1.5-Fluorouracil, Leucovorin ( FL ) Combination Chemotherapy in Advanced or Recurrent Colo - rectal Cancer.
Jeong Hwan CHO ; Hyuk Chan KWON ; Hyo Jin KIM
Journal of the Korean Cancer Association 1999;31(5):1003-1010
PURPOSE: We studied the effectiveness and toxicities of 5-fluorouracil+leucovorin, combination chemotherapy in advanced or recurred colo-rectal cancer patients, who didn't have previous chemotherapy and enrolled from August 1993 to July 1998. MATERIALS AND METHODS: All patients were treated with leucovorin followed by 5-fluorouracil for 5 consecutive days every 4 weeks. Among 43 patients who were enrolled, 40 patients received treatment at least 2 courses, and they were evaluable. Male to female ratio was 21 to 19. In serum CEA level, 27 patients were greater than 5 ng/ml and 13 were less than 5 ng/ml. And primary site was colon in 21 patients and rectum in 19 patients. RESULTS: The complete response rate was 7,5% and the partial response rate was 25%. The median survival duration was 14.7 months, the median response duration was 16.0 months, and median time to progression was 7.3 months. In the analysis of response, survival duration, time to progression according to various characteristics of patients, serum CEA level and liver involvement were revealed significant difference in survival duration, time to progression (p=0.0122, 00350 & 0.0202, 0.0123) on univariate analysis, but no significant difference on multivariates. Hematologic and non-hematologic toxicities were mild and tolerable. CONCLUSION: This study indicates that the combination of 5-fluorouracil (370 mg/m) and leucovorin (20 mg/m) is effective and tolerable regimen in advanced or recurred colo-rectal cancer patients without previous chemotherapy.
Colon
;
Drug Therapy
;
Drug Therapy, Combination*
;
Female
;
Fluorouracil*
;
Humans
;
Leucovorin*
;
Liver
;
Male
;
Rectal Neoplasms*
;
Rectum
2.A study on the change of the lymphocyte subsets after splenectomy by flow cytometer.
Hoi Sang JEONG ; Baik Hwan CHO ; Yong HWANG
Journal of the Korean Surgical Society 1992;43(4):574-584
No abstract available.
Lymphocyte Subsets*
;
Lymphocytes*
;
Splenectomy*
3.A clinical review of upper gastrointestinal bleeding.
Young Hwan CHO ; Joon Heon JEONG ; Il Dong CHUNG
Journal of the Korean Surgical Society 1991;41(2):159-167
No abstract available.
Hemorrhage*
4.A Case of Congenital Ateriovenous Malformation.
Sook Kyeung JUNG ; Dong Hwan CHO ; Jeong Bok LEE ; Won Jae PARK ; Kyeung Soo PARK
Journal of the Korean Pediatric Society 1983;26(10):1029-1032
No abstract available.
5.A study of behavioral aspect for the health promotion among physician and general population.
Jeong Yeol OH ; Young Mee LEE ; Hak Eun SUH ; Kyung Hwan CHO ; Myung Ho HONG
Journal of the Korean Academy of Family Medicine 1992;13(11):879-890
No abstract available.
Health Promotion*
6.The Association Between History Of Disease And Psychometric Characteristics Among The Chronic Disease Patients.
Gyu Nam CHO ; Dae Sik WANG ; Jeong Hwan TAK ; Hyun Sook CHOI
Journal of the Korean Academy of Family Medicine 1997;18(2):202-211
BACKGROUND: The chronic disease patients have various psychological problems during the treatment. Therefore, it is needed about understanding and support for chronic disease patients. The main purposes of this study are to identify the psychometric characteristics. METHODS: To evaluate the psychometric characteristics of chronic disease patients-liver cirrhosis, chronic pulmonary disease, etc. -a questionnaire(SCL-90-R) survey was performed toward 100 chronic disease patients in admission to 2 general hospital. 100 persons without any disease were investigated by the same questionnaire for comparison. The survey was performed from June to August 1996. RESULTS: The disease history among the patients, 31% of patients suffered from liver disease, 19% of patients suffered from chronic respiratory disease. 30% of patients reported that they were not expected a recovery from the disease. The patients have a significant higher score in the somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, psychoticism than normal control (p<0.05). Most of the psychometric characteristics were associated with expectancy of the recovery, education about the disease, number of admission, duration of admission and type of disease(p<0.05). CONCLUSIONS: The chronic disease patients showed higher score psychological symptoms in various characteristics than normal control. Therefore it will be needed that is an proper treatment and psychological support continuously.
Anxiety
;
Chronic Disease*
;
Depression
;
Education
;
Fibrosis
;
Hospitals, General
;
Hostility
;
Humans
;
Liver Diseases
;
Lung Diseases
;
Psychometrics*
;
Surveys and Questionnaires
7.The Association Between History Of Disease And Psychometric Characteristics Among The Chronic Disease Patients.
Gyu Nam CHO ; Dae Sik WANG ; Jeong Hwan TAK ; Hyun Sook CHOI
Journal of the Korean Academy of Family Medicine 1997;18(2):202-211
BACKGROUND: The chronic disease patients have various psychological problems during the treatment. Therefore, it is needed about understanding and support for chronic disease patients. The main purposes of this study are to identify the psychometric characteristics. METHODS: To evaluate the psychometric characteristics of chronic disease patients-liver cirrhosis, chronic pulmonary disease, etc. -a questionnaire(SCL-90-R) survey was performed toward 100 chronic disease patients in admission to 2 general hospital. 100 persons without any disease were investigated by the same questionnaire for comparison. The survey was performed from June to August 1996. RESULTS: The disease history among the patients, 31% of patients suffered from liver disease, 19% of patients suffered from chronic respiratory disease. 30% of patients reported that they were not expected a recovery from the disease. The patients have a significant higher score in the somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, psychoticism than normal control (p<0.05). Most of the psychometric characteristics were associated with expectancy of the recovery, education about the disease, number of admission, duration of admission and type of disease(p<0.05). CONCLUSIONS: The chronic disease patients showed higher score psychological symptoms in various characteristics than normal control. Therefore it will be needed that is an proper treatment and psychological support continuously.
Anxiety
;
Chronic Disease*
;
Depression
;
Education
;
Fibrosis
;
Hospitals, General
;
Hostility
;
Humans
;
Liver Diseases
;
Lung Diseases
;
Psychometrics*
;
Surveys and Questionnaires
8.A Case of Pyogenic Liver Abscess.
Jeong Bok LEE ; Dong Hwan CHO ; Sook Kyeung JUNG ; Won Jae PARK ; Jin Kook KANG
Journal of the Korean Pediatric Society 1983;26(11):1111-1114
No abstract available.
Liver Abscess, Pyogenic*
9.A Case of Congenital Renal Anomalies in Tuner's Syndrome.
Jeong Bok LEE ; Sook Kyeung JUNG ; Dong Hwan CHO ; Won Jae PARK ; Dong Sun PARK
Journal of the Korean Pediatric Society 1984;27(6):616-620
No abstract available.
10.A Statistical Study of Cutaneous Malignant Tumors.
Sang Eun MOON ; Kwang Hyun CHO ; Ji Hwan HWANG ; Jeong Aee KIM ; Jai Il YOUN
Korean Journal of Dermatology 1998;36(1):7-15
BACKGROUND: There is concem about the rising incidence of skin cancer. However, few articles have reported the change in the clinical and epidemiological aspects of skin cancer. OBJECTIVE: We performed this study in order to clarifiy the recent changes in cutaneous premalignant and malignant lesions. METHODS: A statistical analysis was made using 101 cases of cutaneous premalignant lesions and 205 cases of ma]ignant tumors out of a total number of 20,175 new outpatients that visited the Department of Dermatology at the Seoul National University Hospital during a 6 year period(1990-1995). RESULTS: The frequency of premalignant lesions was 0.50% and that of malignant tumors was 1.02%. The frequency showed an increasing tendency compared to previous reports. In the premalignant lesion cases, actinic keratosis was most common and represented a figure of 82.2%. Among the malignant tumors, basal cell carcinoma was most frequent at 24.4%. Age, sex and anatomical site distribution of basal cell carcinoma, malignant melanoma was no different. The mean age of squamous cell carcinoma was greater than in previous reports and main preceding lesions were actinic keratosis and cheilitis. The frequency of lymphoma was markedly increased but the reason for this remains to be determined. CONCLUSION: Our findings showed the continous increasing incidence of skin cancers and emphasize the need for public eduacation, early diagnosis and proper treatment.
Carcinoma, Basal Cell
;
Carcinoma, Squamous Cell
;
Cheilitis
;
Dermatology
;
Early Diagnosis
;
Humans
;
Incidence
;
Keratosis, Actinic
;
Lymphoma
;
Melanoma
;
Outpatients
;
Seoul
;
Skin Neoplasms
;
Statistics as Topic*