1.Production of monoclonal antibody to Epstein-Barr virus antigen.
Jeong Je CHO ; Soon Tae HO ; Seung Min YOO ; Youn Mun HA
Korean Journal of Immunology 1992;14(1):117-131
No abstract available.
Herpesvirus 4, Human*
2.Clinical Outcome after Pancreatectomy in Patients with Persistent Hyperinsulinemic Hypoglycemia of Infancy.
Min Ho JUNG ; Jin Soon HWANG ; Choong Ho SHIN ; Sei Won YANG ; Je G CHI
Journal of Korean Society of Pediatric Endocrinology 2000;5(2):171-181
PURPOSE: The purpose of this study was to describe the clinical outcome after pancreatcetmy and its relationship with pathological appearances and clinical features in patients with persistent hyperinsulinemic hypoglycemia of infancy(PHHI). METHODS: Medical records of 10 patients(9 males and 1 female, mean age:40.4+/-1.5 months) who were diagnosed as PHHI and underwent pancreatectomy from 1988 to 2000 were reviewed. Clincal and biochemical data were recorded. Subjects were classified arbitrarily into early-onset or late-onset group according to age of onset. Pathologic appearance of pancreas was divided into 2 forms:diffuse or focal. The former had a focal pancreatic adenomatous hyperplasia and the latter was characterized by increased number of betacells with similar distribution seen in normal neonates. RESULTS: One patient had focal, and nine had diffuse lesions. After near-total pancreatectomy, 4 patients(40.0%) showed complete response, 4(40.0%) had persistent hypoglycemia, and 2(20.0%) developed diabetes mellitus. As neurological sequelae, 6 patients(60.0%) had persistent seizures, and 6(60.0%) had delayed motor and speech development. No clinical or biochemical factors related to postoperative outcome were found. CONCLUSION: This data indicate that early diagnosis of patients who present with hypoglycemic symptoms in infancy, especially early in life, and development of more effective therapy are warranted, because there is no clinical or biochemical factor predicting final outcome after near-total pancreatectomy and only 40% of patients with PHHI remained euglycemic after surgery with possible severe neurological sequelae.
Age of Onset
;
Congenital Hyperinsulinism*
;
Diabetes Mellitus
;
Early Diagnosis
;
Female
;
Humans
;
Hyperplasia
;
Hypoglycemia
;
Infant, Newborn
;
Male
;
Medical Records
;
Pancreas
;
Pancreatectomy*
;
Seizures
3.S Antigen Specific Rat Helper T Cell Line Induced Experimental Autoimmune Uveoretinitis.
Youn Mun HA ; Soon Tae HO ; Jeong Je CHO ; Seung Min YOO
Korean Journal of Immunology 1997;19(2):181-188
No abstract available.
Adaptive Immunity
;
Animals
;
Cell Line*
;
Rats*
4.Production of human monoclonal antibodies against tetanus toxoid using the Epstein-Barr virus transformation.
Seung Min YOO ; Jeong Je CHO ; Soon Tae HO ; Youn Mun HA
Korean Journal of Immunology 1993;15(2):139-146
No abstract available.
Antibodies, Monoclonal*
;
Herpesvirus 4, Human*
;
Humans*
;
Tetanus Toxoid*
;
Tetanus*
5.A Comparison of Peripheral Doses Scattered from a Physical Wedge and an Enhanced Dynamic Wedge.
Jong Min PARK ; Hee Jung KIM ; Je Soon MIN ; Je Hee LEE ; Charn Il PARK ; Sung Joon YE
Korean Journal of Medical Physics 2007;18(3):107-117
In order to evaluate the radio-protective advantage of an enhanced dynamic wedge (EDW) over a physical wedge (PW), we measured peripheral doses scattered from both types of wedges using a 2D array of ion-chambers. A 2D array of ion-chambers was used for this purpose. In order to confirm the accuracy of the device, we first compared measured profiles of open fields with the profiles calculated by our commissioned treatment planning system. Then, we measured peripheral doses for the wedge angles of 15 degrees, 30 degrees, 45 degrees, and 60 degrees at source to surface distances (SSD) of 80 cm and 90 cm. The measured points were located at 0.5 cm depth from 1 cm to 5 cm outside of the field edge. In addition, the measurements were repeated by using thermoluminescence dosimeters (TLD). The peripheral doses of EDW were (1.4% to 11.9%) lower than those of PW (2.5% to 12.4%). At 15 MV energy, the average peripheral doses of both wedges were 2.9% higher than those at 6MV energy. At a small SSD (80 cm vs. 90 cm), peripheral dose differences were more recognizable. The average peripheral doses to the heel direction were 0.9% lower than those to the toe direction. The results from the TLD measurements confirmed these findings with similar tendency. Dynamic wedges can reduce unnecessary scattered doses to normal tissues outside of the field edge in many clinical situations. Such an advantage is more profound in the treatment of steeper wedge angles, and shorter SSD.
Heel
;
Silver Sulfadiazine
;
Toes
6.A Case of Neuroepithelial(Colloid) Cyst.
Min Sik KIM ; Yo Han KIM ; Mu Young SONG ; Soon Jai LEE ; Young Bae LEE ; Je Geun CHI
Journal of the Korean Pediatric Society 1990;33(5):695-700
No abstract available.
7.Esophageal squamous cell carcinoma associated with gastric adenocarcinoma: total 8 cases analysis-.
Je Yoon YOO ; Young Geun RYU ; Han Sik KIM ; Soon Heung LEE ; Min Chul KIM ; Mun Joong KIM
Journal of the Korean Cancer Association 1992;24(2):323-332
No abstract available.
Adenocarcinoma*
;
Carcinoma, Squamous Cell*
10.Blood glucose/insulin index and carbohydrate-to-insulin ratio in Korean type 2 diabetic patients treated by continuous subcutaneous insulin infusion.
Sun Doo KIM ; Kil Do LEE ; Soon Je KIM ; Ewi Kwang CHOI ; Soo Bong CHOI ; Sun Min PARK
Korean Journal of Medicine 2000;59(6):602-611
BACKGROUND: According to the results of Diabetes Control and Complication Trial, the best strategy to prevent and/or delay diabetic complications is to maintain the normal blood glucose levels. This led to emphasize the necessity of intensive management of diabetes. The purpose of the study was to determine blood glucose/insulin index and carbohydrate (CHO)-to-insulin ratios after normalization of blood glucose levels, and to select the factors to influence the blood glucose/insulin index and CHO-to-insulin ratios in Korean type 2 diabetic patients with continuous subcutaneous insulin infusion (CSII) treatment using insulin pump and CHO counting as a meal management. METHODS: Fifty-five type 2 diabetic patients who started CSII therapy checked their blood glucose levels before and after three meals, and recorded the amounts of insulin injected in fasting and each meal and the amounts of carbohydrates consumed in each meal. Actual blood glucose/insulin index and CHO-to-insulin ratio were determined using the records, and also they were calculated using Functional Insulin Treatment Training Methods (FITTM) proposed by Howorka. Calculated values were compared to actual values. The meaningful factors to influence the actual values were selected by backward stepwise regression analysis. RESULTS: The average age of the subjects was 49.9+/-12.5 years, and the duration of diabetes was 8.7+/-4.5 years. Their body mass index was 22.5+/-3.6 kg/m2. Daily insulin requirements to normalize the blood glucose levels reached to maximum levels at l0 day CSII treatment, and they were reduced and stabilized after 20 days of the treatment. The quotient K, representing insulin sensitivity, was also decreased after CSII treatment. The basal insulin index was 0.21 IU/kg at 10 days and 0.16 IU/kg at 20 days in our study, and these values were lower than the value from FITTM, 0.35 IU/kg The blood/glucose index was -2.5 mmol/L at 10 day CSII treatment, and it was decreased to -4.4 mmol/L at 20 day treatment to the stable levels. CHO-to-insulin ratio provided by FITTM was 2.59 IU/CHO exchange unit and the ratio was 3.12 IU/CHO exchange unit at 10 days, which was decreased to 1.84 IU/CHO exchange unit at 20 days in our study. CHO-to-insulin ratios at breakfast from carbohydrate counting were higher than those of lunch and dinner, and the ratios were 1.5 to 2.5 IU/CHO exchange unit. According to the stepwise regression analysis, the blood glucose/insulin index was affected by gender, age, body mass index (BMI), fasting blood glucose levels and fasting c-peptide levels, and CHO-to-insulin ratios were influenced by gender, age, BMI, post-prandial blood glucose levels and post-prandial c-peptide levels. CONCLUSIONS: CSII treatment can make blood glucose levels maintain in normal ranges in Korean type 2 diabetic patients, and can improve insulin sensitivity. Basal insulin requirements were lower and prandial insulin requirements were higher than those calculated from FITTM. This difference between Korean and the Western can be related to difference of insulin secretion from pancreas and nutrient intake.
Blood Glucose
;
Body Mass Index
;
Breakfast
;
C-Peptide
;
Carbohydrates
;
Diabetes Complications
;
Fasting
;
Humans
;
Insulin Resistance
;
Insulin*
;
Lunch
;
Meals
;
Pancreas
;
Reference Values