1.Teratoid Wilms Tumor: A Case report.
Yeon Lim SUH ; Je G CHI ; Sang Eun LEE
Korean Journal of Pathology 1986;20(2):229-234
A three year old girl with a left renal teratoid Wilms tumor is reported. The tumor was located both inside and outside the kidney parenchyme, to form a well encapsulated mass containing two lobulated solid and cystic masses. The tumor consists predominantly of otherwise typical Wilms tumor irregularly mixed with teratoid tissue elements such as intestinal tract, mucous glands with argentaffin cells, goblet cells and transitional epithelium. These heterologous elements were regarded as diverse epithelial differentiation of totipotent cells in certain nephrogenetic period, and this tumor was considered to be hest called "teratoid Wilms tumor".
2.Gene Expressions of Mouse Submandibular Gland during the Developmental Stage and Their Antisense Inhibition in Organ Culture.
Yeon Sook KIM ; Suk Keun LEE ; Je G CHI
Korean Journal of Pathology 2000;34(6):395-412
This study is aimed to observe the expressions of different genes, including the extracellular matrix proteins, growth factors, and transcription factors during different developmental stages of mouse submandibular gland. Reverse transcription-polymerase chain reaction (RT-PCR) and the antisense inhibition in organ culture system were performed using mouse embryos and newborns. Total 140 mouse embryos (E14(80), E15(20), E16(20), E18(20)) and 30 newborn mice (D2(10), D3(10), D6(10)) obtained from 60 pregnant mice and 3 adult mice (3 weeks old) were used for the cDNA production and the salivary gland organ culture. Syndecan, perlecan, laminin alpha1 chain, TGF beta1, beta 3, and sonic hedgehog mRNAs were expressed in the early stage (E14~E16) of the submandibular gland development, whereas transglutaminase C (TGase C), E-cadherin, epimorphin, laminin beta2 and gamma1 chains, and HGF mRNAs were expressed in the middle and late stages (E16~E18, D2~D6). Antisense inhibition of different genes in the organ culture of E14 mouse embryos of submandibular gland showed specific growth retardation in the development of ductal and acinar cells. Especially, the antisense inhibition of perlecan, E-cadherin, laminin alpha1 chain, laminin beta2 chain, and syndecan mRNA arrested the growth of ductal and acinar cells. While the antisense inhibition of integrin beta5 greatly affected the acinar cell differentiation and also produced cystic dilatation of salivary ducts, the antisense inhibition of fibronectin showed aberrant growth of ectomesenchymal tissues of the mouse submandibular gland.
Acinar Cells
;
Adult
;
Animals
;
Cadherins
;
Dilatation
;
DNA, Complementary
;
Embryonic Structures
;
Extracellular Matrix Proteins
;
Fibronectins
;
Gene Expression*
;
Hedgehogs
;
Humans
;
Infant, Newborn
;
Intercellular Signaling Peptides and Proteins
;
Laminin
;
Mice*
;
Organ Culture Techniques*
;
RNA, Messenger
;
Salivary Ducts
;
Salivary Glands
;
Submandibular Gland*
;
Syndecans
;
Transcription Factors
3.Histopathological Differences between Silicone Granuloma and Paraffinoma.
Yeon Mee KIM ; Hye Kyung LEE ; Hye Je CHO ; Je Geun CHO
Korean Journal of Pathology 1996;30(5):427-436
During the past two decades, silicone (polydimethylsiloxane) has become one of the most extensively applied biomaterials. Although pure silicone is relatively inert and usually causes only minimal tissue reactions, it has been reported to evoke a definite foreign body reaction. We studied five cases of silicone-induced granulomas in various sites; two in the breast, one in the breast and axillary lymph nodes, one in the subcutis of the abdomen, back and extremities and one in the eyeball, to illustrate the salient histopathologic features of reactions to silicone with particular emphasis to its differences from paraffin granuloma. For this, 17 paraffinomas were also studied. Tissue reaction to silicone liquid and gel was characterized by numerous round to oval empty cystic vacuoles, mild to moderate fat necrosis, foreign body reaction, a variable degree of mononuclear inflammatory cell infiltration and mild focal fibrosis. The cystic spaces were relatively uniform and showed a snow-man like appearance. In contrast to the silicone granulomas, the paraffinomas, also refered to as sclerosing lipogranulomas showed diffuse sclerosis and frequent calcification around the cystic vacuoles. The cystic spaces in paraffinomas were swiss cheese-like configuration, and the content of the cystic spaces was dirty and frequently calcified. However, there were certain similarities between these two types of granulomas particularly in the early phases of the reaction, therefore, the history of silicone injection or implant, is sometimes critical to the diagnosis of silicone granuloma. Despite great technologic advances in the manufacturing of prostheses and medical equipment, droplets and/or particles of silicone still escape into the body tissues in a variety of ways; therefores, the pathologist should always wonder whether the histologic reaction observed is due to silicone or to some other foreign material including paraffin.
4.Sturge-Weber Syndrome: Report of an incomplete form.
Hye Yeon KIM ; Kap No LEE ; Seung Young PAIK ; Ki Chan LEE ; Chang Soo LIM ; Suck Ho NAM ; Je G CHI
Korean Journal of Pathology 1985;19(2):226-230
The Sturge Weber syndrome is an uncommon disorder characterized by port-wine nevus of the face with angiomatosis of the ipsilateral cerebral leptomeninges and extensive calcification in the underlying cerebral cortex. Associated with this syndrome are mental retardation, choroidal angioma, buphthalmus or glaucoma, seizure and hemiplegia. We studied a case of incomplete form of Sturage Weber syndrome in a 12 year-old boy, who had generalized seizure, a homonymous hemianopsia, intracranial calcification and leptomeningeal angiomatosis. There are no characteristic facial nevus, mental retardation, occular changes and hemiplegia.
5.Different Influence of Negative and Positive Spillover between Work and Life on Depression in a Longitudinal Study
Dong-Wook LEE ; Yun-Chul HONG ; Hwo-yeon SEO ; Je-Yeon YUN ; Soo-hyun NAM ; Nami LEE
Safety and Health at Work 2021;12(3):377-383
Background:
This study investigated the longitudinal associations between the degrees of positive and negative spillover in work–life balance (WLB) at baseline and reports of depressive mood at a 2-year follow-up in Korean women employees.
Methods:
We used a panel study design data of 1386 women employees who participated in the Korean Longitudinal Survey of Women and Families in both 2014 and 2016. Depressive mood was measured using the “10-item Center for Epidemiologic Studies Depression Scale.” Associations between the positive and negative spillover in WLB at baseline and reports of new incidence of depressive mood at 2-year follow-up were explored using a multivariate logistic regression model.
Results:
Negative spillover in WLB at baseline showed a significant linear association with reports of depressive mood at 2-yearfollow-up after adjusting for age, education level, marital status, number of children, and positive spillover (P = 0.014). The highest scoring group in negative spillover (fourth quartile) showed a significant higher odds ratio of 1.95 compared with the lowest scoring group (first quartile; P = 0.036).
Conclusion
Positive spillover in WLB showed a U-shaped association with depression. The degrees of positive and negative spillover in WLB among Korean women employees at baseline were associated with new incidence of depressive mood within 2 years. To prevent depression of female workers, more discrete and differentiated policies on how to maintain healthy WLB are required.
6.Different Influence of Negative and Positive Spillover between Work and Life on Depression in a Longitudinal Study
Dong-Wook LEE ; Yun-Chul HONG ; Hwo-yeon SEO ; Je-Yeon YUN ; Soo-hyun NAM ; Nami LEE
Safety and Health at Work 2021;12(3):377-383
Background:
This study investigated the longitudinal associations between the degrees of positive and negative spillover in work–life balance (WLB) at baseline and reports of depressive mood at a 2-year follow-up in Korean women employees.
Methods:
We used a panel study design data of 1386 women employees who participated in the Korean Longitudinal Survey of Women and Families in both 2014 and 2016. Depressive mood was measured using the “10-item Center for Epidemiologic Studies Depression Scale.” Associations between the positive and negative spillover in WLB at baseline and reports of new incidence of depressive mood at 2-year follow-up were explored using a multivariate logistic regression model.
Results:
Negative spillover in WLB at baseline showed a significant linear association with reports of depressive mood at 2-yearfollow-up after adjusting for age, education level, marital status, number of children, and positive spillover (P = 0.014). The highest scoring group in negative spillover (fourth quartile) showed a significant higher odds ratio of 1.95 compared with the lowest scoring group (first quartile; P = 0.036).
Conclusion
Positive spillover in WLB showed a U-shaped association with depression. The degrees of positive and negative spillover in WLB among Korean women employees at baseline were associated with new incidence of depressive mood within 2 years. To prevent depression of female workers, more discrete and differentiated policies on how to maintain healthy WLB are required.
7.A Case of Potter Syndrome with Bilateral Polycystic Kidneys.
Chun Hwa LEE ; Jung Hwan CHOI ; Yong CHOI ; Chong Ku YUN ; Yeon Lim SUH ; Je G CHI ; Son Moon SHIN
Journal of the Korean Pediatric Society 1987;30(11):1282-1286
No abstract available.
Polycystic Kidney Diseases*
8.A Case of Retroperitoneal Liposarcoma.
Jae Eop SHIM ; Moo Yeon LEE ; Cheol Min KIM ; Un Yong JUNG ; Hyun Je NA
Korean Journal of Urology 1984;25(3):369-371
Retroperitoneal liposarcoma comprises 12 to 45 percent of all liposarcoma. It has been a therapeutic dilemma and a less prognosis because of its tendency to attain a tremendous size due to early silent growth and difficult wide en bloc excision in the retroperitoneum. Here in we report a case of retroperitoneal liposarcoma in 51 year old male patient with a brief review of the literatures.
Humans
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Liposarcoma*
;
Male
;
Middle Aged
;
Prognosis
9.A Case of Pulmonary Candidiasis.
Hye Ran BYUN ; Kung Ha RYU ; Moon Ja KIM ; Keun LEE ; Yeon Lim SUH ; Je Geun CHI
Journal of the Korean Pediatric Society 1988;31(5):621-626
No abstract available.
Candidiasis*
10.Toxic Effect of Mitomycin C in the Rabbit Ciliary Epithelium.
Sahng Yeon KIM ; Jung Je PARK ; Joo Hwa LEE
Journal of the Korean Ophthalmological Society 1995;36(10):1737-1744
Mitomycin C(MMC) is one of the alkylating agents, which is commonly used adjunctively to inhibit the over-growth of the fibroblasts in high-risk filtering surgery. However, it increases the incidence of the complications including persistent postoperative hypotony. The hypotony may be caused by the toxic effect of MMC on the ciliary epithelium. The morphological changes of the ciliary epithelium were evaluated using transmission electron microscope four and twelve weeks after the application of balanced salt solution(BSS) and MMC on the exposed sclera against the ciliary body in the rabbit eyes. There was no specific change in the ciliary epithelium four and twelve weeks after the application of BSS. Four weeks after the application of 0.2mg/ml of MMC, the mitochondria in the nonpigmented epithelium of the applied region were swollen mildly. The mitochondria of both pigmented and nonpigmented epithelia were swollen moderately in the region applied with 0.5mg/ml of MMC. Twelve weeks after the application of either 0.2 or 0.5mg/ml of MMC, the mitochondria were swollen markedly, the nuclear membranes in the pigmented and nonpigmented epithelia were wrinkled, and the heterochromatins of the nuclei faded in both applied and contralateral ciliary epithelia. These findings indicate that mitomycin C causes degenerative changes in the ciliary epithelium decrease aqueous production.
Alkylating Agents
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Ciliary Body
;
Epithelium*
;
Fibroblasts
;
Filtering Surgery
;
Heterochromatin
;
Incidence
;
Mitochondria
;
Mitomycin*
;
Nuclear Envelope
;
Sclera