1.Selective Cytotoxicity of the New Platnum ( 2 ) Complexes on Human Gastric Cancer Cell - lines and Normal Kidney Cells.
Jee Chang JUNG ; Sung Goo CHANG ; Young Soo RHO
Journal of the Korean Cancer Association 1999;31(5):1035-1043
PURPOSE: Platinum coordination complex (cisplatin) has been currently used as one of the most effective compound in the treatment of various solid tumors. However, its use has been limited by severe side effects such as renal toxicity. Our platinum-based drug discovery program has been aimed at developing drugs capable of diminishing toxicity and selective cytotoxicity. MATERIALS AND METHODS: A new series of highly water soluble platinum (II) complexes Pt (II) [1,3-Bis (phenylthio) propane) (trans-l-1,2-diaminocyclohexane) (PC-1) and Pt (II) [1,3-Bis-(phenylthio) (propane)]-1,2-diaminocyclohexane (PC-2) were synthesized and characterized by their elemental analysis and by various spectroscopic techniques [infrared (.IR), ""C-nuclear magnetic resonance (NMR)]. In vitro antitumor activity and nephrotoxi -cities of new Pt (II) complexes were tested against MKN-45 human gastric cancer cell- lines and normal kidney cells using colorimetric MTT[3-(4,5-dimethyl thiazol-2-yl)-2,5- diphenyl tetrazolium bromide] assay for cell survival and proliferation. RESULTS: PC-1 showed activity against MKN-45/P and MKN-45/CDDP human gastric adenocarcinoma cells, and the antitumor activity of this compound was comparable or superior to that of PC-2 and cisplatin. The nephrotoxicity of PC-1 and PC-2 were found quite less than that of cisplatin using MTT, [H] thymidine uptake and glucose consumption tests in rabbit proximal tubule cells, human kidney cortical cells and human renal cortical tissues. CONCLUSION: Based on these results, this novel platinum (II) complex compound (PC-1) represent a valuable lead in the development of a new anticancer chemotherapeutic agent capable of improving antitumor activity and low nephrotoxicity.
Adenocarcinoma
;
Cell Survival
;
Cisplatin
;
Drug Discovery
;
Glucose
;
Humans*
;
Kidney*
;
Platinum
;
Stomach Neoplasms*
;
Thymidine
2.Microcystic Adnexal Carcinoma: Report of a case.
Eun Deok CHANG ; Young Hee JEE ; Sun Moo KIM
Korean Journal of Pathology 1993;27(3):290-292
Microcystic adenxal carcinoma is an unusual, locally aggressive neoplasm that has recently been recongized as a clincopathologic entity. Its histologic appearance includes both pilar and eccrine differentiation. Microscopically, the tumor consisted of small cysts and gland-like structures in superficial portion. In other area, basaloid cell nests and abortive hair follicles in the sclerotic stroma were seen. The cysts were filled with secretory eosinophilic material, which was positively stained with Periodic acid-Schiff and carcinoembryonic antigen. Immuno-peroxidase staining for carcinoembryonic antigen supported the dual differnetiation of this neoplasm. Despite the benign histologic appearance, there was deep and extensive infiltration of the subcutaneous tissue.
Cysts
3.Adenoid Cystic Carcinoma of Skin: A case report.
Eun Duk CHANG ; Young Hee JEE ; Sun Moo KIM
Korean Journal of Pathology 1989;23(3):378-381
A primary skin adenoid cystic carcinoma first described by Boggio in 1975, is one of the rarest type of eccrine sweat gland carcinoma. Histologically, a tumor with typical morphologic features closely resembles adenoid cystic carcinoma was found in other tissues but in the skin must be distinguished from aggressive basal cell carcinoma. The natural history of this tumor is not yet fully determined but suggests a long indolent and progressive course. We report a case of a 77-year-old male with a small skin nodule in the abdomen.
Male
;
Humans
4.Malignant Mixed Mullerian Tumor of the Fallopian Tube: Report of a Case.
Eun Deok CHANG ; Young Hee JEE ; Sun Moo KIM
Korean Journal of Pathology 1988;22(1):92-96
Malignant mixed mullerian tumor of the fallopian tube is an extremely rare neoplasm. To date, only 26 cases of primary malignant mixed mullerian tumor of the fallopian tube have been reported, and no report has been published in Korea. This is not surprising, since as a group these meoplasms are least likely to occur in the fallopian tube; the most common sites being the endometrium, vagina, cervix and ovary. We report a case of malignant mixed mullerian tumor of the fallopian tube ina 63-year-old woman with brief review of the literatures.
Female
;
Humans
5.The Study for GER in Patients with Chronic Unexplained Cough Using Combined 24 Hour Esophageal pH and Motility Monitoring.
Young Koo JEE ; Yoon Seob KIM ; Chang Young LIM ; Kye Young LEE ; Kun Yeol KIM
Korean Journal of Medicine 1997;53(5):636-644
No abstract available.
Cough*
;
Humans
;
Hydrogen-Ion Concentration*
6.Development of Keratitis by Soft Contact Lenses Contaminated with Candida albicans.
Jee Yun KANG ; Young Ho HAHN ; Myung Woong CHANG
Journal of the Korean Ophthalmological Society 1996;37(6):945-952
In order to study the development of fungal keratitis in wearing of the soft contact lenses contaminated with fungus in various conditions of the cornea, we contaminated the soft contact lenses with Candida albicans, and then placed them on the corneas in rabbits. The rabbits were divided into 4 groups(each 8 eyes). In group 1, dexamethasone was injected subconjunctivally once a day for 4 days and the corneal epithelium was removed 7mm in diameter. In group 2, dexamethasone was injected subconjunctivally once a day for 4 days without removal of the corneal epithelium. In group 3, the corneal epithelium was removed 7mm in diameter without subconjunctival injection of dexamethasone. In group 4, normal corneas were used as a control. The corneas were observed daily with slit-lamp. After 10 days, the infected corneas were examined with light microscope. Keratitis was developed in 5 eyes in group 1(5/8), 3 eyes in group 2(3/8), 2 eyes in group 3(2/8). But keratitis was not developed in group 4. Light microscopic examination showed active invasion of C, albicans forming pseudohyphae into the cornea associated with severe inflammation in group 1 and 2, but it showed mild inflammation and only a small number of C, albicans in the superficial cornea in group 3. In this study, it was found that immunosuppressed and de-epithelialized corneas are susceptible to C, albicans.
Candida albicans*
;
Candida*
;
Contact Lenses, Hydrophilic*
;
Cornea
;
Dexamethasone
;
Epithelium, Corneal
;
Fungi
;
Inflammation
;
Keratitis*
;
Rabbits
7.Cystic Adventitial Disease of the Popliteal Artery: Resection and Repair with Autologous Vein Patch.
Young Hee MAENG ; Jee Won CHANG ; Sun Hyung KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 2011;44(3):266-268
Cystic adventitial disease is rare, but it is one of the well-recognized causes of non-atherosclerotic arterial stenosis or obstruction. Despite one of its most common symptoms being chronic intermittent claudication, it may be misdiagnosed as arterial embolism when presented with acute ischemic symptoms. Surgical resection is recommended because of recurrence or a low success rate with aspiration or endovascular stent. We performed resection and repair with autologous vein patch for cystic adventitial disease of the popliteal artery of a 57-year-old man presenting with pain, pallor, and paresthesia, without any postoperative complications or recurrence.
Constriction, Pathologic
;
Embolism
;
Humans
;
Intermittent Claudication
;
Middle Aged
;
Pallor
;
Paresthesia
;
Popliteal Artery
;
Postoperative Complications
;
Recurrence
;
Stents
;
Vascular Diseases
;
Veins
8.Renal Cell Carcinoma Associated with Rhabdomyosarcomatous Component: Report of a case.
Mee Soo CHANG ; Mi Kyung JEE ; Kyo Young LEE ; Sang In SHIM ; Sun Moo KIM
Korean Journal of Pathology 1987;21(1):40-44
Renal cell carcinoma, intimately associated with a sarcomatous component, is a rare malignant renal tumor. There is disagreement whether these represent true sarcomas or are sarcomatoid metaplasia. Therefore, this sarcomatous component is at times still a troublesome problem for pathologists. In March, 1986, we experienced a case of renal cell carcinoma associated with rhabdomyosarcomatous component in 47 year-old woman who had a rapidly enlarged, palpable abdominal mass. Grossly, a spherical renal cell carcinoma, 17x14x10 cm, in upper and middle portions of the right kidney showed extension through the renal capsule into the perirenal fat. Area of myxoid change was evident in the reanl cell carcinoma, with extensive hemorrhagic necrosis. Microscopically, in the myxoid area, there was malignant spindle cell proliferation in which many rhabdomyoblasts showing distinct cross striation could be demonstrated. This rhabdomyosarcomatous component intermixed with renal cell carcinoma of clear cell type could be also identified in the focal area.
Female
;
Humans
9.Change of volume of isoflow in pneumoconiosis patients with small opacity.
Sang Yong OH ; Jee Won KIM ; Chang Young JUNG ; Kyung Ah KIM ; Im Goung YUN
Tuberculosis and Respiratory Diseases 1993;40(5):540-547
No abstract available.
Humans
;
Pneumoconiosis*
10.A Case of Spindle Cell Thymoma with Spinal Cord Compression.
Jong In BYUN ; Sang Min SEONG ; Kyung Tai WHANG ; Eun Deok CHANG ; Young Hee JEE
Journal of the Korean Pediatric Society 1988;31(9):1237-1242
No abstract available.
Spinal Cord Compression*
;
Spinal Cord*
;
Thymoma*