1.Nesidioblastosis of the Pancreas.
Young Bae KIM ; Jin Sook JEONG ; Ahn Hong CHOI
Korean Journal of Pathology 1992;26(5):484-489
The morphologic abnormalities of the endocrine pancreas that underlie persistent neonatal hyperinsulinemic hypoglycemia and are included under the heading "nesidioblastosis" appears to be heterogeneous. This characteristic morphologic finding is ductuloinsular complexes showing endocrine cells budding off the ductoepithelium and merging with adjacent endocrine cell clusters. A case of nesidioblastosis associated with hyperinsulinemic hypoglycemia occurred in a 6/365 year-old male neonate. Microscopic finding of near totally resected pancreas revealed irregular sized islets and ductuloinsular complexes, both of which contained hypertrophied B cells with a few mitosis. Because of persistent hypoglycemia after first operation, he received second operation 8 days after. This histologic finding was more severe comparative to that of first operation. According to these findings, the pathogenesis of nesidioblastosis may be congenital or developmental defect of a kind of compensatory mechanism by unknown stimuli to acquire persistent hypoglycemia.
Male
;
Infant, Newborn
;
Humans
2.Change of Auditory Brainstem Response(ABR) on Neonatal Asphyxia.
Jeong Sam JEON ; Chong Woo BAE ; Sa Jun CHUNG ; Chang Il AHN
Journal of the Korean Pediatric Society 1989;32(10):1391-1396
No abstract available.
Asphyxia*
;
Brain Stem*
3.Comparison of Orbital Anatomy in Korean and Caucasian Patients Using Computed Tomography.
Journal of the Korean Ophthalmological Society 2015;56(9):1311-1315
PURPOSE: In this study we analyzed and compared the orbital anatomy in Korean and Caucasian subjects using computed tomography (CT) measurements. METHODS: Two observers performed a cross-sectional, retrospective analysis of 44 CT scans of subjects (22 Koreans, 22 Caucasians) with no appreciable orbital or globe disease. Ten length measurements and 3 angle measurements of various orbital aspects were obtained. Analysis was performed to determine if changes in these parameters were associated with race. RESULTS: Anterior medial interorbital length was 24.05 +/- 2.00 mm in Korean and 21.96 +/- 1.96 mm in Caucasian subjects. Anterior vertical orbital length was 34.19 +/- 1.67 mm in Korean and 35.03 +/- 1.18 mm in Caucasian subjects. The anterior medial interorbital length and anterior vertical orbital length (p < 0.05) were significantly different. Interorbital angle was 47.69degrees +/- 1.49degrees in Korean and 46.15degrees +/- 2.19degrees in Caucasian subjects; the difference was statistically significant (p < 0.05). CONCLUSIONS: Compared with Caucasians, the orbit of Korean subjects has a narrower orbital opening and longer interorbital distance. The present study regarding the anatomy of Korean and Caucasian orbits will assist physicians with the evaluation and treatment of orbital diseases.
Continental Population Groups
;
Humans
;
Orbit*
;
Orbital Diseases
;
Retrospective Studies
;
Tomography, X-Ray Computed
4.Developmental Changes of Auditory Brainstem Responses in Children.
Jeong Sik MIN ; Yeong Ho RA ; Chong Woo BAE ; Sa Jun CHUNG ; Chang Il AHN
Journal of the Korean Pediatric Society 1987;30(12):1387-1400
No abstract available.
Child*
;
Evoked Potentials, Auditory, Brain Stem*
;
Humans
5.Hypertrophic Cardiomyopathy in Infant of Diabetic Mother.
Jeong Sam JEON ; Soo Chun KIM ; Chong Woo BAE ; Sung Ho CHA ; Chang Il AHN
Journal of the Korean Pediatric Society 1989;32(8):1138-1143
No abstract available.
Cardiomyopathy, Hypertrophic*
;
Humans
;
Infant*
;
Mothers*
6.Osteoblastoma in lumbar spine: a case report.
Seong Bae KIM ; Seung Ki JEONG ; Jae Yo HYUN ; Eon Sub PARK ; Chan Seog AHN
The Journal of the Korean Orthopaedic Association 1991;26(3):1016-1020
No abstract available.
Osteoblastoma*
;
Spine*
7.Comparison of the Effectiveness and Clinical Outcome of Everolimus Followed by CDK4/6 Inhibitors with the Opposite Treatment Sequence in Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer
Hyehyun JEONG ; Jae Ho JEONG ; Jeong Eun KIM ; Jin-Hee AHN ; Kyung Hae JUNG ; Sung-Bae KIM
Cancer Research and Treatment 2022;54(2):469-477
Purpose:
In hormone receptor-positive, human epidermal growth factor receptor 2–negative metastatic breast cancer (HR+ HER2–MBC), the mainstay treatment options include cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) and everolimus (EVE) in combination with endocrine treatment. This study aims to compare the outcomes of the following treatment sequences: CDK4/6i followed by EVE and EVE followed by CDK4/6i.
Materials and Methods:
Data from HR+ HER2– MBC patients treated between January 2014 and November 2020 with both CDK4/6i and EVE were retrospectively analyzed.
Results:
Among the 88 patients included in the study, 51 received CDK4/6i before EVE (C→E group), and 37 received EVE before CDK4/6i (E→C group) with endocrine treatment. More patients in the E→C group had endocrine resistance (13.7% vs. 40.5%), experienced palliative chemotherapy (7.8% vs. 40.5%), and were heavily treated (treated as ≥ 3rd line, 5.9% vs. 40.5%). Median overall survival was 46.8 months in the C→E group and 38.9 months in the E→C group (p=0.151). Median composite progression-free survival (PFS), defined as the time from the start of the preceding regimen to disease progression on the following regimen or death, was 24.8 months in the C→E group vs. 21.8 months in the E→C group (p=0.681). Median PFS2/PFS1 ratio did not differ significantly between groups (0.5 in the C→E group, 0.6 in the E→C group; p=0.775). Ten patients (11.4%) discontinued EVE, and two patients (2.3%) discontinued CDK4/6i during treatment.
Conclusion
Although the CDK4/6i-based regimen should be considered as an earlier line of treatment, CDK4/6i- and EVE-based treatments can be valid options in circumstances where the other treatment had been already given.
8.The Characteristics of Senile Entropion of Lower Eyelid with Kinked Tarsus.
Woo Jin JEONG ; Mun Chong HUR ; Hee Bae AHN
Journal of the Korean Ophthalmological Society 2011;52(7):777-782
PURPOSE: To report the clinical features and surgical results for lower lid entropion with kinked tarsus compared with entropion with weakened capsulopalpebral fascia. METHODS: From March 2008 to December 2009, 20 patients (24 eyes) with lower lid entropion were examined. The patients were divided into the aggravated entropion with kinked tarsus group or the weakened capsulopalpebral fascia group based on the height of tarsus, the shapes of the lower lid and tarsus, and conjunctiva changes. For treatment of entropion in the kinked tarsus group, full thickness tarsotomy with rotatory suture (tarsal fracture operation) was performed, and in the weakened CPF group, a CPF tight procedure was performed. The results of the operations were retrospectively evaluated. RESULTS: The mean age of the patients with entropion in the kinked tarsus group (15 cases) was 66.7 +/- 11.4 years, and the mean age of the patients with entropion in the weakened CPF group (9 cases) was 67.2 +/- 6.2 years. The height of the lower lid tarsus of each group was 3.80 +/- 0.39 mm and 5.20 +/- 0.30 mm, respectively. Except for one case of recurrence after tarsal fracture operation in the kinked tarsus group and reoperation with CPF tightening, there were no significant complications or recurrence in either group. CONCLUSIONS: Entropion with kinked tarsus was more common than entropion with weakened CPF in the present study. In addition, surgical treatment based on the shape and cause of entropion showed good results.
Animals
;
Ankle
;
Conjunctiva
;
Entropion
;
Eyelids
;
Fascia
;
Humans
;
Recurrence
;
Reoperation
;
Retrospective Studies
;
Sutures
9.Chinical Analysis of Lower Leg Reconstruction with Free Flaps (47 Cases).
Hyung Sik AHN ; Min Shng TAK ; Jae Hoon KIM ; Hyun Gyo JEONG ; Yong Bae KIM ; Soon Jae YANG
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1999;26(5):976-983
Traumatic injury to the lower legs has been increasing in Korea and often leads to skin and soft tissue loss, exposing blood vessels, nerves, tendons or bones. Salvaging these legs often requires free flaps. Over the past two decades, the use of free tissue transfer has produced an increasing salvage rate for severely injured lower leg. Between April. 1988 to July, 1997, 47 cases of lower soft tissue defects were reconstructed with free flaps, and retrospective analysis was performed to determine more about the factors associated with free flap failure or immediate vascular complications. We evaluated wound status before operation, operation time after injury, vascular status of recipient site, use of vein graft, use of reverse flow, salvage protocol in compromised anastomosis, survival rate and complications. There were 9 cases of venous thrombosis and 2 cases of arterial insufficiency while 7 out of 9 cases of venous thrombosis were reexplorated. However, 2 cases of partial flap necrosis and 1 case of total necrosis. Two cases of arterial insufficiency were necrotized, so the overall free flap failure rate was 9.6%. The results were analyzed to determine the factors promoting either failure or vascular complication, Many factors which are often blamed for failure (trauma cause, preoperative general condition, preoperative infection status, intraoperative ischemic time) were not significant in this study, but prolonged time after injury correlated with free flap failure, We concluded the adequate debridement and infection control, adequate selection of recipient vessel, accurate vascular anastomosis and most of all, early free flap transfer after injury, will improve the success rate.
Blood Vessels
;
Debridement
;
Free Tissue Flaps*
;
Infection Control
;
Korea
;
Leg*
;
Necrosis
;
Retrospective Studies
;
Skin
;
Survival Rate
;
Tendons
;
Transplants
;
Vascular System Injuries
;
Veins
;
Venous Thrombosis
;
Wounds and Injuries
10.Surgical Outcome of Minimal Resection with Full Thickness Rotating Suture Technique for Lower Lid Epiblepharon.
Hyun Chul JEONG ; Eun Jung SOHN ; Hee Bae AHN
Journal of the Korean Ophthalmological Society 2016;57(9):1348-1353
PURPOSE: To introduce the minimal skin and orbicularis oculi muscle resection with the full thickness rotating suture technique for lower lid epiblepharon and to assess its surgical outcome. METHODS: A retrospective review of medical records was performed on lower lid epiblepharon patients who were followed for more than 6 months after surgical correction performed between January 2004 and December 2015. All surgeries were performed by one surgeon using minimal skin and orbicularis oculi muscle resection and the full thickness rotating suture technique for lower lid epiblepharon correction. RESULTS: A total of 943 lower lid epiblepharon patients (403 male, 540 female) were included in the analysis. The mean patient age was 6.7 ± 2.4 years, and the mean postoperative follow-up was 12.9 ± 7.2 months. Eyelid shape and function were well maintained in 904 patients (95.9%), with no recurrence during follow-up. Among the recurrent cases (39 patients [4.1%]), 19 patients (2%) underwent a second correction surgery. CONCLUSIONS: Minimal skin and orbicularis oculi muscle resection with the full thickness rotating suture technique for lower lid epiblepharon showed good surgical outcome with few complications and high success rate.
Eyelids
;
Follow-Up Studies
;
Humans
;
Male
;
Medical Records
;
Recurrence
;
Retrospective Studies
;
Skin
;
Suture Techniques*
;
Sutures*