1.A Study on Serum Creatinine and BUN Levels in Newborn Infants.
Journal of the Korean Pediatric Society 1985;28(8):741-750
No abstract available.
Creatinine*
;
Humans
;
Infant, Newborn*
2.Clinical, Laboratory and Epidermiology Feature of Human Rota Virus(HRV) Gastroenteritis.
Bok Hee OH ; Soo Jee MOON ; Keun Soo LEE
Journal of the Korean Pediatric Society 1983;26(10):959-966
No abstract available.
Gastroenteritis*
;
Humans*
3.Selective Cytotoxicity of the New Platnum ( 2 ) Complexes on Human Gastric Cancer Cell - lines and Normal Kidney Cells.
Jee Chang JUNG ; Sung Goo CHANG ; Young Soo RHO
Journal of the Korean Cancer Association 1999;31(5):1035-1043
PURPOSE: Platinum coordination complex (cisplatin) has been currently used as one of the most effective compound in the treatment of various solid tumors. However, its use has been limited by severe side effects such as renal toxicity. Our platinum-based drug discovery program has been aimed at developing drugs capable of diminishing toxicity and selective cytotoxicity. MATERIALS AND METHODS: A new series of highly water soluble platinum (II) complexes Pt (II) [1,3-Bis (phenylthio) propane) (trans-l-1,2-diaminocyclohexane) (PC-1) and Pt (II) [1,3-Bis-(phenylthio) (propane)]-1,2-diaminocyclohexane (PC-2) were synthesized and characterized by their elemental analysis and by various spectroscopic techniques [infrared (.IR), ""C-nuclear magnetic resonance (NMR)]. In vitro antitumor activity and nephrotoxi -cities of new Pt (II) complexes were tested against MKN-45 human gastric cancer cell- lines and normal kidney cells using colorimetric MTT[3-(4,5-dimethyl thiazol-2-yl)-2,5- diphenyl tetrazolium bromide] assay for cell survival and proliferation. RESULTS: PC-1 showed activity against MKN-45/P and MKN-45/CDDP human gastric adenocarcinoma cells, and the antitumor activity of this compound was comparable or superior to that of PC-2 and cisplatin. The nephrotoxicity of PC-1 and PC-2 were found quite less than that of cisplatin using MTT, [H] thymidine uptake and glucose consumption tests in rabbit proximal tubule cells, human kidney cortical cells and human renal cortical tissues. CONCLUSION: Based on these results, this novel platinum (II) complex compound (PC-1) represent a valuable lead in the development of a new anticancer chemotherapeutic agent capable of improving antitumor activity and low nephrotoxicity.
Adenocarcinoma
;
Cell Survival
;
Cisplatin
;
Drug Discovery
;
Glucose
;
Humans*
;
Kidney*
;
Platinum
;
Stomach Neoplasms*
;
Thymidine
4.The Effect of theophylline on eotaxin mRNA expression in pulmonary epithelial cell line A549.
Min Soo HAN ; Jee Hong YOO ; Hong Mo KANG
Tuberculosis and Respiratory Diseases 2000;48(6):898-908
BACKGROUND: Eotaxin, a CC chemokine specific for eosinophils, is implicated in the pathogenesis of asthma recruiting eosinophils into the airways. Theophylline has been used for the treatment of asthma and rece was proposed to have an anti-inflammatory action. The aim of this study is to examine whether theophylline may inhibit the eosinophilic airway inflammation by reducing the expression of eotaxin. METHODS: The expression of eotaxin mRNA was assessed by Northern analysis in A549 cells 4 h after stimulation with TNF-α or IL-1β And then, theophylline was added to A549 cells stimulated with 0.1 ng/ml IL-1β. RESULTS: Eotaxin mRNA expression rates induced by 0.1, 1, 10 ng/mL TNF-α as compared with β-action were 7%, 22%, 28%, respectively. Eotaxin mRNA expression rates induced by 0.01, 0.1, 1, 10 ng/ml IL-1β as compared with β-action, were 10%, 42%, 63%, 72%, respectively. Eotaxin mRNA expression rates after addition of 0, 0.001, 0.01, 0.1 µM dexamethasone induced by 10 ng/mL TNF-α, as compared with β-action were 27%, 18%, 8%, respectively. Eotaxin mRNA expression rates after the addition of 0.001, 0.01, 0.1 mM dexamethasone induced by 0.1 ng/mL IL-1β, as compared with β -action, were 43%, 47%, 12%, 8%, respectively. Eotaxin mRNA expression rates after the addition of 0, 0.001, 0.01, 0.1, 1, 10 mM theophylline induced by 0.1 ng/mL IL-1β, as compared with β-action, were 48%, 40%, 33%, 22%, 16%, 14%, respectively. CONCLUSION: These results suggest that theophylline may reduce eosinophil infiltration of the airway at least in part by reducing the expression of eotaxin under the conditions of these experiments.
Asthma
;
Dexamethasone
;
Eosinophils
;
Epithelial Cells*
;
Inflammation
;
RNA, Messenger*
;
Theophylline*
5.Surgical treatment of cervical tuberculosis lymphadenitis.
Jee Soo KIM ; Dong Young NOH ; Seung Keun OH
Journal of the Korean Surgical Society 1992;43(2):157-166
No abstract available.
Lymphadenitis*
;
Tuberculosis*
6.Antiviral Effect of Antisense Phosphorothioate Oligonucleotides Targeted to Herpes Simplex Virus.
Yoo Chul LEE ; Soo Jee KIM ; Yoo Jin CHO
Journal of the Korean Society for Microbiology 1999;34(3):233-243
To search the effective antisense oligonucleotide that inhibit the growth of Herpes simplex virus type 1 (HSV-1), six kinds of phosphorothioate oligodeoxynucleotides (S-ODNs) were synthesized and the antiviral activity was assessed by measuring cytopathic effect in Vero cells infected with HSV-1. Of the three dodecamer S-ODNs, cornplernentary to the translation initiation site of IE2 (AS2) and scrambled S-ODN (AS1) showed more significant antiherpetic activity than AS4 complementary to the IE4. Accordingly, the antiviral effect of dodecamer S-ODN was not specific. In contrast to the no inhibitory effect of sense strand S-ODN of ICP8 (AS6), two S-ODNs complementary to the translation initiation site of ICP8 (AS3) and that of IE1 (AS5) showed potent antiherpetic activity assessed in vitro HSV-1 virus yield assay. Antiherpetic effect of AS3 was decreased in proportion to the addition of AS6. The synthesis of viral protein ICPS and IE1 were inhibited in AS3 and AS5 treated HSV-1 infected Vero cells, respectively. These findings suggest that antiherpetic effect of AS3 is specifically mediated by targeting ICPS. S-ODNs had no effect on Vero cell viability. The data suggest that the 19-mer S-ODNs may be effective in antiviral chemotherapy.
Drug Therapy
;
Herpes Simplex*
;
Herpesvirus 1, Human
;
Oligodeoxyribonucleotides
;
Phosphorothioate Oligonucleotides*
;
Simplexvirus*
;
Vero Cells
7.A case of rudimentary uterine horn associated with agenesis of a kidney and pelvic endometriosis.
Hwan KIM ; Woo Kang CHUNG ; No Soo PARK ; Jee Hak JEONG
Korean Journal of Obstetrics and Gynecology 1993;36(7):2367-2370
No abstract available.
Animals
;
Endometriosis*
;
Female
;
Horns*
;
Kidney*
8.A case of rudimentary uterine horn associated with agenesis of a kidney and pelvic endometriosis.
Hwan KIM ; Woo Kang CHUNG ; No Soo PARK ; Jee Hak JEONG
Korean Journal of Obstetrics and Gynecology 1993;36(7):2367-2370
No abstract available.
Animals
;
Endometriosis*
;
Female
;
Horns*
;
Kidney*
9.Intermittent Hydronephrosis.
Hong Kun KIM ; Woo Gill LEE ; Soo Jee MOON
Journal of the Korean Pediatric Society 1987;30(7):805-811
No abstract available.
Hydronephrosis*