1.Fatty Hamartoma of Epicardium.
Hyun Wook KANG ; Jung Ran KIM ; Jeong Wook SEO ; Je G CHI
Korean Journal of Pathology 1989;23(1):132-135
The fatty hamartoma of pericardium is characterized by abnormal accumulations of adipose tissue forming a recognizable mass. We reported a case that could best be put into "fatty hamartoma" group. This 66 year old male presented with atrial fibrillation came in for a anterior mediastinal mass. He received an operation for adenocarcinoma of ascending colon several months ago. The chest CT revealed an inhomogeneous mass in the right anterior mediastinal area, which was not clearly demarcated from the right cardiac border. The heart was deviated to the left side due to the mass. Surgical excision was performed under the impression of cardiac teratoma. The large mass was well encapsulated, and was bright yellow and partly pink, and measured 12x8 cm. Microscopically, the mass consisted predominantly of mature fat cells and abundant fibrous tissue with scattered nests of primitive cardiac muscle cells. Reviewing the literature we found the term "fatty hamartoma" could also refer to rhabdomyolipoma or fibrolipoma. Since it contains entrapped cardiac muscle cells, abundant fibrous tissue, multiple blood vessels and fetal fat cells, it could best the categorized into "hamartoma". The term "fatty" represents it's main component. Therefore we propose the term "fatty hamartoma" that could to be used further.
Male
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Humans
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Adenocarcinoma
;
Hamartoma
2.Intracranial Encephalocele: an autopsy case of anterior basal type.
Hyun Wook KANG ; Je G CHI ; Tae Dong PARK ; Hum Rae PARK
Korean Journal of Pathology 1988;22(4):500-504
Encephalocele is a relatively rare congenital anomaly which is classified into occipital, parietal, anterior syncipital and anterior basal type regarding to the protrusion site through the bony defect of the skull. Anterior basal type of encephalocele is important in view of it's pathogenesis as well as diagnostic difficulty because of invisibility on external appearance. We have experienced a case which could be best fit to anterior basal encephalocele. This type of encephalocele is extremely rare. This report deals with a case of deadborn of 34 weeks of gestation with body weight of 2400gm and head circumference of 32 cm. There was no evidence of protrusion of brain on external examination. On autopsy the normal brain structure was compressed by abnormal mass of brain with normal consistency which was found in the petrous portion of the parietal area and covered partly by the dura. In this case, there were another associated anomalies, such as atrophy of the left optic nerve, hemihypoplasia of the left mandible, patent ductus arteriosus, bilateral hydrocele, and Meckel's diverticulum.
3.Mental Health Changes in Korean Adolescents After the COVID-19 Pandemic: Using the Korea Youth Risk Behavior Survey (KYRBS) From 2020, 2021
Journal of Korean Neuropsychiatric Association 2022;61(4):317-324
Objectives:
This study aimed to investigate the changes in the mental health of adolescents after the coronavirus disease 2019 (COVID-19) pandemic.
Methods:
The data for the study were obtained from the Korea Youth Risk Behavior Web-based Survey (KYRBWS), 2020–2021. Overall, the data of 88184 students were included. The data were analyzed using multiple logistic regression analysis with complex sampling using weighted values. The odds ratios (ORs) with 95% confidence intervals (CIs) for subjective stress perception, loneliness, pan-anxiety disorder scale, suicide-related indicators, and high-risk smartphone usage groups were used as major variables.
Results:
The results suggest that the mental health of adolescents deteriorated in 2021 compared to 2020. Adolescents experiencing stress (OR=1.18; 95% CI, 1.08–1.16; p<0.01) and reporting loneliness were also higher (OR=1.07; 95% CI, 1.02–1.12; p<0.01). The high-risk group for pananxiety disorders also increased more than in 2020 (OR=1.05; 95% CI, 1.00–1.11; p<0.01). It was also found that adolescents experiencing suicide accidents increased (OR=1.09; 95% CI, 1.04–1.16; p<0.01). In addition, the high-risk group for smartphone use also increased compared to 2020 (OR=1.17; 95% CI, 1.12–1.23; p<0.01). On the other hand, there was no statistically significant difference in depression, suicide plans, and suicide attempts.
Conclusion
This study found that the mental health problem of adolescents, which had temporarily decreased after the COVID-19 pandemic, was deteriorating again. These findings suggest that it is necessary to follow up and closely monitor the mental health problems of adolescents from the longitudinal perspective during the COVID-19 pandemic.
4.A Review of Pharmacological Strategy for Cognitive Deficits in Schizophrenia.
Dong Wook JEON ; Do Un JUNG ; Bo Geum KONG ; Je Wook KANG ; Jung Joon MOON ; Joo Cheol SHIM
Korean Journal of Schizophrenia Research 2014;17(2):55-62
Cognitive deficit is frequently observed in patients with schizophrenia. It is significantly associated with functional outcome. In the past 20 years, due to significant advances on the concept of schizophrenia, cognitive deficit has been accepted as a core feature. In the DSM-5, cognitive deficit does not introduce diagnostic criteria of schizophrenia, but did one dimension of diagnosis of psychosis. Existing schizophrenia drugs are effective in treatment of positive symptoms of schizophrenia, but lack of effectiveness on improving cognitive function. Led by NIMH (National Institute of Mental Health), the MATRICS (Measurement and Treatment Research to Improve Cognition in Schizophrenia) meeting was conducted in order to achieve consensus on measuring tools and neuropharmacological targets for clinical trials for development of new drugs for improvement of cognitive function in schizophrenia. At the MATRICS consensus meeting, glutamatergic modulators and nicotinic and muscarinic agonists are expected to be promising, but should be proven by a double-blind placebo-controlled multicenter study for patients.
Cognition
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Consensus
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Diagnosis
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Drug Therapy
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Humans
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Muscarinic Agonists
;
National Institute of Mental Health (U.S.)
;
Psychotic Disorders
;
Schizophrenia*
5.Uterine artery doppler velocimetry in growth-retarded pregnancies.
Bo Hyun YOON ; Yeong Je KANG ; Pyl Ryang LEE ; Hyun Jin SONG ; Hee Chul SYN ; Syng Wook KIM
Korean Journal of Perinatology 1991;2(2):102-110
No abstract available.
Pregnancy*
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Rheology*
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Uterine Artery*
6.Perinatal outcome in pregnancies associated with absent or reverse end-diastolic flow velocity on umbilical artery doppler velocimetry.
Yeong Je KANG ; Bo Hyun YOON ; Soon Ki HONG ; Pyl Ryang LEE ; Hee Chul SYN ; Syng Wook KIM
Korean Journal of Perinatology 1991;2(2):18-27
No abstract available.
Pregnancy*
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Rheology*
;
Umbilical Arteries*
7.Comparative Study of Adolescents' Mental Health between Multicultural Family and Monocultural Family in Korea.
Jung Min KIM ; Bo Geum KONG ; Je Wook KANG ; Jung Joon MOON ; Dong Wook JEON ; Eun Chan KANG ; Hyun Bin JU ; Yoon Ho LEE ; Do Un JUNG
Journal of the Korean Academy of Child and Adolescent Psychiatry 2015;26(4):279-287
OBJECTIVES: With the observation of factors influencing depression, self-reported happiness, self-reported stress and suicidal attempt, this study compared and evaluated the mental health of adolescents from multicultural families and monocultural families in Korea. METHODS: This study compared the characteristics of adolescents from multicultural and monocultural families based on the analysis of data of The Tenth Korea Youth Risk Behavior Web-based Survey and analyzed the factors influencing adolescent depression, self-reported happiness, self-reported stress and suicidal attempt. RESULTS: There was no significant difference in the levels of depression, self-reported happiness, and self-reported stress between adolescents from multicultural and monocultural families. However, suicidal ideation and suicidal attempt were significantly higher in adolescents from multicultural families. CONCLUSION: There was no significant difference between the mental health of adolescents from multicultural and monocultural families. Because depression is the greatest factor for suicidal attempt, and violence has stronger relationship with depression of adolescents from multicultural families, further study is needed to prevent this trend.
Adolescent
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Depression
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Happiness
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Humans
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Korea*
;
Mental Health*
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Risk-Taking
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Suicidal Ideation
;
Suicide
;
Violence
8.Visual Perception of ADHD Children with Sensory Processing Disorder.
Hyerim JUNG ; Young Jae WOO ; Je Wook KANG ; Yeon Woo CHOI ; Kyeong Mi KIM
Psychiatry Investigation 2014;11(2):119-123
OBJECTIVE: The aim of the present study was to investigate the visual perception difference between ADHD children with and without sensory processing disorder, and the relationship between sensory processing and visual perception of the children with ADHD. METHODS: Participants were 47 outpatients, aged 6-8 years, diagnosed with ADHD. After excluding those who met exclusion criteria, 38 subjects were clustered into two groups, ADHD children with and without sensory processing disorder (SPD), using SSP reported by their parents, then subjects completed K-DTVP-2. Spearman correlation analysis was run to determine the relationship between sensory processing and visual perception, and Mann-Whitney-U test was conducted to compare the K-DTVP-2 score of two groups respectively. RESULTS: The ADHD children with SPD performed inferiorly to ADHD children without SPD in the on 3 quotients of K-DTVP-2. The GVP of K-DTVP-2 score was related to Movement Sensitivity section (r=0.368*) and Low Energy/Weak section of SSP (r=0.369*). CONCLUSION: The result of the present study suggests that among children with ADHD, the visual perception is lower in those children with co-morbid SPD. Also, visual perception may be related to sensory processing, especially in the reactions of vestibular and proprioceptive senses. Regarding academic performance, it is necessary to consider how sensory processing issues affect visual perception in children with ADHD.
Attention Deficit Disorder with Hyperactivity
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Child*
;
Humans
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Outpatients
;
Parents
;
Visual Perception*
9.Morphological Study on the Mechanism of the Central Nervous System Dysfunction Induced by Unipolar Pulsating Magnetic Field in Mice.
Ro Hyun SUNG ; Gyeong Hoon KANG ; Chong Heon LEE ; Suk Keun LEE ; Young Hae CHUNG ; Yoo Hurn SUH ; Jeong Wook SEO ; Je G CHI
Korean Journal of Pathology 1996;30(12):1073-1082
The morphologic change of the mouse brain after exposure to magnetic field is studied. Our magnetic field model was a pulsed unipolar magnetic field with the flux density of 0.2 - 0.3 tesla and the frequency of 60 hertz. Twelve adult male mice were exposed to the magnetic field for 2, 4, 8, 12, 18 and 24 hours. After the exposure to the magnetic field mice were anesthetized with chloral hydrate, and paraformaldehyde was infused through the left ventricle for fixation. During exposure to the magnetic field, behavioral and weight changes of mice were observed. Mice became irritable and restless, especially during first 2 hours of the exposure. Microscopic and ultrastructural examination on the brain revealed nuclear chromatin clumping of the neuron in mice exposed to the magnetic field for more than four hours. The change was proportional to the exposed time and more prominent in the cerebral cortex. An immunohistochemical study for amyloid precursor protein (APP) was also performed. There was an increased expression of APP in the neuronal cytoplasm of the mouse brain exposed to the magnetic field for 4 hours or more. But the reaction was not proportional to the exposure time and reactive neuron was diffusely distributed through the whole brain. Anti-APP antibody reactivity was not correlated with the chromatin clumping. The mechanism of APP induction was postulated as stress-induced APP-gene induction, and the role of APP was presumed to protect the neuron against hazardous environment.
Adult
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Male
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Female
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Humans
;
Mice
;
Animals
10.Bilateral Diverticula with Recurrent Urinary Tract Infection.
Hyun Chul KIM ; Jin Wook KIM ; Kang Soo SHIM ; Du Geon MOON ; Je Jong KIM
Korean Journal of Urology 2005;46(1):103-104
Most bladder diverticula are associated with a neurogenic bladder or obstructive condition, but a congenital diverticulum is believed to be a congenital failure of normal muscular development. Often solitary and large congenital bladder diverticulum leads to various complications, including recurrent urinary tract infection, vesicoureteral reflux, stone formation, and incontinence. A diverticulectomy, with ureteral reimplantation, is recommended in Hutch's diverticula, as they are usually accompanied with reflux that does not spontaneously subside. We experienced a case of bilateral Hutch's diverticula, without vesicoureteral reflux, in a 15-month-old boy. This patient was successfully treated using only a bilateral diverticulectomy.
Diverticulum*
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Humans
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Infant
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Male
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Muscle Development
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Replantation
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Ureter
;
Urinary Bladder
;
Urinary Bladder, Neurogenic
;
Urinary Tract Infections*
;
Urinary Tract*
;
Vesico-Ureteral Reflux