1.The effects of lactation on spinal bone mineral density in healthy postpartum women.
Jai Hyuck YANG ; Jung Bae YOO ; Soo Hyun CHO ; Yeoun Young HWANG ; Hyung MOON ; Doo Sang KIM ; Suck Shin CHO
Korean Journal of Obstetrics and Gynecology 1992;35(1):11-16
No abstract available.
Bone Density*
;
Female
;
Lactation*
;
Postpartum Period*
2.The Assessment of the Method of Monitoring in Liver Transplant Recipients Treated with Microemulsion Cyclosporine (Neoral(R)) and Mycophenolate Mofetil (CellCept(R)).
Sung Hoon YANG ; Kyung Suk SUH ; Nam Joon YI ; Hae Won LEE ; Choon Hyuck KOWN ; Jai Young CHO ; Yong Beom CHO ; Eung Ho CHO ; Kuhn Uk LEE
The Journal of the Korean Society for Transplantation 2005;19(2):175-181
PURPOSE: Cyclosporine (CsA) dosing is traditionally based on trough levels (C0) rather than area under the concentration- time curve (AUC), although AUC correlates better with post- transplantation acute rejection and toxicity. It was reported that C2 (2-hour post-dose blood level) is an accurate single- sample marker for AUC0-4 in patients receiving CsA. No trials of C2 monitoring have been carried out in liver transplant recipients who are immunosuppressed with the combination of CsA and Mycophenolate Mofetil (MMF). The purpose of this study was to evaluate the correlation between C0, 1, 2, 3, 4 levels and AUC0-4 and define recommended target C2 in liver transplant recipients who are treated with CsA and MMF. METHODS: Thirty adult living donor liver transplant recipients were followed up 12 weeks after transplantation. CsA and MMF were administered in all recipients. CsA dose was reduced to the half level of target C0 in recipients treated solely with CsA. C0 and C2 were measured during in-patient period post-transplant. RESULTS: The best correlation between CsA concentration at various time points and the AUC0-4 was found at C2 (r2=0.931) (P<0.05). Mean C2 was 543.2+/-260.1 ng/mL (mean+/-SD). We observed complications associated with the immunosuppressants in six patients (20%). But, only one patient experienced acute rejection proven by biopsy and, there is no the graft loss and nephrotoxicity. CONCLUSION: In early post-transplant days, AUC0-4 was strongly correlated with C2. Reduced CsA dosing can be attempted in recipients who are immunosuppressed with the combination of CsA and MMF. The optimal target C2 probably can be suggested as about 543.2+/-260.1 ng/mL (mean+/-SD). During the in-patient period, C0 matched with target C2 can be decided. Target C0 can be individualized because C0 matched with target C2 differs in each recipients and C2 can't be checked routinely during the out-patient period.
Adult
;
Area Under Curve
;
Biopsy
;
Cyclosporine*
;
Humans
;
Immunosuppressive Agents
;
Liver Transplantation
;
Liver*
;
Living Donors
;
Outpatients
;
Transplantation*
;
Transplants
3.Terlipressin Effect of Portal Pressure Control on Liver Regeneration in 90% Hepatectomized Rats.
Nam Joon YI ; Seong Hwan CHANG ; Choon Hyuck KWON ; Jai Young CHO ; Eun Lan YANG ; Kyung Suk SUH ; Kuhn Uk LEE ; Eung Bum PARK
Journal of the Korean Surgical Society 2005;69(2):157-165
PURPOSE: Liver regeneration is crucial following major liver resection or partial liver transplantation. The inhibition mechanism of regeneration is portal hypertension caused by excessive portal flow to the small liver. Portal hypertension can be controlled with terlipressin, an effective splanchnic vasoconstrictor. The purpose of this study was to investigate the effect of terlipressin on the portal pressure and liver regeneration in 90% hepatectomized rats. METHODS: Forty-eight male Sprague-Dawley (250 gm) rats were divided into three groups; Group N (n=16) underwent Sham operation, Group C (n=16) was injected with 0.1 mL saline after 90% hepatectomy, and Group T (n=16) was injected with 50microgram/kg terlipressin after 90% hepatectomy. To assess the liver regeneration response, the changes in proliferating cell nuclear antigen (PCNA) and tumor necrosis factor-alpha (TNFalpha) were monitored for 48 hours. RESULTS: The baseline portal pressures in Groups N, C, and T were 4.9, 12.4, and 14.1 mmHg (P<0.05). In Group T, the injection of terlipressin induced a significant reduction of the portal pressure (-30.2%, P<0.05). There was no difference in PCNA between Groups C and T. However, serum TNFalpha levels were significantly higher in Group T (248.4 pg/ mL) than Group C (52.3 pg/mL) 48 hours postoperatively (P<0.05). CONCLUSION: The control of portal pressure with the use of terlipressin was correlated with serum TNFalpha. These data provide evidence that the administration of terlipressin during the early postoperative period following major liver resection may have an attenuating effect on portal hypertension, which may also stimulate the initiation of the regenerative process.
Animals
;
Hepatectomy
;
Humans
;
Hypertension, Portal
;
Liver Regeneration*
;
Liver Transplantation
;
Liver*
;
Male
;
Portal Pressure*
;
Postoperative Period
;
Proliferating Cell Nuclear Antigen
;
Rats*
;
Rats, Sprague-Dawley
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Regeneration
;
Tumor Necrosis Factor-alpha
4.Analysis of Androgen Receptor Gene in Korean Patients with Androgen Insensitivity Syndrome.
Seo Yeong PARK ; Young Min CHOI ; Sung Hyo PARK ; Se Won YANG ; Seung Yup KU ; Seok Hyun KIM ; Soo Woong KIM ; Jai Seung PAIK ; Do Hoon YANG ; Doo Seok CHOI ; Hyuck Chan KWON ; Dong Hee CHOI ; Sook Hwan LEE
Korean Journal of Obstetrics and Gynecology 2001;44(4):655-662
Androgen insensitivity syndrome (AIS) is a X-linked disorder of sexual differentiation resulting from defective androgen receptor (AR) function. Androgens are secreted by the testes of 46,XY individuals, but there is loss of target organ response to the hormone. The abnormalities of AR are due to defects in the AR gene, and many mutations causing AIS have been reported since the cloning of AR gene. In this study, we analyzed the AR genes in twelve Korean patients with androgen insensitivity syndrome: 9 patients with complete AIS and 3 patients with partial AIS DNAs were isolated from patients with AIS, and the coding region of AR gene was amplified by a polymerase chain reaction using 7 pairs of primers (exon B-H). Sequence analysis of the AR gene was performed using direct sequencing and single strand conformational polymorphism (SSCP). The AR gene mutations were identified in 7 out of 12 patients: 6 of 9 patients with complete AIS, and one of 3 patients with partial AIS. Mutations found were as follows: the point mutation (ATT->ACT) at position 680 of exon D, point mutation (TGG->TGC) at position 751 of exon E, point mutation (CAA->TAA) at position 792 of exon F, point mutations (CGC->TGC, GTG->ATG) at position 855 and 866 of exon G, and the deletion of 13 nucleotides (CGTATCATTGCAT) at position 840 of exon G, respectively. To the best of our knowledge, the point mutations found in exon D, exon E, and exon F, and the deletion in exon G have not been observed before. SSCP revealed bands with abnormal mobility in 10 out of 12 patients tested. Mutations were found 5 out of these 10 patients. The other two patients showed no abnormal band on SSCP, but showed mutations by direct sequencing. In conclusion, we have demonstrated the AR gene mutations, including three novel mutations, in Korean patients with AIS, and these abnormalities might be related to the pathogenesis of androgen insensitivity syndrome.
Androgen-Insensitivity Syndrome*
;
Androgens
;
Clinical Coding
;
Clone Cells
;
Cloning, Organism
;
DNA
;
Exons
;
Humans
;
Male
;
Nucleotides
;
Point Mutation
;
Polymerase Chain Reaction
;
Polymorphism, Single-Stranded Conformational
;
Receptors, Androgen*
;
Sequence Analysis
;
Sex Differentiation
;
Testis
5.Clinical Usefulness of Sentinel Lymph Node Biopsy in the Surgical Treatment of Malignant Melanoma.
Sung Mo HUR ; Sung Hoon KIM ; Se Kyung LEE ; Wan Wook KIM ; Jae Hyuck CHOI ; Sangmin KIM ; So Young LIM ; Jai Kyung PYON ; Goo Hyun MUN ; Jun Ho CHOE ; Jeong Eon LEE ; Jee Soo KIM ; Seok Jin NAM ; Jung Hyun YANG ; Jung Han KIM
Journal of the Korean Surgical Society 2010;79(3):163-172
PURPOSE: The aim of this study was to evaluate the usefulness of sentinel lymph node (SLN) biopsy in the treatment of primary melanoma. METHODS: Fifty-one cases that were diagnosed as malignant melanoma of the skin without clinical evidence of regional lymph node metastasis and underwent SLN biopsy at Samsung Medical Center were analyzed retrospectively. A lymphoscintigraphy with peritumoral injection of radionuclide was performed preoperatively. SLNs were identified using a hand-held gamma probe and by methylene blue dye injection intraoperatively. RESULTS: Twenty patients (39%) had metastasis in the SLN and they underwent immediate complete radical dissection of the nodal basin. Among the 20 patients who had SLN metastasis, additional metastatic lymph nodes were detected in 5 patients after the complete lymph node dissection. When several clinico-pathologic parameters such as gender, age, primary tumor location, draining nodal basin, tumor depth and size of tumor were compared between SLN positive group and negative group, there was a significant difference in the mean thickness of melanoma between SLN (+) group (5+/-2.9 mm) and SLN (-) group (4.5+/-5.0 mm) (P<0.05). In the same way, as the thickness of melanoma increased, positive SLN were detected more frequently (P<0.05). Recurrences occurred in 18 patients (35.3%) during the follow-up period, but only one case in 31 patients with negative SLN recurred at the SLN basin without evidence of distant or loco-regional recurrence (false negative rate 4.8%). Lymphedema of extremity developed in 9 patients who underwent complete radical lymph node dissection and 2 patients who underwent only SLN biopsy had a very mild-form lymphedema. CONCLUSION: SLN biopsy in the treatment of cutaneous melanoma is a safe, useful and feasible method to identify status of regional lymph node with low false negative rates and low complications.
Biopsy
;
Extremities
;
Follow-Up Studies
;
Humans
;
Lymph Node Excision
;
Lymph Nodes
;
Lymphedema
;
Lymphoscintigraphy
;
Melanoma
;
Methylene Blue
;
Neoplasm Metastasis
;
Nitriles
;
Pyrethrins
;
Recurrence
;
Retrospective Studies
;
Sentinel Lymph Node Biopsy
;
Skin
6.Current Status of Laparoscopic Liver Resection in Korea.
Joon Seong PARK ; Ho Seong HAN ; Dae Wook HWANG ; Yoo Seok YOON ; Jai Young CHO ; Yang Seok KOH ; Choon Hyuck David KWON ; Kyung Sik KIM ; Sang Bum KIM ; Young Hoon KIM ; Hyung Chul KIM ; Chong Woo CHU ; Dong Shik LEE ; Hong Jin KIM ; Sang Jae PARK ; Sung Sik HAN ; Tae Jin SONG ; Young Joon AHN ; Yung Kyung YOO ; Hee Chul YU ; Dong Sup YOON ; Min Koo LEE ; Hyeon Kook LEE ; Seog Ki MIN ; Chi Young JEONG ; Soon Chan HONG ; In Seok CHOI ; Kyung Yul HUR
Journal of Korean Medical Science 2012;27(7):767-771
Since laparoscopic liver resection was first introduced in 2001, Korean surgeons have chosen a laparoscopic procedure as one of the treatment options for benign or malignant liver disease. We distributed and analyzed a nationwide questionnaire to members of the Korean Laparoscopic Liver Surgery Study Group (KLLSG) in order to evaluate the current status of laparoscopic liver resection in Korea. Questionnaires were sent to 24 centers of KLLSG. The questionnaire consisted of operative procedure, histological diagnosis of liver lesions, indications for resection, causes of conversion to open surgery, and postoperative outcomes. A laparoscopic liver resection was performed in 416 patients from 2001 to 2008. Of 416 patients, 59.6% had malignant tumors, and 40.4% had benign diseases. A total laparoscopic approach was performed in 88.7%. Anatomical laparoscopic liver resection was more commonly performed than non-anatomical resection (59.9% vs 40.1%). The anatomical laparoscopic liver resection procedures consisted of a left lateral sectionectomy (29.3%), left hemihepatectomy (19.2%), right hemihepatectomy (6%), right posterior sectionectomy (4.3%), central bisectionectomy (0.5%), and caudate lobectomy (0.5%). Laparoscopy-related serious complications occurred in 12 (2.8%) patients. The present study findings provide data in terms of indication, type and method of liver resection, and current status of laparoscopic liver resection in Korea.
*Hepatectomy/statistics & numerical data
;
Humans
;
*Laparoscopy/statistics & numerical data
;
Liver/*surgery
;
Liver Diseases/pathology/surgery
;
Liver Neoplasms/pathology/surgery
;
Postoperative Complications/epidemiology
;
Questionnaires
;
Republic of Korea