No Abstract Available.

Crohn's disease, a chronic relapsing, multisystemic, inflammatory disorder, may involve any part of the gastrointestinal tract and shows a cobblestone-like appearance on intestinal mucosa. There are also extraintestinal features, including lesions of the skin, eye, and joints. Ulcers, fissures, sinus tracts, abscesses, and vegetant plaques have been reported for the perianal skin lesions of Crohn's disease. We experienced a case of Crohn's disease in a 21-year-old Korean female showing a skin lesion with a cobblestone-like appearance in the perianal region.
Abscess ; Crohn Disease* ; Female ; Gastrointestinal Tract ; Humans ; Intestinal Mucosa ; Joints ; Skin* ; Ulcer ; Young Adult

BACKGROUND: It has been suggested that the regulation of hair growth might involve complex interaction between dermal papilla cells and hair matrix cells. Dermal papilla cells secrete diffusible factors that would act an hair matrix cells. During anagen the papilla appears to have prominent capillary loop, whereas in telogen it is nonvascularized. Vascular endothelial growth factor(VEGF) was recently reported to be produced by dermal papilla cells in rats. OBJECTIVES: We performed this study in order to evaluate the effect of VEGF on human hair growth in vitro and on the proliferation of dermal papilla cells and to define the splice forms of VEGF. METHODS: To detect the isoforms of VEGF, RT-PCR was performed on RNA isolated from dermal papilla cells and RT-PCR products were hybridized with VEGF-specific oligonucleotide probe located in exon 4. Isolated human hair follicles were cultured with various concentrations of VEGF165 and VEGF121. Hair follicle growth was measured by an Olympus inverted microscope with an eyepiece measuring graticule. RESULTS: The following results were obtained from this study. 1. Southern hybridization and size calculation of RT-PCR products revealed that mRNA species corresponding to 121, 165, 189, and 206 amino-acid forms of VEGF were praduced by cultured human dermal papilla cells. 2. 10 ng/ml of rhVEGF165, 0.1 ng/ml of rhVEGF165 and 10 ng/ml of rhVEGF121 stimulated follicle elongation in vitro(p < 0.05). 3. rhVEGF165 and rhVEGF121 had no effect on the numbers and thymidine incorporation of dermal papilla cells. CONCLUSION: These results suggest that VEGF is produced by dermal papilla cells and is able to promote hair growth in vitro. Increased hair growth by VEGF might occur other than by proliferation of dermal papilia cells.
Animals ; Capillaries ; Endothelial Growth Factors* ; Exons ; Hair Follicle ; Hair* ; Humans ; Protein Isoforms ; Rats ; RNA ; RNA, Messenger ; Thymidine ; Vascular Endothelial Growth Factor A

Kyrle's disease is a rare disorder characterized by hyperkeratotic papules containing a central, cone-shaped plug on the extensor surface of the extremites. We describe two cases of Kyrle's disease. The first case is 65-year-old male patient. He had multiple pruritic hyperkeratotic papules with a central plug on both lower extremities. He has suffered from Diabetes mellitus for 20 years. The second case is 54-year-old male patient. He had multiple pruritic hyperkeratotic papules with a central plug on the back, upper and lower extremities. He has been suffered from Diabetes mellitus for 20 years and chronic renal failure for 6 months. Histopathologic findings showed central epidermal invagination filled with heavy keratotic, partly parakeratotic plug and basophilic debries. Many vacuolated cells and a few dyskeratotic cells were seen below the keratotic plug.
Aged ; Basophils ; Diabetes Mellitus ; Humans ; Kidney Failure, Chronic ; Lower Extremity ; Male ; Middle Aged

Lichen striatus usually occurs in a solitary and unilateral fashion. Its multiple and bilateral distribution is a very rare finding. We report two cases of multiple lichen striatus. The first case is a 3 year-old boy, whose skin lesions were distributed bilaterally on both upper arms and buttock. The second case is a 6 year-old girl whose skin lesions were two separated linear lesions from left chest and left upper back to left arm.
Arm ; Buttocks ; Child ; Child, Preschool ; Female ; Humans ; Lichens* ; Male ; Skin ; Thorax

Color developing agents which are derivatives of p-phenylenediamine, e.g. KODAK CD-2(2- amino-5 diethylaminotoluene) and CD-3(4-amino-N-ethylN beta m-toluidine sesquisulfate monohydrate), are known to cause contact allergy. There are two types of reactions to these chemicals. The first one is an acute eczematous lesion, and the other is a lichenoid lesion. A 33-year-old man developed a lichenoid contact dermatitis on both forearms and posterior neck after exposure to a color developing agent. Patch test revealed positive reaction to CD-2. Histopathologic finding from the skin lesion showed a lichen planus-like appearance.
Adult ; Dermatitis, Contact* ; Forearm ; Humans ; Hypersensitivity ; Lichens ; Neck ; Patch Tests ; Skin

Palisaded neutrophilic and granulomatous dermatitis (PNGD) is an uncommon skin eruption and characterized histopathologically by the presence of granulomatous inflammation with or without leukocytoclastic vasculitis. PNGD is known to be associated with various immune-mediated connective tissue diseases such as rheumatoid arthritis and lupus erythematosus. However, to our knowledge, a case of PNGD in a patient with Behçet’s disease is extremely rare and only one case has been reported in foreign literature to date. Herein, we report an unusual case of a 60-year-old female with Behçet’s disease who presented multiple erythematous to flesh-colored papules on the extremities, buttocks, and ear lobes and was diagnosed with PNGD. After the treatment of systemic corticosteroids, colchicine and azathioprine, the skin lesions and oral ulcers improved. The patient is under observation without recurrence of skin lesions for 6 months.

No abstract available.
Nephrotic Syndrome* ; Prenatal Diagnosis*

BACKGROUND/AIMS: Recently reported prognostic models for primary biliary cholangitis (PBC) have been shown to be effective in Western populations but have not been well-validated in Asian patients. This study aimed to compare the performance of prognostic models in Korean patients and to investigate whether inflammation-based scores can further help in prognosis prediction. METHODS: This study included 271 consecutive patients diagnosed with PBC in Korea. The following prognostic models were evaluated: the Barcelona model, the Paris-I/II model, the Rotterdam criteria, the GLOBE score and the UK-PBC score. The neutrophil-to-lymphocyte ratio (NLR) was analyzed with reference to its association with prognosis. RESULTS: For predicting liver transplant or death at the 5-year and 10-year follow-up examinations, the UK-PBC score (areas under the receiver operating characteristic curve [AUCs], 0.88 and 0.82) and GLOBE score (AUCs, 0.85 and 0.83) were significantly more accurate in predicting prognosis than the other scoring systems (all p < 0.05). There was no significant difference between the performance of the UK-PBC and GLOBE scores. In addition to the prognostic models, a high NLR (>2.46) at baseline was an independent predictor of reduced transplant-free survival in the multivariate analysis (adjusted hazard ratio, 3.74; p < 0.01). When the NLR was applied to the prognostic models, it significantly differentiated the prognosis of patients. CONCLUSIONS: The UK-PBC and GLOBE scores showed good prognostic performance in Korean patients with PBC. In addition, a high NLR was associated with a poorer prognosis. Including the NLR in prognostic models may further help to stratify patients with PBC.
Asian Continental Ancestry Group ; Cholangitis* ; Follow-Up Studies ; Humans ; Korea ; Liver ; Liver Cirrhosis, Biliary ; Multivariate Analysis ; Prognosis ; ROC Curve