No Abstract available.
Diagnosis* ; Female ; Fetal Heart* ; Humans ; Pregnancy ; Pregnancy Trimester, Second*

No Abstract available.
Echocardiography*

No abstract available.
Arthritis, Rheumatoid* ; Humans ; Hyperplasia* ; NF-kappa B*

No abstract available
Ultrasonography, Prenatal*

We report an extremely specific case of Pendred's syndrome, originally described with an association of thyroid organification defect and hearing impairment; normal-sized thyroid, severe hypothyroidism manifested by profoundly retarded physical and mental development, cardiomegaly and severe hypochromic & microcytic anemia associated with asymmetrical septal hypertrophy.
Adolescent* ; Anemia* ; Cardiomegaly ; Hearing Loss ; Humans ; Hypertrophy* ; Hypothyroidism ; Thyroid Gland

Recent advancements in various technologies have shed light on the critical role of metabolism in immune cells, paving the way for innovative disease treatment strategies through immunometabolism modulation. This review emphasizes the glucose metabolism of myeloid-derived suppressor cells (MDSCs), an emerging pivotal immunosuppressive factor especially within the tumor microenvironment. MDSCs, an immature and heterogeneous myeloid cell population, act as a double-edged sword by exacerbating tumors or mitigating inflammatory diseases through their immune-suppressive functions. Numerous recent studies have centered on glycolysis of MDSC, investigating the regulation of altered glycolytic pathways to manage diseases. However, the specific changes in MDSC glycolysis and their exact functions continue to be areas of ongoing discussion yet. In this paper, we review a range of current findings, including the latest research on the alteration of glycolysis in MDSCs, the consequential functional alterations in these cells, and the outcomes of attempts to modulate MDSC functions by regulating glycolysis. Ultimately, we will provide insights into whether these research efforts could be translated into clinical applications.

Background: Pemphigus is an autoimmune blistering disease characterized by the production of autoantibodies against desmosomal proteins. Owing to its high mortality rate, prompt and accurate diagnosis of pemphigus is crucial. Objective: To determine the positivity rates of immunoblotting in patients diagnosed with pemphigus using clinical, histopathological, direct immunofluorescence (DIF), and enzyme-linked immunosorbent assay (ELISA). Methods: We retrospectively evaluated 84 patients diagnosed with pemphigus between 2001 and 2021 at the Chonnam National University Hospital in Gwangju, Korea. Results: Among the 55 patients with pemphigus vulgaris included in the immunoblotting study, 46 (83.6%) exhibited positive findings for the 130 kDa band. Of the 29 patients with pemphigus foliaceus, 17 (58.6%) showed positive findings for the 160 kDa band. In cases where autoantibodies were difficult to detect with negative DIF and ELISA results, immunoblotting aided in the diagnosis of 18.2% of pemphigus vulgaris cases and 6.9% of pemphigus foliaceus cases. Conclusion Immunoblotting can serve as an alternative diagnostic method for patients with mild-to-moderate disease or those who have undergone treatment, especially when DIF or ELISA tests yield negative or atypical results.

PURPOSE: The purpose of this study was to evaluate the effectiveness of a health promotion program utilizing action planning strategy for young adults. METHODS: A non-equivalent control group pre-post-test design was used. One hundred three university students participated in the study. Participants in the experimental group (n=51) were provided the health promotion program utilizing action planning strategy for five weeks. The program consisted of weekly sessions that included action planning and group feedback. The control group (n=52) was provided with health information every week for 5 weeks. Program outcomes, including self-efficacy, physical activity health behaviors, total exercise time per week, daily cigarette consumption, frequency of alcohol drinking per month, nutritional health behaviors, and subjective health status, were assessed at baseline and at follow-up after 5 weeks. RESULTS: The participants in the experimental group demonstrated significant increases in self-efficacy, physical activity health behaviors, weekly exercise time, and nutritional health behaviors and significant decreases in daily cigarette consumption than those in the control group. CONCLUSION The health promotion program utilizing action planning strategy is a brief and effective intervention to promote health behaviors among young adults. Further investigation is warranted to assess the program's effectiveness among other age groups and populations at high risk for chronic illness.

PURPOSE: The purpose of this study was to evaluate the effectiveness of a health promotion program utilizing action planning strategy for young adults. METHODS: A non-equivalent control group pre-post-test design was used. One hundred three university students participated in the study. Participants in the experimental group (n=51) were provided the health promotion program utilizing action planning strategy for five weeks. The program consisted of weekly sessions that included action planning and group feedback. The control group (n=52) was provided with health information every week for 5 weeks. Program outcomes, including self-efficacy, physical activity health behaviors, total exercise time per week, daily cigarette consumption, frequency of alcohol drinking per month, nutritional health behaviors, and subjective health status, were assessed at baseline and at follow-up after 5 weeks. RESULTS: The participants in the experimental group demonstrated significant increases in self-efficacy, physical activity health behaviors, weekly exercise time, and nutritional health behaviors and significant decreases in daily cigarette consumption than those in the control group. CONCLUSION: The health promotion program utilizing action planning strategy is a brief and effective intervention to promote health behaviors among young adults. Further investigation is warranted to assess the program's effectiveness among other age groups and populations at high risk for chronic illness.
Alcohol Drinking ; Chronic Disease ; Diagnostic Self Evaluation ; Follow-Up Studies ; Health Behavior ; Health Promotion ; Humans ; Motor Activity ; Self Efficacy ; Tobacco Products ; Young Adult

PURPOSE: Ghrelin, a 28-amino-acid peptide predominantly produced by the stomach, is endogenous ligand of growth hormone secretagogue receptor and potent stimulator of growth hormone. Ghrelin is also proposed to be orexigenic peptide that induce weight gain by increasing food intake. In general, ghrelin level increase preprandially and decrease after meals and ghrelin is reduced in obese, insulin resistance adults. There is a few available data of ghrelin level in obese children. The aim of this study was to determine whether there was difference of serum ghrelin level between obese and lean children and to evaluate the relationship between ghrelin and insulin resistance. METHODS: The study population consisted of 104 Children (65 males and 39 females) aged 8.0 to 15.0 years. We measured serum glucose and lipid profiles after 8 hr of fasting. Serum insulin and ghrelin were measured by radioimmunoassay. We compared serum ghrelin level between 52 obese children whose body mass index (BMI) greater than the 95th percentile for age and sex and 31 lean children and evaluated the relationship of ghrelin with BMI, fasting glucose, lipid profile and insulin resistance. We also compared serum ghrelin level of fasting and two-hour postprandial state by oral glucose tolerance test in 23 obese children. RESULTS: Mean serum ghrelin concentrations were 445.4 pg/mL in obese children, 504.9 pg/mL in lean children, but not different significantly. The decrease in serum ghrelin with advancing pubertal stage was significantly marked between prepuberty and overt puberty group (P<0.05). The fasting serum ghrelin concentration were negatively associated with height (r=-0.25, P<0.05), weight (r=-0.28, P<0.01), BMI (r=-0.21, P<0.05), fasting insulin concentration (r=-0.27, P<0.01) and HOMA-IR (r=-0.24, P<0.05). After two-hour postprandial state in obese children group, serum ghrelin level were decreased than fasting state (P<0.01). CONCLUSION: Serum ghrelin had no significant difference between obese and lean children but negatively correlated with body mass index and ghrelin were associated with fasting insulin concentration and HOMA-IR. This findings suggest that ghrelin is regulated by feeding state and also modulated by insulin secretion.
Adolescent* ; Adult ; Blood Glucose ; Body Mass Index ; Child* ; Eating ; Fasting ; Ghrelin* ; Glucose ; Glucose Tolerance Test ; Growth Hormone ; Humans ; Insulin Resistance* ; Insulin* ; Male ; Meals ; Obesity ; Puberty ; Radioimmunoassay ; Receptors, Ghrelin ; Stomach ; Weight Gain