1.Correlation of Ki-67, p53 and bcl-2 Expression with Grade and Behavior of Ependymoma.
Korean Journal of Pathology 1999;33(9):723-728
Ependymomas constitute no more than 5 to 7% of all primary CNS neoplasm and their biologic behavior is difficult to predict by microscopic appearances. Recently, many studies have attempted to correlate biologic behavior with tumor proliferation index, tumor suppressor gene and oncogene using immunohistochemical stains. We evaluated 25 cases of surgically resected intracranial ependymomas for the proliferation activity using Ki-67, and expression of p53 and bcl-2 protein with regard to the prognosis. The cases were divided into 17 ependymomas (WHO Grade II), 3 papillary ependymomas (WHO Grade II), and 5 anaplastic ependymomas. Clinically, the patients were divided into two groups, recurrent (18 cases) or non-recurrent (7 cases). The Ki-67 proliferation index was significantly higher in the recurrent group (p<0.05) and in the younger ages (correlation index=0.534). Although Ki-67 proliferation index was higher in anaplastic ependymoma, it was not significant statistically (p>0.05). p53 protein expression tended to increase in the patients who had anaplastic ependymoma and in the recurrent group. bcl-2 expression was not correlated with histologic grade or recurrence of the tumor. We conclude that Ki-67 proliferation index and p53 expression are important markers for predicting biologic behavior of ependymoma.
Coloring Agents
;
Ependymoma*
;
Genes, Tumor Suppressor
;
Humans
;
Oncogenes
;
Prognosis
;
Recurrence
2.Two cases of distal renal tubular acidosis associated with immune-mediated diseases.
Korean Journal of Medicine 1993;45(5):664-669
No abstract available.
Acidosis, Renal Tubular*
3.Male Sexual Dysfunction Associated with the Treatment for Benign Prostatic Hyperplasia.
Jae Seung PAICK ; Soo Woong KIM
Korean Journal of Andrology 1998;16(2):121-128
No abstract available.
Humans
;
Male*
;
Prostatic Hyperplasia*
4.Prevalence of Penicillinase-Producing Neisseria Gonorrhoeae (PPNG) in Seoul (1995).
Annals of Dermatology 1997;9(4):258-262
BACKGROUND: In recent years gonorrhea has been pandemic and remains one of the most common sexually transmitted diseases(STD) in the world, especially in developing countries. OBJECTIVE & METHOD: For the detection of a more effective therapeutic regimen and to assess the prevalence of penicillinase-producing Neisseria gonorrhoeae (PPNG), we have been studying patients who have visited the VD Clinic of Choong-ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. RESULTS: In 1995, 97 strains of N. gonorrhoeae were isolated, among which 41(42.3%) were PPNG. CONCLUSION: Since the prevalence of PPNG was reported as 21.9% in 1981, the rate fluctuated. However, in 1993, there was an increase up to 74.3%. Thereafter, the prevalence rate decreased to 64.3% in 1994 and 42.3% in 1995. These changes will therefore need continuous observation.
Developing Countries
;
Gonorrhea
;
Humans
;
Methods
;
Neisseria gonorrhoeae*
;
Neisseria*
;
Pandemics
;
Prevalence*
;
Public Health
;
Seoul*
5.Upper Abdominal Pain.
Seung Jae MYUNG ; Myung Hwan KIM
Journal of the Korean Medical Association 1998;41(3):330-335
No abstract available.
Abdominal Pain*
6.Large hypopharyngeal schwannoma producing acute respiratory distress.
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(5):1080-1082
No abstract available.
Neurilemmoma*
8.A Clinical Study of the Effects of Finasteride on Androgenetic Alopecia.
Seung Il KIM ; Jae Hak YOO ; Kea Jeung KIM
Annals of Dermatology 2000;12(4):264-270
BACKGROUND: The 5α-reductase inhibitor finasteride blocks the conversion of testosterone to dihydrotestosterone(DHT), the androgen responsible for androgen- etic alopecia in genetically predisposed men. OBJECTIVE: The purpose of this study was to determine the efficacy of finaster- ide treatment according to the type of androgenetic alopecia in Korea. METHODS: 196 patients with finasteride(1.25mg/day) were registered in this study and 68 patients were followed over 8 months. Efficacy was evaluated by globa1 photographs, investigator assessment of clinical change,and patients' self assessment via self administered hair growth questionnaire. RESULTS: Patients' self-assessment demonstrated that finasteride treatment slowed hair loss, increased hair growth, and improved appearance of hair. These improvements were corroborated by objective assessments after 4 months of treatment. Adverse effects such as sexual dysfunction were minimal. CONCLUSION: Oral finasteride 1.25mg/day slowed the progression of hair loss and increased hair growth in clinical tria1s of men with androgenetic alopecia over 8 months. With its generally good tolerability profile, finasteride is a new approach to the management of this condition, for which treatment options are few.
Alopecia*
;
Finasteride*
;
Hair
;
Humans
;
Korea
;
Male
;
Research Personnel
;
Self-Assessment
;
Testosterone
9.A clinical study of traumatic hemoperitoneum.
Seung Kyun PARK ; Jae Man KIM ; Han Sun KIM
Journal of the Korean Surgical Society 1993;45(4):517-526
No abstract available.
Hemoperitoneum*
10.Correction of the hump nose using excision of protruded nasal dorsum and nasal tip elevation.
Jae Deok KIM ; Seung Han KIM ; Moo Hyun PAIK ; Seung Hong KIM ; Dae Hong MIN
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1992;19(6):976-984
No abstract available.
Nose*