1.Clinical and epidemiologic features of respiratory sybcytial virus infection.
Hoan Jong LEE ; Seong Hee JANG
Journal of the Korean Pediatric Society 1992;35(10):1389-1401
No abstract available.
Bronchiolitis
;
Epidemiology
;
Pneumonia
;
Respiratory Syncytial Viruses
2.A Medicolegal Consideration on Persistent Vegetative State in Korea.
Jang Han KIM ; Jung Bin LEE ; Yoon Seong LEE
Korean Journal of Legal Medicine 1999;23(1):35-42
This treatise summarizes the medical facts about the persistent vegetative state(PVS) and the associated issues. In August 1998, the opinions of the 380 neurologists and the 1007 neurosurgeons are inquired about the diagnostic criteria of PVS, the degree and the withdrawal of treatment on PVS patients. The response rate is 18.8%. The diagnostic criteria of PVS is determined by the items approved above 5007o of responses. (1) no evidence of cerebral function and an inability to interact with visual, auditory stimuli and follow commands. (2) maintaining the respiratory function with spontaneous respiration and normal respiratory pattern. (3) spontaneous eye opening and eye ball movements without sustained tracking. (4) variably preserved brain stem reflexes. (5) presence of sleep-wake cycles. (6) (1)-(5) symptoms should be persist for 6 months after the development of vegetative state. (7) the diagnostic criteria of PVS should be applied more than 3 times during the minimum observation period. (8) this diagnostic criteria of PVS could be applied to adults over 7 ages. As to the degree of treatment, nasogastric tube feeding and air-way keeping through the tracheostomy are approved over 9007b. Also antibiotics can be used in infection. As to the withdrawal of treatment, do not resuscitate order of patient s family is accepted by 46.1% in an emergency condition like cardiac arrest. But discharge against medical advice by the patient s family is accepted by 73.107o in non-emergency condition. In the case of neonates, parents decision is more determinative than any other thing.
Adult
;
Anti-Bacterial Agents
;
Brain Stem
;
Emergencies
;
Enteral Nutrition
;
Heart Arrest
;
Humans
;
Infant, Newborn
;
Korea*
;
Parents
;
Persistent Vegetative State*
;
Reflex
;
Respiration
;
Tracheostomy
3.Operative Treatment in the Radial Head Fractures.
Hung Dae SHIN ; Kwang Jin LEE ; June Kyu LEE ; Seong Hyeong KIM ; Ik Jang LEE
The Journal of the Korean Orthopaedic Association 1997;32(4):853-860
Sixteen patients who had radial head fractures were treated with open reduction and internal fixation using Herbert screws (10 patients), and with silastic prosthetic replacement (6 patients) from March, 1992 to December, 1994 in Chungnam National University hospital. The average duration of follow up was 19.5 months. The purpose of this study is to examine the role of Herbert screw fixation and silicone replacement arthroplasty and to asscess the clinical results of two groups functionally, radiologically in raidial head fractures. By functional rating index (modified After B.F. Morrey et al), the results were classified as excellent (9 patients), good (6 patients), fair (No patient) and poor (1 patient). Nine of the ten patients treated by open reduction and internal fixation using Herbert screws had resulted in excellent or good. All patients were inserted silastic implants were showed excellent or good results. Especially, in Mason Type III radial head fractures, three of four patients treated by Herbert screws and all 5 patients treated by silastic prosthesis were considered to excellent or good results. We concluded that Herbert screw fixation or silastic prosthetic replacement had satisfactorily appeared to be the alternative treatment option for Mason Type III radial head fractures.
Arthroplasty, Replacement
;
Chungcheongnam-do
;
Follow-Up Studies
;
Head*
;
Humans
;
Prostheses and Implants
;
Silicones
4.The Growth Hormone-Binding Proteins in Human Serum: Partial Characterization and Regulation.
Ji Young SUH ; Bu Hun LEE ; Jeh Hoon SHIN ; Hang LEE ; Seong Ryul JANG
Journal of the Korean Pediatric Society 1994;37(10):1427-1436
We assessed about growth hormone binding proteins (GHBP) activity which was measured eluted biotin GH fraction with alkaline phosphatase-streptavidine in children with insulin dependent diabetes mellitus (IDDM), short stature due to growth hormone deficiency (GHD), chronic renal failure, short stature due to nutritional deficiency. hypothyroidism and normal control groups using high pressure liquid chromatography protein pak 300 sw column. The following results are observed: 1) There were 3 types of growth hormone (GH) in serum: first GH binded with type I (minor) GHBP suggesting 200K dalton of molecular weight, second GH binded with type II (major) GHBP suggesting 60~70K dalton of molecular weight, and third GH were free form GH suggesting 20~25K dalton of molecular weight. 2) Type II (major) GHBP showed considerable individual variation in all ages. Neonates had the lowest levels of GHBP activity, but by the puberty the levels had increased & remained stable from adolescent to adult periods. 3) GHBP activity of children with IDDM at diagnosis was low value as compared to the same agenormal control group (p<0.05), and difference of GHBP activity among children with IDDM was related with height velocity (r=+0.92). Follow up GHBP activity during insulin therapy was reverse correlation with HbAlc. 4) GHBP activity of children with GHD at diagnosis was a slightly low compared to aged matched control and follow-up GHBP activity after 1 dose GH therapy showed increasing tendency (r=-0.68). 5) Otherwise, children with chronic renal failure, short stature due to nutritional deficiency, and hypothyroidism were assessed lower value than normal control group. Above results, GHBP activity had the lowest levels at neonatal period and then increasing tendency until puberty period and remained steady level until adult period. Regulation of GHBP may be closely related with metabolic control state by insulin, GH, nutritional status, and thyroid hormone..
Adolescent
;
Adult
;
Biotin
;
Carrier Proteins
;
Child
;
Chromatography, Liquid
;
Diabetes Mellitus
;
Diabetes Mellitus, Type 1
;
Diagnosis
;
Follow-Up Studies
;
Growth Hormone
;
Humans*
;
Hypothyroidism
;
Infant, Newborn
;
Insulin
;
Kidney Failure, Chronic
;
Malnutrition
;
Molecular Weight
;
Nutritional Status
;
Puberty
;
Thyroid Gland
5.Chronic injury to the distal ulnar growth plate.
Eun Woo LEE ; Eui Chan JANG ; Ki Seong KIM ; Ho Rim CHOI ; Jun Han LEE
The Journal of the Korean Orthopaedic Association 1993;28(3):1079-1083
No abstract available.
Growth Plate*
6.Measurement of oxygen saturation of the diabetic limbs by pulse oximetry.
Eun Woo LEE ; Eiu Chan JANG ; Ki Seong KIM ; Hyun Kyem KIM ; Han Jun LEE
The Journal of the Korean Orthopaedic Association 1993;28(7):2491-2497
No abstract available.
Extremities*
;
Oximetry*
;
Oxygen*
7.The Clinical Application of Tensor Fascia Lata Myocutaneous Free Flap: Two Cases Report
Jae Lim CHO ; Kwang Suk LEE ; Kwang Hoe KIM ; Jang Seong LEE
The Journal of the Korean Orthopaedic Association 1982;17(6):1195-1202
The increased knowledge of the cutaneous circulation of the body and refinements in surgical technique have provided the basis for the successful microvascular transfer of various muscle, skin and myocutaneous free flap. We have found the tensor fascia lata(TFL) inyocutaneous flap to be reliable one and its transfer as a free flap. The TFL myocutaneous free flap was first introduced by Hill et al in 1978 and our two cases report were first introduced in Korea. Two cases of microvascular TFL myocutaneous free flap transfer were performed at the department of Orthopaedic Surgery of Hanyang University Hospital and satisfactory result was obtained from the one of those.
Fascia Lata
;
Fascia
;
Free Tissue Flaps
;
Korea
;
Skin
8.The Measurement of 99mTc-DTPA Pulmonary Clearance in Normals, Asymptomatic Smokers and Diabetic Patients.
In Ju KIM ; Seong Jang KIM ; Yong Ki KIM ; Yun Seong KIM ; Min Ki LEE ; Soon Kew PARK
Korean Journal of Nuclear Medicine 1998;32(3):266-275
PURPOSE: We measured pulmonary epithelial permeability by Tc-DTPA radioaerosol clearance in patients with diabetes and correlated with the presence of microangiopathy to understand the pathophysiology of pulmonary microangiopathy and evaluate Tc-DTPA radioaerosol clearance as a diagnostic test to assess pulmonary microangiopathy. MATERIALS AND METHODS: We performed ' Tc-DTPA radioaerosol scan in 10 normal subjects, 10 asym-ptomatic smokers, 20 diabetic patients without history of smoking (10 with microangiopathy, 10 without microangiopathy). Tc-DTPA clearance half-time (T1/2) was calculated, then compared with the result of chest radiography and pulmonary function test. RESULTS: Chest radiography and pulmonary function test were normal in all subjects. There were no significant difference of clinical or laboratory characteristics between these groups except age. The diabetic patients with micraangiopathy were significantly older (p<0.05). The T1/2of normal subjects and asyrnptomatic smokers were significantly different (65.2+23.7min vs 39.6+9.8min, p<0.05). For diabetic patients with microangiopathy, the T, was 90 5+46.5min and significantly delayed when compared with those of normals and asymptomatic smokers (p<0.05). However, the T1/2of diabetic patients without microangiopathy, 70.0+12.7 min, was not significantly different from those of normals or asyrnptomatic smokers (p>0.05). No significant correlation was found between the T1/2and spirometric parameters including DLcc>, FVC, FEV>, FEV(/FVC (%) and FEF)5-75g in all subjects, and between the T1/2 and duration of diabetes in diabetic patients. CONCLUSION: Eventhough the influence of age cant be excluded, delayed Tc-DTPA clearance half-time (T1/2)in diabetic patients with microangiopathy indicates decreased pulmonary cspillary permeability as one of the pathophysiologic results of pulmonary microangiopaththy. Further studies are needed in larger number of age matched control and diabetic patients to evaluate the diagnostic efficacy.
Diabetes Mellitus
;
Diagnostic Tests, Routine
;
Humans
;
Permeability
;
Radiography
;
Respiratory Function Tests
;
Smoke
;
Smoking
;
Technetium Tc 99m Pentetate
;
Thorax
9.A Clinical Study on the Hypotensive Effect of Nilvadipine in Patients with Essential Hypertension.
Gil Jin JANG ; Heung Soo KIM ; Seong Kyu HA ; Ho Young LEE ; Dae Suk HAN
Korean Circulation Journal 1992;22(4):667-675
BACKGROUND: As an antihypertensive drug, Nifedipine, a calcium channel blocker was introduced recently, which also has antianginal effect. But due to the relatively short duration of action, another antihypertensive agents having longer duration of action and stronger hypertensive effect were under investigation. Nilvadipine, a new calcium channel blocker, was introduced to have more prologned duration of action and to act more specifically on vascular smooth muscle. So the efficacy and safety of oral Nilvadipine on essestial hypertension was investigated and represented by our institute. METHODS: In order to investigate the efficacy and safety of oral Nilvadipine, daily doses of 4mg twice a day were administered in 30 hypertensive patients whose states were compatible to the criteria : 1) severity of hypertension rated in Stage I and Stage II according to the classification by WHO, 2) ages ranging from 30 to 74 years regardless of sex, 3) blood pressure with 95mmHg or higher but less than 115mmHg in diastolic pressure which was the mean in a sitting position at the last two out of not less three consultations in the 2 week observation period, 4) outpatients with informed consent for 6 weeks. Blood pressure and heart rate were measured every 2 weeks. The complete with blood count with platelet, uronalysis and the electrocardiography were performed at the beginning period and the 6th weeks of therapy. And kinds of side effects were questioned by examining physicians. RESULTS: The following results were obtained : 1) Blood pressure fell significantly in 6 weeks of treatment with Nilvadipine(Mean pressure+/-S.D., 6.00mmHg vs 108.90+/-9.68mmHg p<0.05), 2) There was no significant change in EKG in 6 weeks of treatment with Nilvadipine, 3) Pulse rate was decreased in 6 weeks of treatment with Nilvadipine(80.14+/-11.90/min vs 75.39+/-6.47/min, p<0.05). 4) No significant chsange in body weight was observed(64.50+/-8.7kg vs 63.50+/-10.25kg, p<0.05). 5) There were no significant changes in blood chemistry including blood sugar, cholesterol, electrolytes, serum creatinine and alkaline phosphatase values, 6) Hematologic findings and urinalysis findings reamained unchanged, 7) Total 10 patients(33.30%) had various side effects;facial flushing 30.00%, palpitation 23.33%, headache 20.00%, nausea 10.00%, drowsiness 3.33%, heaviness 3.33% and indigestion 3.33%. But there was no serious side effect that requires to discontinue the medication of the test drug. And there was no need to reduce the dosage due to the side effect, 8) The antihypertensive effect was judged to decrease markedly in 76.70%, decrease 20.00%, unchange 3.30% and increase 0.00%, 9) The utility which was assessed with the data from the overall safety and antihypertensive effect, the drug was judged to be very useful in 60.00%, useful 33.30%, useless 6.67% and inhibited 0.00%. CONCLUSION: From the above results, Nilvadipine in doses of 4mg twice a day was effective and useful in most cases without severe side effects in essential hypertensive patients with diastolic blood pressure of 95 to 115mmHg.
Alkaline Phosphatase
;
Antihypertensive Agents
;
Blood Glucose
;
Blood Platelets
;
Blood Pressure
;
Body Weight
;
Calcium Channels
;
Chemistry
;
Cholesterol
;
Classification
;
Creatinine
;
Dyspepsia
;
Electrocardiography
;
Electrolytes
;
Flushing
;
Headache
;
Heart Rate
;
Humans
;
Hypertension*
;
Informed Consent
;
Muscle, Smooth, Vascular
;
Nausea
;
Nifedipine
;
Outpatients
;
Referral and Consultation
;
Sleep Stages
;
Urinalysis