We report a case of acral persistent papular mucinosis in a 5 year-old female with multiple papules on both dorsa of the hands, wrists and forearms. Examination of a biopsy specimen showed a domeshaped lesion in the dermis composed of spindle-shaped fibrobla,sts and widely spaced collagen fibers. These spaces were filled with mucinous material, as demonstrated by positive staining with aleian blue at pH 2.5 and pH 0.5.
Biopsy ; Child, Preschool ; Collagen ; Dermis ; Female ; Forearm ; Hand ; Humans ; Hydrogen-Ion Concentration ; Mucinoses* ; Mucins ; Scleromyxedema ; Wrist

No abstract available.
Facial Nerve* ; Paralysis* ; Temporal Bone*

A 26-year-old man presented with a bluish speckled patch on the dorsum of the left hand. It had apperaed at birth as a bluish spot. Since adolescence the lesion extended and at the time of visiting hospital it covered the most part of the dorsum of the left hand and even some palmar aspect. The histopathological and ultrastructural examination revealed numerous dermal melanocytes, mainly in the upper dermis. Clinically and pathologically, the patient was diagnosed as having dermal melanocyte hamartoma, a distinct type of dermal melanocytosis.
Adolescent ; Adult ; Dermis ; Hamartoma* ; Hand ; Humans ; Melanocytes* ; Parturition

No abstract available.
Animals ; Iproniazid* ; Monoamine Oxidase* ; Rats* ; Tyramine*

Exogenoue exposurea to pathogenic fungi have been suggested as causes of acute atta.eks of tinea pedis. Psthogenic fungi is rarely present on the skin aurfaces without cauaing definite and characteristic reactions. However, it was suspected by eome observers that pathogenic fungi might be more or liesa normal inhabitant of the human skin. Alterations in host susceptibility and loss, of local immunity are more to blame than new exposure to exogenous micro-ganisms. To determine this point, fungal culture was done from the fourth toe web of 824 high school students. The results of the study were summarized as follows,' l. Among 824 cases, 780 cases(94.7%) had grossly normal appearing toe web and 44 cases(5,3%) were suspected superficial fungal infection. 2. Positive rate of KOH examination was 4.6%(36,'780) in normal toe web and 45.4%(20/44) in dermatophytic lesion. 3, The positive rate of fungal culture from normal and infected toe web are 7.9 %(62/780) a.nd 40.9%(18/44), respectively. In the normal toe web, Trichophyton rubrum(66.1%), T, entagrophytea(include T. interdigitaLe) and Epidermophyton, floccosum(3.2%) were isolated. In the dermatophytic lesion, T. rubrurn(88.8%) and T. me ntagrophytes(11.2% ) w ere isolated. Although toe webs do not present clinical symptoms and signs, pathogenic fungi as a normal inhabitant can be isolated from clinically normal toe webs. Some of these cases, therefore, will develope to tinea pedis in time.
Epidermophyton ; Fungi ; Humans ; Skin ; Tinea Pedis ; Toes* ; Trichophyton

A small proportion of diabetics treated with exogenous insulin, reportedly ranging from 0.1% to 2%, experience systemic allergic reactions to insulin. We saw a 55-year-old male patient with insulin-dependent diabetes mellitus who had developed an anaphylatic reaction immediately after subcutaneous injections of neutral protamine Hagedorn (NPH) human recombinant insulin. Skin tests with insulins and a passive transfer test demonstrated that his reaction was IgE mediated. Since there were no therapeutic alternatives, desensitization with insulin was done following a slow protocol. It was successful and he was able to resume insulin therapy. During two year follow-up period, he did not developed any adverse reaction to insulin.
Anaphylaxis* ; Diabetes Mellitus, Type 1 ; Follow-Up Studies ; Humans ; Hypersensitivity ; Immunoglobulin E ; Injections, Subcutaneous ; Insulin* ; Insulins ; Intradermal Tests ; Male ; Middle Aged ; Skin Tests

Among the patients visting Department of Dermatology, Chungman National University, 58 cases had various side effects due to the malpractice of skin disorders. We analysed these 58 cases and the results can be summerized as follows ; 1. 37 cases(64%) were in the second and third decades and 11 cases(19%) were under 19 years-old. 2. Drug medication from pharmacy was the most common(79%), and then local clinics(12%), herb clinics(9%) in decreasing orders. 3. In the route of administration, oral ingestion(38%) was the most common, and 47 cases (81%) were medicated with adrenocorticoids. 4. In motivation to the visit, 31 cases(53%)were by advice, 15 cases by advertizement and 12 cases (21%) by themselves. 5. Acne and psoriasis were about a half of pre-existing skin diseases. 6. Side effects due to malpractice may be divided into 5 items : systemic side effects due to adrenocorticoids (59%), aggravation of pre-existing skin diseases (22%), topical side effects due to adrenocorticoids (10%), chemical irritation and burn (7%), and mercury intoxication (2%) in decreasing orders.
Acne Vulgaris ; Administration, Oral ; Burns ; Dermatology ; Humans ; Malpractice* ; Motivation ; Pharmacy ; Psoriasis ; Skin Diseases* ; Skin* ; Young Adult

OBJECTIVES: The aims of this study were to discriminate the clinical differences, to measure the estrogen and homovanillic acid levels. to evaluate a correlation between estrogen and homovanillic acid. and to identify an association of cognitive deficit with estrogen and homovanilli acid among male and female schizophrenics. METHODS: In addition to the structured interviews, the plasma estrogen levels by radioimmunoassay and the homovanillic acid levels by HPLC were measured in 20 male and 21 female schizophrenics as well as 10 healthy male and 9 female controls. RESULTS: 1) The plasma estrogen levels were higher in females than males, and significantly higher in female schizophenics than female controls. The homovanillic acid levels were higher in female schizophrenics than female controls, and were lower in male schizophrenics than male controls. 2) The onset age seemed to be earlier in male schizophrenics, and the frequency of admission, duration of antipsychotic drug administration. dosage of antipsychotics and duration of illnesses were more in males. The estrogen and homovanillic acid levels were significantly higher in female schizophrenics. 3) The estrogen levels had a significant positive correlation with sex, age and onset age, while the homovanillic acid levels did with sex. However, estrogen wee not correlated with homovanillic acid levels. 4) The estrogen and homovanillic acid levels were not significantly different between male and female schizophrenics with cognitive deficits. In the schizophrenic patients without cognitive deficits, the estrogen levels were significantly higher in females, while here were no significant sex differences in homovanillic acid. 5) In the male and female schizophrenics predominantly with negative symptoms, there were no significant differences in estrogen and homocanillic acid levels. In those predominantly with positive symptoms, the estrogen levels wee significantly higher in females, while there were no sex differences in homovanillic acid levels. 6) In schizophrenics with undifferentiated subtype, the estrogen and homovanillic acid levels were significantly higher in females. In those with paranoid or disorganized subtypes. the estrogen levels were significantly higher females, while there were no sex differences in the homovanillic acid levels. 7) The mean values of PANSS-negative. PANSS-total, PANSS-CF, MMSE-K and estrogen levels were significantly higher in male schizophrenics with cognitive deficits. The mean values of illness duration, CGI PANSS-positive, PANSS-negative, PANSS-total, PANSS-CF and MMSE-K were significantly higher in female schizophrenics with cognitive deficits. 8) The variables which showed significant correlation with cognitive deficits were PANSS-nagative, PANSS-total, PANSS-CF, MMSE-K and estrogen levels in male schizophrenics. The variables which showed significant correlation with cognitive deficits were subtypes, onset age, illness duration, CGI, PANSS-positive, PANSS-negative, PANSS-total, PANMSS-CF and MMSE-K in female schizophrenics. The estrogen levels were significantly correlated with admission frequencies, history of antipsychotic administration, duration of antipsychotic administration and cognitive deficits in male schizophrenics. while age were not correlated with in females. The homovanillic acid levels had a significant correlation with subtypes and onset age in male schizophrenics, while there were no correlation among variables in females. CONCLUSIONS: Although the plasma concentrations of estrogen and homovaillic acid in female schizophrenics were significantly higher than males, we could not find an association between them. Furthermore, the various factors affecting on the cognitive deficits, estrogen and homovanillic acid levels seemed to be somewhat different according to sex.
Age of Onset ; Antipsychotic Agents ; Chromatography, High Pressure Liquid ; Dopamine* ; Estrogens* ; Female ; Homovanillic Acid ; Humans ; Male ; Plasma ; Radioimmunoassay ; Schizophrenia* ; Sex Characteristics

We report herein a. case of angio-Behqets syndrome, arterial occlusion type in a 31 year-old male. He had a history of scrotal ulceration, frequent oral ulceration and ocular pain with decreased visual acuity. About 8 months ago, moderately dull pain developed on the volar aspect of left index finger. Subsequently, a bean sized bluish patch developed on the previous painful area and on the ipsilateral thumb tip. Subungual splinter hemorrhages developed on the distal portions of left thumb and index finger nails at the same time. The result of saline puncture test showed the positive reaction in both intradermal and subeutaneous injections. The hrachial angiography showed an obliteration of digital artery at the second proxirnal phalanx of ulnar side.
Adult ; Angiography ; Arteries ; Behcet Syndrome* ; Fingers ; Hemorrhage ; Humans ; Male ; Oral Ulcer ; Punctures ; Thumb ; Ulcer ; Visual Acuity

We describe a 8-year-old girl with erythrokeratodermia varibilis (EKV). This diagnosis was supported by erythematous, configurate patches over the entire body. Their size, shape and location varyed with enviromental factors and emotional state. In addition, well defined brownish, hyperkeratotic plaques were scattered over the trunk and extremities. Also, this patient had alopecia universalis, which is not typical of EKV. Etretinate therapy resulted in an almost complete clinical clearing of the plaques; however, her alopecia universalis and erythematous lesions were not affected.
Acitretin ; Alopecia* ; Child ; Diagnosis ; Erythrokeratodermia Variabilis* ; Etretinate ; Extremities ; Female ; Humans