1.In vitro Evaluation of Anti-Human Immunodeficiency Virus Activity of Nucleoside Derivatives and Studies on Their Mode of Action.
Chong Kyo LEE ; Dong Ki KIM ; Jee Hyun KIM ; Hae Soo KIM ; Mi Kyoung PI ; Jong Beak PARK ; Baek KIM
Journal of the Korean Society of Virology 1997;27(1):69-75
To evaluate in vitro anti-HIV efficacies of nucleoside derivatives, MT-4 cell line was infected with HIV-1 and HIV-2 respectively and treated with various compounds and the formerly approved drugs such as AZT, d4T, ddC and ddI. CPE method was used to evaluate their antiviral activity Most dideoxynucleosides, AZT, d4T, ddC and ddI, showed anti-HIV activities against both viruses but no other compounds including anti-herpesvirus drugs did any. Further experiments were carried out to study their inhibitory mechanism of viral adsorption. The results showed no inhibition of syncytium formation due to an interaction between the gp120 expressed in HIV-infected cell surface and CD4 receptor on the uninfected cell surface in the presence of AZT. AZT showed no activity up to 100 microgram/ml. Inhibition of reverse transcriptase (RT) in the presence of AZT-triphosphate was tested by using RT expressed in E. coli and purified and its IC50 was 4.5 nM.
Adsorption
;
Cell Line
;
Dideoxynucleosides
;
Giant Cells
;
HIV-1
;
HIV-2
;
Inhibitory Concentration 50
;
RNA-Directed DNA Polymerase
;
Stavudine
4.Evaluation of the cytotoxicity of calcium phosphate root canal sealers.
Jee Hyun LEE ; Seung Ho BAEK ; Kwang Shik BAE
Journal of Korean Academy of Conservative Dentistry 2003;28(4):295-302
No abstract available.
Calcium*
;
Dental Pulp Cavity*
5.Can medical drama motivate students to have an interest in the healthcare professionalism?.
Jee Young HWANG ; Seolhyang BAEK ; Jong Im LEE ; Joo Hyun NAM ; Yung Kyu KIM
Korean Journal of Medical Education 2013;25(4):279-288
PURPOSE: This study was planned to evaluate that a lecture employing medical drama could motivate students to have an interest in the professionalism of healthcare personnel, which has currently become a critical subject in the field of medical education. METHODS: We analyzed subject headings, learning objectives, and further plans developed by students and their responses after two drama modules, 'car crash' and 'refusal of instruction', which were selected based on the conditions made by our faculty members, were given through video or paper to our 121 second-grade medical and nursing students in year 2012. RESULTS: Meaningful subject headings and learning objectives developed by students were 58.2%~60.0% and 36.8%~38.0% and significantly more in the 'refusal of instruction' than the 'car crash' (p=0.000). According to the students' major, medical students developed significantly more than nursing students (p=0.000). In the analysis of responses, 91.7% of students reported as impressive to the educational modules and 55.3% of them described their ideas associated with healthcare professionalism. CONCLUSION: Our study results suggest a possibility that the educational module employing selected medical drama could motivate students' healthcare professionalism.
Delivery of Health Care*
;
Drama*
;
Humans
;
Learning
;
Students, Medical
;
Students, Nursing
;
Subject Headings
6.Expression of Hepatocyte Growth Factor and its receptor in Placentas of Mild and Severe Preeclampsia.
Jee Hyun LEE ; Jong Chul SHIN ; Dae Young JUNG ; Eun Jung BAEK ; Hee Bong MOON ; Dong Eun YANG ; Sa Jin KIM ; Chang Yee KIM ; Soo Pyung KIM
Korean Journal of Obstetrics and Gynecology 2000;43(8):1444-1449
No abstract available.
Hepatocyte Growth Factor*
;
Hepatocytes*
;
Placenta*
;
Pre-Eclampsia*
7.Pulp tissue regeneration and root formation of permanent teeth with pulpal/periapical deseases.
Yeon Jee YOO ; Seung Ho BAEK ; Ho Hyun SON
Journal of Korean Academy of Conservative Dentistry 2010;35(4):238-245
Numerous cases about additional growth of roots or pulp tissue regeneration by using various intracanal medicaments in immature permanent teeth with periapical or pulpal disease have been reported. The underlying mechanism has not been clearly delineated, but it has been widely accepted that undifferentiated mesenchymal cells and stem cells are involved. Moreover, the growth and deposition of osteoid or cementoid tissues have been observed in regenerated pulp and roots. This new and non-invasive treatment has brightened the future of endodontics, and enlarged the vision of regenerative root canal treatment with multi-potent stem cells and various tissue engineering techniques.
Dental Pulp Cavity
;
Endodontics
;
Regeneration
;
Stem Cells
;
Tissue Engineering
;
Tooth
;
Vision, Ocular
8.CT and MR Imaging Findings of Cystic Adenomyosis of the Uterus: Report of Three Cases.
Sung Eun KIM ; Byung Gil CHOI ; Jee Hee BAEK ; Jae Young BYUN ; Bo Hyun KIM
Journal of the Korean Radiological Society 2000;42(6):971-974
Adenomyosis of the uterus is a relatively common gynecologic disease characterized by the presence of ectopic endometrial glands and stroma within the myometrium. Small cystic spaces (not larger than several mil-limeters) are invariably present, and these are filled with blood. Extensive hemorrhagic cystic adenomyosis,however, is rare, and there have been very few radiologic reports of this condition. We describe the CT and MRI features of three cases of histologically confirmed huge cystic adenomyosis.
Adenomyosis*
;
Animals
;
Female
;
Genital Diseases, Female
;
Magnetic Resonance Imaging*
;
Mice
;
Myometrium
;
Uterus*
9.Marginal and internal fit of nano-composite CAD/CAM restorations.
So Hyun PARK ; Yeon Jee YOO ; Yoo Jin SHIN ; Byeong Hoon CHO ; Seung Ho BAEK
Restorative Dentistry & Endodontics 2016;41(1):37-43
OBJECTIVES: The purpose of this study was to compare the marginal and internal fit of nano-composite CAD-CAM restorations. MATERIALS AND METHODS: A full veneer crown and an mesio-occluso-distal (MOD) inlay cavity, which were prepared on extracted human molars, were used as templates of epoxy resin replicas. The prepared teeth were scanned and CAD-CAM restorations were milled using Lava Ultimate (LU) and experimental nano-composite CAD/CAM blocks (EB) under the same milling parameters. To assess the marginal and internal fit, the restorations were cemented to replicas and were embedded in an acrylic mold for sectioning at 0.5 mm intervals. The measured gap data were pooled according to the block types and measuring points for statistical analysis. RESULTS: Both the block type and measuring point significantly affected gap values, and their interaction was significant (p = 0.000). In crowns and inlays made from the two blocks, gap values were significantly larger in the occlusal area than in the axial area, while gap values in the marginal area were smallest (p < 0.001). Among the blocks, the restorations milled from EB had a significantly larger gap at all measuring points than those milled from LU (p = 0.000). CONCLUSIONS: The marginal and internal gaps of the two nano-composite CAD/CAM blocks differed according to the measuring points. Among the internal area of the two nano-composite CAD/CAM restorations, occlusal gap data were significantly larger than axial gap data. The EB crowns and inlays had significantly larger gaps than LU restorations.
Computer-Aided Design
;
Crowns
;
Fungi
;
Humans
;
Inlays
;
Molar
;
Tooth
10.Marginal and internal fit of nano-composite CAD/CAM restorations.
So Hyun PARK ; Yeon Jee YOO ; Yoo Jin SHIN ; Byeong Hoon CHO ; Seung Ho BAEK
Restorative Dentistry & Endodontics 2016;41(1):37-43
OBJECTIVES: The purpose of this study was to compare the marginal and internal fit of nano-composite CAD-CAM restorations. MATERIALS AND METHODS: A full veneer crown and an mesio-occluso-distal (MOD) inlay cavity, which were prepared on extracted human molars, were used as templates of epoxy resin replicas. The prepared teeth were scanned and CAD-CAM restorations were milled using Lava Ultimate (LU) and experimental nano-composite CAD/CAM blocks (EB) under the same milling parameters. To assess the marginal and internal fit, the restorations were cemented to replicas and were embedded in an acrylic mold for sectioning at 0.5 mm intervals. The measured gap data were pooled according to the block types and measuring points for statistical analysis. RESULTS: Both the block type and measuring point significantly affected gap values, and their interaction was significant (p = 0.000). In crowns and inlays made from the two blocks, gap values were significantly larger in the occlusal area than in the axial area, while gap values in the marginal area were smallest (p < 0.001). Among the blocks, the restorations milled from EB had a significantly larger gap at all measuring points than those milled from LU (p = 0.000). CONCLUSIONS: The marginal and internal gaps of the two nano-composite CAD/CAM blocks differed according to the measuring points. Among the internal area of the two nano-composite CAD/CAM restorations, occlusal gap data were significantly larger than axial gap data. The EB crowns and inlays had significantly larger gaps than LU restorations.
Computer-Aided Design
;
Crowns
;
Fungi
;
Humans
;
Inlays
;
Molar
;
Tooth