No abstract available.

Between sept. 1982 and June 1985, the authors have performed arthroscopic debridement on 32 knees of 30 patients with primary osteoarthritis of the knee. Operative procedures including lavage, partial meniscectomy, excision of shelf, partial or total synovectomy of the anterior compartment, debridement of the articular cartilage, removal of loose bodies and multiple drilling of the articular cartilage were variously combined case by case. The follow-up period was between 18 and 52 months, with on average of 30.6 months. Clinical results were evaluated with the modified method of Sprague, III and were classified “Excellent”. “Good”, “Fair” and “Poor”. The data were analyzed by Fishers exact test to clarify the relationship between clinical results and various preoperative factors. The results were as follows: l. Of the total 32 knees, results were “excellent” in 17(53.1%), “good” in 9(28.1%), “fair” in 3 (9.4%) and “poor” in 3(9.4%) knees respectively. Satisfactory results, including “excellent” and good, were achieved in more than 3/4 cases(81.2%) . 2. Of the 3 “poor” cases, 2 cases seemed to be affected by major depression and the other one case had no specific cause to be considered. 3. The unsatisfactory cases, including “fair” and “poor” cases, commonly had degenerative changes of patellofemoral joint arthroscopically although the correlation between it and the results were not significantly proved statistically(P>0.05). 4. The correlation between amount of effusion, degree of degeneration of articular cartilage and amount of fibrinoid debris were not significantly proved statistically(P>0.05). 5. The correlation between clinical results and amout of effusion. degreq or site of degeneration of articular cartilage, degree of flexion contracture, meniscal tear, synovectomy, debridement of articular cartilage and number of operative procedures could not be significanly proved statistically. In conclusion, arthroscopic treatment of the primary osteoarthritis of the knee shows relatively satisfactory results in most cases with fewcomplications and a short rehabilitation period, and the procedure could be recommended as a process inbetween conservative treatment and definitive treatment such as total knee replacement. But any specific relationship between clinical results and various preoperative factors could not be proved statistically. The clinical results seemed to be attected by individual unknown factors and further precise analysis and long term follow-up will be necessary to clarify them.
Arthroplasty, Replacement, Knee ; Arthroscopy ; Cartilage, Articular ; Contracture ; Debridement ; Depression ; Follow-Up Studies ; Humans ; Knee ; Methods ; Osteoarthritis ; Patellofemoral Joint ; Rehabilitation ; Surgical Procedures, Operative ; Tears ; Therapeutic Irrigation

Proliferations of the endometrial glands form a continuum from focal glandular crowding through simple hyperplasia, complex hyperplasia and atypical hyperplasia to frank adenocarcinoma. But objective criteria to distinguish these proliferative endometrial lesions are not clear-cut and terminology is confusing. The p53 protein is a nuclear phosphoprotein that can regulate cell proliferation and suppress tumor growth. Mutation in the p53 gene have been reported in a variety of human tumors, and in selected malignancies overexpression of p53 has been associated with poor prognosis. In this study we examined a series of endometrial proliferative lesion, including hyperplasia, adenocarcinoma, and adenomyosis to determine whether or not p53 is overexpressed in these lesions. In the result, p53 immunoreactivity was observed in 3 of 17 (17.6%) simple hyperplasia, one of 6 (16.6%) complex hyperplasia, none of 3 (O%) atypical hyperplasia, 6 of 13 (46.1%) adenocarcinoma and none of 10 (O%) adenomyosis. In conclusion, p53 mutation seems to play a role in oncogenesis of endometrial adenocarcinoma in early phase but there was no significant relationship between p53 overexpression and histologic grade of adenocarcinoma.
Adenocarcinoma* ; Adenomyosis ; Carcinogenesis ; Cell Proliferation ; Crowding ; Endometrial Hyperplasia* ; Female ; Genes, p53 ; Humans ; Hyperplasia ; Prognosis

No abstract available.
Adenomyosis* ; Humans ; Uterus*

No abstract available.
Adenomyosis* ; Humans ; Uterus*

Clavicle medial end fracture is rare, and it has not been studied extensively. Although there is debate regarding its treatment methods, because of the complications of conservative treatment, surgical treatment has been considered more than conservative treatment. This study describes a surgical method using double-plate fixation for treatment of clavicle medial end fractures in which plates were used on each anterior and superior border according to the anatomical structure of the clavicle. In addition, we report operative results of three patients treated by double-plate fixation.
Clavicle* ; Humans

The patients of developmental dislocation of the hip(DDH) are almost found after walking age because of early diagnosis of DDH in younger children is not easy. A controversy still exists as to the relative value of closed and operative management in the treatment of a child who has reached walking age. This study is a report of the results of 16 patients(17 cases) in developmental dislocation of the hip who have visited our hospital at the age of 9 months to 3 years old, and have been followed more than 12 months (12-112 months) on review of plain radiographs and arthrograms. The results were as follows 1. The age at diagnosis was 16.4 months(9-31 months) in average. The methods of treatment were conservative for 8 cases, and operation for 4 cases and secondary operation for 5 cases who were failed with conservative therapy. 2. By Severin's radiologic grade, the result was good in 4 cases, fair in 3 cases and poor in 1 case in conservative treatment. In operative treatment, fair was in 2 cases and poor in 2 cases. In secondary operative -patients who were failed with conservative therapy, good was in 2 cases, fair in 2 cases and poor in 1 case. 3. Avascular necrosis of femoral head was developed in 3 cases. 4. In the good reduction as determined by arthrogram according to Race and Herring, we can get a favorable result in conservative treatment, and in the poor reduction as determined by arthrogram, the better
Child ; Continental Population Groups ; Diagnosis ; Dislocations* ; Early Diagnosis ; Head ; Hip* ; Humans ; Necrosis ; Walking*

No abstract available.
Child* ; Drug Therapy ; Humans ; Radiotherapy

Tuberculosis of the puboischium is an uncommon entity. The two constant features in tubereulosis of the pubis are limping and abscess formation. This disesse should be differentiated from other diseases such as osteitis pubis, suppurative osteomyelitis, postpartum synphysiolysis, and adolescent osteochondritis. Kirker advocated that wide excision of the lesion for the treatment of this disease is the best method. However, Nicholson(1953) reported that the lesion has a good prognosis snd responds well to simple curettage. Since the first reports by Thilesen(1855) and by Heinnies(1888), there were paucity of reports. Also in Korea, there have been no report about this disease. The five patients who were treated at the Ksng-Nsm St. Marys Hospitsl between 1982 and 1987 were reported. The results were as follows ; 1. Four patients were boys and one was a female. 2. All cases had clinically abscess, tenderness at the lesion, and limp. 3. Lesions in four cases responded well to simple curettage and18 months of chemotherapy. However, in one case fusion of the symphysis using a plate was performed because of tuberculosis-induced instability of the sacroiliac joint. 4. In a child, destroyed symphysis pubis was well restituted after treatment. Through the cases it is concluded that simple curettage and anti-tuberculous chemotherapy are good treatment modality for tuberculosis of the puboischium.
Abscess ; Adolescent ; Child ; Curettage ; Drug Therapy ; Female ; Humans ; Korea ; Methods ; Osteitis ; Osteochondritis ; Osteomyelitis ; Postpartum Period ; Prognosis ; Pubic Bone ; Sacroiliac Joint ; Tuberculosis

BACKGROUND AND OBJECTIVES: Marfan syndrome is an autosomal dominant heritable disease of connective tissue which is characterized by cardinal features mainly in the cardiovascular, ocular and skeletal systems. Aneurysms or dissections of the aorta are the major cardiovascular complications of the disorder causing early mortality. Mutations in the fibrillin-1 (FBN1) gene on chromosome 15q21.1 have been found to be major causes of Marfan syndrome. The purpose of this study was to characterize the molecular defect in Korean Marfan patients, thus contributing to the effort of correlating the genotype with the phenotype. SUBJECTS AND METHODS: We screened all 65 exons of the FBN1 gene in 14 subjects diagnosed as Marfan syndrome by the method of single strand conformation polymorphism-heteroduplex analysis. RESULTS: We found mutations in only 10 among 14 patients. This study identified 8 novel mutations and 2 previously reported mutations in 14 Korean Marfan patients. Two cases were nonsense mutations and 8 were missense mutations, including 3 frameshift. Seven cases of the mutations occurred in one of the 43 calcium binding epidermal growth factor-like domains within an FBN1 gene. Mutations in Marfan patients occurred variably over the whole field of this FBN1 gene. CONCLUSION: Our results will contribute to the establishment of a database of Korean Marfan patients. Extending this study and using the database will help early detection of the disease and prevention of complications.
Aneurysm ; Aorta ; Calcium ; Codon, Nonsense ; Connective Tissue ; Exons ; Genotype ; Humans ; Marfan Syndrome* ; Mortality ; Mutation, Missense ; Phenotype