1.Opponensplasty.
Soo Bong HAHN ; Ye Yeon WON ; Jang Kwon HONG
The Journal of the Korean Orthopaedic Association 1993;28(7):2626-2632
No abstract available.
2.Acute Hydrops of the Cornea in Keratoconus.
Hong Bok KIM ; Jang Sool KWON ; Joon Dal YOUN ; Oh Woong KWON
Journal of the Korean Ophthalmological Society 1978;19(4):479-483
Keratoconus (conical cornea) is a condition, beginning about puberty and developing mainly in females, in which the apex of the cornea thins gradually and usually bilaterally. The etiology is unknown. The presenting symptom is a reduction of the patient's vision owing to the development of a high degree of irregular myopic astigmatism. Early in the course of the disease the cornea does not look conical. The diagnosis of Keratoconus is confirmed by the distorted reflex observed with a Placido's disc and abnormal keratometer readings. In more advanced stages, signs include the obvious cone-shaped cornea and indentation of the lower lid by the cornea. By slit lamp biomicroscopy, vertical lines are noted in the deep layers of the stroma: the corneal nerve fibers are increasingly visible; and in about 50% of cases a yellow or green line is present around the base of the corn (Fleischer's ring). In advanced cases Bowman's membrane and Descemet's membrane rupture. Microscopically there is thinning of the tissue spaces between the corneal lamellae, fragmentation of the basement membrane of the comeal epithelium, fibrillation of Bowman's membrane, and folds or ruptures in Descemet's membrane. Acute hydrops may occur when Descemet's membrane ruptures. This is characterized by sudden cloudiness of vision due to imbibition of aqueous in the corneal stroma. However, as Descemet's membrane regenerates, the edema subsides. Permanent scarring may result if Bowman's membrane ruptures. Acute hydrops of the cornea was developed respectively in left eye on Oct, 1976 and in right eye on Dec, 1976 in a 13 year old Korean girl with Keratoconus O.U.
Adolescent
;
Astigmatism
;
Basement Membrane
;
Bowman Membrane
;
Cicatrix
;
Cornea*
;
Corneal Stroma
;
Descemet Membrane
;
Diagnosis
;
Edema*
;
Epithelium
;
Female
;
Humans
;
Keratoconus*
;
Nerve Fibers
;
Puberty
;
Reading
;
Reflex
;
Rupture
;
Zea mays
3.Angioid Streaks of the Retina Associated with Pseudoxanthoma Elasticum.
Jang Sool KWON ; Hong Bok KIM ; Ouk CHOI
Journal of the Korean Ophthalmological Society 1978;19(3):303-307
Angioid streaks are a peculiar spoke-like distribution of dark-colored broad lines in the retinaradiating out from the optic nerve in a fashion similiar to the branching of blood vessels. It is thought to be due to breaks in the elastic lamina of Bruch's membrane. Their colour may be reddish-brown. dark-brown, grey or even in parts white. During a ophthalmoscopic examination they may be mistaken for retinal vessels. The lesion, however, lies beneath the retinal and above the choroidal vessels. Angioid streaks are most commonly seen in pseudoxanthoma elasticum, Paget's disease of bone and sickle cell anemia. Angioid streaks with pseudoxanthoma elasticum have been reported in all races and in all decades of life. The peak age lies between 30 and 50. Pseudoxnnthoma elasticum is a dermatologic condition characterized by changes in the elastic tissue of the skin. A 21 year old Korean lady with pseudoxanthoma e!asticum has been found to have angioid streaks in her both fundi.
Anemia, Sickle Cell
;
Angioid Streaks*
;
Blood Vessels
;
Bruch Membrane
;
Choroid
;
Continental Population Groups
;
Elastic Tissue
;
Humans
;
Optic Nerve
;
Osteitis Deformans
;
Pseudoxanthoma Elasticum*
;
Retina*
;
Retinal Vessels
;
Retinaldehyde
;
Skin
;
Young Adult
4.Adenoid Cystic Carcinoma in Lacrimal Gland.
Journal of the Korean Ophthalmological Society 1978;19(3):289-293
Neoplasms are the most common among the diseases of the lacrimal gland. Mixed tumor is the commonest tumor of the lacrimal gland. And adenoid cystic carcinoma is the most common in malignancy of lacrimal gland. Adenoid cystic carcinoma appears past middle life and has no sexual prevalence. The first important clinical sign is proptosis with eventual displacement of the globe downwards and inwards. Limitation of ocular movements may be noted to up and out. Often the vision is not greatly disturbed. The fundus is usually normal. The adenoid cystic carcinoma is seldom rapidly fatal. Metastasis may occur in the regional lymph nodes the pre-auricular, cervical and mediastinal-and occasionally general dissemination may appear in other organs as the liver and lungs. Intracranial spread of the tumor results in death. The treatment of choice is surgical removal of the tumor. However, if they are not completely removed, it will recur repeatedly. It is important to save the eyeball when the tumor can not be removed completely. Radiation therapy may be tried preoperatively and post-operatively, but response to radiation therapy is generally unsatisfactory. A 27 year old Korean woman has been healthy until October, 1975, when she began to complain of painful progressive exophthalmos (O.D.). On physical examination, she was found to have a tender and hard mass in superior and temporal region of right orbit. Her visual acuity was 20/50(O.D.) and 20/20 (O.S.). There were no other abnormalities in her both eyes. On July 15, 1976, the surgical removal of the tumor was followed by radiation therapy. The tumor was reported to be a adenoid cystic carcinoma, She has been in good health for about 2 years since she received operation.
Adenoids*
;
Adult
;
Carcinoma, Adenoid Cystic*
;
Exophthalmos
;
Female
;
Humans
;
Lacrimal Apparatus*
;
Liver
;
Lung
;
Lymph Nodes
;
Neoplasm Metastasis
;
Orbit
;
Physical Examination
;
Prevalence
;
Visual Acuity
5.Time-Sequencing Morphometric Changes of Target Vessel Immediately after Percutaneous Coronary Balloon Angioplasty.
Dongsoo KIM ; Yangsoo JANG ; Hyuckmoon KWON ; Bum Kee HONG ; Hyun Seung KIM
Korean Circulation Journal 1998;28(2):222-229
BACKGROUND: Plaque compression (and/or redistribution) and vessel expansion are important mechanisms of percutaneous coroanry balloon angioplasty. We investigated the mechanisms of balloon angioplasty according to plaque characteristics by intravascular ultrasound and assessed the time-sequencing morphometric changes of target vessel after balloon dilation without catheter change using intravascular ultrasound balloon catheter. METHOD: We studied balloon angioplasty in 10 patients (eight male, average age of 55.3 years). Quantitative coronary angiography and intravascular ultrasound images were attained at baseline and at timed intervals of 0sec, 60sec and 180sec post-balloon angioplasty. The following categories were attained : reference diameter, minimal lumen diameter, cross sectional area (CSA) of lumen (L), external elastic membrane (EEM), and plaque + media (P+M). We also assessed the plaque morphology of target lesion and classified them into two groups according to intravascular ultrasound imaging : a soft plaque group versus a group characterized by fibrous and/or mildly calcified plaque. RESULTS: The proportions of plaque compression in the total luminal gain were 80% in the soft plaque group and 70% in the other ; the absolute amount of plaque compression was 26.9% in soft plaque and 24.0% in the other group. The time sequencing changes of target lesion EEM CSA of both group were 14.4+/-2.9mm2, 14.3+/-3.8mm2 (baseline) 15.1+/-2.5mm2, 15.4+/-3.7mm2 (immediate) 15.0+/-2.8mm2, 14.5+/-3.9mm2 (180sec), those of P+M CSA (target lesion) were 10.4+/-3.3mm2, 10.7+/-2.4mm2 (baseline) 7.6+/-2.7mm2, 8.1+/-2.4mm2 (immediate) 7.9+/-2.9mm2, 8.5+/-3.4mm2 (180sec). Target lesion lumen CSA were 4.0+/-1.1mm2, 3.6+/-2.0mm2 (baseline) 7.5+/-1.1mm2, 7.3+/-3.2mm2 (immediate) 7.1+/-1.3mm2, 6.0+/-1.7mm2 (180sec) respectively. CONCLUSION: Plaque compression (and/or redistribution) is the predominant mechanism of luminal gain in both groups. The absolute amounts of P+M CSA changes and time sequencing increment of target lesion were similar in both groups. In the non-soft group, the immediate increment and time sequencing reduction of EEM CSA in target lesion were greater than those of the soft plaque group.
Angioplasty
;
Angioplasty, Balloon
;
Angioplasty, Balloon, Coronary*
;
Catheters
;
Coronary Angiography
;
Humans
;
Male
;
Membranes
;
Phenobarbital
;
Ultrasonography
6.Tumoral Calcinosis at Hand and Foot: A Case Report
Ki Hong CHOI ; Chung Nam KANG ; Jin Man WANG ; Kwon Jae ROH ; Dong Woo JANG
The Journal of the Korean Orthopaedic Association 1987;22(3):775-779
In 1943, Alberto Inclan reported tumoral calcinosis in 3 cases at major joints. This condition usually showed large, painless calcified mass in major juxtaarticular sites, and evidence of familial or racial predisposition in blacks but abnormal values of serum calcium and phosphorus, association with renal disease, metabolic disorder and collagen disease are seldom seen. Tumoral calcinosis in large joints such as hip, knee, elbow and shoulder was reported several cases. Tumoral calcinosis in hand and foot is very rare and not reported yet in this country. Recently, authors experienced a case of tumoral calcinosis in both hands and right foot and cured without recurrence in 1 year follow up.
African Continental Ancestry Group
;
Calcinosis
;
Calcium
;
Collagen Diseases
;
Elbow
;
Follow-Up Studies
;
Foot
;
Hand
;
Hip
;
Humans
;
Joints
;
Knee
;
Metabolic Diseases
;
Phosphorus
;
Recurrence
;
Shoulder
7.Preemptive antiviral therapy with entecavir can reduce acute deterioration of hepatic function following transarterial chemoembolization.
Sun Hong YOO ; Jeong Won JANG ; Jung Hyun KWON ; Seung Min JUNG ; Bohyun JANG ; Jong Young CHOI
Clinical and Molecular Hepatology 2016;22(4):458-465
BACKGROUND/AIMS: Hepatic damage during transarterial chemoembolization (TACE) is a critical complication in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Apart from its role in preventing HBV reactivation, there is some evidence for the benefits of preemptive antiviral therapy in TACE. This study evaluated the effect of preemptive antiviral therapy on acute hepatic deterioration following TACE. METHODS: This retrospective observational study included a prospectively collected cohort of 108 patients with HBV-related HCC who underwent TACE between January 2007 and January 2013. Acute hepatic deterioration following TACE was evaluated. Treatment-related hepatic decompensation was defined as newly developed encephalopathy, ascites, variceal bleeding, elevation of the bilirubin level, prolongation of prothrombin time, or elevation of the Child-Pugh score by ≥2 within 2 weeks following TACE. Univariate and multivariate analyses were conducted to identify factors influencing treatment-related decompensation. Preemptive antiviral therapy involves directing prophylaxis only toward high-risk chronic hepatitis B patients in an attempt to prevent the progression of liver disease. We regarded at least 6 months as a significant duration of preemptive antiviral treatment before diagnosis of HCC. RESULTS: Of the 108 patients, 30 (27.8%) patients received preemptive antiviral therapy. Treatment-related decompensation was observed in 25 (23.1%) patients during the follow-up period. Treatment-related decompensation following TACE was observed more frequently in the nonpreemptive group than in the preemptive group (29.5% vs. 6.7%, P=0.008). In the multivariate analysis, higher serum total bilirubin (Hazard ratio [HR] =3.425, P=0.013), hypoalbuminemia (HR=3.990, P=0.015), and absence of antiviral therapy (HR=7.597, P=0.006) were significantly associated with treatment-related hepatic decompensation. CONCLUSIONS: Our findings suggest that preemptive antiviral therapy significantly reduces the risk of acute hepatic deterioration. Preventing hepatic deterioration during TACE by applying such a preemptive approach may facilitate the continuation of anticancer therapy and thus improve long-term outcomes.
Aged
;
Antiviral Agents/*therapeutic use
;
Bilirubin/blood
;
Carcinoma, Hepatocellular/*therapy
;
Chemoembolization, Therapeutic/*adverse effects
;
Female
;
Gastrointestinal Hemorrhage/etiology
;
Guanine/*analogs & derivatives/therapeutic use
;
Hepatitis B/complications/*drug therapy
;
Humans
;
Hypoalbuminemia/etiology
;
Incidence
;
Liver/physiopathology
;
Liver Diseases/epidemiology/*etiology
;
Liver Neoplasms/*therapy
;
Male
;
Middle Aged
;
Proportional Hazards Models
;
Retrospective Studies
;
Risk Factors
;
Treatment Outcome
8.Exposure Assessment of PCDD/Fs and Monitoring of Health Effects on Workers and Residents near the Waste Incinerators in Korea.
Jong Han LEEM ; Yun Chul HONG ; Kwan Hee LEE ; Ho Jang KWON ; Jae Yeon JANG
Korean Journal of Preventive Medicine 2003;36(4):314-322
OBJECTIVES: In this study, the exposure status of the hazardous substances from incinerators, such as polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), were studied, and the relationship between the exposure of these hazardous substances and their heath effects on the workers and residents near municipal solid waste (MSW) incinerators and an industrial incinerator investigated. METHODS: Between July 2001 and June 2002, 13 workers at two MSW incinerators, 16 residents from the area around the two MSW incinerators, 6 residents from the control area, and further 10 residents near an industrial incinerator, estimated to emit higher levels of hazardous substances, were interviewed. Information, including sociodemographic information, personal habits, and work history, detailed gynecologic and other medical history were collected through interviews. Blood samples were also collected from 45 subjects, and analyzed for PCDD/DFs, by high resolution gas chromatography - high resolution mass spectrometry, using the US EPA 1613 method. In addition to the questionnaire survey, urinary concentrations of 8-hydroxydeoxyguanosine (8-OH-dG) and malondialdehyde (MDA) were measured as oxidative injury biomarkers. The urinary concentrations of 8-OH-dG were determined by in vitro ELISA, and the MDA by HPLC, using an adduct with thiobarbituric acid. RESULTS: The PCDD/DFs concentrations in the residents near the industrial incinerator were higher than those in the controls, workers and residents near the MSW incinerators. The average TEQ (Toxic Equivalencies) concentrations of the PCDD/DFs in residents near the industrial incinerator were 53.4pg I-TEQs/g lipid. The estimated daily intakes were within the tolerable daily intake range (1-4 pg I-TEQ/Kg bw/day) suggested by WHO (1997) in only 30% to the people near the industrial incinerator. Animal studies have already shown that even a low body burden of PCDD/DFs, such as 10ng TEQ/kg bw, can cause oxidative damage in laboratory animals. Our study also showed that the same body burden of PCDD/DFs can cause oxidative damage to humans. CONCLUSIONS: The exposures to PCDD/DFs and the oxidative stress of residents near the industrial incinerator, were higher than those in the controls, workers and residents near the MSW incinerators. Proper protection strategies against these hazardous chemicals are needed. Because a lower body burden of PCDD/Fs, such as 10ng TEQ/kg bw, can cause oxidative damage, the tolerable daily intake range should be restrictedly limited to 1pg I-TEQ/kg bw/day.
Animals
;
Animals, Laboratory
;
Biomarkers
;
Body Burden
;
Chromatography, Gas
;
Chromatography, High Pressure Liquid
;
Enzyme-Linked Immunosorbent Assay
;
Hazardous Substances
;
Humans
;
In Vitro Techniques
;
Korea*
;
Malondialdehyde
;
Mass Spectrometry
;
Methods
;
No-Observed-Adverse-Effect Level
;
Oxidative Stress
;
Solid Waste
9.A case of pheochromocytoma with electrocardiographic changes mimicking angina pectoris, and hypotensive crises.
Tae Ho JUNG ; Jae Kwon JANG ; Hong Su JUNG ; Sung Kee KIM ; Jong Woon AN ; Kyung Ho JANG ; Yong Keun JO ; Yong Koo OH
Korean Journal of Medicine 1993;45(6):801-807
No abstract available.
Angina Pectoris*
;
Electrocardiography*
;
Pheochromocytoma*
10.A Case of Arteriovenous Hemangioma showing Darier's Sign.
Hee Joon YU ; Sang Jin KWON ; Ji Hyeung CHO ; Hong Yoon YANG ; Yong Wook PARK ; Se Jin JANG
Korean Journal of Dermatology 1997;35(1):209-213
We experienced a case of arteriovenous hemangioma showing Dariers sign on the forehead of a 43-year-old man. He presented with a single, 1 * 1.5cm sized, violaceous, asymptomatic nodule with a history of an intermittent wheal at the lesional site. This skin lesion showed Dariers sign clinically and proliferation of mast cells histopathologically with the punch biopsy specirnen suggesting urticaria pig- mentosa. Howerer, we could diagnose it as a arteriovenous hemangioma on complete excision, as the specimen showed arteriovenous proliferation with increased mast cells in a perivascular pattern. This case showed confusing clinical signs and showed the importance of complete excision for the diagnosis of a small skin tumor especially when a vascular proliferating tumor is suspected.
Adult
;
Biopsy
;
Diagnosis
;
Forehead
;
Hemangioma*
;
Humans
;
Mast Cells
;
Skin
;
Urticaria