Aged ; Bile Ducts ; pathology ; Cholangitis ; complications ; Humans ; Jaundice ; complications ; Male

Crigler-Najjar Syndrome ; complications ; diagnosis ; Female ; Humans ; Infant ; Jaundice ; etiology

OBJECTIVETo investigate the research on neonatal jaundice in recent years by co-word analysis and to summarize the hot spots and trend of research in this field in China.

METHODSThe CNKI was searched with "neonate" and "jaundice" as the key words to identify the papers published from January 2009 to July 2013 that were in accordance with strict inclusion and exclusion criteria. To reveal the relationship between different high-frequency key words, Microsoft Office Excel 2013 was used for statistical analysis of key words, and Ucinet 6.0 and Netdraw were used for co-occurrence analysis.

RESULTSA total of 2 054 papers were included, and 44 high-frequency key words were extracted. The current hotspots of research on neonatal jaundice in China were displayed, and the relationship between different high-frequency key words was presented.

CONCLUSIONSThere has been in-depth research on clinical manifestations and diagnosis of neonatal jaundice in China, but further research is needed to investigate the etiology, mechanism, and treatment of neonatal jaundice.

We experienced a case of chronic fibrosing pancreatitis in an 18/12-year-old girl, which was idiopathic because there were no familial back ground, no cystic fibrosis of pancrease, no ductal anomalies and obstruction. The patient presented intermittent colicky abdominal pain and progressive obstructive jaundice, but T-tube drainage and removal of the lymph nodes around the common bile duct relieved her symptoms and disease process. This seems to be the first case reported in a Korean child. Idiopathic fibrosing pancreatitis should be considered in the differential diagnosis of abdominal pain with obstructive jaundice in children.
Abdominal Pain/complications ; Female ; Fibrosis ; Humans ; Infant ; Jaundice, Chronic Idiopathic/complications ; Pancreatitis/complications/*pathology

Porphyria cutanea tarda (PCT) is a disease characterized by an early appearance of severe photosensitivity with an increase in urinary uroporphyrin excretion and other porphyrins, high isocoproporphyrin fecal levels and an accumulation of protoporphyrin in erythrocyte. This disease has been known to be caused by a dramatic decrease in the activity of the uroporphyrinogen decarboxylase. Multiple infectious and environmental factors may contribute to PCT by influencing oxidative stress in the hepatocytes. We report here on a case of porphyria cutanea tarda that presented with jaundice and photosensitivity.
Adult ; English Abstract ; Humans ; Jaundice/*complications ; Male ; Photosensitivity Disorders/complications ; Porphyria Cutanea Tarda/complications/*diagnosis

Aged ; Female ; Humans ; Jaundice ; complications ; Liver Cirrhosis ; etiology ; Liver Diseases ; complications ; Sarcoidosis ; complications

Acute Disease ; Female ; Hepatitis A ; complications ; Humans ; Jaundice ; complications ; Middle Aged ; Myelinolysis, Central Pontine ; complications ; virology

The authors experienced three cases of cholangiocarcinoma associated with profuse mucin production. We intended to review and summarize the clinical features of these patients to emphasize the clinical importance of mucin-producing cholangiocarcinoma. All patients were female. Symptoms were mainly right upper quadrant pain and jaundice. Diagnosis was made by characteristic endoscopic retrograde cholangiographic findings and computed tomography. Bile ducts were dilatated and obstructive jaundice had developed as a result of the accumulation of mucin realeased by the tumor. Treatments were hepatic lobectomies for two intrahepatic cholangiocarcinoma patients and extrahepatic bile duct resection and hepaticojejunostomy for one patient. There was no postoperative complication. Pathologies were well differentiated papillary adenocarcinoma in two cases. Two patients are still living without recurrence for over three and four years respectively. One patient who had T4 lesion died of recurrence 38 months after operation. Conclusively, aggressive surgical treatment may be justified in the treatment of mucin hypersecreting cholangiocarcinoma even in advanced stage in view of the favorable outcome after radical operation. Further study is needed to clarify its biological behavior.
Adenocarcinoma, Papillary ; Bile Ducts ; Bile Ducts, Extrahepatic ; Cholangiocarcinoma* ; Diagnosis ; Female ; Humans ; Jaundice ; Jaundice, Obstructive* ; Mucins ; Pathology ; Postoperative Complications ; Recurrence

BACKGROUND/AIMS: Pancreaticoduodenectomy is accompanied by considerable rates of postoperative complications and mortalities. Obstructive jaundice is associated with periampullary lesions. The role of preoperative biliary drainage in patients with biliary obstruction undergoing pancreaticoduodenectomy remains controversial. Some authors show the disadvantages of biliary drainage that increased perioperative infectious complications. We analyzed retrospectively the effect of biliary drainage on pancreaticoduodenectomy and surgical outcome. METHODS: One hundred ten consecutive cases of pancreaticoduodenectomy performed between March 1992 and December 2000 were analyzed. We classified Group A as the patients who performed preoperative biliary drainage and Group B as the patients who did not perform biliary drainage. Multiple preoperative, intraoperative, postoperative variables were examined. Student's T-test, chisquare test or Fisher's Exact test was used for univariate comparison of all variables. RESULTS: Preoperative Biliary drainage was performed in 52 patients (47%) and the remaining 58 patients (53%) did not undergo any form of biliary drainages. The overall morbidity and mortality was 37% and 1.8% each. Total Bilirubin was higher in Group A (13.15 mg/dl) than Group B (4.11 mg/dl) (P=0.000). In Group A complication occurred in 21 patients and 20 patients in Group B (P=0.561). No differences were found between Group A and Group B in the incidence of all complications. More transfusion was needed for Group A (P=0.043). Postoperative hospital stay presented no differences (P=0.375). CONCLUSIONS: Biliary drainage is not required in patients who are planed pancreaticoduodenectomy except that the patient had cholangitis or bleeding tendency due to jaundice and hepatic derangements. The biliary drainage should be reserved for the potential for delay in definitive surgery. And it demands randomized prospective study in the future.
Bilirubin ; Cholangitis ; Drainage* ; Hemorrhage ; Humans ; Incidence ; Jaundice ; Jaundice, Obstructive ; Length of Stay ; Mortality ; Pancreaticoduodenectomy* ; Postoperative Complications ; Retrospective Studies

No abstract available.
Aged, 80 and over ; Cholecystitis/*complications/diagnosis ; Hemobilia/diagnosis/*etiology ; Humans ; Jaundice, Obstructive/etiology ; Male