No abstract available.
Animals ; Endometriosis* ; Female ; Horns* ; Kidney*

No abstract available.
Animals ; Endometriosis* ; Female ; Horns* ; Kidney*

No abstract available.
Hamartoma*

Trichoblastic fibroma is a rare, benign trichogenic tumor that has both an epithelial and mesenchymal component. This tumor may be confused clinically and/or histologically with basal cell carcinoma and other tumors with hair follicle differentiation. We describe here a patient with trichoblastic fibroma on the nose. For further characterization of the tumor, we studied the bcl-2 expression in this case and compared it with those of trichoepitheliomas and basal cell carcinomas. The bcl-2 expression in this case and trichoepitheliomas were positive at the periphery of the tumor nest only, whereas those of basal cell carcinomas were positive diffusely throughout the tumor nest.
Carcinoma, Basal Cell ; Fibroma* ; Hair Follicle ; Humans ; Nose

Recent advancements in various technologies have shed light on the critical role of metabolism in immune cells, paving the way for innovative disease treatment strategies through immunometabolism modulation. This review emphasizes the glucose metabolism of myeloid-derived suppressor cells (MDSCs), an emerging pivotal immunosuppressive factor especially within the tumor microenvironment. MDSCs, an immature and heterogeneous myeloid cell population, act as a double-edged sword by exacerbating tumors or mitigating inflammatory diseases through their immune-suppressive functions. Numerous recent studies have centered on glycolysis of MDSC, investigating the regulation of altered glycolytic pathways to manage diseases. However, the specific changes in MDSC glycolysis and their exact functions continue to be areas of ongoing discussion yet. In this paper, we review a range of current findings, including the latest research on the alteration of glycolysis in MDSCs, the consequential functional alterations in these cells, and the outcomes of attempts to modulate MDSC functions by regulating glycolysis. Ultimately, we will provide insights into whether these research efforts could be translated into clinical applications.

Purpose: We report a case of post-pterygium excisional Pseudallescheria boydii (P. boydii) necrotizing scleritis successfully treated with multi-antifungal agents.Case summary: A 73-year-old female with a history of pterygium excision 6 years prior was referred to our institute because of worsening scleritis in the left eye during high-dose, 2-week steroid treatment. On the initial visit, an oval ulcer was observed in the temporal sclera adjacent to the limbus. All steroids were stopped and 1% voriconazole, 5% natamycin, 2.5% vancomycin, and 5% ceftazidime eyedrops were applied every hour and oral voriconazole 200 mg prescribed once a day, but the scleral necrosis continued to worsen. On day 10, the filamentous fungus P. boydii was isolated; 0.5% caspofungin eyedrops were added and the topical voriconazole concentration increased to 2%. Six weeks later, despite epithelization over the scleral necrosis, choroidal detachment developed. The antifungal treatment was continued and a dispersive, ophthalmic viscosurgical device inserted in the anterior chamber. At 14 weeks of treatment, the scleral necrosis was completely epithelialized and the choroidal detachment had disappeared. Conclusions When encountering a case of P. boydii-caused necrotizing scleritis developing after pterygium excision surgery, long-term intensive treatment with several antifungal agents must be considered.

OBJECTIVE: The aim of this study were to compare the effects of EG and PROH on cryopreservation of mouse and human embryos, and to find the optimal protocol for embryo freezing. METHODS: Human embryos derived from fertilized eggs showing 3 pronuclei (PN) and mouse embryos were divided into two groups respectively: dehydrated with 1.5 M EG+0.2 M sucrose or 1.5 M PROH+0.2 M sucrose using the slow freezing method. Moreover mouse embryos were controlled the exposure time of cryoprotectant during dehydration or rehydration steps. RESULTS: The survival rates of human embryos were 79.2% (84/106) in EG group and 77.9% (88/113) in PROH group. In mouse embryos, the survival and development rates up to blastocyst were 70.6% (245/347), 44.1% (123/279) in EG group and 62.1% (198/319), 45.1% (123/279) in PROH group, respectively. However, in EG group, partially damaged embryos after thawing were decreased compared to PROH group. In combination group, when the exposure time during dehydration and rehydration were reduced, the survival and embryonic developments were increased slightly, but not significant. CONCLUSION: Cryopreservation of mouse and human embryos at cleavage stage by using EG or PROH exhibited no statistical difference in the survival rate and/or developmental rate to blastocyst. However, the use of EG for cryopreservation of embryos might reduce the exposure time of the cryoprotectant because of a high permeation of EG and result in lessen its toxic effects.
Animals ; Blastocyst ; Cryopreservation ; Dehydration ; Embryonic Development ; Embryonic Structures ; Ethylene Glycol* ; Female ; Fluid Therapy ; Freezing ; Humans* ; Mice* ; Pregnancy ; Propylene Glycol* ; Sucrose ; Survival Rate ; Zygote

The augmentation rhinoplasty using silicone implant is one of the most popular cosmetic procedure in Asians. But complications such as deviation and extrusion are often noted. For prevention of these problems, we discussed and assessed the effectiveness of augmentation rhinoplasty through unilateral infracartilaginous incision and fixation of the silicone to the septal cartilage. Among 121 patients who underwent closed rhinoplasty using anchoring suture in silicone fixation and covering the silicone tip with medial border of lateral crus in both alar cartilage by intercrural suture, we analyzed 47 patients. No other procedures were used. The average follow-up period was 11 months. This technique showed good results without deviation or extrusion of silicone implants. In addition, this procedure yields good nasal tip projections. Herein, this treatment will be a future promising treatment modality for reducing complications with high level of patient satisfaction
Asian Continental Ancestry Group ; Cartilage ; Follow-Up Studies ; Humans ; Patient Satisfaction ; Rhinoplasty* ; Silicones* ; Sutures*

The human acelluar allogenic dermis has been used for soft tissue augmentation of sunken areas. Because of high price, extra-acelluar allogenic dermis is resterilized after being used. The purpose of this experiment is to evaluate the safety and efficacy of ethylene oxide (E.O) gas sterilized acellular allogenic dermal graft(Sure Derm(R)). Twenty-four white rats, weighing about 200 grams and of 5 weeks of age were divided into 3 groups. The prepared SureDerm(R) sheets(10x10mm sized , each 1 mm in thickness) were implanted into the pockets of back area. Biopsy specimens were taken after 4, 8 and 12 weeks and examined histologically for inflammatory reaction, neocollagen synthesis. The initial volume of the graft was measured by immersing it in a 2cc of normal saline and the volume of fluid displaced was checked. The changes in graft volume were measured by the same method. There was a tiny decrease in the volume of the E.O. gas sterilized graft. However, there was no significant difference in the survival rate among the groups(p<0.05). Histological analysis demonstrated progressive monocytes and fibroblast infiltration, sparce collagen bundle organization with time in E.O. gas sterilized grafts. Our experimental study suggests that E.O. gas re- sterilized SureDerm(R) might not be a safe material to use as an implant.
Animals ; Biopsy ; Collagen ; Dermis* ; Ethylene Oxide* ; Fibroblasts ; Humans ; Monocytes ; Rats ; Survival Rate ; Transplants

BACKGROUND: To evaluate the effects of alendronate in preventing bone loss at the spine and hip in Korean cases of primary osteoporosis, we treated 138 patients with 10 mg of alendronate daily. Of the 138 patients treated, 50 were treated for one complete year, and at their final visit, measurements were taken to assess the completed outcome of the reatment, and the results from this small group were compared with those of the rest. The way this has been written causes ambiguity concerning exactly who was being studied. Check that my rewrite of this section conveys correctly the group that was studied, and how. METHODS: The serum levels of calcium(Ca) and phosphorous(P), total alkaline phosphatase(ALP), the urine calcium creatinine ratio(Uca/cr) and urine deoxypyridinoline(DPD) were measured before, during, and after the 1 year treatment period. The bone mineral densities(BMDs) at the spine and hip were also measured before and after the treatment period. New clinical fractures and side effects, were evaluated during the treatment period. RESULTS: The total serum ALP and urine DPD were decreased significantly, after the treatment period, by 38.3 and 40.5% respectively. The bone mineral density at the spine and hip were significantly increased after 1 year, by 6.7 and 2.0%, respectively. Of the 50 subjects who had completed a full year of treatment, only 4(8%) had developed new clinical fractures. Of the 138 patients who had been treated, 8(5.8%) discontinued the medication due to side effects. Of these, 7 had gastrointestinal symptoms, and 1 had skin eruption. CONCLUSION: Alendronate significantly decreased the total serum ALP and urine DPD and significantly increased spine and hip bone mineral density. Alendronate 10mg was effective in preventing bone loss in Korean cases of primary osteoporosis.
Alendronate* ; Bone Density ; Calcium ; Creatinine ; Hip ; Humans ; Metabolism* ; Osteoporosis* ; Skin ; Spine