1.Multiple Pyogenic Granulomas within Port-Wine Stain.
Sung Woo LEE ; Hyo Chan JANG ; Hyun CHUNG
Annals of Dermatology 2004;16(4):201-203
No abstract available.
Granuloma, Pyogenic*
;
Port-Wine Stain*
2.A Case Dermal Melanocyte Hamartoma.
Jin Gon JANG ; Sung Hyun PARK ; Kwang Hoon LEE
Korean Journal of Dermatology 1988;26(6):956-959
A 26-year-old man presented with a bluish speckled patch on the dorsum of the left hand. It had apperaed at birth as a bluish spot. Since adolescence the lesion extended and at the time of visiting hospital it covered the most part of the dorsum of the left hand and even some palmar aspect. The histopathological and ultrastructural examination revealed numerous dermal melanocytes, mainly in the upper dermis. Clinically and pathologically, the patient was diagnosed as having dermal melanocyte hamartoma, a distinct type of dermal melanocytosis.
Adolescent
;
Adult
;
Dermis
;
Hamartoma*
;
Hand
;
Humans
;
Melanocytes*
;
Parturition
3.The Influence of Estrogen on Dopamine Metabolites in Schizophrenia.
Jin Sook CHEON ; Jang hyun LEE ; Byoung Hoon OH
Journal of the Korean Society of Biological Psychiatry 1999;6(2):209-218
OBJECTIVES: The aims of this study were to discriminate the clinical differences, to measure the estrogen and homovanillic acid levels. to evaluate a correlation between estrogen and homovanillic acid. and to identify an association of cognitive deficit with estrogen and homovanilli acid among male and female schizophrenics. METHODS: In addition to the structured interviews, the plasma estrogen levels by radioimmunoassay and the homovanillic acid levels by HPLC were measured in 20 male and 21 female schizophrenics as well as 10 healthy male and 9 female controls. RESULTS: 1) The plasma estrogen levels were higher in females than males, and significantly higher in female schizophenics than female controls. The homovanillic acid levels were higher in female schizophrenics than female controls, and were lower in male schizophrenics than male controls. 2) The onset age seemed to be earlier in male schizophrenics, and the frequency of admission, duration of antipsychotic drug administration. dosage of antipsychotics and duration of illnesses were more in males. The estrogen and homovanillic acid levels were significantly higher in female schizophrenics. 3) The estrogen levels had a significant positive correlation with sex, age and onset age, while the homovanillic acid levels did with sex. However, estrogen wee not correlated with homovanillic acid levels. 4) The estrogen and homovanillic acid levels were not significantly different between male and female schizophrenics with cognitive deficits. In the schizophrenic patients without cognitive deficits, the estrogen levels were significantly higher in females, while here were no significant sex differences in homovanillic acid. 5) In the male and female schizophrenics predominantly with negative symptoms, there were no significant differences in estrogen and homocanillic acid levels. In those predominantly with positive symptoms, the estrogen levels wee significantly higher in females, while there were no sex differences in homovanillic acid levels. 6) In schizophrenics with undifferentiated subtype, the estrogen and homovanillic acid levels were significantly higher in females. In those with paranoid or disorganized subtypes. the estrogen levels were significantly higher females, while there were no sex differences in the homovanillic acid levels. 7) The mean values of PANSS-negative. PANSS-total, PANSS-CF, MMSE-K and estrogen levels were significantly higher in male schizophrenics with cognitive deficits. The mean values of illness duration, CGI PANSS-positive, PANSS-negative, PANSS-total, PANSS-CF and MMSE-K were significantly higher in female schizophrenics with cognitive deficits. 8) The variables which showed significant correlation with cognitive deficits were PANSS-nagative, PANSS-total, PANSS-CF, MMSE-K and estrogen levels in male schizophrenics. The variables which showed significant correlation with cognitive deficits were subtypes, onset age, illness duration, CGI, PANSS-positive, PANSS-negative, PANSS-total, PANMSS-CF and MMSE-K in female schizophrenics. The estrogen levels were significantly correlated with admission frequencies, history of antipsychotic administration, duration of antipsychotic administration and cognitive deficits in male schizophrenics. while age were not correlated with in females. The homovanillic acid levels had a significant correlation with subtypes and onset age in male schizophrenics, while there were no correlation among variables in females. CONCLUSIONS: Although the plasma concentrations of estrogen and homovaillic acid in female schizophrenics were significantly higher than males, we could not find an association between them. Furthermore, the various factors affecting on the cognitive deficits, estrogen and homovanillic acid levels seemed to be somewhat different according to sex.
Age of Onset
;
Antipsychotic Agents
;
Chromatography, High Pressure Liquid
;
Dopamine*
;
Estrogens*
;
Female
;
Homovanillic Acid
;
Humans
;
Male
;
Plasma
;
Radioimmunoassay
;
Schizophrenia*
;
Sex Characteristics
4.Respiratory Effects of Acute Coronary Embolism.
Jang Baik LEE ; Si Rhae LEE ; Hyun Woo LEE ; Hi Myung PARK
Korean Circulation Journal 1975;5(1):19-24
Respiratory effects of acute coronary embolism were studied in mongrel dogs. Coronary embolism was produced by Agress's method and respirtory effects were observed for two hours. In the experimental group, in which coronary embolism was produced, there were relative decreases in respiratory rate and arterial oxygen saturation along with relative increases in tidal volume, minute ventilation, ventilation equivalent and arteriovenous oxygen difference compared to those in the control group. However, differences in these various measurements between tow groups, those in tidal volume and arterial oxygen saturation, have greatly diminished in two hours. These facts suggest that changes in respiratory rate, minute ventilation, ventilation equivalent and arteriovenous oxygen difference in the experimental group are early but short-lasting responses to acute coronary embolism, whereas changes in tidal volume and arterial oxygen saturation occur early and last longer.
Animals
;
Dogs
;
Embolism*
;
Oxygen
;
Respiratory Rate
;
Tidal Volume
;
Ventilation
5.DNA Profiling via Short Tandem Repeat Analysis by Using Serum Samples.
Ji Hyun LEE ; Hye Young LEE ; Sohee CHO ; Joo Youn CHO ; In Jin JANG ; Soong Deok LEE
Korean Journal of Legal Medicine 2013;37(4):220-223
Serum is free of cellular components. Because DNA is located in the nuclei or mitochondria of cells, serum could be assumed DNA free. Few previously published case reports to date have used serum for DNA typing. Here, we report on human genotyping via short tandem repeat (STR) analysis using serum as a sample, and discuss problems involved in the process.
DNA Fingerprinting*
;
DNA*
;
Humans
;
Microsatellite Repeats*
;
Mitochondria
6.A Clinical Review in 31 Patients with Ulcerative Colitis.
Sam Beom LEE ; Byeong Ik JANG ; Heon Ju LEE ; Moon Kwan CHUNG ; Hyun Woo LEE
Korean Journal of Gastrointestinal Endoscopy 1991;11(2):355-361
Ulcerative colitis is diffuse inflammatory condition at mucosal lining of the colon & rectum and rare in Korea but there are no pathognomonic features or specific diagnostic tests. However, recently the diagnostic methods for ulcerative colitis are much developed and the incidence of ulcerative colitis is increased in Korea. Therefor, an analysis of 31 cases of ulcerative colitis which was diagnosed and treated in the department of the YeungNam University Hospital from May l983 to April 1991 was reviewed. The results were as following: 1) The sex distribution assumed a ratio of 1 to 2.1 and the age distribution was vqriable but the most prevalent age group was 5th decade(29.0%). 2) The most common clinical manifestations were abdominal pain & bloody diarrhea. 3) As to the extent of disease determined by the barium enema & endoscopy, rectum or rectosigmoid colon was involved in majority of the cases 22.6%, 41.9 (respectively). 4) Significant laboratory findings were elevated ESR, anemia, leukocytosis, hypoalbuminemia. 5) The endoscopic examination was performed in all 31 cases and showed sinificant findings such as hyperemia, mucosai edema, superficial ulceration & mucosal friability. 6) 23 of 26 cases treated by sulfasalazine medication showed improved, and 3 cases were improved by steriod medication and the surgical operation was indicated in 1 case.
Abdominal Pain
;
Age Distribution
;
Anemia
;
Barium
;
Colitis, Ulcerative*
;
Colon
;
Diagnostic Tests, Routine
;
Diarrhea
;
Edema
;
Endoscopy
;
Enema
;
Humans
;
Hyperemia
;
Hypoalbuminemia
;
Incidence
;
Korea
;
Leukocytosis
;
Rectum
;
Sex Distribution
;
Sulfasalazine
;
Ulcer*
7.Comparison of Polymerase Chain Reaction Method and CMV Antigenemia Assay for Diagnosis of Cytomegalovirus Infection in Transplanted Patients.
Yong Wha LEE ; Myung Hyun NAM ; Jang Ho LEE ; Nam Yong LEE
Korean Journal of Clinical Microbiology 1999;2(2):177-181
BACKGROUND: Early detection and treatment of cytomegalovirus (CMV) infection is very important because CMN infection is a major cause of morbidity and mortality after organ transplantation. CMV antigenemia assay has been reported to be very sensitive and specific for detection of CMV infection among many laboratory methods. However, there is no single method correlated well with the infection state up to now. We compared the results of SHARP Signal System Assay (Digene, USA) using PCR and hybridization with those of CMV antigenemia assay (Clonab CMV-kit; Biotest AG, Germany) to evaluate their clinical usefulness. METHODS: We performed SHARP Signal Assay on whole blood samples of 125 from 56 transplanted patients submitted for CMV antigenemia at Samsung Medical Center. We compared the results with those of CMV antigenemia and evaluated the correlation with CMV disease state. RESULTS: Fifty six patients were classified as three groups; 43 patients with no evidence of CMV infection, four patients with CMV infection and 9 patients with CMV disease. Twenty four cases (19.2%) showed discrepant results between the two methods. Of the 22 cases showing positive only by SHARP Signal Assay, two cases were proved to be CMV disease, 12 cases were on antiviral treatment and remaining cases had no evidence of infection. Two cases showing positive only by CMV antigenemia were confirmed to be CMV disease. For CMV disease, the sensitivity of SHARP Signal Assay and CMV antigenemia were 85.7% and 90.5%, respectively and the specificity of them were 73.1% and 93.3%, respectively. CONCLUSIONS: CMV antigenemia is thought to be useful for early diagnosis and follow-up of antiviral treatment as a quantitative and highly specific method, and SHARP Signal Assay can be used as a complementary method because it correlates well with disease state.
Cytomegalovirus Infections*
;
Cytomegalovirus*
;
Diagnosis*
;
Early Diagnosis
;
Follow-Up Studies
;
Humans
;
Mortality
;
Organ Transplantation
;
Polymerase Chain Reaction*
;
Sensitivity and Specificity
;
Transplants
8.Flecainide Improve Sepsis Induced Acute Lung Injury by Controlling Inflammatory Response.
Jia SONG ; Young Joong SUH ; Hyun Jung LEE ; Eun A JANG ; Hong Beom BAE ; Sang Hyun KWAK
Korean Journal of Critical Care Medicine 2016;31(3):194-201
BACKGROUND: Flecainide is an antiarrhythmic agent that is used primarily in the treatment of cardiac arrhythmias. Some evidences also suggest that flecainide can participate in alveolar fluid clearance and inflammatory responses. This experiment was aimed to evaluate the effects of flecainide on sepsis induced acute lung injury in a rat model. METHODS: Rats were treated with subcutaneous infusion of saline or flecainide (0.1 or 0.2 mg/kg/hr) by a mini-osmotic pump. Subcutaneous infusion was started 3 hours before and continued until 8 hours after intraperitoneal injection of saline or endotoxin. Animals were sacrificed for analyses of severity of acute lung injury with wet to dry (W/D) ratio and lung injury score (LIS) in lung and inflammatory responses with level of leukocyte, polymorphonuclear neutrophils (PMNs) and inteleukin-8 (IL-8) in bronchoalveolar lavages fluid (BALF). RESULTS: Flecainide markedly improved dose dependently sepsis induced acute lung injury as analysed by W/D ratio (from 2.24 ± 0.11 to 1.76 ± 0.09, p < 0.05) and LIS (from 3 to 1, p < 0.05), and inflammatory response as determined by leukocyte (from 443 ± 127 to 229 ± 95, p < 0.05), PMNs (from 41.43 ± 17.63 to 2.43 ± 2.61, p < 0.05) and IL-8 (from 95.00 ± 15.28 to 40.00 ± 10.21, p < 0.05) in BALF. CONCLUSIONS: Flecanide improve sepsis induced acute lung injury in rats by controlling inflammatory responses.
Acute Lung Injury*
;
Animals
;
Arrhythmias, Cardiac
;
Bronchoalveolar Lavage
;
Flecainide*
;
Infusions, Subcutaneous
;
Injections, Intraperitoneal
;
Interleukin-8
;
Leukocytes
;
Lung
;
Lung Injury
;
Models, Animal
;
Neutrophils
;
Rats
;
Sepsis*
9.Isolation of borrelia burgdorferi, the causative agent of lyme disease, from ixodes ticks in Korea.
Kyung Hee PARK ; Seung Hyun LEE ; Woong Jae WON ; Won Jong JANG ; Woo Hyun CHANG
Journal of the Korean Society for Microbiology 1992;27(4):307-312
No abstract available.
Borrelia burgdorferi*
;
Borrelia*
;
Ixodes*
;
Korea*
;
Lyme Disease*
;
Ticks*
10.Serological and antigenic analysis against borrelia burgdorferi of febrile patients in Korea.
Kyung Hee PARK ; Seung Hyun LEE ; Won Jong JANG ; Sang Mahn KIM ; Woo Hyun CHANG
Journal of the Korean Society for Microbiology 1993;28(5):397-408
No abstract available.
Borrelia burgdorferi*
;
Borrelia*
;
Humans
;
Korea*