1.Hoping for Prospective Works on Fundamentals and Academic Promotion of Korean Medicine.
Journal of the Korean Medical Association 2000;43(8):701-702
No abstract available.
Hope*
;
Prospective Studies*
2.Prospects of Medical Suspecialty Board System in Korea.
Journal of the Korean Medical Association 2001;44(11):1146-1147
No abstract available.
Korea*
3.Alobar Holotelencephaly Associated with Microphthalmia and Choanal Atresia.
Hyon Sook SEO ; Gun Tae YI ; Jung Hye CHOI ; Fan Chen MONG ; Hee Dae PARK ; Soo Nam RHEE ; Je Geun CHI
Journal of the Korean Pediatric Society 1989;32(7):1007-1011
No abstract available.
Choanal Atresia*
;
Microphthalmos*
4.The Effects of Autologous Structural Bone Graft without Internal Fixation on Posteromedial Tibial Bone Defect in Primary Total Knee Arthroplasty.
Je Gyun CHON ; In Soo SONG ; Jun Beom KIM ; Gun Il JANG ; Chi Hoon AHN ; Ja Yeong YOON
The Journal of the Korean Orthopaedic Association 2017;52(6):514-520
PURPOSE: To evaluate the radiological and clinical outcomes of the standard total knee arthroplasty without internal fixation or extended long stem in tibial bone defect with severe varus deformity. MATERIALS AND METHODS: Between July 2012 and April 2014, 32 patients (45 cases; 4 men and 41 women with a mean age of 74.2 years) who underwent total knee arthroplasty with autologous bone grafting were enrolled for analysis. The mean follow-up period was 34.4 months. The cancellous bone defect site was exposed, and a longitudinal sulcus was made. Subsequently, a premolded bone graft was inserted in the sulcus at 45°. The defect size was measured, and the radiological and clinical results were evaluated. RESULTS: The mean defect size according to the radiograph was found to be 15.31×30.36 mm in the frontal view and 15.46×45.98 mm in the sagittal view. The mean defect size of depth during the operation was found to be 8.38 mm. The preoperative mean varus angle was 14.1° (4.0°–26.9°), and the follow-up mean valgus angle was 5.4° (0.5°–10.5°). The implant position was α=95.7°, β=90.4°, γ=2.1°, δ=89.1° on the follow-up. No implant loosening was observed, and the mean bone union period was 4.3 months. The Hospital for Special Surgery score was improved from a preoperative mean of 50.1 to a postoperative mean of 90.4. CONCLUSION: Standard total knee arthroplasty using autologous structural bone grafting without internal fixation in a tibial bone defect demonstrated a rapid, stable bone healing and excellent radiological and clinical results. Thus the index procedure was considered to be simple, and effective for bone grafting.
Arthroplasty, Replacement, Knee*
;
Bone Transplantation
;
Congenital Abnormalities
;
Female
;
Follow-Up Studies
;
Humans
;
Male
;
Transplants*
5.Safety and Pharmacokinetics of Intravenous Busulfan as Conditioning prior to Allogeneic Stem Cell Transplantation.
Yoon Hee PARK ; Seok LEE ; Yoo Jin KIM ; Dong Gun LEE ; Chi Young PARK ; Ho Jin SHIN ; Hee Je KIM ; Chang Ki MIN ; Dong Wook KIM ; Jong Wook LEE ; Woo Sung MIN ; Chun Choo KIM
Korean Journal of Hematology 2002;37(2):127-133
BACKGROUND: The unpredictable intestinal absorption and bioavailability of oral busulfan (BU) has limited the drug's use in high-dose pretransplant conditioning therapy. To overcome these problems, several trials for the evaluation of pharmacokinetics and clinical usefulness of an intravenous BU (IVBU) formulation have been reported. Here we present clinical and pharmacokinetic data on patients receiving IVBU as a component of conditioning regimens for allogeneic stem cell transplantation (SCT) in our center. METHODS: A total of 6 adult patients were entered onto this study. All patients were treated with IVBU (0.8mg/kg every 6 hours x 8~16)-containing conditioning regimen followed by HLA-identical allogeneic SCT. We also investigated the pharmacokinetics of IVBU using high-performance liquid chromatography in two cases. RESULTS: All patients achieved successful engraftment. No patient experienced hepatic veno-occlusive disease or neurologic toxicity. Five of 6 patients still alive in complete remission have been followed for 8~12 months after SCT. The measured maximum concentration for the first dose was 1,175ng/mL and 951ng/mL, and the half-life was 2.25h and 3.09h, respectively. The area under the plasma concentration-time curve was 4,596ng h/ mL and 3,067ng h/mL, respectively. There was no significant difference between the first and last dose pharmacokinetic parameters. CONCLUSION: We suggest that IVBU should be considered as appropriate replacement for oral BU in pretransplant conditioning therapy prior to SCT in Korea. Further studies with sizable patients are needed to define the role of IVBU in SCT setting.
Adult
;
Behavior Therapy
;
Biological Availability
;
Busulfan*
;
Chromatography, Liquid
;
Half-Life
;
Hepatic Veno-Occlusive Disease
;
Humans
;
Intestinal Absorption
;
Korea
;
Pharmacokinetics*
;
Plasma
;
Stem Cell Transplantation*
;
Stem Cells*