1.A Case of Glomangiomyoma.
Jee Youn WON ; Seok Jong LEE ; Eun Sup SONG
Korean Journal of Dermatology 1998;36(2):376-379
Glomus tumor shows histologically characteristic three components of glomus cells, vascular structures, and spindle-shaped smooth muscle cells. It is classified into solid glomus tumor, glomangioma and glomangiomyoma according to relative proportions of components. Glomangiomyoma, the least frequent type of glomus tumor, has its overall histopathologic pattern identical to common solid glomus tumor or glomangioma. In contrast to the foregoing types, however, it has an important number of spindle-shaped smooth muscle cells, which blend with the glomus cells. A 49-year-old woman presented with 2-year history of painful bluish red nodule beneath nail plate of right 4th finger. We made a diagnosis of glomangiomyoma by virtue of routine histopathologic examinations and immunohistochemical stains such as vimentin, smooth muscle actin and desmin.
Actins
;
Coloring Agents
;
Desmin
;
Diagnosis
;
Female
;
Fingers
;
Glomus Tumor
;
Humans
;
Intervertebral Disc
;
Middle Aged
;
Muscle, Smooth
;
Myocytes, Smooth Muscle
;
Spine
;
Vimentin
;
Virtues
2.A Case of Transient Acrodermatitis Enteropathica in a Full-Term Breast-Fed Infant.
Jee Youn WON ; Gi Bong JUNG ; Young Min JEON ; Jee Bum LEE ; Eun Sup SONG
Korean Journal of Dermatology 1999;37(6):790-793
We herein report a case of transient acrodermatitis enteropathica in a 3-month-old, breast-fed, full-term infant. The patient was presented with a 2-month history of diarrhea and crusted erythema- tous patches on the periorificial area. Similar lesions were seen in his siblings. His serum zinc level and the zinc level in his mother's breast milk were markedly reduced. Diarrhea and skin lesions disappeared promptly with oral zinc supplementation and did not recur when zinc was discontinued after three weeks. Our case indicates that even full-term infants, who feed excl-usively on mothers milk, run a risk of developing zinc deficiency, if the concentration of zinc in the breast milk is very low.
Acrodermatitis*
;
Diarrhea
;
Humans
;
Infant*
;
Milk
;
Milk, Human
;
Mothers
;
Siblings
;
Skin
;
Zinc
3.A Clinical and Histopathologic Study of Rubella.
Jee Youn WON ; Young Min JEON ; Eun Sup SONG
Korean Journal of Dermatology 2001;39(2):155-160
BACKGROUND: Although rubella is a mild exanthematous viral infection and its incidence has been greatly decreased after effective vaccination, epidemics of rubella has been noted at 5- to 7-year intervals. But there has been few report about the clinical and histopathologic study of rubella in Korean literatures. OBJECTIVE: The purpose of this study was to review the clinical and histopathologic characteristics of rubella of 1996 outbreak. METHODS: We reviewed the clinical features and histopathologic findings in 50 patients diagnosed as rubella in Department of Dermatology, Presbyterian Medical Center from January 1996 through to May 1996. RESULTS: 1. The male-female ratio was 1: .17. The age distribution was 13-32 years and 72% of patients were aged 16-25 years. 2. Erythematous maculopapular rash on whole body was developed in all patients. Eighty two percent of the patients had fever and lymphadenopathy, and 36% of the patients had petechiae of soft palate. The main prodromal symptoms were sore throat(50%), headache(34%), and upper respiratory symptoms(22%), as order of frequency. 3. Positive serologic test for rubella IgM antibody was 79.5%. 4. The most common abnormal laboratory finding was leukopenia(58%), and followed by positive ASO(34%), the presence of atypical lymphocytes(21%), and thrombocytopenia(8%). 5. Histologically, epidermal changes were mild to moderate vacuolopathy(92.3%), the presence of dyskeratotic cells(30.8%), spongiosis(23.1%), and exocytosis(15.4%). Dermal findings were mild superficial perivascular lymphohistiocytic infiltration(100%), upper dermal edema(53.8%), perivascular edema(38.4%), pigmentary incontinence(30.8%), and the presence of extravasated RBC(23.1%). Eosinophil infiltration(15.4%) and the presence of large nucleated lymphocytes(92.3%) were also observed. Conclusions: According to the results of our study about rubella outbreak in 1996, clinical signs and symptoms were similar to those of previously described. Histologically, superficial perivascular dermatitis with mild to mederate vacuolar interface change was a main feature and large nucleated lymphocytes were frequently noted.
Age Distribution
;
Dermatitis
;
Dermatology
;
Eosinophils
;
Exanthema
;
Fever
;
Humans
;
Immunoglobulin M
;
Incidence
;
Lymphatic Diseases
;
Lymphocytes
;
Palate, Soft
;
Prodromal Symptoms
;
Protestantism
;
Purpura
;
Rubella*
;
Serologic Tests
;
Vaccination
4.A Case of Toxic Epidermal Necrolysis Due to Contact of Paraquat(Gramoxone(R)).
Jee Youn WON ; Young Min JEON ; Eun Sup SONG
Korean Journal of Dermatology 2000;38(12):1676-1678
Occasionally, erythema multiforme has been reported to occur in association with allergic contact dermatitis to various substances including paraquat(Gramoxone(R)). In these cases the erythema multiforme has ranged from mild localized exanthem to life-threatening toxic epidermal necrolysis. We report a case of toxic epidermal necrolysis developed from erythema multiform due to contact of paraquat.
Dermatitis, Allergic Contact
;
Erythema
;
Erythema Multiforme
;
Exanthema
;
Paraquat
;
Stevens-Johnson Syndrome*
5.Mask Phenomenon; Five Cases of Unusual Facial Purpura.
Jee Youn WON ; Gi Dong JUNG ; Eun Sup SONG
Korean Journal of Dermatology 2000;38(7):937-939
Purpura is discoloration of the skin and mucous membranes due to extravasation of red blood cells and may be due to a variety of factors, but it is sometimes difficult to identify the exact cause. Some forms of purpura can frighten the patient and puzzle the physician. Mask phenomenon is an unusual purpura of the relatively loose tissues of the face and neck occuring after prolonged coughing, vigorous vomiting, valsalva's maneuver, parturition, or any other exertion that raises intrathoracic or abdominal pressure. This occurs with acute onset and fades within twenty-four to seventy-two hours spontaneously. A work-up for a coagulation or platelet defect is usually not required. We herein describe five cases of mask phenomenon(unusual facial purpura).
Blood Platelets
;
Cough
;
Erythrocytes
;
Humans
;
Masks*
;
Mucous Membrane
;
Neck
;
Parturition
;
Purpura*
;
Skin
;
Valsalva Maneuver
;
Vomiting
6.Mask Phenomenon; Five Cases of Unusual Facial Purpura.
Jee Youn WON ; Gi Dong JUNG ; Eun Sup SONG
Korean Journal of Dermatology 2000;38(7):937-939
Purpura is discoloration of the skin and mucous membranes due to extravasation of red blood cells and may be due to a variety of factors, but it is sometimes difficult to identify the exact cause. Some forms of purpura can frighten the patient and puzzle the physician. Mask phenomenon is an unusual purpura of the relatively loose tissues of the face and neck occuring after prolonged coughing, vigorous vomiting, valsalva's maneuver, parturition, or any other exertion that raises intrathoracic or abdominal pressure. This occurs with acute onset and fades within twenty-four to seventy-two hours spontaneously. A work-up for a coagulation or platelet defect is usually not required. We herein describe five cases of mask phenomenon(unusual facial purpura).
Blood Platelets
;
Cough
;
Erythrocytes
;
Humans
;
Masks*
;
Mucous Membrane
;
Neck
;
Parturition
;
Purpura*
;
Skin
;
Valsalva Maneuver
;
Vomiting
7.Four Cases of Cutaneous Sinus Tract of Dental Origin.
Gi Dong JUNG ; Jee Youn WON ; Eun Sup SONG
Korean Journal of Dermatology 2001;39(10):1118-1122
The most common cause of chronic cutaneous sinus tract in the face and neck is chronically draining dental infection. The diagnosis is easily confirmed by dental examination and dental roentgenogram of the involved area, but this disease is frequently misdiagnosed and incorrectly treated in dermatologic department. We report four cases of cutaneous sinus tract of dental origin. First patient had a painful nodule with chronically draining pus and a dimple on the left cheek. Second patient had a dimple with draining bloody fluid on the right chin. Third patient had a pea-sized papule with draining serous fluid on the left chin. Fourth patient had a fluctuant erythematous plaque with draining pus and a dimple on the left buccal area. In all four patients radiologic examination of the maxillary and mandibular regions demonstrated radioluency at the apex of tooth consistent with periapical abscess.
Cheek
;
Chin
;
Diagnosis
;
Humans
;
Neck
;
Periapical Abscess
;
Suppuration
;
Tooth
8.A Case of Lentigo Maligna Melanoma.
Jee Youn WON ; Young Min JEON ; Eun Sup SONG
Korean Journal of Dermatology 2000;38(10):1362-1365
Lentigo maligna melanoma(LMM) is the least common type of melanoma and most commonly affects the sun-exposed skin of the elderly. We herein report a case of LMM evolved from lentigo maligna(LM). A 71-year-old female presented with a longstanding irregular brown patch containing two black papules on the left cheek which developed 8 months ago. Histopathologic findings were consistent with LM and LMM. We performed a wide excision and dufourmental flap for reconstruction with no recurrence for 30 months. Sun exposure has been known as the most important etiologic factor for the development of malignant melanoma including LMM and the incidence has an increasing tendency. Thus, skin biopsy is recommended in the evaluation of a longstanding irregular brown patch on the face to prevent LMM.
Aged
;
Biopsy
;
Cheek
;
Female
;
Humans
;
Hutchinson's Melanotic Freckle*
;
Incidence
;
Lentigo*
;
Melanoma*
;
Recurrence
;
Skin
;
Solar System
9.Axial Lenth of Eye as a Risk Factor of the Branch Retinal Vein Occlusion.
Tae Kon YI ; Jung Won PARK ; Jee Youn KIM
Journal of the Korean Ophthalmological Society 1998;39(10):2335-2342
Branch retinal vein occlusion(BRVO), along with central retinal vein occlusion, is second only to diabetic retinopathy as a cause of retinal vascular disease. It has been suggested that eyes with shorter axial length have smaller lamina cribrosa and a narrower scleral canal through which the central retinal vein and artery could pass, causing physical blockage in the vein which predisposes to thrombus formation. The subsequent narrowing of the venous lumen will lead to trubulence. reduced flow, venous stasis and thrombus formation at the level of the arteriovenous crossing. This study was conducted to determine whether there was any difference between the axial lengths of eyes with BRVO and those of control eyes. The axial lengths of the eyes in the group of 37 patients with a unilateral BRVO was compared with those of eyes in the control group. The BRVO group consisted of 23 male and 14 female patients and their mean ages were 61.5+/-7.0 years(51~75years) in male and 63.7+/-7.0 years(52~76years) in female. The control group consisted of 46 male and 28 female patients and their mean ages were 62.5+/-6.5 years(50~73years) in male and 63.9+/-6.1 years(52~75years) in female. The mean axial length of eyes of the BRVO group was 23.08+/-0.57mm(21.92~24.19mm) in male and 22.71+/-0.65mm(21.08~24.00mm) in female. The mean axial length of control eyes was 23.74+/-0.73mm(22.46~25.24mm) in male and 23.18+/-0.81mm(21.62~24.76mm) in female. The difference between the mean axial length of eyes of the BRVO group and that of control eyes was statistically significant(p<0.05). In conclusion, the short axial length may play as a risk factor in the occurrence of a BRVO.
Arteries
;
Diabetic Retinopathy
;
Female
;
Humans
;
Male
;
Retinal Vein Occlusion*
;
Retinal Vein*
;
Retinaldehyde*
;
Risk Factors*
;
Thrombosis
;
Vascular Diseases
;
Veins
10.Tumor Necrosis Factor Alpha Promoter Polymorphism of Systemic Lupus Erythematosus in Korean.
Kyung Sook KANG ; Ho Youn KIM ; Sang Heon LEE ; Jee Won MOK
Korean Journal of Immunology 1998;20(4):443-449
"It was reported that polymorphism of TNF alpha gene was present in promoter region and involves the substitution of guanine by adenosine in the uncommon (TNFA 2) allele. In this study, we investigated the significance of TNFA gene polymorphism in relation to various clinical characteristics and autoantibody profiles in SLE as well as comparing it with that of other countries, and also studied its association with peripheral TNF-a production in vitro. TNFA genotyping was performed in 126 SLE patients and 300 controls using DNA extracted from peripheral leucocytes. The biallelic polymorphism at position -308 of the TNFA promotor was determined by Ncol- RFLP. Peripheral mononuclear cell production of TNF-a was investigated by bioassay using L-929 cell cytotoxicity. The TNFA ""1 homozygote was a predominant allele (77.0%) in SLE, which was not different from the controls. TNFA ""2 homozygate was extremely rare in both patients and controls (0.8%, 1.3% respectively). The clinical manifestations between TNFA '1 and TNFA""2 did not differ. The production of autoantibodies including dsDNA, anti-La, anti-nRNP and anti-Sm was not different between two alleles, whereas anti- Ro antibody was more frequent in TNFA""1/TNFA '1 than in TNFA'1/TNFA'2 (62.1% vs 38.4%, P=0.022). The polymorphism of TNFA gene did not influence the lipopolysaccharide stimulated peripheral mononuclear cell production of TNF-a (1356+/-293 vs 1119+/-385 pg/ml; TNFA'1/TNFA'1, TNFA'1/TNFA'2 respectively). These results suggested that promoter polymorphism of TNFA was not directly involved in the susceptibility of SLE and was not responsible for differential peripheral TNF-a production, but TNFA ' may be associated with anti-Ro antibody production."
Adenosine
;
Alleles
;
Autoantibodies
;
Biological Assay
;
DNA
;
Guanine
;
Homozygote
;
Humans
;
Lupus Erythematosus, Systemic*
;
Polymorphism, Restriction Fragment Length
;
Promoter Regions, Genetic
;
Tumor Necrosis Factor-alpha*