1.Interventions of side branches in the management of left ventricular dysfunction: a study based on the virtual dual chamber of the left ventricle.
Thach NGUYEN ; Dan LE ; James NGUYEN ; Joseph HACKLER ; Katrina NGUYEN ; Hung PHAN ; Tuan D NGUYEN ; Quoc NGUYEN
Chinese Medical Journal 2012;125(22):4126-4129
3.Peripheral vascular bifurcation: features and techniques.
Gianluca RIGATELLI ; Paolo CARDAIOLI ; Dell AVVOCATA ; Dan LE ; Hung PHAN ; Katrina NGUYEN ; Quoc NGUYEN ; James NGUYEN ; Thach NGUYEN ; Massimo GIORDAN
Chinese Medical Journal 2012;125(19):3561-3564
5.Therapeutic Trends of Cerebrovascular Disease during the COVID-19 Pandemic and Future Perspectives
James E. SIEGLER ; Mohamad ABDALKADER ; Patrik MICHEL ; Thanh N. NGUYEN
Journal of Stroke 2022;24(2):179-188
As of May 2022, there have been more than 400 million cases (including re-infections) of the systemic acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), and nearly 5 million deaths worldwide. Not only has the coronavirus disease 2019 (COVID-19) pandemic been responsible for diagnosis and treatment delays of a wide variety of conditions, and overwhelmed the allocation of healthcare resources, it has impacted the epidemiology and management of cerebrovascular disease. In this narrative review, we summarize the changing paradigms and latest data regarding the complex relationship between COVID-19 and cerebrovascular disease. Paradoxically, although SARS-CoV-2 has been associated with many thrombotic complications—including ischemic stroke—there have been global declines in ischemic stroke and other cerebrovascular diseases. These epidemiologic shifts may be attributed to patient avoidance of healthcare institutions due to fear of contracting the novel human coronavirus, and also related to declines in other transmissible infectious illnesses which may trigger ischemic stroke. Despite the association between SARS-CoV-2 and thrombotic events, there are inconsistent data regarding targeted antithrombotics to prevent venous and arterial events. In addition, we provide recommendations for the conduct of stroke research and clinical trial planning during the ongoing COVID-19 pandemic, and for future healthcare crises.
6.Antibiotic-Resistant Gram-negative Bacteria Carriage in Healthcare Workers Working in an Intensive Care Unit
Bich Thuy DUONG ; Minh Cuong DUONG ; James CAMPBELL ; Van Minh Hoang NGUYEN ; Huu Hien NGUYEN ; Thi Bich HANH BUI ; Van Vinh Chau NGUYEN ; Mary-Louise MCLAWS
Infection and Chemotherapy 2021;53(3):546-552
Little is known about antibiotic-resistant Gram-negative bacteria (GNB) intestinal carriage among healthcare workers (HCWs) in Vietnam. All HCWs at a tertiary intensive care units were asked to undertake weekly rectal swabs. Among 40 participants, 65% (26/40) carried extended spectrum β-lactamases (ESBL)/AmpC β-lactamase-producing Escherichia coli. Two HCWs colonized with ESBL/AmpC β-lactamase-producing Klebsiella pneumoniae. One HCW colonized with Acinetobacter baumannii. No one carried Pseudomonas spp.. A quarter (10/40) of HCWs were identified as persistent and frequent carriers. There is an urgent need to screen antibiotic-resistant GNB among HCWs and improve HCWs' hand hygiene compliance to reduce the transmission of antibiotic-resistant GNB in the hospital.
7.Antibiotic-Resistant Gram-negative Bacteria Carriage in Healthcare Workers Working in an Intensive Care Unit
Bich Thuy DUONG ; Minh Cuong DUONG ; James CAMPBELL ; Van Minh Hoang NGUYEN ; Huu Hien NGUYEN ; Thi Bich HANH BUI ; Van Vinh Chau NGUYEN ; Mary-Louise MCLAWS
Infection and Chemotherapy 2021;53(3):546-552
Little is known about antibiotic-resistant Gram-negative bacteria (GNB) intestinal carriage among healthcare workers (HCWs) in Vietnam. All HCWs at a tertiary intensive care units were asked to undertake weekly rectal swabs. Among 40 participants, 65% (26/40) carried extended spectrum β-lactamases (ESBL)/AmpC β-lactamase-producing Escherichia coli. Two HCWs colonized with ESBL/AmpC β-lactamase-producing Klebsiella pneumoniae. One HCW colonized with Acinetobacter baumannii. No one carried Pseudomonas spp.. A quarter (10/40) of HCWs were identified as persistent and frequent carriers. There is an urgent need to screen antibiotic-resistant GNB among HCWs and improve HCWs' hand hygiene compliance to reduce the transmission of antibiotic-resistant GNB in the hospital.
8.Review of the role of EBUS-TBNA for the pulmonologist, including lung cancer staging.
David FIELDING ; Farzad BASHIRZADEH ; Phan NGUYEN ; Alan HODGSON ; James DANIEL
Chinese Journal of Lung Cancer 2010;13(5):410-417
Adult
;
Aged
;
Biopsy, Fine-Needle
;
adverse effects
;
methods
;
Bronchi
;
diagnostic imaging
;
pathology
;
Endosonography
;
adverse effects
;
methods
;
Female
;
Humans
;
Lung Neoplasms
;
diagnosis
;
pathology
;
Male
;
Middle Aged
;
Neoplasm Staging
9.Neuroimaging of Acute Ischemic Stroke: Multimodal Imaging Approach for Acute Endovascular Therapy
Mohamad ABDALKADER ; James E. SIEGLER ; Jin Soo LEE ; Shadi YAGHI ; Zhongming QIU ; Xiaochuan HUO ; Zhongrong MIAO ; Bruce C.V. CAMPBELL ; Thanh N. NGUYEN
Journal of Stroke 2023;25(1):55-71
Advances in acute ischemic stroke (AIS) treatment have been contingent on innovations in neuroimaging. Neuroimaging plays a pivotal role in the diagnosis and prognosis of ischemic stroke and large vessel occlusion, enabling triage decisions in the emergent care of the stroke patient. Current imaging protocols for acute stroke are dependent on the available resources and clinicians’ preferences and experiences. In addition, differential application of neuroimaging in medical decision-making, and the rapidly growing evidence to support varying paradigms have outpaced guideline-based recommendations for selecting patients to receive intravenous or endovascular treatment. In this review, we aimed to discuss the various imaging modalities and approaches used in the diagnosis and treatment of AIS.
10.Increased Neutrophil Elastase in Affected Lobes of Bronchiectasis and Correlation of Its Levels between Sputum and Bronchial Lavage Fluid
Lam NGUYEN-HO ; Hoang Kim Tu TRINH ; Vu LE-THUONG ; Kieu Minh LE ; Van Thanh Niem VO ; Diem My VU ; Ngoc TRAN-VAN ; James D. CHALMERS
Tuberculosis and Respiratory Diseases 2025;88(2):399-407
Background:
Neutrophil elastase (NE) has been proposed as a potential biomarker for evaluating the severity and prognosis of bronchiectasis. This study aimed to compare bronchial lavage quantification of NE levels and activities with those of sputum.
Methods:
A cross-sectional study was conducted in which 24 Vietnamese adults with bronchiectasis were enrolled from June 2023 to August 2023. All participants underwent bronchoscopy to collect bronchial lavage fluid (BLF) from two bronchial locations: one in the region with the greatest bronchial dilatation and one in the normal bronchi or in patients with all lobes affected, the least abnormal lobe (abnormal BLF [ABLF] and normal BLF [NBLF], respectively). Spontaneously expectorated sputum was also collected.
Results:
Out of 24 cases, the prevalence of mild, moderate and severe bronchiectasis was 14/24 (58.4%), 5/24 (20.8%), and 5/24 (20.8%), respectively. NE concentration and activity were significantly higher in sputum and ABLF than in NBLF (p<0.001). Sputum and ABLF were highly correlated (r=0.841, p<0.001) with no significant difference in NE activity between sputum and ABLF. Higher levels of NE activity were seen in more severe bronchiectasis than in mild bronchiectasis in all samples but were only statistically significant for NE activity in sputum (r=0.418, p=0.042).
Conclusion
NE activity and concentration are elevated in areas of the lung most affected by bronchiectasis. Sputum is a valid surrogate of pulmonary NE levels, as they correlate strongly with ABLF and confirm in a Vietnamese population the relationship between NE activity and disease severity.