1.The Effects of Superoxide Radical on Rat Detrusor Contractility.
Hyung Jee KIM ; Jeong Hwan JIN ; Gil Ho LEE
Korean Journal of Urology 2000;41(4):538-542
No abstract available.
Animals
;
Rats*
;
Superoxides*
2.5-Fluorouracil, Leucovorin ( FL ) Combination Chemotherapy in Advanced or Recurrent Colo - rectal Cancer.
Jeong Hwan CHO ; Hyuk Chan KWON ; Hyo Jin KIM
Journal of the Korean Cancer Association 1999;31(5):1003-1010
PURPOSE: We studied the effectiveness and toxicities of 5-fluorouracil+leucovorin, combination chemotherapy in advanced or recurred colo-rectal cancer patients, who didn't have previous chemotherapy and enrolled from August 1993 to July 1998. MATERIALS AND METHODS: All patients were treated with leucovorin followed by 5-fluorouracil for 5 consecutive days every 4 weeks. Among 43 patients who were enrolled, 40 patients received treatment at least 2 courses, and they were evaluable. Male to female ratio was 21 to 19. In serum CEA level, 27 patients were greater than 5 ng/ml and 13 were less than 5 ng/ml. And primary site was colon in 21 patients and rectum in 19 patients. RESULTS: The complete response rate was 7,5% and the partial response rate was 25%. The median survival duration was 14.7 months, the median response duration was 16.0 months, and median time to progression was 7.3 months. In the analysis of response, survival duration, time to progression according to various characteristics of patients, serum CEA level and liver involvement were revealed significant difference in survival duration, time to progression (p=0.0122, 00350 & 0.0202, 0.0123) on univariate analysis, but no significant difference on multivariates. Hematologic and non-hematologic toxicities were mild and tolerable. CONCLUSION: This study indicates that the combination of 5-fluorouracil (370 mg/m) and leucovorin (20 mg/m) is effective and tolerable regimen in advanced or recurred colo-rectal cancer patients without previous chemotherapy.
Colon
;
Drug Therapy
;
Drug Therapy, Combination*
;
Female
;
Fluorouracil*
;
Humans
;
Leucovorin*
;
Liver
;
Male
;
Rectal Neoplasms*
;
Rectum
3.A Case of Pyogenic Liver Abscess.
Jeong Bok LEE ; Dong Hwan CHO ; Sook Kyeung JUNG ; Won Jae PARK ; Jin Kook KANG
Journal of the Korean Pediatric Society 1983;26(11):1111-1114
No abstract available.
Liver Abscess, Pyogenic*
4.Follow-up study of Surgical Treatment of Lumbar Spinal Stenosis Using Wiltse Instrumentation.
Byung Jik KIM ; Jeong Gook SEO ; Han Sang JIN ; Dong Hwan SIN ; Lyl Kyu CHOI
Journal of Korean Society of Spine Surgery 1997;4(1):129-135
No abstract available.
Follow-Up Studies*
;
Spinal Stenosis*
5.Analysis of Kinship Index Distributions in Koreans Using Simulated Autosomal STR Profiles.
In Seok YANG ; Hwan Young LEE ; Su Jeong PARK ; Woo Ick YANG ; Kyoung Jin SHIN
Korean Journal of Legal Medicine 2013;37(2):57-65
Kinship testing in forensic casework is largely based on a likelihood ratio (LR) approach with short tandem repeat (STR) markers; however, in order to efficiently identify potential relatives in a specific population, the threshold values for kinship prediction should be determined by analyzing the kinship index distributions of the population in question. In this study, 250,000 DNA profiles were simulated using allele frequencies at 20 autosomal STR loci in Koreans, then the LRs were calculated for true close relatives and unrelated pairs. The LR distributions in related and unrelated pairs under a given relationship were compared in 2 sets of 13 Combined DNA Index System (CODIS) and 20 STR profiles. Using 13 CODIS STRs, true relatives in parent/child and full-sibling relationships were sufficiently discriminated from unrelated pairs with LR thresholds of 1,000 and 100, respectively. However, the CODIS STRs lacked the discriminatory power to differentiate between related and unrelated pairs in uncle/nephew and first cousin relationships due to high false-positive and false-negative rates with a LR threshold of 10. Increasing the number of STR loci to 20 increased discrimination of close relatives, but high false results remained in uncle/nephew and first cousin relationships. The kinship index data from this study will help make decisions on various kinship testing and familial searching in Koreans.
Asian Continental Ancestry Group
;
Discrimination (Psychology)
;
DNA
;
Gene Frequency
;
Humans
;
Microsatellite Repeats
6.A New Treatment Method of Mandibular Fracture using Acrylic Splint.
Doo Seong JEONG ; Jae Hyun PARK ; Jin Hwan KIM ; Joon CHOE
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1999;26(3):482-486
As modern society becomes increasingly complex, there has been a steady increase in violence, as well as in automobile and industrial accidents. This has resulted in an increased incidence of facial injuries, including mandibular fractures. Many methods have been advocated to achieve reestablishment of normal feature and function. The choice generally depends upon such factors as location of the fractures, displacements, status of the dentition and favorability of the fracture line. Many cases of mandibular fracture are treated by intermaxillay fixation using an arch bar or bite block(acrylic splint)for rapid bone union and minimal displacement. However, there had been some problems, such as discomfort to patients, limitation to eating and weight loss, poor oral hygiene, and temporomandibular joint ankylosis. As a consequence, we have modified the shape of the acrylic splint and method of fixation for circum-mandibular fixation instead of intermaxillary fixation. Acrylic splints are rigid, strong, easily adjusted and repaired, translucent, lightweight and well tolerated by the oral mucosa. The splints are properly secured to each tooth and bind all the teeth together as a single unit. Authors have used modified acrylic splints as tools of circum-mandibular fixation in 12 cases of mandibular symphysis and body fracture from May 1997 to August 1998, achieving the results of very good occlusal relationship, oral hygiene and comfort to patients.
Accidents, Occupational
;
Ankylosis
;
Automobiles
;
Dentition
;
Eating
;
Facial Injuries
;
Humans
;
Incidence
;
Mandibular Fractures*
;
Mouth Mucosa
;
Oral Hygiene
;
Splints*
;
Temporomandibular Joint
;
Tooth
;
Violence
;
Weight Loss
7.An Anatomical Study of the Human Caudate Lobe.
Baik Hwan CHO ; Hee Chul YU ; Zhe Wu JIN ; Eun Jeong JO
Korean Journal of Hepato-Biliary-Pancreatic Surgery 2004;8(1):1-12
No abstract available.
Humans*
8.Three Cases of Mobius Syndrome in a Family.
Hwan Mo JEONG ; Seung Hee HONG ; Dong Jin SHIN
Journal of the Korean Neurological Association 1996;14(4):1035-1041
Mobius syndrome is generally considered to be a static disorder of congenital origin, and is manifested as unilateral or bilateral facial weakness and lateral gaze limitation. In most instances the syndrome occurs sporadically, but rarely familial cases have been reported. We report a family of three members with Mobius syndrome; a 7-year-old girl, a 6-year-old boy, and their 29-year-old mother. Each patient revealed facial diplegia, and unilateral or bilateral lateral rectus palsy. Brain MRI scans showed normal and there were no definite brainstem dysfunctions on electrophysiologic studies.
Abducens Nerve Diseases
;
Adult
;
Brain
;
Brain Stem
;
Child
;
Female
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Mobius Syndrome*
;
Mothers
9.Three Cases of Mobius Syndrome in a Family.
Hwan Mo JEONG ; Seung Hee HONG ; Dong Jin SHIN
Journal of the Korean Neurological Association 1996;14(4):1035-1041
Mobius syndrome is generally considered to be a static disorder of congenital origin, and is manifested as unilateral or bilateral facial weakness and lateral gaze limitation. In most instances the syndrome occurs sporadically, but rarely familial cases have been reported. We report a family of three members with Mobius syndrome; a 7-year-old girl, a 6-year-old boy, and their 29-year-old mother. Each patient revealed facial diplegia, and unilateral or bilateral lateral rectus palsy. Brain MRI scans showed normal and there were no definite brainstem dysfunctions on electrophysiologic studies.
Abducens Nerve Diseases
;
Adult
;
Brain
;
Brain Stem
;
Child
;
Female
;
Humans
;
Magnetic Resonance Imaging
;
Male
;
Mobius Syndrome*
;
Mothers
10.Ground-Glass Opacity in Lung Metastasis from Adenocarcinoma of the Stomach: A Case Report.
Mi Ran JUNG ; Jeong Kon KIM ; Jin Seong LEE ; Koun Sik SONG ; Tae Hwan LIM
Journal of the Korean Radiological Society 2000;43(2):191-193
Ground-glass opacity is a frequent but nonspecific finding seen on high-resolution CT scans of lung parenchyma. Histologically, this appearance is observed when thickening of the alveolar wall and septal interstitium is minimal or the alveolar lumen is partially filled with fluid, macrophage, neutrophils, or amorphous material. It has been shown that ground-glass opacity may be caused not only by an active inflammatory process but also by fibrotic processes. When a focal area of ground-glass opacity persists or increases in size, the possibility of neoplasm-bronchioloalveolar carcinoma or adenoma, or lymphoma, for example- should be considered. Diffuse nonsegmental ground-glass opacity in both lung fields was incidentally found on follow up abdominal CT in a stomach cancer patient and signet-ring cell-type metastatic lung cancer was confirmed by transbronchial lung biopsy. We report a case of diffuse ground-glass opacity seen in metastatic lung cancer from adenocarcinoma of the stomach.
Adenocarcinoma*
;
Adenoma
;
Biopsy
;
Follow-Up Studies
;
Humans
;
Lung Neoplasms
;
Lung*
;
Lymphoma
;
Macrophages
;
Neoplasm Metastasis*
;
Neutrophils
;
Stomach Neoplasms
;
Stomach*
;
Tomography, X-Ray Computed