1.MULTI DRUG RESISTANT TB PATIENTS SURGICAL TREATMENT
Rentsenmygmar Ts ; Sukhee E ; Munkhzul B ; Tsagaan B ; Batbayar D ; Javzandulam O ; Batzaya Ts ; Uuganbayar G
Journal of Surgery 2016;20(2):25-29
Introduction: We began treatment of
multi drug resistant tuberculosis first from
2003. At that time there was a 1960 cases and
most of the cases were from Ulaanbaatar,
Darkhan, Selenge, Tuv, Dornod provinces.
From all the cases only 62% or 1058 cases
were included in treatment. From that 336
patient or 19% deceased, 296 patient or 18%
didn’t get a treatment. We did this study
because there were never done any research
or study of surgical treatment of multi drug
resistant tuberculosis in Mongolia.
Materials and Methods: We studied
cases of patients who undergone lobectomy,
since 2007. There were 48 cases of 46
patients, 2 patients surgery were done on
both sides. Respondents aged between 14-
45, 25 male (52%), 23 female (48%), all
patients got a first - line anti-tuberculosis
treatment, such as cat-1, cat-1+cat-2 and 10
variants of these drugs. It was done based
on sputum culture test results of NCCD
TB surveillance and research department’s
laboratory.
Results: From the all patients only
77.08% had undergone surgery within the
first 3 years. 92% patients were diagnosed
with multi drug resistance TB only with the
sputum and sputum culture test results, and
the rest of the patients were diagnosed
using a tissue analyses on the above tests.
It was revealed that HR resistant -91.66%,
HR+(Z,E,S) -3 drugs resistant -18.78%,
HR+(ZSE)-4 or 5 drugs resistant. In the
patients TB lesion locations was on the right
upper lobe 54%, left upper lobe 31%, on
a both upper lobes 85%, cavernous fibrosis
tubercles 60%, combined TB lesions 77%,
tubercles 21%.87.5% of total patients
received a multi - drug resistant TB treatment
between 7 - 24 months prior surgery.
All 48 patients had a totally 69 surgeries.
Surgeries included 9% pneumonectomy,
28% lobectomy, 30% Wedge resection,
23% pleurectomy decortication, 7% Wedge
resection on both sides, one bilobectomy.
There were no complications during the
surgery but 5 of patients had an empyema
after surgery. No fatal cases.Three patients
out of 5 who had a surgery due to pulmonary
hemorrhage developed an empyema after
surgery. Drainage tubes were taken after
the surgery within 2-3 months.Therewere no
complication and escalations in the patients
who received a surgical treatment, after the
surgery from 6 months to 5 years.
Conclusion: In study it shows that surgical
treatment is effective to do after 6 months
of anti-tuberculosis drug treatment in multi -drug resistant TB patients.Also it shows that
combining of medical and surgical treatment
is healing up to 98% in the patients who
were rightly chosen according to surgical
indications.This research result shows that in
our country multi - drug resistant TB surgical
treatment complication is only 10.41%,
which is below in the other countries who
have same anti-tuberculosis drug treatment.
2. MULTI DRUG RESISTANT TB PATIENTS SURGICAL TREATMENT
Rentsenmygmar TS ; Sukhee E ; Munkhzul B ; Tsagaan B ; Batbayar D ; Javzandulam O ; Batzaya TS ; Uuganbayar G
Journal of Surgery 2016;20(2):25-29
Introduction: We began treatment ofmulti drug resistant tuberculosis first from2003. At that time there was a 1960 cases andmost of the cases were from Ulaanbaatar,Darkhan, Selenge, Tuv, Dornod provinces.From all the cases only 62% or 1058 caseswere included in treatment. From that 336patient or 19% deceased, 296 patient or 18%didn’t get a treatment. We did this studybecause there were never done any researchor study of surgical treatment of multi drugresistant tuberculosis in Mongolia.Materials and Methods: We studiedcases of patients who undergone lobectomy,since 2007. There were 48 cases of 46patients, 2 patients surgery were done onboth sides. Respondents aged between 14-45, 25 male (52%), 23 female (48%), allpatients got a first - line anti-tuberculosistreatment, such as cat-1, cat-1+cat-2 and 10variants of these drugs. It was done basedon sputum culture test results of NCCDTB surveillance and research department’slaboratory.Results: From the all patients only77.08% had undergone surgery within thefirst 3 years. 92% patients were diagnosedwith multi drug resistance TB only with thesputum and sputum culture test results, andthe rest of the patients were diagnosedusing a tissue analyses on the above tests.It was revealed that HR resistant -91.66%,HR+(Z,E,S) -3 drugs resistant -18.78%,HR+(ZSE)-4 or 5 drugs resistant. In thepatients TB lesion locations was on the rightupper lobe 54%, left upper lobe 31%, ona both upper lobes 85%, cavernous fibrosistubercles 60%, combined TB lesions 77%,tubercles 21%.87.5% of total patientsreceived a multi - drug resistant TB treatmentbetween 7 - 24 months prior surgery.All 48 patients had a totally 69 surgeries.Surgeries included 9% pneumonectomy,28% lobectomy, 30% Wedge resection,23% pleurectomy decortication, 7% Wedgeresection on both sides, one bilobectomy.There were no complications during thesurgery but 5 of patients had an empyemaafter surgery. No fatal cases.Three patientsout of 5 who had a surgery due to pulmonaryhemorrhage developed an empyema aftersurgery. Drainage tubes were taken afterthe surgery within 2-3 months.Therewere nocomplication and escalations in the patientswho received a surgical treatment, after thesurgery from 6 months to 5 years.Conclusion: In study it shows that surgicaltreatment is effective to do after 6 monthsof anti-tuberculosis drug treatment in multi -drug resistant TB patients.Also it shows thatcombining of medical and surgical treatmentis healing up to 98% in the patients whowere rightly chosen according to surgicalindications.This research result shows that inour country multi - drug resistant TB surgicaltreatment complication is only 10.41%,which is below in the other countries whohave same anti-tuberculosis drug treatment.
3.Study results of the composition of oral microflora in Mongolian patients with Behcet’s disease
Javzandulam B ; Osamu U ; Nobuyoshi K ; Baasankhuu J ; Sarantuya J
Innovation 2021;14(1-Ophthalmology):42-45
Purpose:
Behcet’s disease is characterized by repeated acute inflammatory attacks with
aphthous ulcers of the oral mucosa, uveitis of the eyes, skin symptoms, and genital ulcers. Although
its etiology is still unknown, there is evidence of the involvement of oral bacteria in systemic
diseases. Various types of oral bacteria may be involved in the development and progression of
Behcet's disease. Therefore, the present study investigated alterations in the oral flora of patients
with Behcet’s disease in Mongolia. We collected saliva samples from the Mongolian Behcet's
disease (BD) group and healthy control (HC) group, and the oral flora were analyzed using next generation sequencer (NGS).
Methods:
DNA was extracted from the unstimulated saliva samples from the 47 BD and 48 HC
subjects. The DNA was amplified from the V3-V4 region of 16S rRNA using PCR, and the data were
acquired using NGS. Based on the obtained data, we analyzed the alpha diversity, beta diversity,
and bacterial taxonomy of the salivary flora.
Household survey covered 148 people with visual and hearing impairments to assess social service
accessibility.
Results:
Beta diversity differed significantly between the BD and HC flora, but no significant
differences were observed in alpha diversity. We found that the proportions of three genera—an
S24-7 family unknown species, a mitochondria family unknown species, and Akkermansia species were significantly lower in the BD than in the HC group.
Conclusion
The reduced proportions of the S24-7 family and symbiotic Akkermansia species
may be key phenomena in the oral flora of patients with BD.