1.Short-term, High Dose Methylprednisolone and Narrowband UVB Combination Therapy for 2 Patients with Vitiligo.
Yu Jin KIM ; Kyungmoon LEE ; Young LEE ; Young Joon SEO ; Jeunghoon LEE ; Jangkyu PARK
Korean Journal of Dermatology 2008;46(12):1619-1622
Systemic corticosteroid arrests the progression of vitiligo and leads to repigmentation, but it may produce side effects. It has been reported that the maximum effect for corticosteroid can be achieved without major side effects when it is used at high doses over a short period of time. Recently, narrowband UVB has been used to treat vitiligo. However, there have been no reports on the effectiveness for a combined treatment with narrowband UVB and systemic corticosteroid. We encountered 2 cases of vitiligo patients who had rapid and effective repigmentation after combination therapy with high dose methylprednisolone and narrowband UVB. Intravenous high dose (25 mg/kg) of methylprednisolone for 3 days was followed by narrowband UVB once or twice weekly. After 2 months, rapid improvements were seen in both patients with >75% repigmentation. Combination treatment with high dose methylprednisolone therapy and narrowband UVB may be an effective therapeutic option for vitiligo.
Humans
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Methylprednisolone
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Vitiligo
2.Characteristics of COVID-19 outbreaks and risk factors for transmission at an army training center in South Korea from June to August 2021
U Jin CHO ; Seongjin WANG ; Seonju YI ; Yeon Hwa CHOI ; Eun-Young KIM ; Jin A KIM ; Sanghwan BAE ; Jungyeon YU ; Jangkyu CHOI ; Young-Joon PARK
Osong Public Health and Research Perspectives 2022;13(4):263-272
Objectives:
It is crucial to establish the characteristics of coronavirus disease 2019 (COVID-19) outbreaks at army training centers to develop preventive measures. Therefore, this study aimed to determine the COVID-19 transmission patterns and risk factors in a sequence of outbreaks at an army training center from June to August 2021.
Methods:
This study included 1,324 trainees at an army training center where outbreaks occurred from June to August 2021. The outbreak was qualitatively analyzed according to the period, attack rate, demographic characteristics, vaccination history, and living areas. An aerodynamic experiment was performed to evaluate aerosol transmission in living areas.
Results:
Three outbreaks occurred at the army training center from June to August 2021. The first, second, and third outbreaks lasted for 32, 17, and 24 days, and the attack rates were 12.8%, 18.1%, and 8.9%, respectively. Confirmed cases were distributed in all age groups. Recruits and the unvaccinated were at higher risk for COVID-19. The aerodynamic experiment verified the possibility of aerosol transmission within the same living area.
Conclusion
COVID-19 transmission at army training centers should be minimized through quarantine and post-admission testing during the latency period as part of integrated measures that include facility ventilation, vaccination, indoor mask-wearing, and social distancing.
3.An Open Label, Multi-center Clinical Trial of Topical 5% Minoxidil Solution for the Treatment of Male Androgenetic Alopecia (A Phase IV Study).
Hwa Young PARK ; Won Soo LEE ; Jangkyu PARK ; Do Won KIM ; Seok Yong AHN ; Ye Jin JUNG ; Byung In RO ; Woo Young SIM ; Sung Wook PARK ; Gwang Seong CHOI ; Hyung Ok KIM ; Chang Hun HUH ; Tae Young YOON ; Moon Bum KIM ; Ki Ho KIM ; Haejun SONG ; Sook Jung YUN
Korean Journal of Dermatology 2009;47(3):295-302
BACKGROUND: Topical 5% minoxidil solution stimulates new hair growth and it helps stop the loss of hair on individuals with androgenetic alopecia (AGA). OBJECTIVE: We wanted to assess the efficacy and safety of topical 5% minoxidil solution for treating Korean men with AGA. METHODS: This was a 24-week, open label, clinical trial that was conducted at 14 university dermatologic centers nationwide throughout South Korea as a multicenter study of the Korean Hair Research Society. The eligible subjects for this study were 18- to 65 year-old men with androgenetic alopecia, as defined by the Norwood scale as type III vertex, IV and IVA. A total of 175 men (20~62 years old) with AGA applied topical 5% minoxidil solution twice daily. Efficacy was evaluated by 1) the total hair count per 1 cm2 and 2) the mean hair diameter and 3) the patient assessment and 4) the investigator assessment of the change in scalp coverage and the benefit of treatment. RESULTS: At week 24 as compared with baseline, there was a statistically significant increase in the total hair counts and the mean hair diameter (p<.0001). Topical 5% minoxidil solution helped improve the investigator and patient assessments. The topical 5% minoxidil solution was well tolerated over a 24-week period. CONCLUSION: We believe that topical 5% minoxidil solution is a safe and effective drug for Korean men with AGA.
Alopecia
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Hair
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Humans
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Male
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Minoxidil
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Republic of Korea
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Research Personnel
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Scalp