1.Amiloride inhibits the growth of human colon cancer cells(HT-29) in vitro.
Ja Young KOO ; Byung Chae PARK ; James C THOMPSON
Journal of the Korean Cancer Association 1991;23(3):471-478
No abstract available.
Amiloride*
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Colon*
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Colonic Neoplasms*
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Humans*
2.Projecting the number of older singaporeans with activity of daily living limitations requiring human assistance through 2030.
James THOMPSON ; Rahul MALHOTRA ; Sean LOVE ; Truls OSTBYE ; Angelique CHAN ; David MATCHAR
Annals of the Academy of Medicine, Singapore 2014;43(1):51-56
INTRODUCTIONIn the context of rapid population ageing and the increase in number of activity of daily living (ADL) limitations with age, the number of older persons requiring human assistance in Singapore is likely to grow. To promote informed planning for the needs of these elderly, we project the number of resident Singaporeans 60 years of age and older with 1 or more ADL limitations requiring human assistance through 2030.
MATERIALS AND METHODSThe proportion of community-dwelling older adults with ADL limitations requiring human assistance, stratified by gender and age group, was calculated utilising a recent nationally-representative survey of older Singaporeans. The proportion of older adults in nursing homes with ADL limitations was estimated based on available literature. Together, these prevalence estimates were applied to a simulation of the future population of older adults in Singapore to derive an estimate of the number of individuals with ADL limitations requiring human assistance through 2030.
RESULTSBy 2030, the number of resident Singaporeans aged 60 years or older with 1 or more ADL limitations requiring human assistance is projected to be 82,968 persons (7% of the total population aged 60 years or older). Of this number, 38,809 (47%) are estimated to have 1 or 2 ADL limitations, and 44,159 (53%) are estimated to have 3 or more.
CONCLUSIONThe number of elderly Singaporeans with activity limitations is expected grow rapidly from 31,738 in 2010 to 82,968 in 2030. Estimates of the number of older individuals with ADL limitations requiring human assistance are of value for policymakers as well as acute and long-term care capacity planners as they seek to meet demand for health and social services in Singapore.
Activities of Daily Living ; Aged ; Aged, 80 and over ; Female ; Forecasting ; Health Services for the Aged ; statistics & numerical data ; Homes for the Aged ; statistics & numerical data ; Humans ; Independent Living ; Long-Term Care ; statistics & numerical data ; trends ; Male ; Middle Aged ; Singapore
3.The Efficacy of Medial Patellofemoral Ligament Reconstruction Combined with Tibial Tuberosity Transfer in the Treatment of Patellofemoral Instability
Tarek BOUTEFNOUCHET ; Christopher DOWNHAM ; James BASSETT ; Peter THOMPSON ; Andrew SPROWSON
The Journal of Korean Knee Society 2016;28(2):99-109
A systematic review of the literature was undertaken to evaluate the efficacy of medial patellofemoral ligament (MPFL) reconstruction combined with tibial tuberosity transfer (TTT) in the treatment of patellofemoral instability. Using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, a systematic search was carried out to identify and review the published literature pertinent to MFPL reconstruction combined with TTT. Relevant studies were critically appraised with narrative data synthesis. Studies that met the eligibility criteria were suitable for appraisal and consisted of case series and therapeutic series (levels IV & III). All studies had inherent variations in outcomes reporting and limited follow-up. Combined treatment offers restoration of normal anatomy, thus adding clinical value to the currently recommended anatomic approach to MPFL reconstruction. Nevertheless, the current body of evidence does not determine the threshold at which patellofemoral axis requires the need for adjunctive distal realignment as opposed to MPFL reconstruction alone. This review highlighted numerous recurring limitations in the conduct and presentation of the studies, which inadvertently mitigated the interpretation of their results. Future priority should be awarded to larger randomised controlled trials utilising validated patient reported outcome measures.
Awards and Prizes
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Follow-Up Studies
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Humans
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Ligaments
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Outcome Assessment (Health Care)
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Patellar Dislocation