OBJECTIVE: To assess the difference of baseline hormonal status and pathophysiology, and confirm the risk factors for long term complication according to Body Mass Index in women with polycystic ovary syndrome. MATERIALS AND METHODS: Serum level of LH, FSH, Estradiol, Prolactin, Testosterone, DHEA-S, fasting insulin were measured and 100 gm oral glucose tolerance test and endometrial biopsy were performed in total 75 chronic anovulation patients and 20 normal cycling infertility patients. 95 evaluated patients were divided into 3 groups including patients with chronic anovulation having BMI below 25, BMI beyond 25.1, normal cycling infertility patients, Group 1 (n=39), Group 2 (n=36), Group 3 (n=20), respectively. Statistical analysis was performed respect to relationship between BMI and measured hormone level, sum of glucose level during 100 gm OGTT, insulin resistance using t-test, ANOVA test, Post Hoc test, Mann-Whitney test. p<0.05 was considered as statistically significant. RESULTS: Serum LH level and LH/FSH ratio was significantly higher in Group 1, compared than Group 2 or 3 (p<0.05), BMI and LH, LH/FSH ratio was negatively correlated (r=-0.351, r=-0.318). There was no significant difference according to BMI in FSH, testosterone, estradiol, prolactin, DHEA-S level. Fasting insulin and sum of glucose level during 100 gm OGTT were significantly higher in Group 2 compared than Group 1 or Group 3 (p<0.05), there was no significant difference between Group 1 and Group 3. Insulin resistance was more frequently identified in Group 2 compared than Group 1 (p=0.001). CONCLUSIONS: BMI and LH, LH/FSH ratio were negatively correlated, so clinical significance of LH, LH/FSH ratio in diagnosis of PCOS may be attenuated by increasing body weight. Overweight patients with chronic anovulation may be the risk group for developing insulin resistance, hyperinsulinemia, glucose intolerance, later type 2 DM. Hyperinsulinemia may operate mainly in overweight chronic anovulation patients in development of hyperandrogenism.
Anovulation* ; Biopsy ; Body Mass Index* ; Body Weight ; Diagnosis ; Estradiol ; Fasting ; Female ; Glucose Intolerance ; Glucose Tolerance Test ; Glucose* ; Humans ; Hyperandrogenism ; Hyperinsulinism ; Infertility ; Insulin ; Insulin Resistance ; Metabolism* ; Overweight ; Polycystic Ovary Syndrome ; Prolactin ; Risk Factors ; Testosterone

No abstract available.
Killer Cells, Natural* ; Lymphocytes* ; Lymphocytes, Null* ; Schizophrenia*

BACKGROUND: Factors that regulate hair matrix cell division within the hair follicles and control hair growth cycle have been poorly understood untill now. One of the main.causes seems to be lack of good in vitro models. OBJECTIVE: This study was performed to investigate the hair growth promoting potencies of several agents including individual components of keratinocyte growth media. METHODS: Several agents such as epidermal growth factor, insulin, bovine pituitary extract which were contained in keratinocyte growth media as well as minoxidil and transforming growth factor-α were added to the isolated anagen hair follicles. Measuring the length of hair follicle, thymidine and leucine uptake were used for hair growth parameter. RESULTS: Isolated anagen hair follicles in keratinocyte growth media showed a significant increase in length over 48 hours. [Methyl-³H] thymidine and [U-¹⁴Cl leucine uptake were sustained at basal state as well as over 48 hours and [methyl-³H] thymidine uptake increased in the matrix cells under autoradiography. Insulin with a concentration above 0.5µg/ml and transforming growth factor-α with a concentration above 10ng/ml showed a promoting effect on hair growth. However, other agents did not promote hair growth at all. CONCLUSION: Our in vitro model resembles the in vivo status of hair growth for a limited period of time and we think that normal human hair organ culture may be a useful model for developing hair growth promoting agents in vitro.
Autoradiography ; Cell Division ; Epidermal Growth Factor ; Hair Follicle* ; Hair* ; Humans ; In Vitro Techniques ; Insulin ; Intercellular Signaling Peptides and Proteins* ; Keratinocytes ; Leucine ; Minoxidil ; Organ Culture Techniques* ; Thymidine

The propose of this study was to propose for protection of childhood injury or accident and to provide safety measures. Data was collected from 2,052 who visited emergency room of E University Hospital during 1 year period form January to December, 1996. The results were as follows : 1. The most common type of accident was fall down (53.4%). 2. Male patients outnumbered female by the ratio of 1.68 : 1. 3. The highest incidence rate of accidents were observed in children between 1-3 years age group(34.9%). 4. Accidents were seasonally more frequent in spring(28.2%). 5. Accidents mainly took place at home(63%). 6. The time of accidental occurrence appeared to be predominantly high during a day 8:00 PM to 0:00 AM(35.1%). 7. The most frequent involved part of body was head and face(74%). 8. Most patients discharged from the hospital in good condition(85.4%). Though clinical analysis, in the relation to accident, there were statistically significant difference in sex, age, season, injury place(all=0.000).
Child ; Emergency Service, Hospital ; Female ; Head ; Humans ; Incidence ; Male ; Seasons ; Child Health

Formaldehyde and its derivatives are used to improve the wet strength, waterresistance, shrink-resistance, grease-resistance and other characteristics of paper and. paper products. We have recently analyzed 78 different kinds of paper sources which are being used in Korea by the lutidine method. The forma.ldehyde concentrations of the most paper sources were under 50 ug/gm ranges except 4 copying paper sources which were in the 50 to 100 ug/gm ranges.
Formaldehyde* ; Korea

We report a case of nasal BCC in which the skin defect is reconstructed by a local labial-alar transposition flap. In nasal reconstruction, the local flap is the preferred methods. This flap has the advantage of a more acceptable scar, is easy to make, and less edematous than a superiorly based flap. However, for defects larger than 1cm, this flap is not advisable and the defect has to be located adjacent to th nsolabial fold.
Carcinoma, Basal Cell* ; Cicatrix ; Nose* ; Skin*

No abstract available.
Malacoplakia* ; Urinary Bladder*

This study was undertaken to investigate the optimal conditions for challenge testing with DNCB in 3 vehicles applied to guinea pigs in standardized amount/ area (pg/cm2) The results are sumrnarized as follows: 1) All test reactions were negative when tested in 10 unsensitized animals. 2) There were significant difference in positive rate between 0. 05%, DNCB in alcohol and 0.1% DNCB in alcohol, but there were no significant difference between 0. l%, DNCB in alcohol and 0, 2% DNCB in alcohol. Same results were obtaincd when DNCR was dissolved in acetone. 3) Acetone gives the significantly higher degree of positive reactions, indicating that alcohol may be the safer vehicle in eliciting a response than acetone. 4) With DNCB in olive oil, relatively few animals reacted compared to the results obtained with alcohol and acetone. Furthermore, olive oil is slippery and difficult to utilize when attempting to delineate surface area. 5) With alcohol, we obtained a good correlation between the amount applied and the resulting response, showing that this vehicle might be a superior vehicle in eliciting contact allergy.
Acetone ; Animals ; Dinitrochlorobenzene* ; Guinea Pigs* ; Guinea* ; Hypersensitivity* ; Olea ; Olive Oil

PURPOSE: In contracted bladder of various etiologies, if many of conservative managements fail, a surgical treatment seems to be the only therapeutic approach. We tried to evaluate the long term results of aug mentation cystoplasty including the postoperative complication and the degree of satisfaction in patients. MATERIALS AND METHODS: From 1989 to 1988, augmentation cystoplasties had been performed in 11 patients with contracted bladder of various etiologies. We reviewed the patients' medical records including the result of urodynamic examinations, retrospectively. Postoperative follow-up periods were 9 to 114months (mean:61months). Patients were interviewed by telephone. RESULTS: Urinary frequency, nocturia, dysuria and suprapubic pain were improved in all patients, but dysuria persisted in one patient with tuberculous cystitis. Clean intermittent catheterization (CIC) was done in there of 11 patients due to large volume of residual urine. The volume of residual urine was 200-300ml in one with hyperreflexic neurogenic bladder, and 100-200ml in two with interstitial cystitis. Self voiding was possible in 8 patients with residual urine volume less than 90ml. Almost all patients were very satisfied symptomatically in the telephone survey. There were no significant complications which required surgical revision. CONCLUSIONS: It is concluded that augmentation cystoplasty could be an excellent method of treatment for selective patients with contracted bladder, who have not improved symtomatically by medication or conservative management.
Cystitis ; Cystitis, Interstitial ; Dysuria ; Follow-Up Studies ; Humans ; Intermittent Urethral Catheterization ; Medical Records ; Nocturia ; Postoperative Complications ; Reoperation ; Retrospective Studies ; Telephone ; Urinary Bladder* ; Urinary Bladder, Neurogenic ; Urodynamics

No abstract available.
Humans ; Infant, Newborn* ; Microbubbles*