INTRODUCTION: Current international consensus confirms that certain histopathologic factors such as tumor morphology, histologic grade and presence of lymphovascular invasion are correlated with prognosis. This retrospective cohort study evaluated the correlation between histopathologic profile and time to disease progression (UP) within the first 1-2 years follow-up of Filipino Stage I-Ill early breast cancer patients.
METHODS: This is a retrospective cohort study which included breast cancer patients enrolled in the Department of Health¬Breast Cancer Medicine Access Program (DOH-BCMAP) at the medical oncology clinics of two tertiary hospitals in Manila. Clinical and histopathologic factors were gathered from patient records, and the patients were grouped according to the modified St. Gallen definition of risk categories for patients with breast cancer. Kaplan-Meier survival analysis determined the average UP as well as progression-free survival (PFS). Multivariate logistic regression determined factors contributing to disease progression.
RESULTS AND CONCLUSION: Of the 326 patients enrolled in this study, 18% showed progression, with a median HP of 14 months. UP was comparable among the low-, intermediate- and high-risk groups. PFS during the 1st 1-2 years follow-up was estimated to be at 78% for the high-risk group, 83% for the intermediate-risk group, and 86% for the low-risk group. During this 1st 1-2 years follow-up, no studied factors of interest were shown to be significantly correlated with outcome among this predominantly intermediate to high risk for recurrence breast cancer patients. Follow-up of this patients up to 5 or more years would define sustained gains from the DOH-BCMAP.

Human ; Male ; Female ; Breast ; Breast Neoplasms ; Consensus ; Neoplasms ; Prognosis ; Medical Oncology

Objective: This study aimed to determine the prevalence, analyze, and compare the risk factors of anxiety, depression, and quality of life of cancer patients in the out-patient cancer clinic of the Cancer Institute one year into the pandemic. These were compared to the prevalence of anxiety and depression before the pandemic. Methods: A cross-sectional analytic study described the prevalence of anxiety, depression, and quality of life and analysis of its related factors among patients with cancer seen in the outpatient cancer clinic of the Cancer Institute of the Philippine General Hospital from November 1 to 20, 2021, using the Hospital Anxiety and Depression Scale – Pilipino and EORTC (European Organisation for Research and Treatment of Cancer) QLQ-C30 (Quality of Life questionnaire) tools. Results: A total of 408 cancer patients were enrolled in the study. The prevalence of anxiety and depression was 58.33% and 24.51%, respectively. Before the pandemic, the prevalence of anxiety and depression was 9.45% and 4.72%, respectively. Two hundred seventy participants (66.18%) had a positive quality of life. The comparison between the prevalence of anxiety and depression between this study (one year into the pandemic) and the pre-pandemic study revealed a statistically significant difference in the majority of both, with more anxious and depressed cancer patients in this study. The participants agreed that the pandemic had affected their daily activities. Conclusion The study showed that the COVID-19 pandemic significantly increased anxiety and depression among cancer patients. The quality of life (QOL) of cancer patients in this study has not been distinctly affected by the pandemic, but for those who have, they still require the attention and support of not just the physicians but the community as a whole. Our findings highlight the need to integrate better psychosocial support and the important role of carers in the evolving pandemic response measures.
pandemic ; anxiety ; depression ; quality of life ; cancer ; COVID-19