We report a case of pityriasis rotunda occurring in a patient with pancreatic adenocarcinoma. The patient was a 64-year old female who had a pancreatic adenocarcinoma. The skin lesions were asymptomatic, multiple, various sized (1 to 15cm in diameter), isolated or confluent and finely scaly light brownish to grayish colored patches on the lower abdomen, back and thigh. Histopathologic findings shawed mild hyperkeratosis, atrophy, loss of granular layer, increased melanin pigments in basal layer of the epidermis and mild perivascular monocytic infiltration in the upper dermis.
Abdomen ; Adenocarcinoma* ; Atrophy ; Dermis ; Epidermis ; Female ; Humans ; Melanins ; Middle Aged ; Pancreas* ; Pityriasis* ; Skin ; Thigh

We studied 283 patients with herpes zoster who visited to the Hangang Sacred Heart Hospital between January, 1982 and December, 1985 about the distribution of age, sex, seasonal incidence, associated diseases, camplications and the effect of systemic prednisolone on post herpetic neuralgia. And we also examined the functional states of involved sensory nerve endings by observing the axon flare response to histamine test. The results were as follows . 1. There was no significant differences in sexual and seasonal distributions. 2. There were low incidences of herpes zoster in age groups of below 20 years and over 70 years than age groups of 20 69 years. 3. Sites of involvement were thoracic(170 cases), cervical(38 cases), trigeminal(35 cases), lumbar(28 cases), sacral(11 cases) and facial(1 case) dermatomes. 4. Associated diseases were diabetes mellitus(7 cases), hypertension(7 cases). pulmonary tuberculosis(6 cases), malignant neoplasms(3 cases) and renal transplantation (1 case). 5. Complications were post herpetic neuralgia(18 cases), keratoconjunctivitis(9 cases), meningoencephalitis(1 case), Ramsay Hunt syndrome(1 case), urinary difficulty(1 case) and generalized varicelliform eruption(1 case). 6. The incidence of post-herpetic neuralgia was reduced by systemic prednisolone therapy in patients over 60 years. 7. There was no decrease of axon flare by histamine test on the affected area in 18 patients with herpes zoster.
Axons ; Heart ; Herpes Zoster* ; Histamine* ; Humans ; Incidence ; Kidney Transplantation ; Neuralgia ; Prednisolone ; Seasons ; Sensory Receptor Cells

Adenocarcinoma metastatic to the skin usually originates in the lung, breast, large intestine or ovary. Cutaneous metastatic tumors from rectum or colon tend to appear in the abdominal or perineal area, but rarely appear in the perianal and genital skin. A 53-year-old female presented multiple nodules in and near the surgical scars of inguinal, pubie, vulvar, perianal areas and normal skin of left thigh two months after surgical removal of rectal adenocarcinoma. Biopsy specimens from the nodules of the perianal area and left thigh showed adenocarcinoma of well differentiated atruetures like the primary rectal carcinoma.
Adenocarcinoma* ; Biopsy ; Breast ; Cicatrix ; Colon ; Female ; Humans ; Intestine, Large ; Lung ; Middle Aged ; Ovary ; Rectum ; Skin ; Thigh

We reoport a case of multiple basal cell carcinoma in a 51-year-old male who have taken a herb medication for right hemiplegia during 30 years. The patient had a 15-year history of the black colored, ulcerated nodules on left forehead and erythematous, protruded masses on back. Also, he had a 6-year history of black colored, ulcerated nodules on right temporal area of scalp and brownish, flat plaques on anterior chest, Biopsy specimens from lesions revealed typical histopathologic findings of the basal cell carcinoma. Wide excision with graft was done. One year later, he was expired due to lung carcinoma.
Biopsy ; Carcinoma, Basal Cell* ; Forehead ; Hemiplegia ; Humans ; Lung ; Male ; Middle Aged ; Scalp ; Thorax ; Transplants ; Ulcer

No abstract available.
Animals ; Female ; Horns* ; Humans ; Uterus*

PURPOSE: This study was tried to evaluate the potential benefits of concurrent chemoradiation therapy (low dose daily cisplatin combined with split course radiation therapy) compared with conventional radiation therapy alone in stage III non-small cell lung cancer. The end points of analyses were response rate, overall survival, survival without locoregional failure, survival without distant metastasis, prognostic factors affecting survival and treatment related toxicities. MATERIAL AND METHODS: Between April 1992 and March 1994, 32 patients who had stage III non-small cell lung cancer were treated with concurrent chemoradiation therapy. Radiation therapy for 2 weeks (300cGy given 10 times up to 3000cGy) followed by a 3 weeks rest period and then radiation therapy for 2 more weeks (250cGy given 10 times up to 2500cGy) was combined with 6mg/M2 of cisplatin. Follow-up period ranged from 13 months to 48 months with median of 24 months. Historical control group consisted of 32 patients who had stage III non-small cell lung cancer were received conventionally fractionated (daily 170-200cGy) radiation therapy alone. Total radiation dose ranged from 5580cGy to 7000cGy with median of 5940 cGy. Follow-up period ranged from 36 months to 105 months with median of 62 months. RESULTS: Complete reponse rate was higher in chemoradiation therapy (CRT) group than radiation therapy (RT) group (18.8% vs. 6.3%). CRT group showed lower in-field failure rate compared with RT group (25% vs. 47%). The overall survival rate had no significant differences in between CRT group and RT group (17.5% vs. 9.4% at 2 years). The survival without locoregional failure (16.5% vs. 5.3% at 2 years) and survival without distant metastasis (17% vs. 4.6% at 2 years) also had no significant differences. In subgroup analyses for patients with good performance status (Karnofsky performance scale 80), CRT group showed significantly higher overall survival rate compared with RT group (62.5% vs. 15.6% at 2 years). The prognostic factors affecting survival rate were performance status and pathologic subtype (squamous cell cancer vs. nonsquamous cell cancer) in CRT group. In RT alone group, performance status and stage (IIIa vs IIIb) were identified as a prognostic factors. RTOG/EORTC grade 2-3 nausea and vomiting (22% vs. 6%) and bone marrow toxicities (25% vs. 15.6%) were significantly higher in CRT group compared with RT alone group. The incidence of RTOG/EORTC grade 3-4 pulmonary toxicity had no significant differences in between CRT group and RT group (16% vs. 6%). The incidence of WHO grade 3-4 pulmonary fibrosis also had no significant differences in both group (38% vs. 25%). In analyses for relationship of field size and pulmonary toxicity, the patients who treated with field size beyond 200cm2 had significantly higher rates of pulmonary toxicities. CONCLUSION: The CRT group showed significantly higher local control rate than RT group. There were no significant differences of survival rate in between two groups. The subgroup of patients who had good performance status showed higher overall survival rate in CRT group than RT group. In spite of higher incidence of acute toxicities with concurrent chemoradiation therapy, the survival gain in subgroup of patients with good performance status were encouraging. CRT group showed higher rate of early death within 1 year, higher 2 year survival rate compared with RT group. Therefore, to evaluate the accurate effect on survival of concurrent chemoradiation therapy, systematic follow-up for long term survivors are needed.
Bone Marrow ; Carcinoma, Non-Small-Cell Lung* ; Cisplatin ; Follow-Up Studies ; Humans ; Incidence ; Nausea ; Neoplasm Metastasis ; Pulmonary Fibrosis ; Survival Rate ; Survivors ; Vomiting

Authors experienced an anesthesia for aortorenal shunt operation for renovascular hypertension caused by atherosclerosis in a 38-year-old male. Tracheal topical anesthesia with 4% lidocaine was performed prior to induction of anesthesia with intravenous thiopental sodium and nitrous oxide-oxygen by mask. Semiclosed circle system with nitrous oxide-oxygen-halothane was used in the maintenance of anesthesia. Blood pressure and pulse rate were increased during manipulation of perirenal tissues in spite of administration of high concentration of halothane with nitrous oxide-oxygen and controlled respiration under positive pressure.
Adult ; Anesthesia* ; Atherosclerosis ; Blood Pressure ; Halothane ; Heart Rate ; Humans ; Hypertension, Renovascular* ; Lidocaine ; Male ; Masks ; Respiration ; Thiopental

Sneddon's syndrome is a disease characterized by livedo reticularis and cerebrovascular lesions with unknown etiopathogenesis. We report a 16-year-old male patient who had been suffered from livedo reticularis for 10 years and multiple cerebral infarction for 2 years. Although the histologic finding of the skin did not show vasculitis and vascular occlusions, the patient revealed livedo reticularis and central nervous system symptoms. These findings were compatible with Sneddon's syndrome.
Adolescent ; Central Nervous System ; Cerebral Infarction ; Humans ; Livedo Reticularis ; Male ; Skin ; Vasculitis

PURPOSE: Weight loss reduces cardiovascular risk factors in the obese. However, weight reduction through diet negatively affects long-term bone health. The aim of study was to determine the ability of combined aerobic and resistance exercise (CE) to reduce weight and cardiovascular risk without diminishing bone health. METHODS: Twenty-five young adults participated in an 8-week weight loss CE program. Subjects were allocated to an obese group or a control group by body mass index (BMI). Body weight, BMI, body composition, and bone mineral density (BMD) of the lumbar spine and total hip were measured before and after the CE trial. Serum levels of metabolic markers, including adipokines and bone markers, were also evaluated. RESULTS: Weight loss was evident in the obese group after the 8 weeks CE trial. Fat mass was significantly reduced in both groups. Fasting insulin, homeostatic model assessment-insulin resistance (HOMA-IR), leptin and aminotransferases level were significantly reduced from baseline only in the obese group. High density lipoprotein cholesterol increased in both groups. Hip BMD increased in the obese group. In all study subjects, BMI changes were correlated with HOMA-IR, leptin, and HDL changes. BMI decreases were correlated with lumbar spine BMD increases, lumbar spine BMD increases were positively correlated with osteocalcin changes, and lumbar spine bone mineral content increases were correlated negatively with C-terminal telopeptide of type 1 collagen changes. CONCLUSION: These findings suggest that CE provides effective weight loss and improves cardiovascular risk factors without diminishing BMD. Furthermore, they indicate that lumbar spine BMD might be maintained by increasing bone formation and decreasing bone resorption.
Adipokines ; Body Composition ; Body Mass Index ; Body Weight ; Bone Density ; Bone Resorption ; Cholesterol ; Cholesterol, HDL ; Collagen Type I ; Diet ; Fasting ; Hip ; Humans ; Insulin ; Leptin ; Lipoproteins ; Obesity ; Osteocalcin ; Osteogenesis ; Risk Factors ; Spine ; Transaminases ; Weight Loss ; Young Adult

The globus symptom is a condition in which a patient, often middle aged women, complains of a lump andchocking sensation in the throat, Functional disturbance of the cricopharyngeal muscle, rendering it incapable ofrelaxing during swallowing, has long been recognized as a cause of globus symptom and dysphagia. We wanted to findout how often and to what extent distrubed relaxation of the cricopharyngeal muscle can be seen in patients withglobus symptom with routine examination and video esophagogram. The results were as follows: 1. Male : femaleratio was 1:2.4. 2. Globus symptom was most frequent in the age group between 30-39 of female. 3. Organic lesionswere seen in 43.6%(24 Pts) of globus patients. 4. Cricopharyngeal muscle was visualized in 29.1%(16Pts), esophageal diverticulum in 3.6%(2 Pts) and degenerative spondylosis in 3.6%(2 Pts). 5. Incidence of visualizationof cricopharyngeal muscle were higher in male group (50%) than female one (20.5%). 6. Cricopharyngeal muscle wasmost frequently visualized on early swallowing phase(12/16 Pts).
Deglutition ; Deglutition Disorders ; Diverticulum, Esophageal ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Pharynx ; Relaxation ; Sensation ; Spondylosis