1.A Case of Herpes Esophagitis Confirmed by Electron Microscopic Findings.
Dae Soon YIM ; Jae Bock CHUNG ; Won Ho KIM ; Sang In LEE ; Jin Kyung KANG ; In Suh PARK ; Heung Jai CHOI ; Min Geol LEE
Korean Journal of Gastrointestinal Endoscopy 1991;11(1):73-76
Herpetic esophagitis is a rare disease occuring mostly ie immunocompromised and cancer patient. It is also documented as self-limiting esopbagitis in young healthy adults. We report here a 30- year-old immunocompetent male patient with esophageal ulceration. Heryetic esophagitis was diagnosed by characteristic endoscopic and microscopic findings. And the diagnosis was confirmed by electron microscopic appearance. This immunocompetent patient recovered spontaneously with symptomatic treatment only. And repeat endoscopy and histology confirmed absence of herpes infection.
Adult
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Diagnosis
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Endoscopy
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Esophagitis*
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Humans
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Male
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Rare Diseases
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Ulcer
2.Evaluation of Biocompatibility of Extracorporeal Circuit: Development of a Quantification Technique using Invivo Injection of Tc99m Radioactive Platelets.
Sung Ho LEE ; Kyung SUN ; Jai Geol CHOI ; Ho Sung SON ; Jae Seung JUNG ; Sang Soo AHN ; Hye Jung OH ; Whan Sung LEE ; Hye Won LEE ; Kwang Taik KIM ; Yoon Seop JEONG ; Young Ha KIM ; Hyoung Mook KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 2002;35(3):171-176
BACKGROUND: Blood-foreign interaction cause activation of coagulation and inflammatory process that may lead to multiorgan dysfunction and determine the surgical outcomes.Of the methods for assessing the biocompatibility,the platelet adhesion study is considered as the most valuable evaluation step in blood-foreign interaction.As the most studies have used in-vitro or ex-vivo conditions,we have developed a technique of quantification for platelet adhesion on the blood contact surface by using in-vivo injection of radioactive platelets. MATERIAL AND METHOD: A coupled bypass circuit was designed to connect the proximal and descending thoracic aorta in 6 piglets(20~25 Kg).One side of the circuit tube was consisted of a heparin coated PVC tube(10mm in ID, n=6, Experimental group),and the other,a non-heparin coated PVC tube(10mm in ID, n=6, Control group).After cannulation,the blood was circulated through the circuit for 2 hours. Platelet concentrate was prepared from homologous pig blood 24 hours before the experiment.The platelet concentrate was incubated with Tc-99m-HMPAO for 30 min and then centrifuged for 10 min.The supernatant was discarded and the radio-labeling efficacy was measured.The radio-labeled platelet concentrate was mixed with the autologous plasma to make the volume 5 ml,and the mixture was injected intravenously into the experimental animal.After 2 hour circulation, 5 pieces of the specimen(10mm in length each)were obtained from each PVC tube.The radioisotopes were counted with a gamma counter(Cobra II,Packard,USA),and the ratio of radioisotope count was compared between the control and experimental group. RESULT: The radioisotope count number was 537.3221.1 Ci/min in the control group and 311.1 184.5 Ci/min in the experimental group(p=0.0104).The ratio between the groups was 1 to 0.58 (p=0.004). CONCLUSION: In vivo quantification using technetium-99m-HMPAO labeled platelets is simple and reproducible in evaluating platelet adhesion on a foreign surface.We suggest this technique to be a useful tool for blood compatibility test.
Aorta, Thoracic
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Blood Platelets
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Heparin
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Plasma
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Radioisotopes
3.The Profile of Early Sedation Depth and Clinical Outcomes of Mechanically Ventilated Patients in Korea
Dong-gon HYUN ; Jee Hwan AHN ; Ha-Yeong GIL ; Chung Mo NAM ; Choa YUN ; Jae-Myeong LEE ; Jae Hun KIM ; Dong-Hyun LEE ; Ki Hoon KIM ; Dong Jung KIM ; Sang-Min LEE ; Ho-Geol RYU ; Suk-Kyung HONG ; Jae-Bum KIM ; Eun Young CHOI ; JongHyun BAEK ; Jeoungmin KIM ; Eun Jin KIM ; Tae Yun PARK ; Je Hyeong KIM ; Sunghoon PARK ; Chi-Min PARK ; Won Jai JUNG ; Nak-Jun CHOI ; Hang-Jea JANG ; Su Hwan LEE ; Young Seok LEE ; Gee Young SUH ; Woo-Sung CHOI ; Keu Sung LEE ; Hyung Won KIM ; Young-Gi MIN ; Seok Jeong LEE ; Chae-Man LIM
Journal of Korean Medical Science 2023;38(19):e141-
Background:
Current international guidelines recommend against deep sedation as it is associated with worse outcomes in the intensive care unit (ICU). However, in Korea the prevalence of deep sedation and its impact on patients in the ICU are not well known.
Methods:
From April 2020 to July 2021, a multicenter, prospective, longitudinal, noninterventional cohort study was performed in 20 Korean ICUs. Sedation depth extent was divided into light and deep using a mean Richmond Agitation–Sedation Scale value within the first 48 hours. Propensity score matching was used to balance covariables; the outcomes were compared between the two groups.
Results:
Overall, 631 patients (418 [66.2%] and 213 [33.8%] in the deep and light sedation groups, respectively) were included. Mortality rates were 14.1% and 8.4% in the deep and light sedation groups (P = 0.039), respectively. Kaplan-Meier estimates showed that time to extubation (P < 0.001), ICU length of stay (P = 0.005), and death P = 0.041) differed between the groups. After adjusting for confounders, early deep sedation was only associated with delayed time to extubation (hazard ratio [HR], 0.66; 95% confidence inter val [CI], 0.55– 0.80; P < 0.001). In the matched cohort, deep sedation remained significantly associated with delayed time to extubation (HR, 0.68; 95% 0.56–0.83; P < 0.001) but was not associated with ICU length of stay (HR, 0.94; 95% CI, 0.79–1.13; P = 0.500) and in-hospital mortality (HR, 1.19; 95% CI, 0.65–2.17; P = 0.582).
Conclusion
In many Korean ICUs, early deep sedation was highly prevalent in mechanically ventilated patients and was associated with delayed extubation, but not prolonged ICU stay or in-hospital death.
4.The Clinical Profile of Patients with Psoriasis in Korea: A Nationwide Cross-Sectional Study (EPI-PSODE).
Hae Jun SONG ; Chul Jong PARK ; Tae Yoon KIM ; Yong Beom CHOE ; Seok Jong LEE ; Nack In KIM ; Jae We CHO ; Jie Hyun JEON ; Min Soo JANG ; Jai Il YOUN ; Myung Hwa KIM ; Joonsoo PARK ; Ki Ho KIM ; Byung Soo KIM ; Sang Woong YOUN ; Joo Heung LEE ; Min Geol LEE ; Sung Ku AHN ; Young Ho WON ; Seok Kweon YUN ; Bong Seok SHIN ; Seong Jun SEO ; Ji Yeoun LEE ; Kwang Joong KIM ; Young Suck RO ; Youngdoe KIM ; Dae Young YU ; Jee Ho CHOI
Annals of Dermatology 2017;29(4):462-470
BACKGROUND: Psoriasis is an immune-mediated, chronic inflammatory disease affecting multiple aspects of patients' lives. Its epidemiology varies regionally; however, nationwide epidemiologic data on psoriasis depicting profile of Korean patients has not been available to date. OBJECTIVE: To understand nationwide epidemiologic characteristics and clinical features of adult patients with psoriasis visited university hospitals in Korea. METHODS: This multicenter, non-interventional, cross-sectional study recruited 1,278 adult patients with psoriasis across 25 centers in Korea in 2013. Various clinical data including PASI, BSA, DLQI, SF-36 and PASE were collected. RESULTS: A total of 1,260 patients completed the study (male:female=1.47:1). The mean age was 47.0 years with a distribution mostly in the 50s (24.9%). Early onset (<40 years) of psoriasis accounted for 53.9% of patients. The mean disease duration was 109.2 months; mean body mass index was 23.9 kg/m²; and 12.7% of patients had a family history of psoriasis. Plaque and guttate types of psoriasis accounted for 85.8% and 8.4%, respectively. Patients with PASI ≥10 accounted for 24.9%; patients with body surface area ≥10 were 45.9%. Patients with DLQI ≥6 accounted for 78.8%. Between PASI <10 and PASI ≥10 groups, significant difference was noted in age at diagnosis, disease duration, blood pressure, waist circumference of female, and treatment experiences with phototherapy, systemic agents, and biologics. CONCLUSION: This was the first nationwide epidemiologic study of patients with psoriasis in Korea and provides an overview of the epidemiologic characteristics and clinical profiles of this patient population.
Adult
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Biological Products
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Blood Pressure
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Body Mass Index
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Body Surface Area
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Cross-Sectional Studies*
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Diagnosis
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Epidemiologic Studies
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Epidemiology
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Female
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Hospitals, University
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Humans
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Korea*
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Phototherapy
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Psoriasis*
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Waist Circumference