No abstract available.
Exanthema* ; Skin*

Melkersson-Rosenthal syndrome(MRS) is a rare neuro-muco-cutaneous disease of unknown origin. The classic triad of this clinically defined entity consists of orofacial swelling, facial nerve palsy, and lingua plitica. MRS may occur as a complete triad of symptoms or a combination of any features of the classic triad, termed monosymptomatic and oligosymptomatic forms. The complete triad has been reported to occur in only 10% to 20% in different series. Because of the rarity of reported cases in Korea, we report a case of complete form of MRS, in which clofazimine showed a partial response.
Clofazimine ; Facial Nerve ; Korea ; Melkersson-Rosenthal Syndrome* ; Paralysis

Lichen aureus is a variant of pigmented purpuric lichenoid dermatitis. The skin lesions usually appear asymptomatic rusty, copper, or orange colored roundish lichenoid erythematous-purpuric papules and patches on the lower extremities. Histologically, the epidermis shows minimal changes, with a dense lymphohistiocytic infiltrate observed in the superficial derrnis, typically distributed in a band-like fashion. The typical lesion is a single patch localized on the lower extremity. We report a rare case of segmental lichen aureus localized on the right lower extremity.
Citrus sinensis ; Copper ; Dermatitis ; Epidermis ; Lichens* ; Lower Extremity ; Skin

Pigmented lesions of palmar and plantar skin may cause diagnostic problems, because some features of benign lesions in these sites may raise the suspicion of melanoma if considered alone. Transepidermal elimlnation is a mechanism by which a substance is eliminated through the epidermis, and it is apt to be confused with a feature of melanoma that tumor cells are located at all layers of the epidermis. We report a case of transepidermal elimination of nevus cells in acral letiginous nevus which needs a differential dignosis of melanoma.
Epidermis ; Melanoma ; Nevus* ; Skin

BACKGROUND: Optimal management of cutaneous varicella-zoster virus(VZV) and herpes simplex virus(HSV) infections requires rapid and accurate diagnostic method. The Tzanck test is a simple, inexpensive and rapid method, but it shows relatively low sensitivity and cannot distinguish VZV and HSV. The viral culture is the reference method, but it is time-consuming and needs cell culture facilities. Direct immunofluorescence(DIF) method has been known to be rapid and sensitive, but it has not been widely used in Korea. OBJECTIVE: We compared the usefulness of DIF method to Tzanck smear in patients with VZV and HSV infections. METHODS: Smears were collected from the base of fresh vesicular lesions, from a total of 134 patients clinically suspected of having VZV or HSV infections. The two wells of IF slide were stained with FITC-conjugated VZV-specific and HSV-specific monoclonal antibody each. Apple-green fluorescence of cytoplasm was considered positive for VZV or HSV. Glass slide smears were made for Tzanck test and stained with Wright stain. Giant cells with enlarged nucleus were considered positive. RESULTS: Among the 107 patients suspected of having VZV infection, positive rates of DIF method and Tzanck test were 91.6% and 76.6%, respectively. The positive rates of HSV in 27 patients suspected of having HSV infection, were 92.6% and 74.1%, respectively. The positive rates of DIF method were higher than that of the Tzanck test in both VZV and HSV infections. CONCLUSION: The DIF method is a more sensitive and relatively rapid method for the diagnosis of cutaneous VZV and HSV infections.
Cell Culture Techniques ; Cytoplasm ; Diagnosis* ; Fluorescence ; Fluorescent Antibody Technique, Direct* ; Giant Cells ; Glass ; Herpes Simplex* ; Herpesvirus 3, Human* ; Humans ; Korea ; Simplexvirus*

BACKGROUND: Optimal management of cutaneous varicella-zoster virus(VZV) and herpes simplex virus(HSV) infections requires rapid and accurate diagnostic method. The Tzanck test is a simple, inexpensive and rapid method, but it shows relatively low sensitivity and cannot distinguish VZV and HSV. The viral culture is the reference method, but it is time-consuming and needs cell culture facilities. Direct immunofluorescence(DIF) method has been known to be rapid and sensitive, but it has not been widely used in Korea. OBJECTIVE: We compared the usefulness of DIF method to Tzanck smear in patients with VZV and HSV infections. METHODS: Smears were collected from the base of fresh vesicular lesions, from a total of 134 patients clinically suspected of having VZV or HSV infections. The two wells of IF slide were stained with FITC-conjugated VZV-specific and HSV-specific monoclonal antibody each. Apple-green fluorescence of cytoplasm was considered positive for VZV or HSV. Glass slide smears were made for Tzanck test and stained with Wright stain. Giant cells with enlarged nucleus were considered positive. RESULTS: Among the 107 patients suspected of having VZV infection, positive rates of DIF method and Tzanck test were 91.6% and 76.6%, respectively. The positive rates of HSV in 27 patients suspected of having HSV infection, were 92.6% and 74.1%, respectively. The positive rates of DIF method were higher than that of the Tzanck test in both VZV and HSV infections. CONCLUSION: The DIF method is a more sensitive and relatively rapid method for the diagnosis of cutaneous VZV and HSV infections.
Cell Culture Techniques ; Cytoplasm ; Diagnosis* ; Fluorescence ; Fluorescent Antibody Technique, Direct* ; Giant Cells ; Glass ; Herpes Simplex* ; Herpesvirus 3, Human* ; Humans ; Korea ; Simplexvirus*

Pityriasis lichenoides et varioliformis acuta is a cutaneous disease of unknown origin characterized by an acute polymorphous eruption which heals with superficial scarring and pigmentation. It occurs mainly in young adults and less commonly in children. Although various types of therapy have been proposed for pityriasis lichenoides, including systemic steroids, tetracycline, methotrexate, sulfones, an UV radiation, there is no definitive treatment and there is few studies of appropriate, efficacious therapy in children. We report a case of pityriasis lichenoides et varioliformis acuta in children treated with roxithromycin.
Child* ; Cicatrix ; Humans ; Methotrexate ; Pigmentation ; Pityriasis Lichenoides* ; Pityriasis* ; Roxithromycin* ; Steroids ; Sulfones ; Tetracycline ; Young Adult

Pityriasis lichenoides et varioliformis acuta is a cutaneous disease of unknown origin characterized by an acute polymorphous eruption which heals with superficial scarring and pigmentation. It occurs mainly in young adults and less commonly in children. Although various types of therapy have been proposed for pityriasis lichenoides, including systemic steroids, tetracycline, methotrexate, sulfones, an UV radiation, there is no definitive treatment and there is few studies of appropriate, efficacious therapy in children. We report a case of pityriasis lichenoides et varioliformis acuta in children treated with roxithromycin.
Child* ; Cicatrix ; Humans ; Methotrexate ; Pigmentation ; Pityriasis Lichenoides* ; Pityriasis* ; Roxithromycin* ; Steroids ; Sulfones ; Tetracycline ; Young Adult

Actinic granuloma presents in chronically sun-damaged skin as normally colored to erythematous papules that coalesce to form centrifugally enlarging annular patterns. Histologically, a granulomatous infiltrate of giant cells and histiocytes is seen to be intimately related to the presence of elastotic fibers in the upper dermis. We report a typical case of actinic granuloma that developed on the V-area of anterior chest in a 59-year-old male.
Actins* ; Dermis ; Giant Cells ; Granuloma* ; Histiocytes ; Humans ; Male ; Middle Aged ; Skin ; Thorax

Actinic granuloma presents in chronically sun-damaged skin as normally colored to erythematous papules that coalesce to form centrifugally enlarging annular patterns. Histologically, a granulomatous infiltrate of giant cells and histiocytes is seen to be intimately related to the presence of elastotic fibers in the upper dermis. We report a typical case of actinic granuloma that developed on the V-area of anterior chest in a 59-year-old male.
Actins* ; Dermis ; Giant Cells ; Granuloma* ; Histiocytes ; Humans ; Male ; Middle Aged ; Skin ; Thorax