1.Enhancement of Immunogenicity of the Inefficient Antigen Through DNA Vaccine-based Epitope Modification.
Soong Hwa JANG ; Mi Jin KIM ; Yong Suk JANG
Korean Journal of Immunology 2000;22(3):111-116
No abstract available.
DNA*
2.Esophagus, Stomach & Intestine; A Case of Esophageal Candidiasis Presenting Recurrent Abdominal Pain in an Immunocompetent Child.
Korean Journal of Gastrointestinal Endoscopy 1997;17(1):55-58
Candida albicans is the most common cause of infectious esophagitis and usually is an opportunistic infection in immunocompromised patients. Dysphagia and odynophagia are the usual presenting complaints and, importantly, oral lesions are absent in 50 percent of patients. The role of gastrointestinal endoscopy in diagnosing fungal infections of the esophagus is primary. It is the most definitive and often the only method of detecting esophageal candidiasis. Accurate endoscopic diagnosis by biopsy or brushing leads to the initiation nf effective therapy. We have experienced a case of esophageal candidiasis in an 11-year-old girl who was immunologically normal and whose main symptoms were epigastric abdominal pain and nausea for 4 months. The endoscopic and pathologic findings of esophageal candidiasis were presented.
Abdominal Pain*
;
Biopsy
;
Candida albicans
;
Candidiasis*
;
Child*
;
Deglutition Disorders
;
Diagnosis
;
Endoscopy, Gastrointestinal
;
Esophagitis
;
Esophagus*
;
Female
;
Humans
;
Immunocompromised Host
;
Intestines*
;
Nausea
;
Opportunistic Infections
;
Stomach*
3.The clinical observation in Kawasaki disease.
Young Jin JANG ; Joong Gon KIM ; Yong Soo YUN
Journal of the Korean Pediatric Society 1992;35(3):330-341
No abstract available.
Mucocutaneous Lymph Node Syndrome*
4.The Significance of Renal Pelvic Diameter in the Neonates with Congential Ureteropelvic Junction Obstruction.
Byung Jin JANG ; Ki Yong SHIN ; Young Nam WOO
Korean Journal of Urology 2000;41(1):87-91
No abstract available.
Humans
;
Infant, Newborn*
5.Femur neck fracture during open intramedullary nailing of femur shaft fracture: a report of one case.
Kun Yung LEE ; Young Jin CHUNG ; Yong Woo JANG
The Journal of the Korean Orthopaedic Association 1991;26(6):1931-1933
No abstract available.
Femoral Neck Fractures*
;
Femur Neck*
;
Femur*
;
Fracture Fixation, Intramedullary*
6.A clinical study on the postpartum depression.
Yong Jin NA ; Byung Min LEE ; Jin Suk JANG ; Ook Hwan CHOI ; Won Whe KIM
Korean Journal of Obstetrics and Gynecology 1993;36(10):3539-3549
No abstract available.
Depression, Postpartum*
;
Female
;
Postpartum Period*
7.Effect of the Isolation Method of Mouse Inner Cell Mass, Types of Feeder Cells and Treatment Time of Mitomycin C on the Formation Rate of ICM Colony.
Ho Jin JANG ; Kyung Rae KO ; Mi Kyung KIM ; Yong Jin NA ; Kyu Sup LEE
Korean Journal of Fertility and Sterility 2006;33(4):265-272
OBJECTIVE: This study was carried out to evaluate the effect of the isolation methods of inner cell mass from mouse blastocyst, types of feeder cells and treatment time of mitomycin C on the formation rate of ICM colony. METHODS: The inner cells were isolated by conventional immunosurgery, partial trophoblast dissection with syringe needles and whole blastocyst co-culture method. Commercially available STO and primary cultured mouse embryonic fibroblast (pMEF) feeder cells were used, and mitomycin C was treated for 1, 2 or 3 hours, respectively. The formation rate of ICM colony was observed after isolation of ICM and culture of ICM on the feeder cells for 7 days. RESULT: The ICM colony formation rate on STO were significantly higher in partial trophoblast dissection group (58%) than that in immunosurgery (12%) or whole blastocyst culture (16%) group (p<0.05). The formation rate on pMEF feeder layer was higher in partial trophoblast dissection (88%) and whole blastocyst culture (82%) group than that in immunosurgery (16%) group (p<0.05). When mitomycin C treated to pMEF for 2 hours, the formation rate of 88% was significantly higher than those of other conditions. CONCLUSIONS: Above results showed that the efficient isolation method of ICM from blastocyst was the partial trophoblast dissection and the appropriate treatment time of mitomycin C was 2 hours. However, the subculture of ICM colony and characterization of stem cells should be carried out to confirm the efficacy of the partial trophoblast dissection method.
Animals
;
Blastocyst
;
Coculture Techniques
;
Feeder Cells*
;
Fibroblasts
;
Mice*
;
Mitomycin*
;
Needles
;
Stem Cells
;
Syringes
;
Trophoblasts
8.The Property of p53 Gene in Cell Lines of Squamous Cell Carcinoma.
Yu JIN ; Yong Suk MOON ; Hyo Soon JEONG ; Sung Ik JANG ; In Jang CHOI
Korean Journal of Anatomy 2004;37(3):293-299
The mutation of p53 tumor suppressor gene is the most common genetic variation of primary malignant tumors. The occurrence, progression and reaction for medical management of cancers can be different according to the characteristics of p53 gene, even if they are same kinds of malignant tumors. In this study, the property of p53 gene in 4 kinds of squamous cell carcinoma cell lines were investigated by using immunocytochemistry, PCR-SSCP, sequencing and Western blot methods. As a result, p53 mutation detected in 3 kinds of squamous cell carcinoma cell lines. Namely, it is found that T in codon 176 changed to A, and G in codon 281 changed to A in KUMA3 cell lines; CC in codon 241 changed to TT in KUMA4 cell lines; G in codon 266 changed to T in KUMA6 cell lines. In single nucleotide polymorphism of codon 72 of p53 gene, the genetic variations are Arg/Pro heterozygote in KUMA3 and KUMA4 cell lines; Arg/Arg homozygote in KUMA5 cell lines; Pro/Pro homozygote in KUMA6 cell lines. These results will provide useful data for p53 gene researches of various squamous cell carcinomas.
Blotting, Western
;
Carcinoma, Squamous Cell*
;
Cell Line*
;
Codon
;
Genes, p53*
;
Genes, Tumor Suppressor
;
Genetic Variation
;
Heterozygote
;
Homozygote
;
Immunohistochemistry
;
Polymorphism, Single Nucleotide
9.Social Distancing and Transmission-reducing Practices during the 2019 Coronavirus Disease and 2015 Middle East Respiratory Syndrome Coronavirus Outbreaks in Korea
Won Mo JANG ; Deok Hyun JANG ; Jin Yong LEE
Journal of Korean Medical Science 2020;35(23):e220-
Background:
The absence of effective antiviral medications and vaccines increased the focus on non-pharmaceutical preventive behaviors for mitigating against the coronavirus disease 2019 (COVID-19) pandemic. To examine the current status of non-pharmaceutical preventive behaviors practiced during the COVID-19 outbreak and factors affecting behavioral activities, we compared to the 2015 Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in Korea.
Methods:
This was a serial cross-sectional population-based study in Korea with four surveys conducted on June 2 and 25, 2015 (MERS-CoV surveys), and February 4, and April 2, 2020 (COVID-19 surveys). Of 25,711 participants selected using random digit dialing numbers, 4,011 participants (aged ≥ 18 years) were successfully interviewed, for the 2020 COVID-19 (n = 2,002) and 2015 MERS-CoV (n = 2,009) epidemics were included. Participants were selected post-stratification by sex, age, and province. The total number of weighted cases in this survey equaled the total number of unweighted cases at the national level. We measured the levels of preventive behaviors (social distancing [avoiding physical contact with others]), and practicing transmission-reducing behaviors such as wearing face mask and handwashing.
Results:
Between the surveys, respondents who reported practicing social distancing increased from 41.9%–58.2% (MERS-CoV) to 83.4%–92.3% (COVID-19). The response rate for the four surveys ranged between 13.7% and 17.7%. Practicing transmission-reducing behaviors (wearing face masks and handwashing) at least once during COVID-19 (78.8%, 80.2%) also increased compared to that during MERS-CoV (15.5%, 60.3%). The higher affective risk perception groups were more likely to practice transmission-reducing measures (adjusted odds ratio, 3.24–4.81; 95 confidence interval, 1.76–6.96) during both COVID-19 and MERS-CoV.
Conclusion
The study findings suggest markedly increased proportions of non-pharmaceutical behavioral practices evenly across all subgroups during the two different novel virus outbreaks in Korea. Strategic interventions are needed to attempt based on preventive behavior works.
10.Clincal Effect of Ketotifen in Allergic Rhinitis.
Sun Jin EUN ; Yong Dae KIM ; Mun Heum PARK ; Jang Su SUH ; Kei Won SONG
Yeungnam University Journal of Medicine 1990;7(1):105-112
Ketotifen, a benzocycloheptathiophene, has an orally effective antiallergic as well as antihistaminic properties. In pervious studies, Ketotifen has shown encouraging results on patient with allergic rhinitis, either perennial or seasonal. 39 patients with allergic rhinitis had been treated with Ketotifen 1 mg twice daily for 8 weeks. And we obtained following results. 1) The efficacy rate in sneezing attack was 73.5%, in nasal discharge 71%, in nasal obstruction 58%. 2) Some improvements in at least one of three-major symptoms were noted within 1 week in 30.7%, within 2 weeks in 55.8%, within 3 weeks in 66.7%, within 8 weeks in 87.2%. 3) Physical findings such as colour, swelling of turbinate, character of rhinorrhea were not improved significantly. 4) Side effect was observed only in one patient with abdominal pain and diarrhea, which was subsided after interruption of administration. These results suggested that Ketotifen was effective in treatment of allergic rhinitis.
Abdominal Pain
;
Diarrhea
;
Humans
;
Ketotifen*
;
Nasal Obstruction
;
Rhinitis, Allergic*
;
Seasons
;
Sneezing
;
Turbinates