1.An Investigation on Cataract Maimere in Yunnan Province
Journal of Kunming Medical University 1990;0(02):-
In 1987, based on WHO standard, a sampling survey was conducted among 52219 people with one of the five kinds of disablements. 344 of the people had cataract, which made up 46.49% of the visual disacility. There are 180 thousand people suffering from Cataracts in our province whose population is 35 milliom or so according to the census. In our study, the sex, age, distribution of these sufferers and the causes of the cataracts have been generally analysed, and the measures of medical rehabilitation of these people have also been discussed.
2.Diagnostic Endoscopic Sphinteropapillotomy (E.S.T.): An analysis of two cases.
Pan Ki JUNG ; Sang Woon LEE ; Je Weon KIM ; Kyu Soon KIM ; Jae Il MYEONG ; Hyang Soon YEO ; Hong Bae PARK
Korean Journal of Gastrointestinal Endoscopy 1986;6(1):67-70
E.S.T. is performed not only for the treatment but also for the diagnosis of biliary tract diseases. E.S.T. serves as a diagnostic aid for some of biliary tract diseases which require such procedures as a peroral cholangioscopy or biopsy of the biliary duct for precise diagnosis and further differential diagnosis. The diseases of our patients were diagnosed by clinical findings and such diagnostic maneuvers as abdominal ultrasonography, intravenous cholangiography, percutaneous transhepatic chorangiography(P.T.C.), endoscopic retrograde chorangiopancreatography(E.R.C.P.), In all the two cases, abdominal ultrasonography revealed dilated extrahepatic duct, but biliary trees were not visualized at E.R.C.P. In one of the two cases, P.T.C. revealed a filling defect with dilated common bile ducts(CBD) but we could not make a differential diagnosis of CBD stone from CBD cancer. In another of the two cases, on which intravenous cholangiography was done, we could not see CBD. For the purpuse of precise diagnosis and further differential diagnosis, we performed EST and then ERCP thraugh widened papillae. With those procedures, CBD stones were shown.
Bile
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Biliary Tract Diseases
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Biopsy
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Cholangiography
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Cholangiopancreatography, Endoscopic Retrograde
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Diagnosis
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Diagnosis, Differential
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Humans
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Ultrasonography
3.Vessel Wall Changes on Serial High-Resolution MRI and the Use of Cilostazol in Patients With Adult-Onset Moyamoya Disease
Jae Youn KIM ; Hyung Jun KIM ; Eun-Hyeok CHOI ; Kwang Hyun PAN ; Jong-Won CHUNG ; Woo-Keun SEO ; Gyeong-Moon KIM ; Tae Keun JEE ; Je Young YEON ; Jong-Soo KIM ; Seung-Chyul HONG ; Min-Jung SEONG ; Jihoon CHA ; Keon Ha KIM ; Pyoung JEON ; Oh Young BANG
Journal of Clinical Neurology 2022;18(6):610-618
Background:
and Purpose The natural course of adult-onset moyamoya disease (MMD) is unknown, and there is no medical treatment that halts its progression. We hypothesized that progressive shrinkage of large intracranial arteries occurs in adult-onset MMD, and that cilostazol inhibits this process.
Methods:
Serial high-resolution magnetic resonance imaging (HR-MRI) was performed on 66 patients with MMD: 30 patients received cilostazol, 21 received other antiplatelets, and 15 received no antiplatelets or had poor compliance to them. Serial HR-MRI was performed (interval between MRI scans: 29.67±18.02 months, mean±SD), and changes in outer diameter, luminal stenosis, and vascular enhancement were measured. Factors affecting HR-MRI changes were evaluated, including vascular risk factors and the ring finger protein 213 gene variant.
Results:
The progression of stenosis to occlusion, recurrent ischemic stroke, and the development of new stenotic segments were observed in seven, seven, and three patients, respectively. Serial HR-MRI indicated that the degree of stenosis increased with negative remodeling (outer diameter shrinkage). Patients who received cilostazol presented significantly larger outer diameters and lower degrees of stenosis compared with other groups (p=0.005 and p=0.031, respectively). After adjusting for clinical and genetic factors, only cilostazol use was independently associated with negative remodeling (odds ratio=0.29, 95% confidence interval=0.10–0.84, p=0.023). While vascular enhancement was observed in most patients (61 patients), the progression of enhancement or the occurrence of new vascular enhancement was rarely observed on follow-up HR-MRI (6 and 1 patients, respectively).
Conclusions
Adult-onset MMD induces progressive shrinkage of large intracranial arteries, which cilostazol treatment may prevent. Further randomized clinical trials are warranted.