed area. Its pathologic finding shows the patchy granulomatous infiltration composed of multinucleated giant cells, histiocytes, lymphocytes and disappearance of the elastic fibers secondary to being engulfed by the giant cells. We report a case of AEGCG in a 59-year-old-male. He had several annular, erythematous plaques with raised borders on his dorsum of the hand, neck, back and the typical histologic features of AEGCG.
Elastic Tissue
;
Giant Cells*
;
Granuloma, Giant Cell*
;
Hand
;
Histiocytes
;
Lymphocytes
;
Neck
5.Nationwide Mortality Data after Flow-Diverting Stent Implantation in Korea
Tackeun KIM ; O Ki KWON ; Heeyoung LEE ; Min Jai CHO ; Hyun Jean JEONG ; Seung Pil BAN
Journal of Korean Neurosurgical Society 2018;61(2):219-223
OBJECTIVE: To investigate nationwide statistics on flow-diverting stent usage for cerebral aneurysm treatment and related mortality data.METHODS: We requested data extraction from the National Health Insurance Service claims database using electronic data interchange codes (J3207064, J3207073). Patient and hospital information as well as death statistics were collected from the database.RESULTS: A total of 169 procedures were performed using flow-diverting stents for cerebral aneurysm treatment from November 2014 to December 2016 in Korea. The majority of primary diagnosis was unruptured intracranial aneurysm. During the study period, nine subjects died, including one patient initially diagnosed with subarachnoid hemorrhage. The crude mortality rate was 5.3%. Five patients died within one month after the procedure; therefore, the estimated periprocedural mortality rate was 3.0±1.3%. The mortality rate as of the last day of 2016 was 6.3±2.1%.CONCLUSION: In a 171 person-year follow-up in a Korean series, nine deaths occurred after flow-diverting stent treatment. The crude mortality rate in Korea (5.3%) was higher than that reported in a previous meta-analysis (3.8%).
Diagnosis
;
Follow-Up Studies
;
Humans
;
Intracranial Aneurysm
;
Korea
;
Mortality
;
National Health Programs
;
Stents
;
Subarachnoid Hemorrhage
6.Surgical Outcomes of Robotic MRND versus Conventional Open MRND for Papillary Thyroid Carcinoma with Lateral Neck Node Metastasis: Comparative Analysis using Propensity Score Matching.
Kwang Hyun YOON ; Won Woong KIM ; Ji Young YOO ; Eun Jeong BAN ; Hai Young SON ; Sang Wook KANG ; Jong Ju JEONG ; Kee Hyun NAM ; Woong Youn CHUNG ; Cheong Soo PARK
Korean Journal of Endocrine Surgery 2013;13(4):227-233
PURPOSE: During the past decade, various endoscopic thyroid surgeries have been conducted, each with its own benefits. The incorporation of robotic systems to endoscopic thyroid surgery has improved the visualization and precision of endoscopic techniques. We previously reported our initial experience with robotic modified radical neck dissection (MRND) of papillary thyroid carcinoma (PTC) with lateral neck node metastasis (LNM). The aim of this study was to compare surgical outcomes of robotic vs. conventional open MRND of PTC with LNM using propensity score matching. METHODS: From January 2008 to February 2011, 515 patients with PTC with LNM were enrolled. One hundred patients underwent robotic MRND, and 415 patients underwent conventional open MRND. These two groups were retrospectively compared with respect to their clinicopathological characteristics, surgical outcomes, and surgical completeness. Furthermore, to avoid selection bias, propensity score matching analysis was used to compare surgical outcomes of each group without any compounding factors. RESULTS: The operative time for the robotic MRND was longer than for the open MRND (297.9±60.2 min vs. 212.1±55.6 min, P=0.089). However, the mean numbers of retrieved lymph nodes and mean hospital stay after surgery were similar in the two groups (36.0±12.9 vs. 40.8±13.3, P=0.235), (6.1±1.6 days vs. 6.1±2.1 days, P=0.577). The complication rates were similar between the two groups, and there was no statistical difference in postoperative thyroglobulin levels between groups (0.51±0.83 ng/ml vs. 0.89±2.46 ng/ml, P=0.593). CONCLUSION: According to our study, robotic MRND shows similar surgical outcomes to conventional open MRND after case-matched analyses. We suggest that robotic MRND is an acceptable alternative as an operative method for PTC with LNM, resulting in excellent cosmesis and patient satisfaction.
Humans
;
Length of Stay
;
Lymph Nodes
;
Methods
;
Neck Dissection
;
Neck*
;
Neoplasm Metastasis*
;
Operative Time
;
Patient Satisfaction
;
Propensity Score*
;
Retrospective Studies
;
Selection Bias
;
Thyroglobulin
;
Thyroid Gland*
;
Thyroid Neoplasms*
7.Is focused parathyroidectomy appropriate for patients with primary hyperparathyroidism?.
Won Woong KIM ; Yumie RHEE ; Eun Jeong BAN ; Cho Rok LEE ; Sang Wook KANG ; Jong Ju JEONG ; Kee Hyun NAM ; Woong Youn CHUNG ; Cheong Soo PARK
Annals of Surgical Treatment and Research 2016;91(3):97-103
PURPOSE: The aim of this study was to determine whether focused or complete parathyroidectomy was more appropriate and to compare follow-up data in primary hyperparathyroidism (PHPT). METHODS: We retrospectively analyzed 225 operations for PHPT at Yonsei University Health System between 2000 and 2012. After excluding 93 patients, the remaining 132 were divided into 2 groups: those who underwent focused parathyroidectomy (FP) and those who underwent conventional parathyroidectomy (CP). We compared clinicopathological features; preoperative calcium, parathyroid hormone (PTH), phosphorus, vitamin D, 24-hour urine calcium, and alkaline phosphatase levels; postoperative calcium and PTH levels; pathologic diagnosis; multiplicity; and results of a localization study between the 2 groups. RESULTS: There was no significant difference in the rates of development of postoperative persistent hyperparathyroidism (1/122 FP patients and 1/10 CP patients) between the 2 groups due to a technical reason (FP 0.8% vs. CP 10.0%, P = 0.146). Multiglandular disease (MGD) was uncommon in all cases (6 of 132, 4.5%). All MGD cases were diagnosed using a preoperative localization study. Sestamibi scan and ultrasonography sensitivity were 94.2% and 90.2%, respectively. CONCLUSION: We suggest that FP is appropriate in PHPT, except in cases of MGD if detected before the operation using preoperative imaging. Knowledge of hereditary PHPT and improved preoperative localization studies, such as high-resolution ultrasonography, contributed to the decision to perform FP rather than CP in all cases of unilateral results of the localizing study.
Alkaline Phosphatase
;
Calcium
;
Diagnosis
;
Follow-Up Studies
;
Humans
;
Hyperparathyroidism
;
Hyperparathyroidism, Primary*
;
Parathyroid Hormone
;
Parathyroidectomy*
;
Phosphorus
;
Retrospective Studies
;
Technetium Tc 99m Sestamibi
;
Ultrasonography
;
Vitamin D
8.Is focused parathyroidectomy appropriate for patients with primary hyperparathyroidism?.
Won Woong KIM ; Yumie RHEE ; Eun Jeong BAN ; Cho Rok LEE ; Sang Wook KANG ; Jong Ju JEONG ; Kee Hyun NAM ; Woong Youn CHUNG ; Cheong Soo PARK
Annals of Surgical Treatment and Research 2016;91(3):97-103
PURPOSE: The aim of this study was to determine whether focused or complete parathyroidectomy was more appropriate and to compare follow-up data in primary hyperparathyroidism (PHPT). METHODS: We retrospectively analyzed 225 operations for PHPT at Yonsei University Health System between 2000 and 2012. After excluding 93 patients, the remaining 132 were divided into 2 groups: those who underwent focused parathyroidectomy (FP) and those who underwent conventional parathyroidectomy (CP). We compared clinicopathological features; preoperative calcium, parathyroid hormone (PTH), phosphorus, vitamin D, 24-hour urine calcium, and alkaline phosphatase levels; postoperative calcium and PTH levels; pathologic diagnosis; multiplicity; and results of a localization study between the 2 groups. RESULTS: There was no significant difference in the rates of development of postoperative persistent hyperparathyroidism (1/122 FP patients and 1/10 CP patients) between the 2 groups due to a technical reason (FP 0.8% vs. CP 10.0%, P = 0.146). Multiglandular disease (MGD) was uncommon in all cases (6 of 132, 4.5%). All MGD cases were diagnosed using a preoperative localization study. Sestamibi scan and ultrasonography sensitivity were 94.2% and 90.2%, respectively. CONCLUSION: We suggest that FP is appropriate in PHPT, except in cases of MGD if detected before the operation using preoperative imaging. Knowledge of hereditary PHPT and improved preoperative localization studies, such as high-resolution ultrasonography, contributed to the decision to perform FP rather than CP in all cases of unilateral results of the localizing study.
Alkaline Phosphatase
;
Calcium
;
Diagnosis
;
Follow-Up Studies
;
Humans
;
Hyperparathyroidism
;
Hyperparathyroidism, Primary*
;
Parathyroid Hormone
;
Parathyroidectomy*
;
Phosphorus
;
Retrospective Studies
;
Technetium Tc 99m Sestamibi
;
Ultrasonography
;
Vitamin D
9.Lactate Dehydrogenase A as a Potential New Biomarker for Thyroid Cancer
Eun Jeong BAN ; Daham KIM ; Jin Kyong KIM ; Sang-Wook KANG ; Jandee LEE ; Jong Ju JEONG ; Kee-Hyun NAM ; Woong Youn CHUNG ; Kunhong KIM
Endocrinology and Metabolism 2021;36(1):96-105
Background:
Several cancers show increased levels of lactate dehydrogenase A (LDHA), which are associated with cancer progression. However, it remains unclear whether LDHA levels are associated with papillary thyroid cancer (PTC) aggressiveness or with the presence of the PTC prognostic marker, the BRAFV600E mutation. This study aimed to evaluate the potential of LDHA as a PTC prognostic marker.
Methods:
LDHA expression was examined in 83 PTC tissue specimens by immunohistochemistry. Human thyroid cell lines were genetically manipulated to overexpress BRAFV600E or were treated with a BRAF-specific short hairpin RNA (shBRAF), whose effects on LDHA expression were evaluated by Western blotting. Data from 465 PTC patients were obtained from The Cancer Genome Atlas (TCGA) database and analyzed to validate the in vitro results.
Results:
LDHA was aberrantly overexpressed in PTC. Intense immunostaining for LDHA was observed in PTC specimens carrying mutated BRAF, whereas the intensity was less in wild-type BRAF samples. Overexpression of BRAFV600E resulted in LDHA upregulation, whereas treatment with shBRAF downregulated LDHA in human thyroid cell lines. Furthermore, LDHA mRNA expression was significantly elevated and associated with BRAFV600E expression in thyroid cancer tissues from TCGA database. Additionally, LDHA overexpression was found to be correlated with aggressive clinical features of PTC, such as lymph node metastases and advanced tumor stages.
Conclusion
LDHA overexpression is associated with the BRAFV600E mutation and an aggressive PTC behavior. Therefore, LDHA may serve as a biomarker and therapeutic target in PTC.
10.Development of End Stage Renal Disease after Long-Term Ingestion of Chaga Mushroom: Case Report and Review of Literature
Sua LEE ; Hwa Young LEE ; Yohan PARK ; Eun Jeong KO ; Tae Hyun BAN ; Byung Ha CHUNG ; Hyun Soon LEE ; Chul Woo YANG
Journal of Korean Medical Science 2020;35(19):e122-
Chaga mushrooms are widely used in folk remedies and in alternative medicine. Contrary to many beneficial effects, its adverse effect is rarely reported. We here report a case of end-stage renal disease after long-term taking Chaga mushroom. A 49-year-old Korean man with end stage renal disease (ESRD) was transferred to our hospital. Review of kidney biopsy finding was consistent with chronic tubulointerstitial nephritis with oxalate crystal deposits and drug history revealed long-term exposure to Chaga mushroom powder due to intractable atopic dermatitis. We suspected the association between Chaga mushroom and oxalate nephropathy, and measured the oxalate content of remained Chaga mushroom. The Chaga mushroom had extremely high oxalate content (14.2/100 g). Estimated daily oxalate intake of our case was 2 times for four years and 5 times for one year higher than that of usual diet. Chaga mushroom is a potential risk factor of chronic kidney disease considering high oxalate content. Nephrologist should consider oxalate nephropathy in ESRD patients exposed to Chaga mushrooms.