1.Unusual Left Ventricular Endocardial Metastasis from Primary Lung Cancer.
Journal of Cardiovascular Ultrasound 2012;20(3):157-160
The heart is frequently the site of metastasis of various malignant tumors. Lung cancer is one of the most common primary tumors of cardiac metastasis and usually involves the pericardium or epicardium by direct invasion and/or lymphatic spread. However, metastasis of lung cancer involving the left ventricular endocardium is extremely rare. We report a patient with adenocarcinoma of lung, metastasized to the left ventricular myocardium and endocardium, diagnosed by echocardiography and 18-fludeoxyglucose positron emission tomography-computed tomography.
Adenocarcinoma
;
Echocardiography
;
Electrons
;
Endocardium
;
Heart
;
Heart Ventricles
;
Humans
;
Lung
;
Lung Neoplasms
;
Myocardium
;
Neoplasm Metastasis
;
Pericardium
2.Clinical Implications of Serum Biomarkers in Diabetic Cardiovascular Complications.
Korean Diabetes Journal 2009;33(5):363-372
Diabetes is associated with increased risk of cardiovascular disease, with atherosclerosis responsible for most associated morbidity and mortality. Atherosclerosis often causes acute thrombotic events through plaque rupture and formation of platelet-rich thrombi. The principal clinical manifestations of atherosclerosis are coronary artery disease, ischemic stroke, and peripheral arterial disease. Endothelial dysfunction, oxidative stress, and low-grade inflammation are key features in the pathophysiology of atherosclerosis.
Atherosclerosis
;
Biomarkers
;
Cardiovascular Diseases
;
Coronary Artery Disease
;
Diabetes Mellitus
;
Inflammation
;
Oxidative Stress
;
Peripheral Arterial Disease
;
Rupture
;
Stroke
3.Subacute, Silent Embolization of Amplatzer Atrial Septal Defect Closure Device to the Pulmonary Artery.
Journal of Cardiovascular Ultrasound 2012;20(4):201-204
Embolization of the closure device is a rare but potentially fatal complication of percutaneous atrial septal defect (ASD) closure. We report a case of 45-year-old woman who underwent ASD device closure with 32 mm Amplatzer device, which was embolized to the pulmonary artery without symptom one day after successful device implantation.
Female
;
Heart Septal Defects, Atrial
;
Humans
;
Pulmonary Artery
;
Septal Occluder Device
4.Clinical study of peripheral facial nerve paralysis.
Tai Sun SON ; Kwan Ki JUNG ; Bung Won KWANG ; He Hun HWANG ; Chul Ho JANG
Journal of the Korean Academy of Family Medicine 1993;14(4):232-239
No abstract available.
Facial Nerve*
;
Paralysis*
5.Epinephrine-induced lactic acidosis in orthognathic surgery: a report of two cases.
Hee Won SON ; Se Hun PARK ; Hyun Oh CHO ; Yong Joon SHIN ; Jang Ho SON
Journal of the Korean Association of Oral and Maxillofacial Surgeons 2016;42(5):295-300
Submucosal infiltration and the topical application of epinephrine as a vasoconstrictor produce excellent hemostasis during surgery. The hemodynamic effects of epinephrine have been documented in numerous studies. However, its metabolic effects (especially during surgery) have been seldom recognized clinically. We report two cases of significant metabolic effects (including lactic acidosis and hyperglycemia) as well as hemodynamic effects in healthy patients undergoing orthognathic surgery with general anesthesia. Epinephrine can induce glycolysis and pyruvate generation, which result in lactic acidosis, via β2-adrenergic receptors. Therefore, careful perioperative observation for changes in plasma lactate and glucose levels along with intensive monitoring of vital signs should be carried out when epinephrine is excessively used as a vasoconstrictor during surgery.
Acidosis, Lactic*
;
Administration, Topical
;
Anesthesia, General
;
Anesthesia, Local
;
Epinephrine
;
Glucose
;
Glycolysis
;
Hemodynamics
;
Hemostasis
;
Humans
;
Lactic Acid
;
Orthognathic Surgery*
;
Plasma
;
Pyruvic Acid
;
Vital Signs
6.A case of thoracic ectopia cordis.
Yong Kwan KIM ; Won Poong SON ; Young Woo JANG ; Sook CHO ; Byung Moon KANG ; Goo Sang KIM
Korean Journal of Obstetrics and Gynecology 1993;36(7):2839-2842
No abstract available.
Ectopia Cordis*
7.Severe chest pain with mid-ventricular obstruction in a patient with hyperthyroidism.
Jong Ho NAM ; Jang Won SON ; Geu Ru HONG
Yeungnam University Journal of Medicine 2017;34(1):128-131
Mid-ventricular obstruction (MVO) rarely occurs in patients without hypertrophic cardiomyopathy. Increased cardiac contractility may play an important role in causing MVO. We experienced a case of severe chest pain and MVO in a 50-year-old female patient. She had hypertension, diabetes, stroke and peripheral artery disease. Her blood pressure was very high (222/122 mmHg) with severe fluctuation. The transthoracic echocardiography revealed MVO accompanied by hyper-dynamic left ventricular systolic function. We regarded her chest pain and MVO as secondary findings related to other diseases. Coronary angiography and several tests for uncontrolled hypertension were performed, and those evaluations revealed that she had coronary artery disease and hyperthyroidism. We considered that the increase in the myocardial oxygen demand in response to the increase in cardiac contractility and workload associated with hyperthyroidism aggravated her symptoms and MVO. She was treated with methimazole and beta blockers and her symptoms dramatically improved.
Blood Pressure
;
Cardiomyopathy, Hypertrophic
;
Chest Pain*
;
Coronary Angiography
;
Coronary Artery Disease
;
Echocardiography
;
Female
;
Humans
;
Hypertension
;
Hyperthyroidism*
;
Methimazole
;
Middle Aged
;
Oxygen
;
Peripheral Arterial Disease
;
Stroke
;
Thorax*
;
Ventricular Function
8.Congenitally Corrected Transposition of the Great Arteries.
Korean Journal of Medicine 2012;82(6):683-685
No abstract available.
Arteries
;
Cardiac Imaging Techniques
;
Heart Defects, Congenital
;
Transposition of Great Vessels
9.Human Tissue-Engineered Skeletal Muscle: A Tool for Metabolic Research
Ji-Hoon KIM ; Seung-Min YU ; Jang Won SON
Endocrinology and Metabolism 2022;37(3):408-414
Skeletal muscle is now regarded as an endocrine organ based on its secretion of myokines and exerkines, which, in response to metabolic stimuli, regulate the crosstalk between the skeletal muscle and other metabolic organs in terms of systemic energy homeostasis. This conceptual basis of skeletal muscle as a metabolically active organ has provided insights into the potential role of physical inactivity and conditions altering muscle quality and quantity in the development of multiple metabolic disorders, including insulin resistance, obesity, and diabetes. Therefore, it is important to understand human muscle physiology more deeply in relation to the pathophysiology of metabolic diseases. Since monolayer cell lines or animal models used in conventional research differ from the pathophysiological features of the human body, there is increasing need for more physiologically relevant in vitro models of human skeletal muscle. Here, we introduce recent studies on in vitro models of human skeletal muscle generated from adult myogenic progenitors or pluripotent stem cells and summarize recent progress in the development of three-dimensional (3D) bioartificial muscle, which mimics the physiological complexity of native skeletal muscle tissue in terms of maturation and functionality. We then discuss the future of skeletal muscle 3D-organoid culture technology in the field of metabolic research for studying pathological mechanisms and developing personalized therapeutic strategies.
10.Recent Advances in Anti-Obesity Drugs
Journal of Korean Diabetes 2022;23(2):113-127
Obesity is a chronic, complex, and heterogeneous disease that is affected by genetic, developmental, biological, and environmental factors; thus, it is necessary to approach obesity with an integrated and comprehensive treatment strategy. Because it is difficult to achieve and maintain successful long-term weight loss through lifestyle modifications in most obese patients, a pharmacological approach to the treatment of obesity should be considered as adjuvant therapy. According to the Korean Society for the Study of Obesity guidelines, patients who fail to lose weight with comprehensive lifestyle modifications and who have a body mass index of ≥ 25 kg/m2 are eligible for weight loss medication treatment. Four drugs (orlistat, naltrexone extended-release [ER]/bupropion ER, phentermine/topiramate controlled-release, and liraglutide) have been approved for long-term use (> 12 weeks) to promote weight loss in Korea. Here, I will discuss these currently available anti-obesity agents as well as upcoming anti-obesity agents including semaglutide, setmelanotide, and tirzepatide in terms of obesity management.