BACKGROUND: The concept of Mild Cognitive Impairment (MCI) refers to a transitional period between normal aging and clinically demented state such as Alzheimer's disease. Detection of individuals with MCI is critical for prognosis of the disease progression and treatment of patients at risk. The current study manipulated linguistic complexity in naming nouns and verbs to examine whether the linguistically different entities contribute to differentiating individuals with MCI from normal elderly adults. Specific aims of the study are 1) to investigate the noun-verb dissociation in naming between the MCI and normal control groups and 2) to examine the differential effects between the groups depending on the linguistic subtypes of nouns (animate vs. inanimate) and verbs (the argument structure). METHODS: Twenty normal elderly individuals and 19 individuals with MCI participated in this study. A confrontation naming task was employed. Nouns were divided into the two subtypes (animate vs. inanimate), and verbs were classified into the three subtypes depending on the number of argument (1-place, 2-place, and 3-place). RESULTS: Results revealed that there were significant differences between the groups, indicating that individuals with MCI showed worse performance on naming in general than the control group. Furthermore, the MCI group presented differentially impaired performance on verbs than nouns compared to the control group. CONCLUSIONS: The results from the current study suggested that performance on a verb confrontation naming task could serve as a sensitive index to differentiate the MCI group from normal aging group.
Adult ; Aged ; Aging ; Alzheimer Disease ; Disease Progression ; Dissociative Disorders ; Humans ; Linguistics ; Mild Cognitive Impairment ; Prognosis

We report a case of actinic granuloma in a 39 year-old woman who was presented with multiple anetoderma on non-sun exposed skin such as the neck, upper arms, elbows and calfs. The anetodermic presentation of actinic granuloma has never been reported and the common pathogenesis involving reduction of elastic fibers link the two disorders. Anetoderma secondary due to actinic granuloma should to be included in the list of secondary anetoderma and may suggest one of the possible pathogenesis of anetoderma.
Actins* ; Adult ; Anetoderma* ; Arm ; Elastic Tissue ; Elbow ; Female ; Granuloma* ; Humans ; Neck ; Skin

BACKGROUND: This study investigated the efficacy and safety of combined subacromial and intravenous patient-controlled analgesia for control of postoperative pain after arthroscopic rotator cuff repair. METHODS: Between May 2012 and August 2014, 60 patients who underwent arthroscopic rotator cuff repair with acromioplasty and received patient-controlled analgesia were studied prospectively. Cases were divided into 2 groups: combined subacromial and intravenous infusion group (group A, 30 cases) and solitary intravenous infusion group (group B, 30 cases). The visual analogue scale was used to record the patient's level of pain every 12 hours during postoperative 72 hours and the following 48 hours after the suspension of patient-controlled analgesia. RESULTS: The mean preoperative visual analogue scale score was 7.8 in group A and 7.6 in group B, and the immediate postoperative visual analogue scale score was 7.9 and 8.1 for each group. At postoperative time (From 12 hours to 72 hours after operation), the scores of combined subacromial and intravenous infusion were significantly lower than those of solitary intravenous infusion. Significant difference in the frequency of supplemental analgesic injections was observed between group A and group B (p=0.008). However, no significant difference in complication rate was observed between the two groups (p=0.562). CONCLUSIONS: Combined subacromial and intravenous patient-controlled analgesia after arthroscopic rotator cuff repair is more effective than solitary intravenous infusion without significantly increasing complications. Therefore, combined subacromial and intravenous patient-controlled analgesia could be a effective pain control method.
Analgesia, Patient-Controlled* ; Humans ; Infusions, Intravenous ; Methods ; Pain, Postoperative ; Prospective Studies ; Rotator Cuff*

BACKGROUND: The aim of the present study was to determine the correlation between the amount of pain reduction after local anesthetic injection into the subacromial space preoperatively and clinical outcome after arthroscopic rotator cuff repair. METHODS: A total of 127 patients who underwent arthroscopic rotator cuff repair and followed up at least 1 year were analyzed retrospectively. Preoperatively, a visual analogue scale (VAS) for pain was measured in all patients before and after the ultrasound guided impingement test. The participants were divied into four groups according to pain reduntion ater impingement test (Group A: >75%, Group B: 50%–75%, Group C: 25%–50%, Group D: <25%). VAS for pain, shoulder range of motion, shoulder isometric strength, ASES score were evaluated preoperatively and at 3, 6, 9, and 12 months postoperatively. RESULTS: After surgery, the amount of pain reduction shows significantly at 3, 6 months in Groups A, B as compared to Groups C, D (p<0.05). Among the range of motion of shoulder joint, forward flexion was significantly improved in Group A at 3 months (p<0.05). The ASES score significantly improved at 3, 6 months in Groups A, B as compared to Group C, D (p<0.05). CONCLUSIONS: Preoperative degree of pain reduction after impingement test correlates with the improvement of pain after arthroscopic rotator cuff repair, especially in the early phase. Therefore, the impingement test could be effectively used.
Humans ; Range of Motion, Articular ; Retrospective Studies ; Rotator Cuff* ; Shoulder ; Shoulder Joint ; Shoulder Pain ; Ultrasonography

No abstract available.
Female ; Gestational Age* ; Humans ; Membranes* ; Pregnant Women* ; Rupture*

Wiscott-Aldrich syndrome (WAS) is an X-linked recessive disorder affecting males and is characterized by recurrent systemic bacterial and viral infections, purpura due to thrombocytopenia, and an atopic dermatitis-like skin eruption. WAS usually manifests itself early during the first few weeks or months of life with bleeding. A case of WAS with the classical symptoms(eczema, thrombocytopenia and susceptibility to infections) is described in a 12-year-old Korean boy. He had a relatively good outcome.
Child ; Hemorrhage ; Humans ; Male ; Purpura ; Skin ; Thrombocytopenia

Mucinous carcinoma can occur in non-cutaneous visceral sites and may metastasize to the skin. Thus it is important to exclude the possibility of a non-cutaneous visceral primary tumor before diagnosing primary mucinous carcinoma of the skin (PMCS). We describe a PMCS with unusual histopathological 6ndings. Although the microscopical, immunohistochemical, and ultrastructural characteristics of PMCS have been well defined, only less than sixty cases have been published since the disease was first reported by Lennox. This is an unusual case where combined features of apocrine carcinoma and predominant cribriform patterns reminiscent of adenoid cystic carcinoma exist in part, with highly anaplastic cellular features and frequent mitosis. To our knowledge, there have been no reports of this rare neoplasm in Korea.
Adenocarcinoma, Mucinous* ; Carcinoma, Adenoid Cystic ; Korea ; Mitosis ; Mucins* ; Skin*

Plexiform neurilemmoma is a relatively rare, benign peripheral nerve sheath tumor, whieh usually arises in either the dermis or subcutaneous tissue. These tumors may occur singly or as multiple lesions (plexiform neurilemmomatosis), We report an unusual case of plexiform neurilemmomatosis associated with cafe au lait spots reminiscent of neurofibromatosis clinically and another case of plexiform neurilemmoma on the finger. A Biopsy revealed the characteristic palisaded arrangement of spindle cells within well circumscribed elongated nodules, The skin lesions were completely excised without recurrence thereafter.
Biopsy ; Cafe-au-Lait Spots ; Dermis ; Fingers ; Neurilemmoma* ; Neurofibromatoses ; Peripheral Nerves ; Recurrence ; Skin ; Subcutaneous Tissue

Churg-Strauss syndrome (CSS) is a very rare disease which combines the features of asthma, hypereosinophilia, multisystem necrotizing vasculitis and extravascular granuolma. To our knolwedge, there have been four reports in Korean journals, but none in dermatology journals. We report a 37-year-old male who had allergic rhinitis, pansinusitis, a history of atopic dermatitis, multiple prurigo-nodularis like skin lesions, non-fixed interstitial lung in-filtration, hypereosinophilia and subclinical asthma. Clinical and histopathological features of his skin lesions were nonspecific where perivascular lymphocytic infiltration and mild lymphocytic vasculitis were shown. The presence of a pituitary mass and proximal myopathy as op-posed to peripheral neuropathy have not been reported in previous reports of CSS. However, other features of our patient met the criteria of CSS.
Adult ; Asthma ; Churg-Strauss Syndrome* ; Dermatitis, Atopic ; Dermatology ; Humans ; Lung ; Male ; Muscular Diseases ; Peripheral Nervous System Diseases ; Rare Diseases ; Rhinitis, Allergic ; Skin ; Vasculitis

BACKGROUND: The clinical efficacy of oral isotretinoin in the treatment of severe acne is well established but there is no published data about the recurrence rate and the optimum dose for lowest recurrence in Korean patients. OBJECTIVE: The objective of this study was to determine the recurrence rate after one course of isotretinoin in oriental cases. METHODS: Sixty eight cases were available which fulfilled the inclusion criteria ; clearing af- l ter one course more than 10 weeks and at least two year follow-up thereafter. Isotretinoin was used with oral dosage 0.3-1 mg/kg/day (0.6±0.1) with duration from 10 to 46 weeks (19.7±6.2). RESULTS: Overall, 78% of patients had relapsed with most requiring topical antibiotic therapy only. In patients receiving more than 120 mg/kg, the percentage without recurrence was 75 % which was significantly higher (p<0.001) in comparison with only 15 % among patients receiving less than 120 mg/kg. Doses between 100 and 120 mg/kg were not as effective as those ones with more than 120 mg/kg for preventing recurrence. CONCLUSION: The results indicate that moderate doses of isotretinoin are well tolerated and pro-duce excellent clearing. However, in order to minimize recurrence rate, the optimum dose may be at least over 120 mg/kg of the cumulative dose which means more than 6 months of treatment in most of the Korean patients with acne.
Acne Vulgaris* ; Follow-Up Studies ; Humans ; Isotretinoin* ; Recurrence*