BACKGROUND: A definition of granuloma is a focal chronic inflammatory response to tissue injury evolved by a poorly soluble substwice characterized by the accumulation and proliferation of the mono-nuclear histiocytic cells. The accuracy with which rnononuclear cells may be identified in skir. is much improved by the use of both heteroantisera and monoclonal antibodies directed against selected cellular antigens, OBJECTIVE: Our purpose was to examine the staining patterns of anti-lysozyme, anti-a-1-antitrypsin, anti-S-100 protein antibodies, and MAC-387 monoclonal anibody in granulomatous skin diseases. METHOD: We performed imminoperoxidase staining(the labelled str prvidin-biotin peroxidase complex method on the formalin-fixed, paraffin-embedded tissue specimens of granulomatous skin diseases. RESULTS: S-100 protein positive dendritic cells were demonstrated in the granulomatous infiltrates as scattered pattern and MAC-387 positive cells were predominantly found in the center of granulomas, The staining pattern and percentage of positively stained cells of a--antitrypsin were similar to those of lysozyme. A1Pha-1-antitrypsin and lysozyme positive cells w re present in the center as well as lymphohistiocytic infiltrates of granulomas. CONCLUSION: These data sugget that histiocytes are composed of heter igeneous groups of cells such as the mononuclear-phagocyte system and dendritic cell system.
Antibodies ; Antibodies, Monoclonal ; Dendritic Cells ; Granuloma ; Histiocytes ; Muramidase ; Peroxidase ; S100 Proteins ; Skin Diseases ; Skin*

Purpose: This study was performed to investigate the association between step volume and intensity with the prevalence of metabolic syndrome (MS) in Korean adults. Methods: The study analyzed 2,038 adults from the 2014 to 2017 Korea National Health and Nutrition Examination Survey, defining MS based on waist circumference, blood pressure, triglycerides, glucose, and high-density lipoprotein cholesterols. Step volume and intensity were calculated using average number of steps per day and peak 30-minute cadence, respectively. Logistic regression analysis was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of MS by tertiles of step volume and intensity. A joint analysis was conducted to examine the combined association between step volume and intensity with the prevalence of MS. We divided the participants into nine groups according to their step volume (tertiles) and intensity (tertiles). Results: There were 478 MS cases. Compared to the lowest tertile of volume, the ORs of MS were 1.06 (95% CI, 0.79–1.42) and 0.64 (95% CI, 0.47–0.88) in the middle and highest tertile of volume. Compared to the lowest tertile of intensity, the ORs were 1.02 (95% CI, 0.76–1.36) and 0.74 (95% CI, 0.55–1.01) in the middle and highest tertile of intensity. In the joint analysis, compared to the group with both lowest volume and intensity, the ORs were significantly lower in all groups with the highest volume, except the group with the lowest intensity. Conclusion Although only greater step volume, not intensity, was independently related to MS, both step volume and intensity appear to be important for preventing MS.

Purpose: Wrestlers have a lot of direct skin-to-skin contact between wrestlers during matches, and many studies show that wrestlers are vulnerable to the spread of skin infections. However, there have been few studies on skin infections in Korean wrestlers. The purpose of this study was to compare the characteristics of skin diseases in wrestlers and other athletes. Methods: Athletes who visited for skin diseases in the Department of Family Medicine in the Jincheon National Training Center in 2018 were investigated. We calculated the duration of skin disease per training period (DSD/TP) as the number of visits×7 days×1,000/official training days. Athletes with a DSD/TP above the median value or equal to were defined as the high DSD/TP group, and the others were defined as the low DSD/TP group. A chi-square test was used to compare the odds ratio [OR] for these groups about infectious and noninfectious skin diseases. Results: Thirty wrestlers and 89 other sports players visited the infirmary with skin diseases. The probability of belonging to the high DSD/TP group was significantly higher when the wrestlers visited for skin infections than the other athletes (OR, 7.714; 95% confidence interval [CI], 2.699–22.048). However, there was no significant difference in noninfectious skin diseases between wrestling and other sports (OR, 0.569; 95% CI, 0.246–1.320). Conclusion This is the first study that shows Korean national wrestlers with skin diseases receive more treatment for infectious skin diseases than other sports. This study can provide important information on the prevention of wrestlers for skin infections.