No abstract available.
Animals ; Endometriosis* ; Female ; Horns* ; Kidney*

No abstract available.
Animals ; Endometriosis* ; Female ; Horns* ; Kidney*

No abstract available.
Hamartoma*

Trichoblastic fibroma is a rare, benign trichogenic tumor that has both an epithelial and mesenchymal component. This tumor may be confused clinically and/or histologically with basal cell carcinoma and other tumors with hair follicle differentiation. We describe here a patient with trichoblastic fibroma on the nose. For further characterization of the tumor, we studied the bcl-2 expression in this case and compared it with those of trichoepitheliomas and basal cell carcinomas. The bcl-2 expression in this case and trichoepitheliomas were positive at the periphery of the tumor nest only, whereas those of basal cell carcinomas were positive diffusely throughout the tumor nest.
Carcinoma, Basal Cell ; Fibroma* ; Hair Follicle ; Humans ; Nose

Recent advancements in various technologies have shed light on the critical role of metabolism in immune cells, paving the way for innovative disease treatment strategies through immunometabolism modulation. This review emphasizes the glucose metabolism of myeloid-derived suppressor cells (MDSCs), an emerging pivotal immunosuppressive factor especially within the tumor microenvironment. MDSCs, an immature and heterogeneous myeloid cell population, act as a double-edged sword by exacerbating tumors or mitigating inflammatory diseases through their immune-suppressive functions. Numerous recent studies have centered on glycolysis of MDSC, investigating the regulation of altered glycolytic pathways to manage diseases. However, the specific changes in MDSC glycolysis and their exact functions continue to be areas of ongoing discussion yet. In this paper, we review a range of current findings, including the latest research on the alteration of glycolysis in MDSCs, the consequential functional alterations in these cells, and the outcomes of attempts to modulate MDSC functions by regulating glycolysis. Ultimately, we will provide insights into whether these research efforts could be translated into clinical applications.

Purpose: We report a case of post-pterygium excisional Pseudallescheria boydii (P. boydii) necrotizing scleritis successfully treated with multi-antifungal agents.Case summary: A 73-year-old female with a history of pterygium excision 6 years prior was referred to our institute because of worsening scleritis in the left eye during high-dose, 2-week steroid treatment. On the initial visit, an oval ulcer was observed in the temporal sclera adjacent to the limbus. All steroids were stopped and 1% voriconazole, 5% natamycin, 2.5% vancomycin, and 5% ceftazidime eyedrops were applied every hour and oral voriconazole 200 mg prescribed once a day, but the scleral necrosis continued to worsen. On day 10, the filamentous fungus P. boydii was isolated; 0.5% caspofungin eyedrops were added and the topical voriconazole concentration increased to 2%. Six weeks later, despite epithelization over the scleral necrosis, choroidal detachment developed. The antifungal treatment was continued and a dispersive, ophthalmic viscosurgical device inserted in the anterior chamber. At 14 weeks of treatment, the scleral necrosis was completely epithelialized and the choroidal detachment had disappeared. Conclusions When encountering a case of P. boydii-caused necrotizing scleritis developing after pterygium excision surgery, long-term intensive treatment with several antifungal agents must be considered.

No abstract available.
Neurilemmoma* ; Thyroid Gland* ; Thyroid Nodule*

The augmentation rhinoplasty using silicone implant is one of the most popular cosmetic procedure in Asians. But complications such as deviation and extrusion are often noted. For prevention of these problems, we discussed and assessed the effectiveness of augmentation rhinoplasty through unilateral infracartilaginous incision and fixation of the silicone to the septal cartilage. Among 121 patients who underwent closed rhinoplasty using anchoring suture in silicone fixation and covering the silicone tip with medial border of lateral crus in both alar cartilage by intercrural suture, we analyzed 47 patients. No other procedures were used. The average follow-up period was 11 months. This technique showed good results without deviation or extrusion of silicone implants. In addition, this procedure yields good nasal tip projections. Herein, this treatment will be a future promising treatment modality for reducing complications with high level of patient satisfaction
Asian Continental Ancestry Group ; Cartilage ; Follow-Up Studies ; Humans ; Patient Satisfaction ; Rhinoplasty* ; Silicones* ; Sutures*

The human acelluar allogenic dermis has been used for soft tissue augmentation of sunken areas. Because of high price, extra-acelluar allogenic dermis is resterilized after being used. The purpose of this experiment is to evaluate the safety and efficacy of ethylene oxide (E.O) gas sterilized acellular allogenic dermal graft(Sure Derm(R)). Twenty-four white rats, weighing about 200 grams and of 5 weeks of age were divided into 3 groups. The prepared SureDerm(R) sheets(10x10mm sized , each 1 mm in thickness) were implanted into the pockets of back area. Biopsy specimens were taken after 4, 8 and 12 weeks and examined histologically for inflammatory reaction, neocollagen synthesis. The initial volume of the graft was measured by immersing it in a 2cc of normal saline and the volume of fluid displaced was checked. The changes in graft volume were measured by the same method. There was a tiny decrease in the volume of the E.O. gas sterilized graft. However, there was no significant difference in the survival rate among the groups(p<0.05). Histological analysis demonstrated progressive monocytes and fibroblast infiltration, sparce collagen bundle organization with time in E.O. gas sterilized grafts. Our experimental study suggests that E.O. gas re- sterilized SureDerm(R) might not be a safe material to use as an implant.
Animals ; Biopsy ; Collagen ; Dermis* ; Ethylene Oxide* ; Fibroblasts ; Humans ; Monocytes ; Rats ; Survival Rate ; Transplants

PURPOSE: To evaluate the contrast-enhanced MR findings of lesions associated with a radial scar and to compare the MR findings with the histopathology results. MATERIALS AND METHODS: From Mar. 2001 to Sep. 2005, 8 patients with a surgically proven radial scar who had undergone MRI, mammography, and ultrasonography were enrolled in this study. The morphological findings and dynamic enhancement pattern of the time-intensity curve were retrospectively reviewed using non-contrast and contrast-enhanced MRI. Mammography and ultrasonography were also analyzed according to the BI-RADS category and correlated with the histopathological diagnosis. RESULTS: The age of the patients ranged from 42 to 53 years (mean, 47 years). Five patients presented with a left breast lesion and the others presented with a right breast lesion. The histopathological diagnosis associated with the radial scar were fibrocystic changes (n=1), adenosis (n=2), atypical ductal hyperplasia (n=2), lobular carcinoma in situ (n=1), ductal carcinoma in situ (n=1), and invasive ductal carcinoma (n=1). In all patients, architectural distortion without microcalcification was observed with mammography. Irregular shaped hypoechoic lesions with an indistinct, spiculated, or angular margin was observed in all patients with ultrasonography. Posterior shadowing was observed in 4cases. MR enhancement revealed two cases with foci enhancement (adenosis and fibrocystic change), five cases with non-mass-like focal enhancement (fibrocystic change, atypical ductal hyperplasia, lobular carcinoma in situ, ductal carcinoma in situ, invasive ductal carcinoma), and one irregular homogeneous mass enhancement (atypical ducal hyperplasia). The time-signal intensity curves are as follows: persistent type (n=2), adenosis, and fibrocystic changes, respectively; plateu type (n=4), one adenosis, two atypical ductal hyperplasia, and one ductal carcinoma in situ; and washout type (n=2), lobular carcinoma in situ, and invasive ductal carcinoma, respectively. CONCLUSION: Although a combined benign or malignant pathology with a radial scar was not predicted on the preexisting image modality, contrast-enhanced MRI can help to predict a combined benign or malignant pathology with a radial scar using the morphological findings and the dynamic enhancement type of the time-intensity curve.
Breast ; Breast Neoplasms ; Carcinoma, Ductal ; Carcinoma, Intraductal, Noninfiltrating ; Carcinoma, Lobular ; Cicatrix* ; Diagnosis ; Humans ; Hyperplasia ; Magnetic Resonance Imaging ; Mammography ; Pathology ; Retrospective Studies ; Shadowing (Histology) ; Ultrasonography