No abstract available.

No abstract available.

Mefloquine is a common anti-malarial agent used for the treatment and prophylaxis of malaria. Here we report a case of a 39-year-old, otherwise healthy woman from South Korea, who had developed visual and auditory hallucination with sleep disturbance after oral administration of mefloquine before traveling to an endemic region. To our knowledge, this would be the first reported case of mefloquine-induced psychosis in South Korea to date. This report underlines the importance of awareness and detection of neuropsychiatric side effects of mefloquine.
Administration, Oral ; Female ; Hallucinations ; Humans ; Malaria ; Mefloquine ; Psychotic Disorders ; Republic of Korea

No abstract available.
Hospitalization ; Humans

Treatment of schizophrenia is one of the most challenging areas in the field of psychiatry. There has been much improvement in psycho-pharmacotherapy, and at present, psycho-pharmacotherapy along with milieu therapy and social rehabilitation is the standard first-line treatment for schizophrenia. Healing environment, a concept which has arisen from the architectural field, has similarities in meaning to milieu therapy in psychiatry. In other words, healing environment may be an encountering point between psychiatry and architecture. In this encountering, each field can understand each other and expand its concept to aid the treatment of schizophrenia and to plan the build-up of the entire environment considering its social and psychological effects. In this paper, we aim to establish the basic concept of healing environment to alleviate the psychopathologies in schizophrenic patients. We worked under the premise that physical setting affects human behavior and mind, and that physical setting should play a role as a medium with therapeutic potential for patients with medical problems. The aims of this paper are as follows. First, theoretical discussion of the concept and the constructs of healing environment : second, understanding of the schizophrenic symptoms that may be affected by supporting environment : and third, discussion of supporting environment that may alleviate the symptoms of schizophrenia.
Humans ; Milieu Therapy ; Rehabilitation ; Schizophrenia*

Tic disorder is a childhood-onset neuropsychiatric disorder that is characterized by both motor or phonic tics. Two thirds of children with tic disorder experience reduction or complete resolution of tic symptoms during adolescence. Doluble-blind trial have demonstrated that the typical antipsychotics are better than placebo. Recently, atypical antipsychotics have been used successfully. A 37- year- old man, was diagnosed with chronic motor tic disorder during childhood. Over the last 27 years, his tic symptoms have improved. At the age of thirty-seven, he abruptly developed complex motor and vocal tics. The mMotor tics included shoulder shrugging, and neck and leg movement. The severity of tics was assessed at baseline using the Yale global tic severity scale(YGTSS) before initiating treatment. Global severity score of YGTSS at baseline was 58. He was initially prescribed with aripiprazole 5mg /day. After two days, his global severity score of YGTSS decreased to 20, and. this improvement was maintained for eight weeks. Aripiprazole, a newer atypical antipsychotic with a unique pharmacodynamic profile, appears to be efficacious in treatment of tic disorder.
Adolescent ; Antipsychotic Agents ; Child ; Humans ; Leg ; Neck ; Shoulder ; Tic Disorders* ; Tics*

Here we report a case of serotonin syndrome caused by fluoxetine 20 mg and duloxetine 60 mg independently eight week apart. A 65-year old man developed fever, agitation and change of mental status after two weeks treatment with 20 mg of fluoxetine for depressive disorder. He was diagnosed unknown fever origin and discharged when fever subsided as antidepressant stopped. Eight weeks later he was prescribed 60 mg of duloxetine for the treatment of depressed mood. After 18 days on duloxetine he developed fever, agitation, myoclonus and change in mental status again. He improved rapidly after discontinuation of offending drug with supportive care. Despite serotonin syndrome is usually caused by poly-pharmacy of serotonergic drugs, this case shows unusual serotonin syndrome developed by therapeutic dose of two drugs of different classes independently.
Depressive Disorder ; Dihydroergotamine ; Fever ; Fluoxetine ; Humans ; Myoclonus ; Serotonin ; Serotonin Agents ; Serotonin Syndrome ; Thiophenes ; Duloxetine Hydrochloride

Recently the use of hydrochloric acid as a toilet disinfectant has become more common, and the risk of its ingestion is though to be increasing. We experienced a case of 67 year-old man who accidentally ingested hydrochloric acid and as a result developed a postprandial epigastric fullness end pain 3 weeks thereafter, The patient underwent an UGI series, fiberoptic gastroscope and abdominal ultrasonography and was found to have a gastric midbody stricture. A total gastreetomy and Roux-en- Y esophagojejunostomy was performed. We report this case with brief review of the literature.
Aged ; Constriction, Pathologic ; Eating ; Gastritis* ; Gastroscopes ; Humans ; Hydrochloric Acid* ; Ultrasonography

OBJECTIVE: Circadian rhythm is cyclic variations in biological activity, which is crucial for physiology in mammals and alterations in circadian rhythm may be related to mood disorders. However, the effect of mood disorder medications on peripheral tissue is less understood. In this study, we investigated whether treatment with antidepressants, antipsychotics, and mood stabilizers in rat fibroblast influenced circadian rhythm. METHODS: Lithium, bupropion, risperidone, lamotrigine, and paroxetine were used on cultured NIH3T3, peripheral rat fibroblast and we observed the periodic oscillation and rhythmicity of Per2, Bmal1 mRNA for 48 hours. RESULTS: We found that lithium has a dose-dependent effect on phase change of circadian rhythm and buproipion has a tendency to dampen the amplitude. Risperidone, lamotrigine, and paroxetine had no influence on circadian rhythm in NIH3T3 cell. CONCLUSION: These results suggest that lithium treatment may have an effect on circadian rhythm lengthening in peripheral fibroblast tissue.
Animals ; Antidepressive Agents ; Antipsychotic Agents ; Bupropion ; Circadian Rhythm ; Fibroblasts ; Lithium ; Mammals ; Mood Disorders ; Paroxetine ; Periodicity ; Rats ; Risperidone ; RNA, Messenger ; Triazines

There have been a few case reports that clozapine, an atypical antipsychotic, caused acute renal failure of interstitial type. Here we report a case of a 38-year-old Korean male patient with treatment-resistant bipolar I disorder who developed acute renal failure after the initiation of treatment with clozapine. We describe the clinical and laboratory findings of the case and discuss the measures for early detection of this life threating condition. Within our knowledge, this is the first report of clozapine-induced acute renal failure in South Korea.
Acute Kidney Injury ; Clozapine ; Humans ; Male ; Nephritis, Interstitial ; Republic of Korea