Epiclerrnal growth factor(EGF), a low-molecular-weight polypeptide chain consisting of 53 amino acids, stimulates the growth and keratinization of epidermal cells. Recently, some authors reported that hair growth rate and follicular bulb growth were inhibited by EGF in neonatal mice. Since the hair and follicular cells are of epidermal origin, the effect of EGF would appear to be inconsistent with its role promoting the proliferation and differentiation of epidermal cells in vivo and in vitro. We have investigated the effects of EGF on the hair and epidermis in adult male mouse. The results are summarized as follows: l. 1'he hair length and maximum diameter were significantly reduced in EGF- treated regions compared with control group, and inhibition of hair growth was correlated with EGF dose. Thickness of the epidermis was significantly increased in EGF-treated regions compared with control group, and proliferation of the epidermis was correlated with EGF dose. 3 There were no significant differences in the hair length, maximum diameter, and egidermal thickness between untreated contralateral right mid-side regions of EGF-treated groups and control group.
Adult ; Amino Acids ; Animals ; Epidermal Growth Factor* ; Epidermis ; Hair* ; Humans ; Male ; Mice*

Malignant pyoperma is a rare, chronic, progressive, destructive ulcerating skin disease of unknown cause that affects the head and neck region of young adults. The disease is progressive but responds to high doses of systemically administered steroids. We present a case of malignant pyoderma developed on the left retroauricular area in 67 year-old male. The patient died of rapidly progressive, desructive, 15cm x 20 cm sized, phagedenic ulcer on the left retroauricular and neck area despite of various extensive local and systemic treatment. Histopathologic findings of tissue from the edge of the ulcer were non-specific, showing upper dermal necrosis and mixed inflammatory cell infiltrate in the deep dermis.
Aged ; Dermis ; Head ; Humans ; Male ; Neck ; Necrosis ; Pyoderma* ; Skin Diseases ; Steroids ; Ulcer ; Young Adult

No abstract available.
Dermatitis, Contact* ; Tigers*

The fibrofolliculoma is characterized by abnormal hair follicles with epithelial strands extending out from the infundibulum of the hair follicle into a hyperplastic mantle of specialized fibrous tissue. We have seen a peculiar case of a 1 year and 2 months old male who had a solitary papule on the left side of his face which histologically showed a typical fibrofolliculoma pattern.
Hair Follicle ; Humans ; Infant ; Male

BACKGROUND: There has been reports which suggest that the morphologic feature of ventricular premature complex(VPC) might reflect the cardiac state. METHODS: To test this, we studied retrospectively the association between the morphologic feature of VPC(shape and duration) and cardiac state(structural and functional) by analysing the records of ECG(179 cases) obtained from reviewing echocardiogram performed in our hospital from 1988 to early 1991. Group 1(n=84) had VPC-QRS complexes with either smooth and uniterruped contour or narrow(<0.04 sec) notching and group 2(n=95) demonstrated VPC with broad(> or =0.04 sec) notching or shelves. Without taking into account of either the presence of the type of the underlying cardiac disease and other constitutional disease state, we classified the type of VPC on ECG according to the above criteria and analysed its simple association with cardiac size and functional state on echocardiogram. RESULTS: In group 1, 68 of 84 cases with a VPC had no notching. In group 2, the VPC-QRS duration was greater than group 1(0.154+/-0.022 vs 0.141+/-0.011 sec(mean+/-S.D.), p=0.0001).Left ventricular end-diastolic diameter(LVED) and ejection fraction(EF) showed a significant difference between the two groups(5.12+/-0.64 vs 5.72+/-0.95cm, p=0.0003 and 65.89+/-10.84 vs 60.82+/-15.5%, p=0.012 respectively). In group 2, 50 of 95 cases(53%) showed ejection fraction less than 64%. By defining left ventricular structural dilatation and functional impairment on echocardiogram as LEVD greater than 5.5cm and EF less than 64% respectively, the sensitivity and specificity of VPC morphology was 60% and 74% respectively. CONCLUSIONS: We conclude that a broadly(> or =0.04 sec) notched VPC of long duration(> or =0.15 sec) is a simple and reliable 12-lead ECG marker for an abnormal structural and functional state of the heart(dilatation and hypokinetic left ventricle), irrespective to underlying cardiac disease, while a VPC with smooth contour or narrow(<0.04 sec) notching with short duration(<0.15 sec) reflects a normal sized heart with normal systolic function.
Dilatation ; Electrocardiography ; Heart ; Heart Diseases ; Retrospective Studies ; Sensitivity and Specificity

No abstract available.
Amniotic Fluid* ; Female ; Humans ; Infant* ; Prospective Studies*

Sebaceous carcinoma of the eyelids is rare and is usually seen in the elderly persons. The meibomian glands of the tarsus are the frequent sites of origin. The characteristic feature is a firm, painless nodule on the upper eyelid, We present a typical case of the sebaceous carcinoma in 60 year-old female. The patient had 1 * 1cm sized, hard, fixed, non-tender mass with bleeding on the right lateral canthus of 3~4 months duration. The histopathology of the lesion showed irregular sized lobules in the dermis with invasive growth to the surrounding stroma. Many fat containing sebaceous celles are seen in the center of the lobules.
Aged ; Ankle ; Dermis ; Eyelids ; Female ; Hemorrhage ; Humans ; Meibomian Glands ; Middle Aged

Accessory auricle is a relatively rare congenital anomaly arised from the abnormaI development of the auricular tubercles or from the tissues surrounding the second, third and fourth branchial clefts. Clinically this anomaly is a small akin-colored tag or nodule, soft and globular or cartilaginous consistency on or near the tragus along a line drawn from the tragus to the angle of the mouth or along the anterior margin of the sternomastoid muscle. The lesion is usually solitary and located in the preauricular area but may be multiple and rarely bilateral. We present a typical caae of accessory auricles in 4-day-old female infant. The patient had two skin-colored firm nodules on the left preauricular area and well pedunculated one on the Ieft buccal area near the angle of the rnouth. Histopathologic find.ings showed numerous pilosebaceous units, abundant subcutaneous fat and cartilage tissue in the center of the lesion.
Branchial Region ; Cartilage ; Female ; Humans ; Infant ; Mouth ; Subcutaneous Fat

BACKGROUND: Left ventricular hypertrophy is an independent risk factor for coronary artery disease, hypertension or other cardiovasular diseases, and normal health person due to cardiac arrhythmia or coronary microcirculatory insufficiency. According to development of echocardiography, left ventricular mass and the patterns of left ventricular hypertrophy can be measured. Therefore, we tried to classify the left ventricular hypertrophy in coronary artery disease and to differentiate cardiac function and severity of coronary artery disease in these groups. METHOD: From September 1993 to August 1995, in 44 cases(23 males, 21 females) without hypertension with normal coronary angiography and 84 cases(62 males, 22 females) without hypertension with coronary artery disease on coronary angiography were compared by two-dimensional, M-mode, and Doppler echocardiography. RESULTS: In normal control group, mean age was 51+/-11years, and in coronary artery disease group, mean age was 58+/-10years. Atherosclerotic risk factors showed no significant differences in each groups. LVH patterns in normal control group were 31 cases(70%) of normal left ventricle, 6 cases(14%) concentric remodelling, 2 cases(5%) concentric hypertrophy, and 5 cases(11%) eccentric hypertrophy. In coronary artery disease group, 30 cases(36%) were normal left ventricle, 17 cases(20%) concentric remodelling, 14 cases(17%) concentric hypertrophy, and 23 cases(27%) eccentric hypertrophy. CONCLUSIONS: In this study, concentric and eccentric hypertrophy were more common in coronary artery disease group than normal control group. And comparing to one vessel disease grroup, multi-vessel disease group had more common concentric and eccentric hypertrophy. This result were considered that left ventricular concentric hypertrophy may induce coronary heart disease because more oxygen demand required and fixed coronary circulation, and essentric hypertrophy was due to post-infarct left ventricular remodelling and wall thinning.
Arrhythmias, Cardiac ; Coronary Angiography ; Coronary Artery Disease* ; Coronary Circulation ; Coronary Disease ; Coronary Vessels* ; Echocardiography* ; Echocardiography, Doppler ; Heart Ventricles ; Humans ; Hypertension ; Hypertrophy ; Hypertrophy, Left Ventricular* ; Male ; Oxygen ; Risk Factors

No abstract available.
Leukemia, Myeloid, Acute* ; Sarcoma, Myeloid*