This study is designed to apply for cosmeceutical ingredients with Sanguisorba officinalis and Stichopus japonicus distributed all over the country. The antioxidizing effect of the ethanol extract of Stichopus japonicus displayed stronger inhibition than the Sanguisorba officinalis ethanol extract and mixture of Sanguisorba officinalis and Stichopus japonicus extract. They used in the experiment as 63.28% with the density of 50 microgram/mL, and compared with the ascorbic acid used as positive counterpart. Since the physiological activating ingredient generating the antioxidizing effect was confirmed with the Sanguisorba officinalis and Stichopus japonicus with the experiment results, the possibility for natural antioxidants was implied.
Antioxidants ; Ascorbic Acid ; Cosmetics ; Ethanol ; Sanguisorba ; Stichopus

No abstract available.
Eosinophilia ; Eosinophils ; Folliculitis ; Skin Diseases, Vesiculobullous ; Tacrolimus

No abstract available.
Dermatitis*

No abstract available.
Acinar Cells* ; Arthritis* ; Carcinoma, Acinar Cell* ; Humans ; Panniculitis*

No abstract available.
Graft vs Host Disease* ; Liver Transplantation*

No abstract available.
Aged* ; Arm* ; Histiocytoma, Malignant Fibrous ; Humans

No abstract available.
Child* ; Heel* ; Humans

No abstract available.
Granuloma* ; Sea Urchins* ; Sports*

Tuberous sclerosis complex (TSC) is a neurocutaneous disorder with variable manifestations. The diagnosis is based on clinical criteria, and is divided into definite, probable, and possible TSC. If patients present with mild symptoms, clinicians may hesitate to perform further evaluations because of the high economic burden. A 16-year-old male presented with multiple skin-colored papules on the lower back and buttock. The histopathologic findings were compatible with connective tissue nevi (CTN). No other findings were observed with the exception of one hypomelanotic macule on the left shin. As the patient's parents wished to confirm the diagnosis, genetic testing was performed, and a TSC1 gene mutation was detected. With this genetic result, further evaluations were performed without hesitation. Genetic testing is a sensitive and specific modality for the diagnosis of TSC. We report a case of TSC presenting with CTN only, in which genetic testing was very useful to confirm the diagnosis and to determine the appropriateness of further high-cost studies.
Adolescent ; Buttocks ; Connective Tissue* ; Diagnosis ; Genetic Testing* ; Humans ; Male ; Neurocutaneous Syndromes ; Nevus* ; Parents ; Tuberous Sclerosis*

LEOPARD syndrome is an autosomal dominant inherited disease with multiple congenital anomalies. LEOPARD is an acronym for Lentigines, Electrocardiographic conduction defects, Ocular hypertelorism, Pulmonary stenosis, Abnormalities of the genitalia, Retardation of growth, and Deafness. The disorder is caused by mutations in the PTPN11 gene or RAF1 gene. Here we report two typical cases of LEOPARD syndrome with lentigines, electrocardiograph abnormality, ocular hypertelorism which were proven to be the results of genetic mutations. Moreover, one 12-year-old boy showed growth retardation, deficiency in testosterone; the other 5-year-old girl had undergone implantation of a cochlear device and was diagnosed as having hypertrophic cardiomyopathy which has been managed with a beta blocker. Each patient showed a PTPN11 gene mutation: Thr468Met in exon 12 and Tyr279Cys in exon 7, respectively.
Cardiomyopathy, Hypertrophic ; Deafness ; Electrocardiography ; Exons ; Genitalia ; Humans ; Hypertelorism ; Lentigo ; LEOPARD Syndrome ; Panthera ; Pulmonary Valve Stenosis