1.Gorham's Syndrome: A Case Report
Myung Hwan SON ; Dong Jin KIM ; Jae Gong PARK ; Jang Suk CHOI ; Young Goo LEE
The Journal of the Korean Orthopaedic Association 1990;25(4):1292-1296
Gorham's syndrome is a rare disorder involing a proliferation of vascular channels associated with extensive loss of bony matrix. It starts in bone, but it may secondarily involve soft tissue and adjacent bones. Although the osteolysis usuakky arrests spontaneously, its biologic behavior is difficult to predict. The mechanism of steolysis is unkown, and the role of osteoclasts is controverwial We have experienced one case of Gorham's syndrome affecting the scapula and clavicle, which is reported in this paper with brief review of literature.
Clavicle
;
Osteoclasts
;
Osteolysis
;
Scapula
2.Treatment of C.D.H. in Children Who are Six to Thirtysix Months Old
Min Gi KANG ; Myung Hwan SON ; Jang Suk CHOI ; Young Goo LEE
The Journal of the Korean Orthopaedic Association 1990;25(6):1633-1643
The aims of treatment of children with CDH untreated until walking age should be to reestablish the mechanics of the hip joint and avoid complications, especially avascular necosis, thus delaying the devlopment of osteoarthritis. In the child who is first seen between the ages of one and three years, considerable controversy still exists as to the merit of closed versus operative management. The average 29.3 months follow-up results in fifty congenitally dislocated hips in forty-five children with were between six and thirty-six months old when treatment was begun have been reviewed at the Department of Orthopaedic Surgery, In Je University, College of Medicine, Paik Hospital from June, 1979 to Aug, 1989. The results of this study were as follows: 1. Factors affecting method of treatment were age, degree of dislocation and acetabular index; A. Age 1) The children below ages of 18 months were treatment by closed reduction. 2) The children below ages of 18 months were treatment by open reduction with concomittant procedures. B. Degree of dislocation: Open reduction was more frequently reguired in higher degree of dislocation. C. Acetabular index: It was little influenced on method of treatment. 2. The complications were persisten subuxation (3 cases), temporary irregular ossification (16 cases) and avascular necrosis (1 cases).
Acetabulum
;
Child
;
Dislocations
;
Follow-Up Studies
;
Hip
;
Hip Joint
;
Humans
;
Mechanics
;
Methods
;
Necrosis
;
Osteoarthritis
;
Walking
3.Comparison of Piroxicam Pharmacokinetics and Anti-Inflammatory Effect in Rats after Intra-Articular and Intramuscular Administration.
Chan Woong PARK ; Kyung Wan MA ; Sun Woo JANG ; Miwon SON ; Myung Joo KANG
Biomolecules & Therapeutics 2014;22(3):260-266
This study evaluated the pharmacokinetic profile and therapeutic efficacy of piroxicam (PX), a long acting non-steroidal anti-inflammatory drug for the treatment of arthritis, following intra-articular (IA) injection in comparison to the pharmacokinetic profile and therapeutic efficacy of PX after intramuscular (IM) injection. In the pharmacokinetic study in rats, systemic exposure and pharmacokinetic parameters of PX after a single IA dose were compared with systemic exposure and pharmacokinetic parameters of PX after administration of the same dose IM (0.6 mg/kg). The anti-inflammatory and analgesic effects of IA PX were evaluated simultaneously in a monoiodoacetate-induced osteoarthritis rat model. The plasma PX concentration rapidly rose following IA injection, and it was comparable to the plasma PX concentration following IM injection, suggesting the rapid efflux of the drug molecule from the joint cavity. However, in the efficacy study, the IA PX administration significantly reduced the knee swelling by reducing the level of prostaglandin E2 in the joint, compared to that following administration of IA vehicle and after administration of the IM PX dose. In addition, we found that the anti-inflammatory and anti-nociceptive efficacies of IA PX were synergistically increased upon co-treatment with hyaluronic acid (HA), a potent agent for the treatment of osteoarthritis, at the weight ratio of 1:1 or 1:2, and these effects were more pronounced than those following administration of HA or PX alone. In conclusion, this study demonstrated the efficacy of the IA use of PX alone and/or in combination with HA in osteoarthritis.
Animals
;
Arthritis
;
Dinoprostone
;
Hyaluronic Acid
;
Injections, Intra-Articular
;
Joints
;
Knee
;
Models, Animal
;
Osteoarthritis
;
Pharmacokinetics*
;
Piroxicam*
;
Plasma
;
Rats*
4.High Body Mass Index is Associated with Wheezing Among Older Adults Living in High-Altitude Area in Korea.
An Soo JANG ; Myung Ho SON ; Inseon S CHOI ; Young Il KOH
Journal of Korean Medical Science 2002;17(4):479-482
Although the association between obesity and asthma has been well documented, the nature of this association has yet to be clarified. The aim of this study was to examine the association of body mass index (BMI), lipid profiles, and atopy, wheezing, and lung function in older adults living in a rural area in Korea. BMI (kg/m2), lipid profiles, skin prick test, spirometry, and questionnaire including airway symptoms were obtained in a cross-sectional survey in 707 (259 males and 448 females) older adults (aged 50 to 93; mean, 65.7 yr) living in a high-altitude rural area in Korea. The prevalence of self-reported wheezing was 17.1% (121/707). The prevalence of atopy was 13.8%. The mean of BMI was 23.3+/-0.13 (14.6-32.8). The BMI was higher in females than in males (23.8+/-0.16 vs 22.4+/-0.17; p<0.01). The prevalence of wheezing was higher in group with BMI> or = 25 than in group with BMI<25 [57/201 (28.3%) vs 64/505 (12.6%), p<0.01]. The BMI was higher in group with wheezing than in group without wheezing (24.3+/-0.34 vs 23.1+/-0.13, p<0.01). No association between BMI and atopy was found. These findings suggest that BMI associated with wheezing in older adults.
Aged
;
Aged, 80 and over
;
*Altitude
;
Asthma/*epidemiology/metabolism
;
*Body Mass Index
;
Bronchial Hyperreactivity/immunology
;
Comorbidity
;
Female
;
Humans
;
Hypersensitivity/epidemiology/immunology
;
Korea/epidemiology
;
Lipids/blood
;
Male
;
Middle Aged
;
Questionnaires
;
Respiratory Function Tests
;
*Respiratory Sounds/immunology
;
Skin Tests
5.Effect of Ambulatory Chemotherapy (Portable Infusion Pump Use) Video Education on Knowledge, Self-efficacy and Anxiety of Colorectal Cancer Patients
Eun Hee CHOI ; Eun Young PARK ; Young A PARK ; You Hee SON ; Myung Jin JANG
Asian Oncology Nursing 2022;22(3):193-201
Purpose:
The purpose of this study is to identify changes in knowledge, self-efficacy and anxiety achieved through the provision of video education on chemotherapy with a portable infusion pump to colorectal cancer patients.
Methods:
This study is a nonequivalent control group and non-synchronized design as a quasi-experimental study. Participants in this study were colorectal cancer patients who received chemotherapy with a portable infusion pump through an ambulatory care unit. For 48 subjects, the education was divided into printed materials and videos, and knowledge, self-efficacy, and anxiety were measured. Data were analyzed using independent t test, paired t-test, and Wilcoxon’s signed rank test.
Results:
In the video education group, knowledge (Z=-4.09, p<.001) and self-efficacy (Z=-2.72, p=.012) significantly increased after education, and anxiety significantly decreased after education (Z=2.24, p=.035). However, there was no difference in knowledge (t=0.09, p=.931), self-efficacy (t=1.22, p=.229), and anxiety (t=-1.16, p=.250) between the groups after education.
Conclusion
To improve the quality of life of cancer patients, it is necessary to promote self-efficacy and reduce anxiety. The results of this study suggest that more diverse educational methods should be attempted to improve knowledge and self-efficacy and reduce anxiety in colorectal cancer patients.
6.A Case of Lymphocytic Hypophysitis Presented with Hypoglycemia after Delivery.
Jang Myung SON ; Seung Hyun KO ; Yu Bae AHN ; Kang JU ; Jeong Rok LEE ; Seong Eun YANG ; Ki Ho SONG ; Ho Young SON ; Jeong Su JUN
Journal of Korean Society of Endocrinology 2003;18(3):325-331
Lymphocytic hypophysitis, an inflammatory disease of the pituitary gland that is often associated with pregnancy, is caused by autoimmune destruction of the pituitary gland evidenced by diffuse inflammatory cell infiltration of the pituitary gland and some kinds of detectable autoantibodies. We report a case of lymphocytic hypophysitis in a 31-year-old woman presenting with severe hypoglycemia and hyponatremia after delivery. Hormonal study revealed panhypopituitarism and magnetic resonance imaging with enhancement showed the bulging contour of the right side pituitary gland with an ill-defined mass-like lesion and nodular thickening of the stalk. The patient's symptoms and biochemical data improved greatly with replacement of L-thyroxine and glucocorticoid. Partial recovery of panhypopituitarism was also seen. The follow-up tests revealed dramatic resolution of the pituitary lesion.
Adult
;
Autoantibodies
;
Female
;
Follow-Up Studies
;
Humans
;
Hypoglycemia*
;
Hyponatremia
;
Hypopituitarism
;
Magnetic Resonance Imaging
;
Pituitary Gland
;
Pregnancy
;
Thyroxine
7.The Effect of Gradient Ultrafiltration and High Sodium Dialysate on Reducing Complications During Hemodialysis.
Jeong Ah KIM ; Jae Hi YUN ; In Son JANG ; Myung Son LEE ; Young Sook HUR ; Jin Ho SHIN ; Young Joo KWON ; Heui Jung PYO
Korean Journal of Nephrology 2002;21(3):450-459
OBJECTIVE: The objective of this study was to determine whether complications and nursing interventions during hemodialysis could be reduced by using gradient ultrafiltration(GUF) and high sodium dialysate(HSD). METHODS: Thirty outpatients who had been on hemodialysis for more than 3 months were enrolled. Patients received Conventional HD(Na+ 137 mEqX4 hrs, constant UF), GUF(UF 62.5%X2 hrs, UF 37.5 %X2 hrs), HSD(Na+ 145 mEqX2 hrs, Na+ 140 mEqX2 hrs) and HSUF(GUF and HSD). Each methods were prescribed for 2 weeks. The clinical features such as thirst, interdialytic weight gain, postdialytic weight loss and MAP(mean arterial pressure) and the frequency of intradialytic complications and nursing interventions were evaluated. RESULTS: The results were as followings. Interdialytic thirst, weight gain, postdialytic weight loss and MAP(pre/post HD) were not significantly different in each method. On the other hand, there was significant difference between 4 methods in serum sodium, osmolality and Hct. There were significantly fewer episodes of hypotention, muscle cramp and headache when using GUF, HSD and HSUF than CHD. The number of nursing interventions was significantly reduced in GUF, HSD and HSUF than CHD. CONCLUSION: Hemodialysis with gradient ultrafiltration and high sodium dialysate leads fewer complications and nursing interventions, more patient's well being.
Hand
;
Headache
;
Humans
;
Muscle Cramp
;
Nursing
;
Osmolar Concentration
;
Outpatients
;
Renal Dialysis*
;
Sodium*
;
Thirst
;
Ultrafiltration*
;
Weight Gain
;
Weight Loss
8.A case of glomerulonephritis with fever and eosinophilia.
Jun Yong PARK ; Ju Hyuk SON ; Jang Yel SIN ; Joong Ho CHO ; Sung Kwan HONG ; Hyo Youl KIM ; Kyung Hee JANG ; Kyu Heon CHOI ; Soo Kon LEE ; Jun Myung KIM
Korean Journal of Medicine 1999;57(1):127-127
No abstract available.
Eosinophilia*
;
Fever*
;
Glomerulonephritis*
9.Prevalence of allergic rhinitis and its causative allergens in people in rural area of Cheju IsIand.
Kyung Up MIN ; Yoon Keun KIM ; Yoon Suk JANG ; Jae Won JUNG ; Joon Woo BAHN ; Byung Jae LEE ; Hee Yeon KIM ; Sang Rok LEE ; Jee Wong SON ; Sang Heon CHO ; Hae Sim PARK ; Myung Hyun LEE ; You Young KIM
Journal of Asthma, Allergy and Clinical Immunology 1999;19(1):42-49
OBJECTIVE: Cross-sectional survey was performed to evaluate prevalence of allergic rhinitis and its causative allergens in people in rural area of Cheju Isl~and. Subject and METHOD: A total of 1,236 people with 1,055 children and 181 adults in rural area of Cheju Island were enrolled in this study. In children, 544 were males and 511 were females, and their mean age was 12.3(ranging from 7 to 16) years. In adults, 78 were males and 103 were females, and their mean age was 50.1 (ratging from 18 to 87) years. Evaluations included a questionnaire survey, and skin prick test with extracts of Japanese cedar (Cryptomera japonica, J cedar) pollen and citrus red mite (Panonychus citri, CRM) as well as eleven common inhalant allergens. RESULTS: Prevalence of chronic nasal symptoms was 40.6% (429/1,055) in children, and 45.8 % (83/181) in adults. Prevalence of allergic rhinitis based on positive nasal symptoms on the questionnaire and positive skin response to one or more of the 13 inhalant allergens were 15.4 % (159/1.035) in children, and 19.3% (35/181) in adults. Of 1,035 children, skin-test response was positive in 37.6%, and common sensitizing allergens in order of decreasing frequency were Dermatophagoides pteronpssinus (DP) (26.6%), D. farinae (DF)(22.6%), CRM(14.2%), cockroach(11.3%) and J cedar(9.7%). Of 181 adults, skin-test response was positive in 25.9%, and t,he most common sensitizing allergen was CRM(16.5%), followed by cockroach(11.0%), DP(9. 9%), DF(9.4%), and J cedar(6.6%). Of 159 children with allergic rhinitis, the common sensitizing allergens in order of deereasing frequency were DP(79.2%), DF(67.3%), CRM(35.8%), J cedar(32.7%), and cockroach(27.0%). Of 35 adults with allergic rhinitis, the most common sensitizing allergen was CRM(68.6%), followed by DP(40%), DF(34.3%), cockroach(34.3%), and J cedar(28.9%). CONCLUSION: Allergic rhinitis is a very common disease with a prevalence of 15.4% in children and 19.3% in adults in rural area of Cheju island, and common sensitizing allergens include house dust mite, citrus red mite, cockroach, and Japanese cedar pollen.
Adult
;
Allergens*
;
Child
;
Citrus
;
Cockroaches
;
Cross-Sectional Studies
;
Cryptomeria
;
Female
;
Humans
;
Jeju-do*
;
Male
;
Mites
;
Pollen
;
Prevalence*
;
Pyroglyphidae
;
Rhinitis*
;
Skin
;
Surveys and Questionnaires
10.Correlation between HER2 Overexpression and Clinicopathological Characteristics in Gastric Cancer Patients Who Have Undergone Curative Resection.
Ho Sung SON ; Yeon Myung SHIN ; Kwang Kuk PARK ; Kyung Won SEO ; Ki Young YOON ; Hee Kyung JANG ; Sang Ho LEE ; Song I YANG ; Jeong Hoon KIM
Journal of Gastric Cancer 2014;14(3):180-186
PURPOSE: At present, a human epidermal growth factor receptor 2 (HER2)-based concept of tumor biology has been established, and trastuzumab (Herceptin(R); Genentech/Roche, San Francisco, CA, USA), a monoclonal humanized antibody directed against HER2, is a pivotal agent for the management of HER2 positive (HER2+) metastatic breast cancer. It is also known that HER2 has a predictive value in gastric cancer; however, its association with the prognosis of this disease remains uncertain. The purpose of this study was to evaluate both the relationship between HER2 overexpression in the tumors of gastric cancer patients, and the prognosis of these patients who have had curative resection. MATERIALS AND METHODS: A total of 139 consecutive patients with gastric cancer who underwent surgery at the Kosin University Gospel Hospital between October 2011 and March 2012 were included in this retrospective study. All tumor samples were examined for HER2 expression by immunohistochemistry. A retrospective review of the medical records was conducted to determine the correlation between the presence of HER2 overexpression and clinicopathological factors. RESULTS: The HER2+ rate was 15.1%. HER2 overexpression was associated with histological grade (P=0.044) and Lauren classification (P=0.036). There was no significant difference in the 2-year overall survival between HER2+ and HER2- patients (P=0.396). Multivariate analysis showed that HER2 was not an independent prognostic factor. CONCLUSIONS: HER2 overexpression in tumors was associated with histological grade and Lauren classification in gastric cancer patients with curative resection. However, HER2 was not an independent prognostic factor for gastric cancer in our study.
Biology
;
Breast Neoplasms
;
Classification
;
Humans
;
Immunohistochemistry
;
Medical Records
;
Multivariate Analysis
;
Prognosis
;
Receptor, Epidermal Growth Factor
;
Retrospective Studies
;
Stomach Neoplasms*
;
Trastuzumab