1.A Tulip-Shaped Gastric Carcinoid Tumor.
The Korean Journal of Internal Medicine 2012;27(1):118-118
2.Iatrogenic Kaposi Sarcoma Developed in a Membranous Glomerulonephritis Patient after High-dose Intravenous Pulse Steroid Therapy.
Eun hwa LIM ; Jeong min HA ; Young joon SEO ; Young LEE ; Myung IM ; Jeung hoon LEE
Korean Journal of Dermatology 2017;55(1):68-69
No abstract available.
Cutaneous Fistula
;
Glomerulonephritis, Membranous*
;
Humans
;
Sarcoma, Kaposi*
3.A Case of Ipsilateral Neglected DDH Combined with Contralateral LCPD: A Case Report.
In Young OK ; Nan Kyung HA ; Han Young LEE ; Chang Hoon JEONG ; Seok Jung KIM
The Journal of the Korean Orthopaedic Association 1998;33(5):1394-1399
Although many reports have been published about Legg-Calve-Perthes disease, developmental dysplasia of hip, it is difficult to gain a satisfactory results in treatment. We experienced 9 year-old girl with ipsilateral neglected DDH combined with contralateral LCPD, and treated with Klisic operation for DDH and femoral valgus osteotomy for hinged abduction of LCPD. We gained satisfactory results and report this rare case.
Child
;
Female
;
Hip
;
Humans
;
Legg-Calve-Perthes Disease
;
Osteotomy
4.Chiari Pelvic Osteotomy in Children and Adolescent.
In Young OK ; Chang Hoon JEONG ; Han Young LEE ; Nan Kyung HA ; Ji Yun WON
The Journal of the Korean Orthopaedic Association 1998;33(4):1076-1081
Twenty five patients (twenty seven hips) who had Chiari osteotomy at Kang Nam St. Marys Hospital between 1980 and 1995 were reviewed to evaluate the factors in the operative technique that contribute to successful outcome and assess the clinical results in various conditions. The length of follow-up ranged from one to fourteen years and the age of at operation ranged from four to twentythree years. Eighteen patients had developmental dysplasia of the hip: four, septic hip: three had another disorders, Prior to the Chiari osteotomy, fourteen hips had an femoral osteotomy and four, trochanteric arthroplasty. We used to the standard osteotomy as described by Chiari with certain modification. A pneumatic saw and osteotome are used instead of Gigli saw. This technique is simple procedure to make the correct level and angle. Bone graft was not performed in all cases even the osteotomy was displaced more than 50 percent of the iliac width. The overall results were 12 excellent, eight good, five fair, and two poor. In eleven patients, the osteotomy had to be displaced more than 50 percent to provide good coverage of the femoral head. Their results were good or excellent. A good result will be obtained if enough attention is paid to displacing the osteotomy. The osteotomy using the pneumatic saw provides accurate level and direction of osteotomy and it is an simple procedure also.
Adolescent*
;
Arthroplasty
;
Child*
;
Femur
;
Follow-Up Studies
;
Head
;
Hip
;
Humans
;
Osteotomy*
;
Transplants
5.Mouth opening limitation due to oral submucosa fibrosis: a case report
Hoon KIM ; Su Gwan KIM ; Jeong Wan HA
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons 2003;25(2):172-175
Anacardium
;
Capsaicin
;
Carcinogens
;
Child
;
Chronic Disease
;
Cicatrix
;
Esophagus
;
Fibrosis
;
Follow-Up Studies
;
Genetic Predisposition to Disease
;
Humans
;
Hypersensitivity
;
Immunologic Factors
;
Iron
;
Mouth Mucosa
;
Mouth
;
Mucous Membrane
;
Pharynx
;
Precancerous Conditions
;
Skin
;
Thigh
;
Vitamin B Complex
6.Amphetamine-induced ERM Proteins Phosphorylation Is through PKCbeta Activation in PC12 Cells.
Ha Jin JEONG ; Jeong Hoon KIM ; Songhee JEON
The Korean Journal of Physiology and Pharmacology 2011;15(4):245-249
Amphetamine, a synthetic psychostimulant, is transported by the dopamine transporter (DAT) to the cytosol and increases the exchange of extracellular amphetamine by intracellular dopamine. Recently, we reported that the phosphorylation levels of ezrin-radixin-moesin (ERM) proteins are regulated by psychostimulant drugs in the nucleus accumbens, a brain area important for drug addiction. However, the significance of ERM proteins phosphorylation in response to drugs of abuse has not been fully investigated. In this study, using PC12 cells as an in vitro cell model, we showed that amphetamine increases ERM proteins phosphorylation and protein kinase C (PKC) beta inhibitor, but not extracellular signal-regulated kinase (ERK) or phosphatidylinositol 3-kinases (PI3K) inhibitors, abolished this effect. Further, we observed that DAT inhibitor suppressed amphetamine-induced ERM proteins phosphorylation in PC12 cells. These results suggest that PKCbeta-induced DAT regulation may be involved in amphetmaine-induced ERM proteins phosphorylation.
Amphetamine
;
Animals
;
Brain
;
Cytosol
;
Dopamine
;
Dopamine Plasma Membrane Transport Proteins
;
Nucleus Accumbens
;
PC12 Cells
;
Phosphatidylinositol 3-Kinases
;
Phosphorylation
;
Phosphotransferases
;
Protein Kinase C
;
Proteins
;
Street Drugs
;
Substance-Related Disorders
7.Repetitive Pregnancy Loss in inv(22)(p13q12) Carrier.
Do Hoon KIM ; Jung Sook HA ; Jeong Ho RHEE
Journal of Genetic Medicine 2010;7(1):78-81
Pericentric inversion is not rare in humans and is usually benign. However, pericentric inversion can lead to production of an unbalanced recombinant and might be a cause of repetitive pregnancy loss. Pericentric inversion of chromosome 22 is rare and only a few cases have been reported. We report a case of inv(22)(p13q12) carrier who had history of repetitive pregnancy loss including three spontaneous abortions and one fetal hydrops in which the chromosomal complement was rec(22)dup(22q) inv(22)(p13q12)mat. The maternal inv(22) and fetal rec(22) were confirmed by fluorescence in situ hybridization using region-specific probes (TUPLE1 on 22q11.2 and ARSA on 22q13). Because the identification of inv(22) or rec(22) in conventional karyotyping might be easily overlooked, great attention and additional molecular tests are required for accurate diagnosis of inv(22) and rec(22).
Abortion, Spontaneous
;
Chromosomes, Human, Pair 22
;
Complement System Proteins
;
Female
;
Fluorescence
;
Humans
;
Hydrops Fetalis
;
In Situ Hybridization
;
Karyotyping
;
Pregnancy
8.Cerebral Arteriovenous Malformation Associated with Intracranial Meningioma and Aneurysm: Case Report.
Jeong Hoon KIM ; Young Soo HA ; Chong Oon PARK ; Dong Keun HYUN
Journal of Korean Neurosurgical Society 2001;30(1):110-113
The cerebral arteriovenous malformation(AVM) rarely coexists with primary intracranial tumor. The authors experienced a patient with intracerebral hematoma due to AVM rupture in whom intracranial meningioma and intracranial aneurysms coexisted. The meningioma was located at convexity of right frontal lobe, and arteriovenous malformation at temporo-occipital lobe of same hemisphere with feeding from right middle cerebral artery, and three intracranial aneurysms exist at the cavernous portion of right internal carotid artery, AVM feeding artery, and intranidal of the AVM. The authors report a rare case of coexisted intracranial AVM, meningioma and aneurysms with review of literatures.
Aneurysm*
;
Arteries
;
Arteriovenous Malformations
;
Carotid Artery, Internal
;
Frontal Lobe
;
Hematoma
;
Humans
;
Intracranial Aneurysm
;
Intracranial Arteriovenous Malformations*
;
Meningioma*
;
Middle Cerebral Artery
;
Rupture
9.IL-2 Pathway Blocking in Combination with Anti-CD154 Synergistically Establishes Mixed Macrochimerism with Limited Dose of Bone Marrow Cells and Prolongs Skin Graft Survival in Mice.
Jeong Hoon LEE ; Jongwon HA ; Shi Hwa KIM ; Sang Joon KIM
Journal of Korean Medical Science 2006;21(6):1005-1011
To facilitate the establishment of mixed chimerism with limited dose of bone marrow (BM) cells, and to achieve tolerance in skin graft model, combined blocking of costimulatory pathway and IL-2 pathway was used in minimally myeloablative model using busulfan. BM cells (2.5 x 10(7)) of BALB/c were injected into C57BL/6 mice at day 0 with full thickness skin graft after single dose injection of busulfan (25 mg/kg) on day-1. Recipients were grouped and injected the anti-CD154, CTLA4-Ig, anti-IL-2R at days 0, 2, 4, and 6 according to protocol. Mixed macrochimerism were induced in groups treated with anti-CD154+anti-CTLA4-Ig, anti-CD154+anti-IL-2R, and anti-CD154+anti-CTLA4 Ig+anti-IL-2R. Three groups having chimerism enjoyed prolonged graft survival more than 6 months. Superantigen deletion study revealed deletion of alloreactive T cells in combined blockade treated groups. In graft versus host disease model using CFSE staining, CD4+ T cell and CD8+ T cell proliferation were reduced in groups treated with CTLA4-Ig or anti-IL-2R or both in combination with anti-CD154. However, anti-IL-2R was not so strong as CTLA4-Ig in terms of inhibition of T cell proliferation. In conclusion, IL-2 pathway blocking combined with anti-CD154 can establish macrochimerism with limited dose of BM transplantation and induce specific tolerance to allograft.
Skin Transplantation/*immunology/methods
;
Mice, Inbred BALB C
;
Mice
;
Male
;
Interleukin-2/*immunology
;
Immunoconjugates/*administration & dosage
;
Graft Survival/*immunology
;
Drug Combinations
;
CD40 Ligand/*immunology
;
Bone Marrow Transplantation/*immunology/methods
;
Antibodies/*administration & dosage/immunology
;
Animals
10.IL-2 Pathway Blocking in Combination with Anti-CD154 Synergistically Establishes Mixed Macrochimerism with Limited Dose of Bone Marrow Cells and Prolongs Skin Graft Survival in Mice.
Jeong Hoon LEE ; Jongwon HA ; Shi Hwa KIM ; Sang Joon KIM
Journal of Korean Medical Science 2006;21(6):1005-1011
To facilitate the establishment of mixed chimerism with limited dose of bone marrow (BM) cells, and to achieve tolerance in skin graft model, combined blocking of costimulatory pathway and IL-2 pathway was used in minimally myeloablative model using busulfan. BM cells (2.5 x 10(7)) of BALB/c were injected into C57BL/6 mice at day 0 with full thickness skin graft after single dose injection of busulfan (25 mg/kg) on day-1. Recipients were grouped and injected the anti-CD154, CTLA4-Ig, anti-IL-2R at days 0, 2, 4, and 6 according to protocol. Mixed macrochimerism were induced in groups treated with anti-CD154+anti-CTLA4-Ig, anti-CD154+anti-IL-2R, and anti-CD154+anti-CTLA4 Ig+anti-IL-2R. Three groups having chimerism enjoyed prolonged graft survival more than 6 months. Superantigen deletion study revealed deletion of alloreactive T cells in combined blockade treated groups. In graft versus host disease model using CFSE staining, CD4+ T cell and CD8+ T cell proliferation were reduced in groups treated with CTLA4-Ig or anti-IL-2R or both in combination with anti-CD154. However, anti-IL-2R was not so strong as CTLA4-Ig in terms of inhibition of T cell proliferation. In conclusion, IL-2 pathway blocking combined with anti-CD154 can establish macrochimerism with limited dose of BM transplantation and induce specific tolerance to allograft.
Skin Transplantation/*immunology/methods
;
Mice, Inbred BALB C
;
Mice
;
Male
;
Interleukin-2/*immunology
;
Immunoconjugates/*administration & dosage
;
Graft Survival/*immunology
;
Drug Combinations
;
CD40 Ligand/*immunology
;
Bone Marrow Transplantation/*immunology/methods
;
Antibodies/*administration & dosage/immunology
;
Animals