1.The Effects of Human Bone Marrow-Derived Mesenchymal Stem Cell Conditioned Media Produced with Fetal Bovine Serum or Human Platelet Lysate on Skin Rejuvenation Characteristics
Si-Na KIM ; Chan-Ju LEE ; JeeHoon NAM ; Byeol CHOI ; Eunkyung CHUNG ; Sun Uk SONG
International Journal of Stem Cells 2021;14(1):94-102
Background and Objectives:
Human mesenchymal stem cell-conditioned medium (MSC-CM) is produced using mesenchymal stem cell culture technology and has various benefits for the skin, including wrinkle removal, skin regeneration, and increased antioxidant activity. Its popularity is thus increasing in the field of functional cosmetics.
Methods:
and Results: In this study, we analyzed the effects of fetal bovine serum-supplemented MSC-CM (FBSMSC-CM) and human platelet lysate-supplemented MSC-CM (hPL-MSC-CM) on skin rejuvenation characteristics.We found that the concentrations of important growth factors (VEGF, TGF-β1, and HGF) and secretory proteins for skin regeneration were significantly higher in hPL-MSC-CM than in FBS-MSC-CM. Furthermore, the capacity for inducing proliferation of human dermal fibroblast (HDF) and keratinocytes, the migration ability of HDF, extracellular matrix (ECM) production such as collagen and elastin was higher in hPL-MSC-CM than that in FBSMSC-CM.
Conclusions
These results support the usefulness and high economic value of hPL-MSC-CM as an alternative source of FBS-MSC-CM in the cosmetic industry for skin rejuvenation.
2.A Case of Rhabdomyolysis in a Patient with Plasmidium vivax Malaria Treated with Hydroxychloroquine.
Se Jin JUNG ; Yeon A KIM ; Jeehoon GHIL ; Nam Su KU ; Joon Hyung KIM ; Yoon Sun PARK ; Myung Soo KIM ; Young Keun KIM ; So Youn SHIN ; Jun Yong CHOI ; June Myung KIM
Infection and Chemotherapy 2006;38(3):174-178
Rhabdomyolysis is a potentially life-threatening syndrome resulting form the breakdown of skeletal muscle fibers with leakage of muscle contents into the circulation. Rhabdomyolysis may complicate many disease states. In some cases, patients with malaria may be complicated with rhabdomyolysis. Also hydroxychloroquine may induce myopathy and rhabdomyolysis. But there is no case report of rhabdomyolysis after use of hydroxychloroquine in a Korean patient with Plasmodium vivax malaria. Recently we experienced a patient who developed rhabdomyolysis 20 days after starting therapy with hydroxychloroquine for the treatment of P. vivax malaria. We report the case with the review of the literature.
Humans
;
Hydroxychloroquine*
;
Malaria
;
Malaria, Vivax*
;
Muscle Fibers, Skeletal
;
Muscular Diseases
;
Plasmodium vivax
;
Rhabdomyolysis*
3.A Case of Rhabdomyolysis in a Patient with Plasmidium vivax Malaria Treated with Hydroxychloroquine.
Se Jin JUNG ; Yeon A KIM ; Jeehoon GHIL ; Nam Su KU ; Joon Hyung KIM ; Yoon Sun PARK ; Myung Soo KIM ; Young Keun KIM ; So Youn SHIN ; Jun Yong CHOI ; June Myung KIM
Infection and Chemotherapy 2006;38(3):174-178
Rhabdomyolysis is a potentially life-threatening syndrome resulting form the breakdown of skeletal muscle fibers with leakage of muscle contents into the circulation. Rhabdomyolysis may complicate many disease states. In some cases, patients with malaria may be complicated with rhabdomyolysis. Also hydroxychloroquine may induce myopathy and rhabdomyolysis. But there is no case report of rhabdomyolysis after use of hydroxychloroquine in a Korean patient with Plasmodium vivax malaria. Recently we experienced a patient who developed rhabdomyolysis 20 days after starting therapy with hydroxychloroquine for the treatment of P. vivax malaria. We report the case with the review of the literature.
Humans
;
Hydroxychloroquine*
;
Malaria
;
Malaria, Vivax*
;
Muscle Fibers, Skeletal
;
Muscular Diseases
;
Plasmodium vivax
;
Rhabdomyolysis*