The values for regional cerebral blood flow at rest were obtained from 60 right handed normal Korean adults(48 males, 12 females) with an age range of 24 to 69 years. The results were summarized as follows. 1) Mean rCBF were Fg ; 74.8+/-13.3ml/100g/min., Fw ; 19.2+/-3.1ml/100g/min, Wg ; 44.0+/-5.4% and CBF(inf) ; 39.8+/-7.6ml/100g/min. 2) In normal regional flow distributions throughout each hemisphere, values of Fg, Fw and CBF(inf) were higher in the frontal lobes and lower in the parietal lobes. A trend for higher values for Wg was seen in occipital and temporal lobes and lower values in the frontal lobes of both hemispheres. 3) When normal limits of the interregional variety values were predicted as mean ICV+2 SD(p<0.05), those values were Fg ; 12%, Fw ; 12%, CBF(inf) ; 10%, FFg ; 4% and Wg ; 10% of mean hemispheric rCBF. 4) There was a significant progressive decline of parameters of Fg, CBF(inf) and Wg with advancing age.
Adult* ; Frontal Lobe ; Hand ; Humans ; Male ; Parietal Lobe ; Temporal Lobe

Experimental brain infarcts in rats were studied light and electron microscopically to investigate the factor(s) controlling contrast enhancement on CT scans of the infarcts. Brain infarction was induced by injection of fine autologous blood clots through the right internal carotid artery and the affected brain was processed for examination 1 day, 2 day, and 1, 2, 4, 6 and 8 weeks after the injection. The lesion of early, necro - degenerative stage(1 day to 1 week) showed structural disintegration of capillary endothelial cells with dissolution of tight junctions. The lesion of middle, regenerative stage(2 to 4 weeks) was characterized by proliferation of new capillaries, They had well - formed tight junctions and continuos basement membrane. The endothelial cells, however, had intraluminal villous projections and many pinocytotic vesicles, suggesting an increased permeability. The capillaries matured at late, reparative stage(8 weeks), appearing similar to those in normal brain tissue except that they were loosely surrounded by astrocytic foot processes. It was presumed that the ncreased permeability of new capillaries might play an important role for contrast enhancement observable clinically during the middle stage(2 to 4 weeks).
Animals ; Basement Membrane ; Brain Infarction ; Brain* ; Capillaries* ; Carotid Artery, Internal ; Endothelial Cells ; Foot ; Permeability ; Rats* ; Tight Junctions ; Tomography, X-Ray Computed

The microsurgical anatomical characteristics of the anterior cerebral artery(ACA) are described. Inequality of horizontal segment of ACA has been reported. The majority of anterior communicating artery (ACoA) aneurysms occur in association with dominance of one A1 and hypoplasia of the other. ACoA has variation such as dimple, fenestration duplication, string, median artery of the corpus callosum and azygos anterior cerebral artery. ACoA gives rise to the perforating branches which feed subcallosal, hypothalamic area and optic chiasm. The recurrent artery of Heubner arises at A1-A2 junction, proximal A2 or distal A1. The distal ACA gives origin to many cortical branches, but there is the large variety of their origin. The aneurysm arising from A1 could be clipped through the pterional route, and those of distal ACA throuph the interhemispheric approach. ACo aneurysm could be approached through pterional or interhemspheric route. Essential points in ACo aneurysm surgery through any approach are to confirm H complex and to clip aneurysmal neck precisely without compromising feeding arteries or perforating branches.
Aneurysm ; Anterior Cerebral Artery* ; Arteries ; Corpus Callosum ; Neck ; Optic Chiasm ; Socioeconomic Factors

The microsurgical anatomical characteristics of the anterior cerebral artery(ACA) are described. Inequality of horizontal segment of ACA has been reported. The majority of anterior communicating artery (ACoA) aneurysms occur in association with dominance of one A1 and hypoplasia of the other. ACoA has variation such as dimple, fenestration duplication, string, median artery of the corpus callosum and azygos anterior cerebral artery. ACoA gives rise to the perforating branches which feed subcallosal, hypothalamic area and optic chiasm. The recurrent artery of Heubner arises at A1-A2 junction, proximal A2 or distal A1. The distal ACA gives origin to many cortical branches, but there is the large variety of their origin. The aneurysm arising from A1 could be clipped through the pterional route, and those of distal ACA throuph the interhemispheric approach. ACo aneurysm could be approached through pterional or interhemspheric route. Essential points in ACo aneurysm surgery through any approach are to confirm H complex and to clip aneurysmal neck precisely without compromising feeding arteries or perforating branches.
Aneurysm ; Anterior Cerebral Artery* ; Arteries ; Corpus Callosum ; Neck ; Optic Chiasm ; Socioeconomic Factors

This study was undertaken to observe the effects of centrally administred antihistamines on the blood pressure. Diphenhydramine(DPH), a H1-receptor antagonist, and ranitidine(RAN), a H2-receptor antagonist were administered intracerebroventricularly(icv) on urethane-anesthetized rabbits. 1) Both DPH and RAN administered intraccebroventricularly increased blood pressure, however the intravenous(iv) adminstration of them did not affect blood pressure. The pressor response to icv DPH was dose-dependent, but that to icv RAN was not. 2) The pressor response to icv DPH(1mg) was either markedly attenuated or reversed to depressor response by the pretreatment with icv phentolamine(250,500ug), and iv chlorisondamine(0.1, 1mg/Kg) and iv phenoxybenzamine(1mg/Kg). In cord-sectioned rabbtis, icv RAN) 1mg) did not produce pressor response. 3) The pressor responsr to icv RAN(1mg) was not affected by the pretreatment with icv phentolamine(500ug), iv chlorisondamin(1mg/Kg) and iv phenoxybenzamine(1mg/Kg), and iv phenoxybenzamine(1mg/Kg). RAN also producted pressor response in cordsectioned rabbits. These results suggest that the pressor response to icv DPH is elecited by increasing peripheral sympathetic tone via the stimulation of central alpha-adrenoreceptors and the pressor response to icv RAN is produced by releasing some humoral facotr which can increase blood pressure.
Blood Pressure ; Diphenhydramine* ; Histamine Antagonists ; Rabbits* ; Ranitidine*

Purpose: To investigate the extent of bone ingrowth into the porous-coated acetabular cups as well as the factors that correlated with bone ingrowth in total hip arthroplasty. Materials and Methods: Thirty six Harris-Galante porous-coated acetabular cups that were retrieved through revision surgery were examined in this study. Acetabular cups retrieved due to infection or severely destroyed cups (ed note: severe what?) were excluded. The extent of bone ingrowth into the acetabular cups was grossly measured, and its correlation with the variables including age, gender, weight, height, the duration of fixation, size, number of screws, inclination and anteversion was statistically analyzed. Results: The mean proportion of bone ingrowth was 52.9 21.9%(2~90%) and less than 30% in three cups(8.3%). The pattern and the location of bone ingrowth were not consistent. There was no correlation between the extent of bone ingrowth and age, gender, weight, height, the duration of fixation, cup size, number of screws, size, inclination and anteversion. Conclusion: Harris-Galante porous-coated acetabular cups showed satisfactory bone ingrowth regardless of the variables associated with the demographic or surgical conditions. Surface treatments with a fiber-metal porouscoating appears to be suitable for cementless acetabular cups in terms of the long term results.
Acetabulum* ; Arthroplasty, Replacement, Hip

OBJECTIVE: Surgically removed herniated lumbar disc specimen are immunostained to evaluate the production of MMPs(Matrix metalloproteinases) -1, 2, 3 for the investigation of the possible correlation of MMPs in lumbar disc herniation depending on the types of disc herniation. METHODS: The study population consists of 30 patients with lumbar disc herniation. There were 18 men and 12 women with patient age averaging 43.4 years(19-68years). The types of disc herniation identified at the time of surgery were classified as follow ; protruded type(Group 1, 10cases), extruded type(Group 2, 10cases), sequestrated type(Group 3, 10cases). Immunohistochemical study for the MMPs of the herniated disc tissue was performed and results of staining were graded to examine differences in histology among three types of disc herniation . RESULTS: The MMPs immunopositive cells were increased in old patients but statistically it was not significant(p=0.074). A significantly increased incidence of positive cells for MMP-1, 2 was found in the herniated lumbar disc tissue than the control group(p=0.02) but there were no significant differences among the three types of disc herniation. The MMP-3 positive cells were predominantly detected in the sequestrated disc tissue group(p=0.037) more than other groups. CONCLUSION: These results suggest that the MMP-1, 2, 3 may play important roles in the process of degeneration, herniation, and resorption of the lumbar intervertebral discs and that the MMP-3 may express the severity of lumbar disc herniation and play a role in resorption of the sequestrated disc tissue.
Female ; Humans ; Immunohistochemistry ; Incidence ; Intervertebral Disc ; Intervertebral Disc Displacement ; Male ; Matrix Metalloproteinases*

To elucidate the role of CNS GABA ergic system in the regulation of cardiovascular function, the effects of intracerebroventricular(icv) bicuculline(BIC), a selective GABAA antagonist, on blood pressure and heart rate were investigated in urethane anesthetized rabbits. 1) Icv BIC produced dose-dependent pressor and bradycardiac effect, while intravenous(iv) BIC had no effect on blood pressure and heart rate. 2) The pressor effect of BIC(10(g) was significantly attenuated by pretreatments with icv ketamine(5 mg) or icv diazepam(0.1 mg, 1 mg). Bilateral vagotomy and pretreatment with icv mecamylamine(0.2 mg), iv chlorisondamine(1 mg/kg), in phentolamine(1 mg/kg) did not affect the pressor action. 3) The bradycardiac effect of BIC(10(g) was abolished or reversed to slight tachycardia by bilateral vagotomy and pretreatment with icv ketamine(2.5 mg, 5 mg), icv diazepam(0.1 mg, 1 mg) and iv chlorisondamine(1 mg/kg). Neither icv mecamylamine(0.2 mg) nor iv phentolamine(1 mg/kg) affected the bradycardia. These results suggest that blockade of GABAA receptor produce pressor action which is associated with central excitatory amino acid system and produce reflex bradycardia induced by the pressor effect, and that sympathetic nervous system might not be involved in the pressor effect.
Bicuculline* ; Blood Pressure* ; Bradycardia ; Excitatory Amino Acids ; gamma-Aminobutyric Acid ; Heart Rate* ; Heart* ; Rabbits* ; Reflex ; Sympathetic Nervous System ; Tachycardia ; Urethane ; Vagotomy

OBJECTIVES: There have been several studies documenting the changing level of the conus throughout infancy and childhood, but there is only a little detailed study that documents the range of conus positions in a living adult population, especially in Korean, without spinal deformity. METHODS: we made a sequential study of magnetic resonance images of the lumbar spine to determine the variation in position of the conus medullaris in 650 living korean adults population without spinal deformity who checked MRI to identify the cause of low back pain. The study population consisted of patients over the age of 16 years. A T1-weighted, midline, sagittal image was reviewed for identifying the postion of conus. This location was recorded in relation to the upper, middle, or lower third of the adjacent vertebral body or the adjacent intervertebral disc. RESULTS: The study group consisted of 305 men(47%) and 345 women(53%) with a mean age 45.9 years(range, 16-79 years). The conus existed commonly at the middle third of L1(131cases, 20.2%), at the L1-2 intervertebral space(129cases, 19.8%), and the lower third of L1(123cases, 18.9%). The mean position of conus was the lower third of L1(range, middle third of T12 to middle third of L3). Conclusions:The mean position of conus was at the lower third of L1(range, middle third of T12 to middle third of L3). This results was same as that of foreign study. Our results of living korean adult population could allow for safe clinical procedures such as lumbar puncture, spinal anesthesia, and help to explain the differences among observed neurologic injuries from fracture-dislocation at the thoracolumbar junction.
Adult* ; Anesthesia, Spinal ; Congenital Abnormalities ; Conus Snail* ; Humans ; Intervertebral Disc ; Low Back Pain ; Magnetic Resonance Imaging* ; Spinal Puncture ; Spine

An intraosseous ganglion cyst, of which pathogenesis is unclear, is grossly and histologically identical to soft tissue ganglion. It predominates in the subchondral regions of tubular bones and is an osteolytic lesion that is well demarcated, radiographically. Pathologically, it is composed of a multilocular, thick, fibrous walled cyst-like structure filled with a slimy, mucin rich fluid. Curettage or curettage with bone graft is usually curative. Authors experienced a case diagnosed as intraosseous ganglia of both patellae. A 37-year-old man complained of both knee joint pains for about 4 month. About 1 year ago prior to this visit, he was treated one time because of the anterior knee pain. In the following X-rays, a well-defined osteolytic lesion involving the subchondral area of both patellae was showed. After CT and bone scan-ning, excision biopsy with curettage was performed. The thick, jelly-like mucinous fluid oozed out. His-tological findings were consistent with an intraosseous ganglion cyst. At 8 months follow-up, pain was completely resolved and other abnormal findings were not observed clinically.
Adult ; Biopsy ; Bone Cysts* ; Curettage ; Follow-Up Studies ; Ganglion Cysts ; Humans ; Knee ; Knee Joint ; Mucins ; Patella* ; Transplants