1.Three cases of Watson-Alagille syndrome.
Eun Kyeong BOM ; Dae Hyun KIM ; Dong Hoon KOH ; Young Youn CHOI ; Jae Sook MA ; Tae Ju HWANG
Journal of the Korean Pediatric Society 1991;34(12):1699-1706
No abstract available.
Jaundice
2.A clinical study of obstruction jaundice.
Journal of the Korean Surgical Society 1993;45(6):984-992
No abstract available.
Jaundice*
3.Association of TP53 germline variant and choledochal cyst among clinically diagnosed Filipino pediatric patients
Danna Mae S. Opiso ; Germana Emerita V. Gregorio ; Catherine Lynn T. Silao
Acta Medica Philippina 2024;58(Early Access 2024):1-8
Background and Objective. Choledochal cysts (CC) are rare congenital, cystic dilations of the biliary tree occurring predominantly in Asian populations and in females. Patients are usually children presenting with any of the following: abdominal pain, palpable abdominal mass, and jaundice. Its congenital nature hints at a potential genetic cause. A possible causal gene is TP53, a tumor suppressor with a germline variant called rs201753350 (c.91G>A) that changed from a G allele to an A allele, decreasing the cell proliferation suppressing activity of its functional protein. Currently, there is no information on the TP53 rs201753350 germline variant available for the Filipino population. This study determined the prevalence of rs201753350 and the association between the functional G allele, the rs201753350 germline variant A allele, and the occurrence of CCs in Filipino pediatric patients in a tertiary government hospital.
Methods. Genomic DNA was extracted from blood samples of pediatric patients clinically diagnosed with CC. Controls were DNA samples collected from a previous study. The samples underwent PCR, electrophoresis, and sequencing.
Results. A total of 109 participants (22 cases and 87 controls) were included in the study. The A allele (22.94%) occurs at a lower frequency than the G allele (77.06%) among both cases and controls. More individuals have a homozygous G/G genotype (54.13%) than a heterozygous A/G genotype (45.87%) while the homozygous A/A genotype was not observed. The estimated risk of choledochal cyst occurrence is significantly lower in individuals with the A allele (PR: 0.08, 95% CI: 0.01 – 0.55) and the A/G genotype (PR: 0.06, 95% CI: 0.01 – 0.40).
Conclusion. There is no significant evidence to suggest an association between the TP53 rs201753350 germline
variant and the occurrence of choledochal cysts in Filipinos. It is recommended that other mutations within and
beyond the TP53 gene be investigated for possible associations with choledochal cyst occurrence.
Jaundice
4.Repetitive Jaundice and Headache.
Journal of the Korean Medical Association 1997;40(5):640-644
5.Significance of preoperative percutaneous transhepatic biliary drainage(PTBD) in obstructive jaundice.
Sun Pil KIM ; Cheong Yong KIM ; Young Don MIN
Journal of the Korean Surgical Society 1993;44(1):102-108
No abstract available.
Jaundice, Obstructive*
6.Knowledge and Attitude of Neonatal Jaundice – Orang Asli Perspective
Muhammad Nazrin Asyraf Adeeb ; Kartik Kumarasamy ; Sabariah Abdul Hamid ; Nur Ain Mahat ; Kalnissha Arumugam ; Syasya Hannany Abdul Shukor
Malaysian Journal of Health Sciences 2016;14(2):65-68
The incidence of neonatal jaundice among aborigines is increasing with the morbidity and mortality among this group are well recognized. This study aimed to assess the knowledge and attitude status on neonatal jaundice among Orang Asli in Sepang, Selangor. Cross-sectional study was conducted within two weeks in Kampung Orang Asli in Sg. Pelek, Sepang, Selangor. A simple random sample of adults aged 18 years and above was selected. Data were collected by an interviewed structured questionnaire. Overall, out of 152 residents, 67% were aware about neonatal jaundice. Majority of them were female (72%), married (78.4%) and respondents who have children (86%). Among those who were aware, almost 68% have good knowledge, in which 70% recognized jaundice by yellow discoloration on the body. High pitched crying (12.7%) and not feeding (10.8%) were among symptoms they knew. Almost 50% of the respondents believed neonatal jaundice may cause mental retardation. As for management of neonatal jaundice at home, majority of them (47%) will expose the baby under the sun, 7.8% will take herbal medication whereas 2% will continue with breast feeding. Almost eighty percent of the respondents will send their jaundiced baby to the hospital immediately, whereas 23% prefer management by nurse at home. Although majority of respondents in Kg. Orang Asli Sg. Pelek have good knowledge & good attitude on neonatal jaundice, some mothers are still likely to resort to self-treatment with potentially harmful therapies.
Jaundice, Neonatal
7.The analysis of cholescintigraphy in differentiating the causes of jaundice
Jung Gyun KIM ; So Yeob SOON ; Kwang Su BAE ; Moo Chan CHUNG ; Deuk Lin CHOI ; Ki Jung KIM
Journal of the Korean Radiological Society 1985;21(4):639-649
As a adjuvant, 99m Tc-IDA complex cholescintigraphy has been used to differentiate the causes of jaundice,hepatocellular jaundice from the obstructive jaundice. So we conducted the retrospective study from the 41 casesof cholescintigraphy from the Mar, 83 to Sept. 84 at the Dept. of radiology in the Sonnchyunhyang university todetermine the etiology and differential points in the diagnosing the Jaundice. The following results wereobtainend; 1. As a 1st-ordered parameter, the leading edge hepatic parenchymal transit time was very significant in differentiating the causes of jaundice, among the hepatocellular jaundice, obstructive jaundice due to tumor,and obstructive jaundice due to cholelithiasis. (P<0.01 by X2-test) 2. As a 2nd-ordered parameter, hepaticclearance was very significant in differentiating the hepatocellular jaundice from the jaundice due to partialbiliary obstruction. (P>0.01 by t-test) 3. The difference in hepatic clearance between the biliary obstruction dueto tumor and that of the cholelithiasis, was not significant. (P>0.05 by X2-test) 4. The difference in bile ductdilatation among the hepatocellular jaundice obstructive jaundice due to tumor, and obstructive jaundice due tocholelithiasis, was singnificant in differentiating the causes of jaundice. (P<0.05 by X2-test) 5. Intrahepaticstone showed scintigraphic pooling with partial stasis. 6. Cholescintigraphy was useful to differentiated the Rotor's syndrome from the Dubin-Johnson syndrome, supplying the additional criteria.
Bile
;
Cholelithiasis
;
Jaundice
;
Jaundice, Chronic Idiopathic
;
Jaundice, Obstructive
;
Retrospective Studies
8.The Role of Porta Hepatis Irradiation in Relieving Malignant Obstructive Jaundice.
Journal of the Korean Society for Therapeutic Radiology 1990;8(1):79-84
We have analysed 13 patients with malignant obstructive jaundice due to metastasis who were treated with local radiation therapy to the area of porta hepatis at the Radiation Therapy Department of Paik hospital attached to the Inje University between 1984 and 1988. A good response was observed in 6 out of 7 evaluable paitens receiving a total radiation dose ranging from 2600 to 5480 cgy in 2.6 to 6 weeks. A complete response was noted in 5 patients, a partial response in 1 patient, and no response in 1 patient. The overall median survival for 13 patients was 3 months. But two patients lived more than a year without recurrence of jaundice. Moderate dose, localized field radiation therapy appears to the beneficial in relieving obstructive jaundice and gives a good symptomatic relief.
Humans
;
Jaundice
;
Jaundice, Obstructive*
;
Neoplasm Metastasis
;
Recurrence
9.A case of Dubin-Johnson Syndrome.
Ae Jung KWAK ; Mi jung KIM ; Min Jung CHO ; Kwang Hae CHOI
Yeungnam University Journal of Medicine 2002;19(1):68-72
Dubin-Johnson Syndrome is a form of benign, familial idiopathic jaundice presenting with chronic intermittentconjugated hyperbilirubinnmia and a melamin-like pigment has been found in the parenchymal liver cells. This disorder is rarely diagnosed in the neonatal period. We report a case of Dubin-Johnson syndrome presenting with neonatal cholestasis.
Cholestasis
;
Jaundice
;
Jaundice, Chronic Idiopathic*
;
Liver
10.A case of Dubin-Johnson Syndrome.
Ae Jung KWAK ; Mi jung KIM ; Min Jung CHO ; Kwang Hae CHOI
Yeungnam University Journal of Medicine 2002;19(1):68-72
Dubin-Johnson Syndrome is a form of benign, familial idiopathic jaundice presenting with chronic intermittentconjugated hyperbilirubinnmia and a melamin-like pigment has been found in the parenchymal liver cells. This disorder is rarely diagnosed in the neonatal period. We report a case of Dubin-Johnson syndrome presenting with neonatal cholestasis.
Cholestasis
;
Jaundice
;
Jaundice, Chronic Idiopathic*
;
Liver