1.Expression of p53 Protein and Proliferating Cell Nuclear Antigen in Epstein - Barr Virus-associated Gastric Adenocarcinoma.
Jeong Hee KANG ; Chang Hoon LEE ; Kang Suek SUH
Journal of the Korean Cancer Association 1999;31(3):429-440
PURPOSE: Recently, it has been reported that Epstein-Barr virus (EBV) is associated with some gastric cancers. But EBVs role in EBV-associated gastric carcinomas (EBVaGCs) has not been fully elucidated. This study was undertaken to evaluate the characteristics of EBVaGCs and to compare those with non-EBVaGCs. MATERIALS AND METHODS: EBV infection was studied using paraffin-embedded tissue blocks of 119 cases of gastric adenocarcinomas by in situ hybridization for EBV-encoded small RNAs (EBERs). In EBVaGCs and non-EBVaGCs, molecular characteristics were evaluated by immunohistochemical staining for latent membrane protein (LMP)-1, p53 protein, and proliferating cell nuclear antigen (PCNA). RESULTS: EBERs were detected in 12 cases (10.1%) of 119 gastric adenocarcinomas. LMP-1 was negative in all carcinomas tested, p53 protein was positive in 7 cases (58.3%) of 12 EBVaGCs and in 51 (47.7%) of 107 non-EBVaGCs, the difference between two groups being not significant. Mean PCNA index was 38.2+-26.1% in EBVaGCs and 22.8 +- 20.0% in non-EBVaGCs. The index was significantly higher in the former than in the latter. CONCLUSION: These results suggested that neoplastic progression in EBVaGCs was implicated with high expression of PCNA, but not consistently with overexpression of p53 protein or LMP-1.
Adenocarcinoma*
;
Epstein-Barr Virus Infections
;
Herpesvirus 4, Human
;
In Situ Hybridization
;
Membrane Proteins
;
Proliferating Cell Nuclear Antigen*
;
RNA
;
Stomach Neoplasms
2.A study on post-operative complications of radical abdominal hysterectomy with pelvic lymph node dissection.
Jeong Won KANG ; Chul Soo LIM ; Jae Hoon CHUNG
Korean Journal of Obstetrics and Gynecology 1991;34(2):245-252
No abstract available.
Hysterectomy*
;
Lymph Node Excision*
;
Lymph Nodes*
3.A study on post-operative complications of radical abdominal hysterectomy with pelvic lymph node dissection.
Jeong Won KANG ; Chul Soo LIM ; Jae Hoon CHUNG
Korean Journal of Obstetrics and Gynecology 1991;34(2):245-252
No abstract available.
Hysterectomy*
;
Lymph Node Excision*
;
Lymph Nodes*
4.EFFECT OF VARIOUS GROWTH FACTORS IN CULTURE OF EAR CHONDROCYTES OF RABBIT.
Sang Hoon HAN ; Jeong Hoon KANG ; Chang Gi SUNG ; Jae Dam LEE
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1997;24(5):884-892
No abstract available.
Chondrocytes*
;
Ear*
;
Intercellular Signaling Peptides and Proteins*
5.A Case of Heat Stroke after a Marathon.
Bo Seung KANG ; Jeong Hoon LEE ; Hyung Kon SONG ; Keun Jung SONG ; Yeon Kwon JEONG
Journal of the Korean Society of Emergency Medicine 2000;11(3):390-396
Heat stroke, a medical emergency, occurs when the body's thermal regulation is upset and unable to dissipate adequate amounts of heat with a rise in body temperature. It is characterized by hyperyrexia, with a core temperature of 40degrees C or more, hot dry skin, and central nervous system disturbance and usually results in rhabdomyolysis and multiorgan failure. Our case, a 43-year-old healthy male, was caused by a marathon, half course, on a sunny day in late summer. He suddenly fell down on the road and was delivered to a nearby hospital, where a seizure developed. He was transfered to our hospital and then displayed Central Nervous System disturbance, hot dry skin, acute liver failure, rhabdomyolysis, anuric acute renal failure, and disseminated intravasculular coagulopathy. He was treated with general supportive care and hemofiltration. Despite the aggressive management, he died of shock on the fifth day after admission.
Acute Kidney Injury
;
Adult
;
Body Temperature
;
Central Nervous System
;
Emergencies
;
Heat Stroke*
;
Hemofiltration
;
Hot Temperature*
;
Humans
;
Liver Failure, Acute
;
Male
;
Rhabdomyolysis
;
Seizures
;
Shock
;
Skin
6.Concurrent chemoradiotherapy for elderly patients with stage III non-small cell lung cancer.
Ki Mun KANG ; Bae Kwon JEONG ; In Bong HA ; Gyu Young CHAI ; Gyeong Won LEE ; Hoon Gu KIM ; Jung Hoon KANG ; Won Seob LEE ; Myoung Hee KANG
Radiation Oncology Journal 2012;30(3):140-145
PURPOSE: Combined chemoradiotherapy is standard management for locally advanced non-small cell lung cancer (LA-NSCLC), but standard treatment for elderly patients with LA-NSCLC has not been confirmed yet. We evaluated the feasibility and efficacy of concurrent chemoradiotherapy (CCRT) for elderly patients with LA-NSCLC. MATERIALS AND METHODS: Among patients older than 65 years with LA-NSCLC, 36 patients, who underwent CCRT were retrospectively analyzed. Chemotherapy was administered 3-5 times with 4 weeks interval during radiotherapy. Thoracic radiotherapy was delivered to the primary mass and regional lymph nodes. Total dose of 54-59.4 Gy (median, 59.4 Gy) in daily 1.8 Gy fractions and 5 fractions per week. RESULTS: Regarding the response to treatment, complete response, partial response, and no response were shown in 16.7%, 66.7%, and 13.9%, respectively. The 1- and 2-year overall survival (OS) rates were 58.2% and 31.2%, respectively, and the median survival was 15 months. The 1- and 2-year progression-free survivals (PFS) were 41.2% and 19.5%, respectively, and the median PFS was 10 months. Regarding to the toxicity developed after CCRT, pneumonitis and esophagitis with grade 3 or higher were observed in 13.9% (5 patients) and 11.1% (4 patients), respectively. Treatment-related death was not observed. CONCLUSION: The treatment-related toxicity as esophagitis and pneumonitis were noticeably lower when was compared with the previously reported results, and the survival rate was higher than radiotherapy alone. The results indicate that CCRT is an effective in terms of survival and treatment related toxicity for elderly patients over 65 years old with LA-NSCLC.
Aged
;
Carcinoma, Non-Small-Cell Lung
;
Chemoradiotherapy
;
Disease-Free Survival
;
Esophagitis
;
Humans
;
Lymph Nodes
;
Pneumonia
;
Retrospective Studies
;
Survival Rate
7.Study on mRNA expression of p21 and p73 in the cell lines of primary and metastatic squamous cell carcinoma.
Jeong Hoon KANG ; Kyung Wook KIM ; Jae Hoon LEE
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2001;27(6):483-490
There were many controversies in the cause and progress of tumorigenesis. Recently, studies on the mutation of genes related to the tumor have extensively been performed due to development of molecular biology. Structural and morphological changes of chromosomes, which are related to the abnormal activation of oncogenes or inactivation of tumor suppressor genes, transform the normal cells into the tumor cells. p53 and Rb are well known tumor suppressor genes, while oncogenes include c-myc, bcl-2 and ras, etc. When exposed to cell damaging agents, p53 inhibits cell growth by inducing transcription of p21. Especially p73, which is homo-logy of p53, frequently deleted in melanoma, neuroblastoma, colon cancer, and breast cancer. when over produced, p73 activates the transcription of p21, bax-1 and inhibits cell growth by inducing apoptosis. For study on mRNA expression of p21 and p73, normal oral keratinocytes, and cell lines of primary and metastatic oral squamous cell carcinomas were cultured and then electrophoresis and RT-PCR(reverse transcription-polymerase chain reaction) were performed. 1. The mRNA of p21 and p73 in normal oral keratinocyte expressed lower level than that of primary oral squamous cell carcinoma. 2. The mRNA of p21 in metastatic oral squamous carcinoma cell lines was expressed as various patterns compared with that of normal oral keratinocyte. 3. In the metastatic oral squamous cell lines, the mRNA of HN8 expressed higher than that of HN12 or HN19. 4. The mRNA of p73 in primary oral squamous cell lines expressed 4-5 times higher than that of normal oral keratinocyte. 5. In metastatic oral squamous cell lines, there was no significant expression of p73 mRNA compared with that of normal oral keratinocyte. From the results obtained in this study, mRNA expression of p73 in primary oral squamous cell lines was remarkable, while mRNA expression of p21 and p73 in metastatic oral squamous cell lines were statistically insignificant.
Apoptosis
;
Breast Neoplasms
;
Carcinogenesis
;
Carcinoma, Squamous Cell*
;
Cell Line*
;
Colonic Neoplasms
;
Electrophoresis
;
Genes, Tumor Suppressor
;
Keratinocytes
;
Melanoma
;
Molecular Biology
;
Neuroblastoma
;
Oncogenes
;
RNA, Messenger*
8.A Case of Subcutaneous Juvenile Xanthogranuloma.
Jeong Deuk LEE ; Chung Eui YOU ; Chang Nam LEE ; Hoon KANG ; Sang Hyun CHO
Annals of Dermatology 2003;15(1):31-33
Juvenile xanthogranuloma is a congenital or perinatal tumor, 1 to 2 cm in diameter, usually located on the head. The extracutaneous lesions can occur on the eye, the lung, the epicardium, the oral cavity or the testicles. Subcutaneous form of juvenile xanthogranuloma has been reported very rarely in the literature. We report a unique case of a subcutaneous juvenile xanthogranuloma that showed 4 × 4 cm sized plaque and located on the extremity of 9-year-old girl.
Child
;
Extremities
;
Female
;
Head
;
Humans
;
Lung
;
Mouth
;
Pericardium
;
Testis
;
Xanthogranuloma, Juvenile*
9.A Case of Extra-adrenal Paraganglioma of the Retroperitoneum.
Young II KANG ; Jeong Hoon LEE ; Moon Soo YOON
Korean Journal of Urology 1984;25(3):372-374
This rare tumor has been diagnosed postoperatively in a 64-years-old male patient. Herein a case of extra-adrenal paraganglioma of the retroperitoneum is presented with brief review of literatures.
Humans
;
Male
;
Paraganglioma, Extra-Adrenal*
10.Clinical experience of cartilage allograft.
Kyung Suck KOH ; Doo Young OH ; Jeong Hoon KANG ; Sang Hoor HAN ; Kun Chul YOON
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1998;25(4):573-580
Bony defect is one of the most common problems in craniomaxillofacial surgery. Although aurogenous bone graft is the best choice for the treatment of bone defect, it provides many problems such as donor site morbidity, irregular absorption, and limited amount of harvest. To overcome the shortcomings of autogenous bone graft many bone substitutes have been introduced. The ideal bone substitution is to have characteristics such as cheap, easy to obtain, rapid fusion to recipient bone, hard structure, long maintenance of shape and volume, low infection rate, and low exposure rate. Among those bone substitutes which have been widely used we chose lyophilized cartilage allograft because of low antigenecity, low resorption rate, easiness of carving and ling term preservation. From August 1993 to August 1997, 66 patients had been performed craniomaxillofacial reconstruction with lyophilized cartilage allograft. Orbital wall reconstruction and correction of enophthalmos were 24, correction of cleft lip and nose deformity were 19, temporal augmentations were 7, and others 16. Complications such as infection, exposure were not common. And partially removed cartilage was proved some calcification. Radiologic follow-up presented well positioned lyophilized cartilage allograft. Two radiologic works revealed haziness of bone density at the site of cartilage allograft. This suggests the ossification of lyophilized cartilage allograft. Together with liw infection rate, low exposure rate, and good framework for osteoconduction, lyophilized cartilage allograft are regarded as one of the good bone substitutes.
Absorption
;
Allografts*
;
Bone Density
;
Bone Regeneration
;
Bone Substitutes
;
Cartilage*
;
Cleft Lip
;
Congenital Abnormalities
;
Enophthalmos
;
Follow-Up Studies
;
Humans
;
Nose
;
Orbit
;
Tissue Donors
;
Transplants