1.Recurrent Extranodal Marginal Zone B-Cell Lymphoma Presenting as a Huge Cheek Mass after Radiotherapy on Ocular Adnexal Lymphoma.
Young Joon SEO ; Jeong Hun SEOL ; Won Il LEE ; Ja Hyun LEE
Korean Journal of Otolaryngology - Head and Neck Surgery 2011;54(12):875-878
Extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT lymphoma) is a low-grade B-cell lymphoma that presents with an indolent clinicopathologic nature. Although this tumor can occur in various sites, including the gastrointestinal, skin, salivary gland and ocular adnexa, radiation therapy shows high local control in that disease. We report a case of recurrent MALT lymphoma presenting a huge cheek mass after radiotherapy on ocular adnexal lymphomas. An 65-year-old man had a history of treatments on MALT lymphomas of ocular adnexa came again with a huge cheek mass, not recurred and not originated from salivary gland, skin, other related mucosa tissues. He got excisional biopsy and was confirmed immunohistochemically as MALT lymphoma. After diagnosis, he was sent urgently to a radiotherapist for further treatment. He responded well to added radiotherapy with 36 Gy dose and has remained well at 6 months after his initial presentation.
Aged
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Biopsy
;
Cheek
;
Head and Neck Neoplasms
;
Humans
;
Lymphoid Tissue
;
Lymphoma
;
Lymphoma, B-Cell
;
Lymphoma, B-Cell, Marginal Zone
;
Mucous Membrane
;
Porphyrins
;
Salivary Glands
;
Skin
2.Postoperative Residual Juvenile Nasopharyngeal Angiofibroma Treated with Gamma Knife Surgery.
Jeong Hun SEOL ; Dong Woo HYUN ; Yong Cheol KOO ; Chang Hoon KIM
Journal of Rhinology 2012;19(2):131-134
Juvenile nasophayngeal angiofibroma (JNA) is a histologically benign but highly vascular, agressively expansile lesion that occurs exclusively in prepubescent or pubescent males. Traditional treatmemt strategy of JNA has included open surgical approaches for majority of tumors. However, radiosurgery has been rarely applied for juvenile nasopharyngeal angiofibroma (JNA) and cumulative reports are lacking. The authors report a case of successful treatment of postoperative residual JNA with gamma knife radiosurgery.
Angiofibroma
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Humans
;
Male
;
Radiosurgery
3.The Correlation of Grade Point Average of Medical School and the Score of Korean Medical Licensing Examination.
Sung Soo AHN ; Yang Kwon SEO ; Song Ee BAEK ; So Young BAE ; Jeong Hun SEOL ; Hoo Yeon LEE ; Eun Cheol PARK
Korean Journal of Medical Education 2004;16(1):25-32
PURPOSE: This study analyzed the correlation between grade point average (GPA) of medical school and the score of Korean Medical Licensing Examination (KMLE). METHODS: This study based on the results of 67th KMLE applicants who graduated from a college of medicine in 2003. We also gathered data of these applicants from the college of medicine: gender, age, type of entrance, GPA of basic medicine, clinical medicine, clinical clerkships and final test scores. We analyzed whether there was discrimination between achievement of KMLE passed and that of KMLE failed, which of variables affected the results of KMLE. RESULTS: 173 applicants passed KMLE among 189. There were significant correlations between basic medicine, clinical medicine, final test score and the score of KMLE (respective p-value; < 0.0001). There were also significant differences of GPA between KMLE passed applicants and failed. Final test scores were the most correlated with those of KMLE. If the GPA of 2nd grade was below 2.5 and the GPA of 3rd year grade was below 2.3, they was a high-risk group for failing KMLE (sensitivity 100%, specificity 90%). CONCLUSION: There were significant correlations between the GPA of medical school and the score of KMLE, and significant differences between KMLE passed applicants and failed. A high-risk group of failing KMLE was the students that the GPA of 2nd grade was below 2.5 and the GPA of 3rd grade was below 2.3.
Clinical Medicine
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Discrimination (Psychology)
;
Humans
;
Licensure*
;
Schools, Medical*
;
Sensitivity and Specificity
4.Olfactory Identification Test Using Familiar Distracters for Koreans.
Jae Myung KIM ; Mi Soon JEONG ; Dong Hyuk SHIN ; Jeong Hun SEOL ; Seok Chan HONG ; Jae Hoon CHO ; Jin Kook KIM
Clinical and Experimental Otorhinolaryngology 2014;7(1):19-23
OBJECTIVES: Odors used in an odor identification test should be familiar to the subject, but there are some unfamiliar distracters in Korean version of Sniffin' stick (KVSS) II identification test. In this study, we used the results of the original version of KVSS II identification to modify the KVSS II identification test. METHODS: Eighty-three participants took an original version of KVSS II identification test and a visual analogue scale of subjective odor function. KVSS II identification which has 16 items was performed to choose one out of four odors items. And visual analogue scale was checked from 0 to 10 points of their subjective olfactory function. Two weeks later they took the modified version of KVSS II identification test. Hyposmic or anosmic patients were excluded. RESULTS: The mean score of the original version of KVSS II identification and modified version of KVSS II identification were 11.3 and 12.5, respectively (P<0.05). The KVSS II identification test and subjective olfactory function were positively correlated (r=0.247, P<0.05), as were the modified KVSS II identification test and subjective olfactory function (r=0.329, P<0.05). CONCLUSION: After modification of distracters, KVSS II identification test appears to be suited for assessment of olfactory function.
Humans
;
Odors
5.Ultrasonographic Findings of Mammographic Architectural Distortion.
Jeong Hyun MA ; Bong Joo KANG ; Eun Suk CHA ; Seol HWANGBO ; Hyeon Sook KIM ; Changsuk PARK ; Sung Hun KIM ; Jae Jeong CHOI ; Yong An CHUNG
Journal of the Korean Society of Medical Ultrasound 2008;27(2):75-82
PURPOSE: To review the sonographic findings of various diseases showing architectural distortion depicted under mammography. MATERIALS AND METHODS: We collected and reviewed architectural distortions observed under mammography at our health institution between 1 March 2004, and 28 February 2007. We collected 23 cases of sonographically-detected mammographic architectural distortions that confirmed lesions after surgical resection. The sonographic findings of mammographic architectural distortion were analyzed by use of the BI-RADS lexicon for shape, margin, lesion boundary, echo pattern, posterior acoustic feature and orientation. RESULTS: There were variable diseases that showed architectural distortion depicted under mammography. Fibrocystic disease was the most common presentation (n = 6), followed by adenosis (n = 2), stromal fibrosis (n = 2), radial scar (n = 3), usual ductal hyperplasia (n = 1), atypical ductal hyperplasia (n = 1) and mild fibrosis with microcalcification (n = 1). Malignant lesions such as ductal carcinoma in situ (DCIS) (n = 2), lobular carcinoma in situ (LCIS) (n = 2), invasive ductal carcinoma (n = 2) and invasive lobular carcinoma (n = 1) were observed. As ovserved by sonography, shape was divided as irregular (n = 22) and round (n = 1). Margin was divided as circumscribed (n = 1), indistinct (n = 7), angular (n = 1), microlobulated (n = 1) and sipculated (n = 13). Lesion boundary was divided as abrupt interface (n = 11) and echogenic halo (n = 12). Echo pattern was divided as hypoechoic (n = 20), anechoic (n = 1), hyperechoic (n = 1) and isoechoic (n = 1). Posterior acoustic feature was divided as posterior acoustic feature (n = 7), posterior acoustic shadow (n = 15) and complex posterior acoustic feature (n = 1). Orientation was divided as parallel (n = 12) and not parallel (n = 11). There were no differential sonographic findings between benign and malignant lesions. CONCLUSION: This study presented various sonographic findings of mammographic architectural distortion and that it is difficult to differentiate between benign and malignant lesions depicted under sonography. Pathological confirmation is needed for mammographic architectural distortion.
Acoustics
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Breast
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Carcinoma, Ductal
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Carcinoma, Intraductal, Noninfiltrating
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Carcinoma, Lobular
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Cicatrix
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Fibrosis
;
Hyperplasia
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Mammography
;
Orientation
6.High-grade nodal marginal zone lymphoma with diffuse bone marrow involvement and IgM-type monoclonal paraproteinemia: a case report and review of the literature
Sang Hyuk PARK ; Jaewook KIM ; Joseph JEONG ; Seon Ho LEE ; Hee Jeong CHA ; Seol Hoon PARK ; Yunsuk CHOI ; Jae Cheol JO ; Ji Hun LIM
Blood Research 2019;54(3):229-231
No abstract available.
Bone Marrow
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Lymphoma
;
Paraproteinemias
8.A Clinical Analysis of Methylation Status of Tumor Suppressor Genes in Breast Cancer.
Hun JUNG ; Chang Hyeok AN ; Kee Hwan KIM ; Ji Il KIM ; Woo Chan PARK ; Byung Joo SONG ; Sang Seol JUNG ; Keun Woo LIM ; Jeong Soo KIM
Journal of the Korean Surgical Society 2006;70(4):253-264
PURPOSE: Aberrant methylation of CpG islands in gene promoters has been considered as a common mechanism for suppressing gene expression in cells. Hypermethylation of CpG islands in promoters is associated with silencing of transcription in various tumor suppressor genes and recent studies identified a CpG island methylator phenotype (CIMP) suggesting common methylation defect in cancer cells. For breast cancer, several genes were previously reported to be hypermethylated, but it is unclear whether the CIMP status is associated with any clinicopathological characteristics of breast cancer. In this study, we investigated the methylation patterns of several genes such as p16(INK4a), O(6)-methyguanine-DNA methyltransferase (MGMT), Death associated protein kinase (DAPK), E-cadherin, hMLH1, and four loci such as Methylation in tumor (MINT: MINT1, MINT2, MINT25, MINT31) and analyzed the correlation with clinical features. METHODS: 85 patients who underwent curative surgery for breast cancer were studied retrospectively using their paraffin-embedded tissues and medical records. Immunohistochemical staining were performed according to their hormone receptors. DNA extraction, sodium bisulfite modification and methylation specific PCR (MSP-PCR) were performed with some modifications. RESULTS: The rates of E-cadherin and MINT 31 methylation in cancer tissue were significantly higher than those of normal tissues (P<0.05). There was no statistical correlation between methylation status of each suppressor genes and hormone receptor except DAPK methylation with progesteron receptor. The rate of E-cadherin methylation was significantly high in stage II (P=0.010). For 5-year survival and disease-free survival rate, the group with methylated MINT1 and MINT25 had significantly better outcome than unmethylated group (P<0.05). There was no statistical significance between CIMP status and other prognostic factors such as hormone receptor and stage (P=0.885). But, CIMP-High group was significantly lower than CIMP-Low group in 5-year survival (P=0.001) and disease-free survival rate (P=0.024). CONCLUSION: The methylation of E-cadherin and some MINT loci seems closely related to tumorigenesis in breast cancer and CIMP status have some value as a prognostic indicator after surgery in breast cancer but more large scale study will be needed.
Breast Neoplasms*
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Breast*
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Cadherins
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Carcinogenesis
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CpG Islands
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Cyclin-Dependent Kinase Inhibitor p16
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Disease-Free Survival
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DNA
;
Gene Expression
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Genes, Suppressor
;
Genes, Tumor Suppressor*
;
Humans
;
Medical Records
;
Mentha
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Methylation*
;
Phenotype
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Polymerase Chain Reaction
;
Protein Kinases
;
Retrospective Studies
;
Sodium
9.Pulmonary Nodular Lymphoid Hyperplasia Associated with Sjögren's Syndrome.
Moo Kon SONG ; Young Mi SEOL ; Young Eun PARK ; Yun Seong KIM ; Min Ki LEE ; Chang Hun LEE ; Yeon Ju JEONG
The Korean Journal of Internal Medicine 2007;22(3):192-196
Pulmonary nodular lymphoid hyperplasia (NLH) is a term first suggested by Kradin and Mark to describe one or more pulmonary nodules or localized lung infiltrates consisting of reactive lymphoid proliferation. To date, there have been only a few cases of pulmonary NLH reported associated with autoimmune disorders. There is no case of NLH associated with Sj?gren's syndrome from Korea in the medical literature. A 56-year-old woman was referred to our hospital with cough productive of sputum and chest tightness. The Computed tomography scans of the chest revealed multiple and well-defined peribronchiolar nodular opacities. A video assisted thoracoscopic surgery (VATS) biopsy was performed and the nodular opacity in the lung parenchyma was pathologically confirmed as NLH. Through meticulous review of patient's record, we found that she had been suffering from dry eye and dry mouth. The symptoms suggested Sj?gren's syndrome, which was confirmed by specific laboratory tests including the Schirmer test, anti-nuclear antibody and anti-Ro/La antibody. The patient is followed regularly and has no further progression of symptoms.
Biopsy
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Female
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Humans
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Immunohistochemistry
;
Middle Aged
;
Pseudolymphoma/complications/*pathology/*radiography
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Sjogren'
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s Syndrome/*complications
;
Thoracic Surgery, Video-Assisted
;
Tomography, X-Ray Computed
10.The Efficacy of Core Strengthening on the Trunk Balance in Patients with Subacute Stroke.
Seung Don YOO ; Yong Seol JEONG ; Dong Hwan KIM ; Mi Ae LEE ; Seong Gyu NOH ; Yong Won SHIN ; Sung Hun KIM ; Hee Sang KIM
Journal of the Korean Academy of Rehabilitation Medicine 2010;34(6):677-682
OBJECTIVE: To investigate the efficacy of core strengthening on trunk balance in patients with subacute stroke. METHOD: Fifty-nine subacute hemiparetic stroke in-patients participated in this study. All patients were randomly assigned to one of two groups: the control group and the experimental group. Both groups received the same conventional physical therapies for 4 weeks. The experimental group received an additional core strengthening program (CSP). Korean mini-mental state examination (K-MMSE) and Korean Modified Barthel Index (K-MBI) were performed on admission. CSP was performed for 30 minutes a day, 3 days per week for 4 weeks. We selected nine exercises available for stroke patients, and divided them as three steps according to the degree of difficulty. Because of the muscle weakness in stroke patients, a physical therapist often helped them during exercise. Outcome measurement included trunk control test (TCT), trunk impairment scale (TIS), and Berg balance scale (BBS) and we compared both groups before and after the period of training. RESULTS: There were no significant differences in baseline general characteristics and initial values between the two groups. After rehabilitation therapy, both groups showed significant improvements in BBS, TIS, and TCT (p<0.05). Following 4 weeks of therapy, changes of BBS, TIS score in the experimental group were significantly higher than those of the control group (p<0.05). However, the change of TCT score was not significantly different. CONCLUSION: Analysis of different clinical parameters showed that better outcomes in BBS, TIS scores were achieved from CSP. This study suggests that CSP conducted for 4 weeks may be beneficial as a therapeutic technique for use in improvement of trunk balance in patients with subacute hemiparetic stroke.
Exercise
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Humans
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Muscle Weakness
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Physical Therapists
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Stroke