Objective: The purpose of our study was to identify the correlation between clinical characteristics and behavioral psychological symptoms of dementia (BPSD) and to identify factors that predict BPSD changes. Methods: Demographic characteristics were collected and BPSD was assessed using the Korean version of Neuropsychiatric Inventory (K-NPI) for 213 patients with Alzheimer’s disease. BPSD was reassessed to identify changes in the K-NPI score for 65 of the 213 patients. Seoul Neuropsychological Screening Battery was conducted to evaluate specific cognitive functions. Correlation and stepwise regression analyses were conducted to identify the association between several factors and the baseline K-NPI total score. Logistic regression analysis was conducted to identify predictors of improvement of BPSD. Results: Stepwise analysis showed that the baseline K-NPI total score was significantly affected by higher Seoul-Instrumental Activities of Daily Living and having family history of dementia. Multivariate logistic regression analysis showed that improvement of BPSD was significantly associated with a higher baseline K-NPI total score. However, changes in BPSD were not predicted by any specific cognitive functions. Conclusion Severe BPSD at baseline is a significant predictor of improvement of BPSD. The findings support that severe BPSD at baseline had more chance to benefit from the intervention. Therefore, clinicians need more intensive observation and early inter-vention for patients in the early stages of dementia.

Purpose: This clinical study sought to evaluate the possible clinical effectiveness and practicality of URINO, an innovative, incisionless, and disposable intravaginal device, designed for patients suffering from stress urinary incontinence. Methods: A prospective, multicenter, single-arm clinical trial was carried out, involving women diagnosed with stress urinary incontinence who used a self-inserted, disposable intravaginal pessary device. Comparisons were made between the results of the 20-minute pad-weight gain (PWG) test at baseline and visit 3, where the device was applied. After 1 week of device usage, compliance, satisfaction, the sensation of a foreign body, and adverse events were assessed. Results: Out of 45 participants, 39 completed the trial and expressed satisfaction within the modified intention-to-treat group. The average 20-minute PWG of participants was 17.2±33.6 g at baseline and significantly dropped to 5.3±16.2 g at visit 3 with device application. A total of 87.2% of participants exhibited a reduction ratio of PWG by 50% or more, surpassing the clinical trial success benchmark of 76%. The mean compliance was recorded as 76.6%±26.6%, the average visual analogue scale score for patient satisfaction was 6.4±2.6, and the sensation of a foreign body, measured on a 5-point Likert scale, was 3.1±1.2 after 1 week of device use. No serious adverse events were reported; there was 1 instance of microscopic hematuria and 2 cases of pyuria, all of which recovered. Conclusions The investigated device demonstrated significant clinical effectiveness and safety for patients with stress urinary incontinence. It was easy to use, showing favorable patient compliance. We propose that these disposable intravaginal pessaries could potentially be an alternative treatment for patients with stress urinary incontinence who are seeking nonsurgical options or are unable to undergo surgery.Trial Registration: The study was registered as a clinical trial (KCT0008369).